RU2602182C1 - Cosmetic composition for human body and its application method - Google Patents

Abstract

FIELD: cosmetology.

SUBSTANCE: invention relates to cosmetology and represents cosmetic composition for epilation of undesirable hairs on human body, causing oxidative stress, initiating peroxidation of lipids and proteins of hair follicle cells and consequently followed by their death, characterized by fact, that it contains therapeutically effective amount of calcium chloride, ceramides, cytochrome-c, iron (II) chloride and hydrogen peroxide, as well as method of using cosmetic composition for epilation of undesirable hairs on human body.

EFFECT: invention provides hair growth retardation, up to complete stop after application of composition to skin.

2 cl, 8 dwg

Description

The invention relates to the field of cosmetology and medicine, in particular to a cosmetic composition for creating oxidative stress and initiating lipid peroxidation reactions and proteins of hair follicles, intended for radical removal of hair on the human body for cosmetic purposes, as well as the method of its use.

Various means are known in the art for the removal of hair on a human body.

For example, containing fructose, walnut oil, propolis, a decoction of medicinal plants and an acidifier (RU No. 2292191, publ. 01/27/2007), or based on gum, alcoholic infusion of plants and organic acid (RU # 2057526, publ. 10.06.1996) , or in the form of a composition containing barium sulfate and carbonate (RU No. 2155027, publ. 08.27.2000). Known funds are applied to areas of human skin after mechanical hair removal (plucking, applying sticky compositions, etc.). A common drawback of the use of known agents is their low effect on damaged hair follicles, and therefore, after a certain time, the removed hair grows back.

The prior art also known depilatory compositions based on salts of thioglycolic acid, its derivatives and hydroxides of potassium, sodium and calcium to stop the growth of unwanted hair (RU 2557994, publ. 06/10/2014), which are applied to the skin with previously mechanically removed hair from the root.

The used property of thiols and caustic alkalis to destroy keratin has a significant drawback, since keratin of the skin inevitably suffers when processing hair follicles, which may be a contraindication for using this method on the face or other sensitive areas of the human body, such as axillary cavities or groin. In addition, thioglycolic acid compounds have a strong unpleasant odor.

In the description of the patent RU 2557994, a method for applying compositions is indicated, in which it is necessary to mechanically remove hair with a root in a selected area so that through the open mouths of the follicles the active substances freely penetrate the follicles.

However, it is known that the duct of the sebaceous gland opens into the hair canal, therefore, when the hair is removed mechanically with a root, a certain amount of sebaceous secretion is inevitably secreted into the hair canal, blocking it and protecting the hair follicle from infection, and the canal wall from closing. Blockage of the hair canal with sebum prevents the penetration of active substances of any composition into it, excluding exposure to the hair follicle, while the skin on the treated area is subjected to the destructive action of thioglycolic acid compounds and also alkalis and strong bases, such as potassium hydroxides, sodium and calcium.

Patent RU 2557994 is only mentioned as a method of hair removal through chemical compounds and cannot be proposed as a prototype of the present invention, since thioglycolic acid compounds are inhibitors of radical chain reactions, in particular oxidation and radical polymerization reactions - that is, they have a completely different effect, radically different from the action of the substances used in the claimed invention.

In addition, as follows from the name of the patent, the method describes a set of measures for depilation (1).

The objective of the claimed invention is to offer an epilation (2) cosmetic composition for creating oxidative stress and initiating lipid peroxidation reactions of hair follicles, intended for radical hair removal on the human body for cosmetic purposes, as well as a method for its application, including mechanical plucking of hair, degreasing the treated area skin for maximum removal of sebum from the hair canals and application to the skin of the composition according to the invention with a certain p periodicity.

The technical result of the claimed invention is to change the density of the hair, expressed in reducing the amount of hair on the treated area of the skin, as well as changing the quality of the hair itself, expressed in their thinning and discoloration, while hair growth is significantly slowed down until it is completely stopped.

It is known that a high content of Ca 2+ in the intercellular space or cytosol of cells can cause tissue necrosis. So, for example, already a 10% solution of calcium chloride or calcium gluconate, accidentally entering the muscle tissue or under the skin as a result of injection, causes necrosis of the surrounding tissues. However, a 10% solution of calcium chloride, applied to intact skin, does not have a necrotizing effect on tissues and is used in cosmetology as a safe, readily available and inexpensive peeling component that effectively removes dead epidermal cells.

Ceramides, the simplest sphingolipids, are an important lipid component of the cell membrane. They have a healing and anti-inflammatory effect. Ceramides are widely used by cosmetologists as part of anti-aging creams and shampoos to restore damaged hair. At the same time, getting into the cytosol of the cell, ceramides can act as a critical component of apoptosis. (3)

Cytochrome-C, being in the mitochondria of the cell, is an essential component of the respiratory chain, responsible for oxygen transfer. However, when cytochrome-C enters the intermembrane space or into the cytosol of the cell, it can activate the apoptosis process (4).

The property of divalent transition metal ions in the presence of oxygen to form free radicals is known. So, for example, as a result of the interaction of Fe2 + and a peroxide compound through the Haber-Weiss and Fenton reactions, free-radical forms of oxygen are formed that are extremely toxic to lipids and proteins that make up the membranes of the cell and its organoids. (5)

Thus, the task and the technical result are implemented in accordance with the present invention, which declares:

- a cosmetic composition intended for hair removal of unwanted hair on the human body by creating oxidative stress and initiating lipid peroxidation reactions of proteins and hair follicle proteins and, as a result, their subsequent death, characterized in that it contains a therapeutically effective amount of calcium chloride, ceramides, cytochrome -C, iron (II) chloride and hydrogen peroxide,

as well as

- a method of using a cosmetic composition for hair removal of unwanted hair on a human body, characterized in that the hair is plucked mechanically with tweezers, electrical appliances or sticky compositions, degreasing the skin with detergents, including soap, or a soda solution, and then applying the cosmetic composition to the skin with a frequency of 1 time in 2-3 weeks until the complete cessation of hair growth.

The most preferred therapeutically effective amount of calcium chloride is up to 2 g, the most preferred therapeutically effective amount of ceramides is up to 3 ml of a 10% solution, the most preferred therapeutically effective amount of cytochrome-C is up to 15 mg, the most preferred therapeutically effective amount of iron (II) chloride is up to 1 g as well as distilled water to 10 g, 3-5% in excess of hydrogen peroxide.

The claimed cosmetic composition and method of its use are illustrated by photographs, which depict:

Photo 1 - the condition of the hairline on the leg of the man before the procedure.

Photo 2 - change in the density of the hairline on the leg of a man after three procedures.

Photo 3 - the condition of the skin on the leg of the man after five procedures. The photo was taken six months later.

Photo 4 - the condition of the hair on the legs of a woman before the procedure.

Photo 5 - the condition of the hair on the legs of a woman after three procedures.

Photo 6 - the condition of the skin on the legs of a woman after five procedures. Photo taken eight months later.

Photo 7 - the condition of the hairline in the armpit of a woman before the procedure.

Photo 8 - skin condition in the armpit of a woman after five procedures. The photo was taken after eleven months.

Examples

Testing was conducted on a group of volunteers of 20 people. Various parts of the body were treated with the cosmetic composition. Hair is mechanically plucked on the skin area selected for hair removal using tweezers, electric appliances or sticky compositions, after which the treated area is thoroughly washed with soap, detergent or treated with a solution of baking soda to maximize the secretion of the sebaceous glands from the hair canals. Then, successively applied solutions or other compositions containing calcium chloride, ceramides, cytochrome-C, iron chloride (II) and hydrogen peroxide.

The procedures are repeated after 2-3 weeks, as the hair regrowth is sufficient, until their growth is completely stopped.

Performance monitoring was carried out using visual inspection. In total, patients needed from 3 to 10 procedures to completely stop hair growth in the treated areas, which is explained by the different properties of the hair in different patients, as well as by the different treatment accuracy.

12 months after the first procedure, a visual examination showed a complete absence of hair in the treated areas of the body.

Links to sources of information

1. https://ru.wikipedia.org/wiki/%D0%94%D0%B5%D0%BF%D0%B8%D0%BB%D1%8F%D1%86%D0%B8%D1%8F .

2. https://ru.wiktpedia.org/wiki/%D0%AD%D0%BF%D0%B8%D0%BB%D1%8F%D1%86%D0%B8%D1%8F.

3.http: //www.niiopp.ru/netcat_files/195/119/h_486a37b042c974al2aa3a341882fc784.

4. http://www.rusmedserv.com/files/labdiag/42_Apoptoz.pdf.

5. http://dspace.nbuv.gov.ua/bitstream/handle/123456789/53453/19-Syrovaya.pdf?sequence=1.

Claims (2)

1. Cosmetic composition for hair removal of unwanted hair on the human body, causing oxidative stress, initiating peroxidation of lipids and proteins of the hair follicle cells and, as a consequence, their subsequent death, characterized in that it contains a therapeutically effective amount of calcium chloride, ceramides, cytochrome C, iron (II) chloride and hydrogen peroxide. 2. The method of applying the cosmetic composition for hair removal of unwanted hair on the human body, characterized in that they perform mechanical hair removal with tweezers, electrical appliances or sticky compositions, degreasing the skin with detergents, including soap, or a soda solution and then applying cosmetic to the skin composition according to claim 1 with a frequency of once every 2-3 weeks until the complete cessation of hair growth.

Images