RU2603622C1 - Complex method of treating theileriosis in small cattle - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: invention relates to veterinary science and aims at treating theileriosis in sheep and goats. Water solution of DAZ is introduced to animals in combination with antimalarial preparation delagil in following proportions, mg/kg: DAZ in dosage 2.5 mg/kg in 5 %-aqueous solution once a day for 1-2 days, in amount of 0.5 mL/kg of body weight, intramuscularly, delagil in dose of 25 mg/kg with water, once a day for two days. Symptomatic therapy is carried out simultaneously.

EFFECT: invention provides higher clinical effectiveness, while treating theileriosis in sheep and goats.

1 cl, 1 ex, 1 tbl

Description

The invention relates to veterinary medicine, in particular veterinary protozoology, and can be used for the treatment of teileriosis of small cattle (Th.ovis, Th. Recondite). There is a method of treating this disease of sheep and goats by intramuscular injection with a 4% solution of diamidine at a dose of 2 mg / kg and a 7% solution of azidine at a dose of 3.5 mg / kg of live weight (see the abstract of the thesis for the degree of candidate Veterinary Sciences A. Annameredov. “Testing derivatives of diamidine and azidine in sheep pyroplasmidoses”, Samarkand, 1989). The disadvantage of this method is its low therapeutic efficacy in theileriosis of sheep and goats.

The use of these funds provides a therapeutic effect only in those cases when treatment begins on the first day of the manifestation of the disease, as well as in mild forms of the disease. The recovery rate of animals treated with these drugs is - no more than - 35% (1, 3, 4).

Currently, complex regimens with various agents, mainly known from medical practice, with protozoocidal activity (chinocide, berenyl, bigumal, sulfanthrol and oxytetracycline) are used to treat patients with theileriosis of animals (2, 5, 6).

Considering that with theileriosis of sheep and goats, none of the known chemotherapeutic agents has a pronounced therapeutic effect, we have proposed a comprehensive treatment method in which several chemotherapeutic drugs are administered sequentially to the animal.

The aim of this invention is to increase the effectiveness of the treatment of theileriosis of small cattle, by using a pyroplasmocide preparation in combination with an antimalarial agent.

This goal is achieved by the combined use of the pyroplasmocide preparation of DAC granulate with the antimalarial drug Delagil and the simultaneous conduct of symptomatic treatment.

The quantitative content of the components per mg / kg:

granulate DAC 2.5 Delagil 25

Granulate DAC - a drug containing 99.2% of ADV diminacenaceturate.

It is a sterile yellowish-orange powder, highly soluble in water.

The solution is prepared sterile in the following way: 5 g of DAC granulate is added to the flask and dissolved in boiled distilled water, preheated to a temperature of 37 ° C, and adjusted to the mark of 100 ml. The resulting solution was administered to animals intramuscularly, at the rate of 0.5 ml per 10 kg of live weight (at a dose of 2.5 mg / kg).

Delagil - antiprotozoal agent, / Hungary / 4- (7-Chloro-4-quinolinyl) -N, N-diethyl-1,4-pentanediamine (in the form of phosphate, hydrochloride or sulfate). Dosage form - tablets containing chloroquine - 250 mg, which are crushed and suspended in 0.5 liters of water. For therapeutic purposes, they are used internally individually, at the rate of 1 tablet per 10 kg of live weight. In parallel, symptomatic treatment is carried out aimed at removing intoxication of the body, normalizing the activity of the cardiovascular and digestive systems.

For this purpose, an isotonic solution of sodium chloride is intravenously administered to animals within 1-2 days; of the means that regulate the activity of the cardiovascular system, caffeine is used. With atony of the gastrointestinal tract, 1-1.5 liters of milk are given inside in the morning, in the evening - hellebore tincture, at a dose of 2-3 ml, inside with water once a day.

The therapeutic efficacy of the complex method was studied under industrial conditions during a seasonal outbreak of theileriosis of sheep and goats at sheep farms No. 1, 2, 3, 4 of the SEC “Chokh” in the Gunibsky District of the Republic of Dagestan. For the experiment, 120 sheep with theileriosis were selected, aged from 1 year to 2 years.

Animals on the basis of analogues were divided into 2 groups (experimental - 100 and control - 20 animals).

The animals of the experimental group were administered DAC granulate intramuscularly with the simultaneous administration of Delagil inside.

The animals of the control group were used for treatment with the most effective preparations of a similar purpose (0.6 mg / kg - furazolidone, 0.25 mg / kg - DAC granulate) in accordance with the instructions for use. Before treatment, the body temperature of animals ranged from 40.5-41.2 °. The intensity of parasitemia reached 12-31 instances of parasites in the field of view of the microscope.

The first day of treatment, DAC granulate (0.5 ml per 10 kg of live weight) was used, intramuscularly and at the same time Delagil inside, with water (at a dose of 25 mg / kg).

Sodium chloride was administered in the form of a 0.9% solution, intravenously, at the rate of 0.5 ml per 1 kg of weight, vitamin B ₁₂ - 300 μg per animal, intramuscularly - caffeine 20% solution, in a dose of 2-3 ml, once a day - subcutaneously.

The second day - the treatment of the first day is repeated.

The third day - DAC granulate, Delagil was used depending on the condition of the animal and the results of microscopy of blood smears for the presence of blood parasites. Experienced animals were constantly monitored. Daily body temperature was measured and microscopy of smears from peripheral blood was performed.

A decrease in temperature and parasitic reactions was noted after a 2-day course of treatment.

The effectiveness of treatment was taken into account by the disappearance of clinical signs of the disease and the results of laboratory tests - the absence of parasites in smears from peripheral blood. In the treatment of sheep and goats sick with theileriosis, the therapeutic effectiveness of the complex use of DAC, Delagil and symptomatic agents is 95.0%, while the effectiveness of the compared drug was 55.0% (table).

Test results for a comprehensive treatment method for theileriosis of small cattle

This treatment method has undergone experimental and production testing on a livestock of over 1000 sick animals. The economic efficiency in monetary terms amounted to more than 1200 rubles (at prices for 2013). per cured animal. Thus, the pronounced therapeutic effect, low cost of the preparations distinguishes the complex method we are offering from other means and methods of treating such a difficult to treat and difficult disease, like teleriosis.

Information sources

1. Dyakonov L.P. and other parasitic diseases of farm animals. Moscow., Agropromizdat., 1985. P. 21-27.

2. Zhulenko V.N. et al. General Clinical and Veterinary Formulation: A Handbook. - M .: Kolos, 1998.S. 489.

3. Zablotsky V.T. Specific prophylaxis of theileriosis of cattle. - In the book. Arachnoses and protozoal diseases of farm animals, M .: Kolos, 1977, p. 121-129.

4. Zolotareva V.M. Hemosporidiosis of cattle in Dagestan / Abstract. for a job. student Art. Cand. vet. sciences. - Stavropol 1968. - S. 3-15.

5. Brains I.E. Veterinary formulation / I.E. Brains. - M .: Kolos, 1966 .-- S. 99-105.

6. Chervyakov D.K., Evdokimov P.D., Vishker A.S. / Medicines in veterinary medicine // M .: Kolos. 1977.S. 441.

Claims (1)

A method for treating theleriosis of small cattle, which consists in carrying out symptomatic therapy and the combined use of the drug DAC granulate with the antimalarial agent Delagil, while the granulate DAC is used at a dose of 2.5 mg / kg live weight, and Delagil at a dose of 25 mg / kg live weight.