RU2606835C1 - Phytocomplex for treating hepatic cirrhosis and method of treating using it - Google Patents

Abstract

FIELD: pharmaceutics.

SUBSTANCE: invention relates to phytocomplex for treating cirrhosis, containing means of internal and external application. Mean for internal use contains herbal tea with predominance of biologically active substances with antiseptic and adaptogenic action for preparation of water infusion and herbal tea with predominance of biologically active substances of regenerative action for preparation of alcohol infusion, and mean of external application contains herbal tea for preparation of oil infusion. Invention also relates to method of treating cirrhosis, which involves using said phytocomplex.

EFFECT: invention provides intensified antiseptic action and stimulation of rehabilitation process in cells of liver tissue at different stages of disease development.

2 cl, 6 ex

Description

The invention relates to medicine, in particular to herbal medicine, and can be used to treat cirrhosis of the liver.

The causes of liver disease can be different: intoxication, viral and chronic diseases. With a violation of normal functioning, liver cells are affected, a structural change in tissue occurs in it. Restorative therapy involves the use of antiviral and regenerative drugs that restore liver tissue by accelerating the division of healthy hypotocytes.

Since the use of synthetic drugs has a toxic effect on the body, the positive side of herbal medicine is especially favorable in the treatment of liver diseases as having a less harmful effect, without serious metabolic disturbance. The therapeutic effect of medicinal plants is due to the presence of biologically active substances in them, which contribute to the stabilization and improvement of metabolic processes in the body.

Known methods of treating chronic hepatitis and cirrhosis of the liver with the help of infusions and decoctions of medicinal plants that improve the metabolism of liver cells, have anti-inflammatory, detoxification effects [1-2]. Known fees do not include treatment at various stages of the disease, which manifests itself in chronic hepatitis and gradually turns into cirrhosis of the liver, and is rather a phytocorrection means that are not able to completely cure the disease.

According to RF patent No. 2089213, A61K 35/78, a multicomponent phytocorrection tool is known, which provides additives to the main composition, in particular for the treatment of liver dysfunctions (cirrhosis, fatty degeneration, metastasis). The product is based on plants used in folk medicine and contains 28 components (celandine, yarrow, raspberries, St. John's wort, birch, currants, wild strawberries, coltsfoot, chamomile, common tansy, peppermint, dioecious nettle, forest pine , medicinal sweet clover, five-lobed motherwort, ivory-shaped budra, bitter wormwood, European hoof, field horsetail, medicinal valerian, calendula officinalis, goose pads, chicory vulgaris, three-colored violet, wild rose, medicinal dandelion, blackberry, spores ). Treatment involves taking a decoction based on medicinal plants collection.

Of the 28 plants in the collection, only two have a regenerative effect. In a weight ratio it is 2 parts per 100, which will not be enough for regeneration. Only a sufficient content of regenerative herbs in the collection can provide a complete cure for cirrhosis.

It is difficult to single out their sources of information known to the applicant for the analogue closest to the claimed one by the similarity of the composition of medicinal plants that make up the collection for the phytocomplex, and by the achieved result in the treatment method.

The applicant's task is to cure patients with cirrhosis of the liver at various stages of the development of the disease.

EFFECT: increased antiseptic effect of the phytocomplex and stimulation of the recovery process in liver tissue cells at various stages of the development of the disease.

The technical result is achieved by the fact that the phytocomplex for the treatment of cirrhosis contains means of internal and external use. The means of internal use contains the collection of medicinal plants with a predominance of biologically active substances (BAS) of antiseptic and adaptogenic effects for the preparation of water infusion and the collection of medicinal plants with a predominance of biologically active substances of regenerative effect for the preparation of alcohol tinctures. The external product contains a collection of medicinal plants for the preparation of oil infusion.

The collection for the preparation of water infusion contains dried vegetable raw materials containing an antiseptic biologically active substance, which includes: grass repeshka, grass of the common redstalk, grass of red serratus, common calamus roots, grass of narrow-leaved tea, bark of branches and buds of aspen, tansy grass, celandine grass , lemon balm grass, penny woodpecker grass, middle stellate grass, Amur velvet bast and twig, broom wormwood grass, seed garlic bulbs, Daurian moonseed roots, bird mountain grass, bird crown grass oh, grass Boudreau hederacea, herb alfalfa, grass sweet grass, horsetail herb, herb nettle, wild berries and leaves barberry Amur, fragrant roots of Solomon's seal.

In addition to a group of plants containing a biologically active substance with a directed antiseptic effect, a collection of water infusions can be used to identify a group of adaptogens that have a restorative, tonic effect on the body, which contribute to the accumulation of glycogen in the muscles, heart and liver (Manchurian aralia roots, Schisandra berry, and potato roots) high, the roots of Sophora turning yellow, licorice roots, wide-bell roots) [3].

The ratio of the components in the collection of antiseptic action for the preparation of water infusion (wt.h.):

grass repeshka 10-12 bedstraw grass present 8-10 cog grass red 9-10 Calamus roots 17-19 narrow-leaved Ivan-tea grass 10-12 bark of branches and buds of aspen 11-13 tansy grass 10-12 celandine grass 9-12 lemon balm grass 8-9 grass lespedecy kopeechnikova 7-9 medium stellate grass 5-7 dioica nettle grass 8-9 bast and branches of Amur velvet 11-13 roots, berries, leaves of Amur barberry 9-14 roots bought fragrant 7-8 Dioscorea roots 8-10 grass wormwood 7-8 bulbs of garlic seed 5-7 Daurian moonseed roots 4-6 Highlander's grass 8-9 Crowned grass 6-8 ivy budrea grass 5-6 alfalfa seed grass 5-8 fragrant bison grass 7-8 horsetail grass 7-8 widebell roots 8-10 roots of aralia manchurian 7-8 roots of potato 5-7 the roots of Sophora yellowing 10-13 lemongrass berries 12-14 licorice roots 7-9

The collection of medicinal plants containing biologically active substances that have a regenerative effect on liver cells includes dried plant material, which includes: St. John's wort grass, cinnamon grass, marigold flowers, lemongrass berries, licorice roots, meadowsweet grass, purple sedum grass, seed coriander seeds, physalis fruits ordinary. The ratio of the components in the collection of regenerative action for the preparation of alcohol tinctures (wt.h.):

St. John's wort grass 14-16 dried grass 3-4 marigold flowers 10-13 lemongrass berries 12-14 licorice roots 7-9 meadowsweet grass 8-11 stonecrop purple grass 5-7 seed coriander seeds 6-8 fruits of physalis vulgaris 5-6

An external application for the treatment of cirrhosis is an oil infusion, which is prepared on the basis of the collection of medicinal plants, consisting of broad-root roots, Amur barberry roots, Amur bast and velvet branches, ivory grass buds, St. John’s wort, dried cinnamon grass, pennyweed grass, three-leaved grass , broom grass, celandine grass, stellate middle grass, stonecrop purple. The ratio of the components assembled for oil infusion (wt. H):

widebell roots 12-14 Amur barberry roots 8-10 bast and branches of Amur velvet 8-9 ivy budrea grass 6-8 St. John's wort grass 13-15 dried grass 4-5 grass lespedecy kopeechnikova 7-9 three-leaf grass watch 6-8 grass wormwood 5-7 celandine grass 6-8 medium stellate grass 4-5 stonecrop purple grass 8-10

Since with cirrhosis of the liver there is practically no healthy organ in the body, it is necessary to find a treatment that maximally covers the whole person, this explains the multicomponent collection. The collection of herbs included the most powerful plants of antiseptic and regenerative effects, which also have another therapeutic effect - detoxification, antisclerotic, sedative, which increase the body's resistance to external adverse effects, including stressful situations. The use of medicinal plants in assembly for the phytocomplex is due to the presence of biologically active substances (BAS) in their composition. In the proposed phytocomplex, plants contain biologically active substances such as flavonoids, tannins, coumarins, saponins, essential oils, organic acids, vitamins and trace elements.

Of the listed biologically active substances, the proposed composition contains flavonoids to a greater extent; they are included in the 18 components of the collection: Amur velvet, Amur barberry, dioscorea, St. John's wort, Ivan tea, nettle nettle, seed coriander, marigold, penny nettle, meadowsweet, stonecrop purple broom, crown-bearing serpukha, cinnamon, licorice, yellowing sophora, celandine, field horsetail. Flavonoids play an important role in the metabolism of plant cells and have a diverse pharmacological effect, which increases the scope of their therapeutic effect. Substances of P-vitamin action (polyphenols) increase the strength of capillaries, participate in redox processes, contribute to the relaxation of vasospasm, wound healing, and have local anti-inflammatory and astringent effects. The most significant purpose of flavonoids in the treatment of the liver is their hepatoprotective and choleretic effect. The mechanism of hepatoprotective action of many flavonoids is due to the binding of toxic free radicals and stabilization of cell membranes and lysosomes, which is confirmed by scientific studies [4-5].

Another large group of biologically active substances, 15 components of the proposed collection for the phytocomplex is tannins (roots of Manchurian aralia, common calamus roots, ivy grass, grass of the mountaineer, bird grass, St. John's wort, grass of red cattle, grass of willow tea, grass of nettle, calendula flowers, Daurian moon seed seed roots, tansy grass, burlap grass, cinnamon grass, broadbell roots, field horsetail grass), have an astringent effect, they are used as astringents and anti-inflammatory drugs. Astringents have the ability, when interacting with the protein of cells, tissues, tissue fluid of an animal organism, to compact them, densifying and contracting tissue, preventing bleeding. They also have some antimicrobial effect, based on the precipitation of proteins of microbial cells. Astringents protect the nerve endings of the mucous membrane of the stomach and intestines from irritation, slow intestinal motility, which helps to slow the progress of the contents [8].

Many medicinal plants contain saponins, which have an anti-inflammatory, sedative effect. In addition to the indicated action, medicinal plants containing saponins exhibit the following properties: grass of meadowsweet accelerates the regeneration of damaged tissues, has an astringent spasmolytic and choleretic effect; roots of Aralia Manchurian - tonic, stimulating effect and increase the body's resistance; ivy budra grass - choleretic effect; Highlander's grass - choleretic effect; roots bought fragrant - tonic and adaptogenic effect; purple stonecrop grass - used in violation of protein metabolism, enhances the regeneration of blood proteins; the roots of the wide bell have a strong antiseptic effect; horsetail grass - antiseptic and astringent effect [3].

The content in the collection of plants containing essential oils (Manchurian aralia roots, common calamus roots, seeds of coriander seeds, repesa grass, bulbs of garlic seeds) is due to their anti-inflammatory, antimicrobial and antiviral effects [3].

Most of the components of the collection to a greater or lesser extent contain vitamins and minerals, which play an important role in metabolism, the processes of assimilation and use of proteins, fats and carbohydrates, in the protective functions of various organs (common calamus, cactus, Amur velvet, St. John's wort, aromatic bison , asterisk is medium, ivan tea is narrow-leaved, dioica nettle, meadowsweet is dune-shaped, real bedstraw, marshmallow, garlic bulbs, celandine, field horsetail).

Vitamin A increases the body's resistance to infection. Vitamin A comes from plants to the human body in the form of a yellow carotene pigment, such collection plants as dicotyledonous nettle grass, sowing alfalfa grass, St. John's wort grass, dried calendula grass, marigold flowers are especially rich in carotene.

Calendula flowers contain B-carotene, which is a powerful antioxidant that can block the massive formation of free radicals that occurs in pathological conditions. It strengthens the immune system, increases the body's resistance.

Many components of the collection contain Vitamin C (ascorbic acid), which is a powerful antioxidant; it is involved in the regulation of redox processes, carbohydrate metabolism, and tissue regeneration; increases the body's resistance to infections, reduces vascular permeability. It has an antitoxic effect, with various poisonings it manifests itself as a reliable assistant to the liver. In addition, it creates a barrier to infections and increases vascular permeability. If the body lacks ascorbic acid, metabolic processes slow down, and liver cells become more susceptible to damage. The vitamin C assembly contains: dried grass, lemon balm grass, celandine grass, ivy budweed grass, Amur velvet bast grass, St. John's wort grass, St. John's wort grass, fragrant grass, red dentate grass, middle stellate grass, ivan tea grass, dioica grass , grass lespedeca kopeechnikova, grass meadowsweet, Schisandra berries, Schisandra grass, grass flaxseed grass, grass Crowned Serpentum, physalis fruits, bulbs of garlic, grass horsetail.

The selection of plants rich in vitamins contributes to their better assimilation when interacting with each other. Vitamin C is most active in the presence of a large group of plants containing flavanoids. The action of ascorbic acid protects carotene from oxidation, its better absorption and accumulation in the liver occur [6]. Vitamin C in combination with vitamin Ρ exhibits bilateral synergism, especially anti-inflammatory action [7].

The biologically active substances contained in the collection (broom wormwood, bird highlander, high potato, and physalis fruits) in the form of organic acids (malic, citric, oxalic, salicylic, etc.) actively participate in the metabolism, stimulate the activity of the salivary glands, increase the excretion of bile and pancreatic juice, have bactericidal properties.

A method for the treatment of cirrhosis with the use of a phytocomplex, including water infusion, alcohol tincture and oil infusion

Cirrhosis is a very complex disease, and the disease process has complex dynamics. Therefore, in the treatment, depending on the stage of development of the disease, it is necessary to change the quantitative ratio of herbs in the medicinal composition from alcohol tincture and water extract of medicinal plants. For the initial phase of cirrhosis, one tablespoon of alcohol tincture is introduced into the daily dose of water infusion, with moderate severity of the disease, two tablespoons of tincture are introduced, and in severe cirrhosis, three tablespoons of tincture. In this case, the daily dose of water infusion is 500 g. A water infusion with alcohol tincture is taken before meals three times a day for 100 g.

The effect of internal intake of medicinal plants in the form of an aqueous infusion with the addition of alcohol tincture is enhanced by the effect of rubbing the area of the lymph nodes and liver with an oil infusion, which is produced in the evening.

The effectiveness of liver treatment directly depends on nutrition, so treatment is carried out against the background of special diets, built taking into account the nature of the course of the disease.

Water infusion, alcohol tincture and oil infusion are prepared as follows.

Water infusion. Dried, crushed vegetable raw materials at the rate of 2 tbsp. tablespoons per 500 g of boiling water are kept in a water bath for 15 minutes and insisted 30 minutes in a turned off water bath.

Alcohol tincture. The dried plant material is crushed, filled with a 40% aqueous-alcoholic solution in the ratio of 4 tablespoons of collection per 1 liter of vodka, heated to 60 ° C and insisted for 10 days in a dark place.

An oil infusion is prepared on the basis of olive oil by boiling the crushed vegetable raw materials in oil for 15 minutes at the rate of 4 tablespoons of collection per 1 liter of oil.

Examples of treatment of patients suffering from hepatitis, turning into cirrhosis, are given from the case histories of patients of the Far Eastern Research and Innovation Center Fitotherapy LLC (founded in 1992, Khabarovsk).

Example 1

Case history 20538. Patient P., 51 years old. Diagnosis: cholelithiasis, surgery, introduction of hepatitis C virus during blood transfusion, the transition of hepatitis C to cirrhosis. Fibrosis of the liver of the IV degree. Pain in the liver. Esophageal varicose veins 2-3 degrees, gastropathy, gastric reflux. The skin is red, itchy. The abdomen is enlarged due to the accumulation of fluid, the liver is not palpable. Drug treatment (essentials, veroshpiron, furosemide, mesim forte, vitamins B ₁ , B ₆ , C) did not bring a significant effect. At Phytotherapy LLC, the patient underwent three courses of treatment using drugs for the treatment of severe illness with a total duration of 6 months. After the first course (2 months), redness on the skin passed, gastropathy decreased, and pain in the liver decreased. After the second course of treatment, the work of the gastrointestinal tract returned to normal, the stomach decreased in size, the pain in the liver stopped. During the third course, the size of the abdomen returned to normal, the liver is palpated. Due to a significant improvement, the patient stopped treatment.

Example 2

The history of the disease 20610. Patient M., 68 years old. Hepatitis C with a transition to cirrhosis. Lymph nodes, diffuse changes in the pancreas are enlarged. Chronic calculous cholecystitis. Fluid retention in the body, the abdomen is increased in volume due to ascitic fluid. 4 courses of treatment have been completed using agents for the treatment of severe illness. After the first course (2 months), appetite increased, physical condition improved slightly. After the second course (2 months), pain significantly decreased, the amount of fluid in the body decreased, and the volume of the abdomen decreased. After the third (2 month) course, ascites in the body disappeared, and health improved. After the fourth course (2 months), the pain disappeared, the liver function improved, and his health returned to normal.

Example 3

The history of the disease 12354. Patient A., 56 years old, chronic parenchymal pancreatitis, concomitant with chronic hepatitis C with the transition to cirrhosis. Chronic erosive gastritis and cholecystitis. In the esophagus there are two varicose veins with a diameter of 0.4-0.5 cm, chronic hemorrhoids, and sediment in the gallbladder. Diffuse changes in the liver. The patient underwent 4 courses of treatment using drugs for the treatment of severe illness. After the first course (2 months), the condition of the stomach improved, hemorrhoids healed. After the second course (2 months), pain in the liver decreased, varicose veins in the esophagus disappeared, and the sediment in the gall bladder disappeared. After the third course (2 months), the manifestations of parenchymal pancreatitis are insignificant. After the fourth course, the patient stopped treatment due to a significant improvement in well-being.

Example 4

Medical history 20559. Patient 56 years old. Viral hepatitis C with a transition to cirrhosis. Gynecomastia on the right, liver hypertrophy, class A. Liver increased by 2 cm, pain in the liver, chronic calcifying pancreatitis, gastric ulcer with bleeding. After the first course with the use of drugs for the treatment of moderate illness (2 months), headaches and liver pains decreased. After the second course (2 months), the state of the stomach improved, the bleeding stopped. After the third course (2 months), the liver decreased in volume, the pain stopped, the appetite improved, and pancreatitis disappeared. After the fourth course, a cure came.

Example 5

The history of the disease 14540. Patient N., 57 years old. Internal hemorrhoids of the 1st stage, chronic cholecystic pancreatitis, pain in the liver, chronic hepatitis C, the initial form of cirrhosis. In the area of the liver, one small lymph node with an outcome in cirrhosis. Portal Hypertension Syndrome. Yellow complexion. At the same time, atrophic gastritis, the intestines work poorly (stool 1 time in three days), erythematous gastropathy. The patient was treated using treatment for the initial form of the disease. After the first course, the work of the gastrointestinal tract returned to normal, the complexion was restored. After the second course, pain decreased, seizures became rare, and overall health improved. After the third course, ultrasound showed the absence of cirrhosis.

Example 6

Case history 20538. Patient P., 50 years old. Gallstone disease, surgery, introduction of hepatitis C virus during blood transfusion. Fibrosis of the liver of the IV degree, cirrhosis in the initial stage, pain in the liver, liver increased by 2.5 cm, varicose veins of the esophagus 2-3 degrees. Gastropathy, reflux. The skin is itchy and red. After the first course of treatment with the use of drugs for treatment, the pain decreased in the initial form of the disease, the stomach function returned to normal, and the general condition improved. After the second course, itching and redness disappeared, the veins of the esophagus returned to normal. After the third course, the volume of the liver decreased significantly. The fourth course, ultrasound showed no signs of liver disease.

Information sources

1. RF patent №2014842.

2. RF patent No. 2089213.

3. Pekhterev A.K., Pekhtereva I.A., Pekhtereva N.A. Phytotherapy. Khabarovsk, 2003.

4. Tsydendambaev P. B., Khyshiktuev B. S., Nikolaev S. M. Biological effects of flavonoids // Bulletin of the VSSC SB RAMS, 2006, 6 (52).

5. Maksyutina M.P., Litvinenko V.I. Methods for the isolation and study of flavonoid compounds // Phenolic compounds and their biological functions. M., 2001.

6. Karnaukhov V.N. Biological functions of carotenoids. M., 1988.

7. Shumov I.V. Alternative medicine in the system of modern knowledge. M., 2000.

8. Elements of herbal medicine. Features and rules for the use of plants in medicine. Department of Pharmacy FPK and PPS. Tomsk State Medical University. Tomsk, 2003.31 s.

Claims (7)

1. Phytocomplex for the treatment of cirrhosis of the liver, containing internal and external use, while the internal use contains the collection of medicinal plants with a predominance of biologically active substances of antiseptic and adaptogenic effects for the preparation of water infusion and the collection of medicinal plants with a predominance of biologically active substances of regenerative effect for the preparation alcohol tinctures, and the external product contains a collection of medicinal plants for the preparation of m aslynoy infusion, while the collection for the preparation of water infusion contains dried plant material, which includes: grass repeshka, grass of the common bedstraw, grass of red serratus, common calamus roots, grass of narrow-leaved tea, bark of branches and buds of aspen, tansy grass, celandine grass , lemon balm grass, penny wood grass, middle stellate grass, Amur velvet bast and twig, broom wormwood grass, sowing garlic bulbs, Daurian moon seed seed roots, bird mountain grass, bird crown grass, Budra grass scyphoid, alfalfa sowing grass, aromatic bison grass, field horsetail grass, dioecious nettle grass, Amur barberry berries and leaves, roots bought fragrant, Manchurian aralia roots, magnolia vine, high potato roots, yellowing ground roots, licorice roots, licorice roots, the following ratio of components (weight. hours): grass repeshka 10-12 bedstraw grass present 8-10 cog grass red 9-10 Calamus roots 17-19 narrow-leaved Ivan-tea grass 10-12 bark of branches and buds of aspen 11-13 tansy grass 10-12 celandine grass 9-12 lemon balm grass 8-9 grass lespedecy kopeechnikova 7-9 cricket grass medium 5-7 dioica nettle grass 8-9 bast and branches of Amur velvet 11-13 berries, leaves of Amur barberry 9-14 roots bought fragrant 7-8 Dioscorea roots 8-10 grass wormwood 7-8 bulbs of garlic seed 5-7 Daurian moon seed seed roots 4-6 Highlander's grass 8-9 Crowned grass 6-8 ivy budrea grass 5-6 alfalfa seed grass 5-8 fragrant bison grass 7-8 horsetail grass 7-8 widebell roots 8-10 roots of aralia manchurian 7-8 roots of potato 5-7 the roots of Sophora yellowing 10-13 lemongrass berries 12-14 licorice roots 7-9 the collection of medicinal plants for the preparation of alcohol tincture contains dried and ground vegetable raw materials, including St. John's wort grass, cinnamon grass, calendula flowers, magnolia vine berries, licorice roots, grass meadowsweet grass, purple purse grass, sowing coriander seeds, common physalis fruits in the following ratio of components (weight h.): St. John's wort grass 14-16 dried grass 3-4 marigold flowers 10-13 lemongrass berries 12-14 licorice roots 7-9 meadowsweet grass 8-11 stonecrop purple grass 5-7 seed coriander seeds 6-8 fruits of physalis vulgaris 5-6 the external application for oil infusion contains the collection of dried plant-ground raw materials, including the roots of the bellflower, the roots of the Amur barberry, the bast and Amur velvet branches, the ivory grass, the St. John’s wort, the cod grass, the penny grass, the leafy grass, the shrub grass celandine, middle stellate grass, purple stonecrop grass in the following ratio of components (wt. h): widebell roots 12-14 Amur barberry roots 8-10 bast and branches of Amur velvet 8-9 ivy budrea grass 6-8 St. John's wort grass 13-15 dried grass 4-5 grass lespedecy kopeechnikova 7-9 three-leaf watch grass 6-8 grass wormwood 5-7 celandine grass 6-8 medium stellate grass 4-5 stonecrop purple grass 8-10 2. A method for the treatment of cirrhosis of the liver, which consists in the fact that in the treatment of patients using a phytocomplex of means of internal and external use according to claim 1, while in the initial phase of cirrhosis, add one tablespoon of alcohol tincture to 500 g of water infusion, with an average degree of cirrhosis - two tablespoons of alcohol tincture, and in severe form - three tablespoons of alcohol tincture, and water infusion with added alcohol tincture is taken before meals 3 times a day for 100 g, and in the evening rub the oil infusion into the area lymph nodes and liver.