RU2599482C1 - Medicinal herb repertory for treating gall bladder functional disorders accompanying hyptonic-hypodynamic dyskinesia - Google Patents

Abstract

FIELD: pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, namely to a medicinal herb repertory for treating gall bladder functional disorders accompanying hyptonic-hypodynamic dyskinesia. Medicinal herb repertory for treating gall bladder functional disorders accompanying hyptonic-hypodynamic dyskinesia, comprising dandelion roots, additionally comprises stiles of maize snouts, calendula flowers, flowers of Centaurea cyanus, yarrow herb and rosehips in equal ratio.

EFFECT: said repertory is effective for treating gall bladder functional disorders accompanying hyptonic-hypodynamic dyskinesia, has improved pharmacological properties, improves metabolic processes of hepatocytes and normalizes the vegetative regulation that provides prolonged remission.

1 cl, 1 tbl, 4 ex

Description

The present invention relates to medicine, namely to gastroenterology, and can be used for the prevention and complex treatment of functional disorders of the gallbladder.

Diseases of the biliary tract are one of the most common diseases of the digestive system. Currently, this pathology is detected in more than half of the adult population, and every year the number of patients is growing steadily. Modern medications are widely used to treat functional disorders of the gallbladder. For the prevention of functional disorder of the gallbladder, herbal remedies are used that have a wide range of therapeutic and prophylactic effects, are able to eliminate the symptoms of the disease, are safe and contribute to recovery.

It is known to treat functional gallbladder disorder using herbal remedies with antispasmodic (medicinal lemon balm herb, dill, fennel, tansy flowers), choleretic (immortelle flowers, corn stigmas, chamomile flowers, rose hips) and anti-inflammatory effect (flax seeds, plantain leaves , chamomile flowers).

стакана 3-4 раза в день за 15-20 мин до еды [Соколов С.Я. Фитотерапия и фитофармакология: Руководство для врачей. - М.: Медицинское информационное агентство, 2000. 976 с.].The closest analogue of the invention is the collection for the treatment of functional disorders of the gallbladder with hypotonic-hypokinetic type of dyskinesia of the following composition, g: St. John's wort 30.0; dandelion roots 30.0; immortelle flowers 10.0; leaves of a three-leaf watch 10.0; chamomile flowers 10.0; centaury grass 10.0. For treatment used infusion from the collection of

cup 3-4 times a day for 15-20 minutes before eating [Sokolov S.Ya. Herbal Medicine and Phytopharmacology: A Guide for Physicians. - M.: Medical News Agency, 2000. 976 p.].

The above collection is not effective enough, since its use does not take into account the characteristics of the impact on all links of the pathogenetic chain.

The objective of the invention is to expand the arsenal of herbal medicines of various directions of pharmacological action and a rational combination of medicinal plants for the treatment of functional disorders of the gallbladder.

The technical result achieved by using the invention is the expansion of the therapeutic effect by improving the metabolic processes of hepatocytes and normalizing autonomic regulation, which ensures an increase in the duration of remission.

The proposed collection for the treatment of functional gallbladder disorder with hypotonic-hypokinetic type of dyskinesia contains columns with stigmas of corn, calendula flowers, blue cornflower flowers, dandelion roots, yarrow grass and rosehips with a ratio of 1: 1: 1: 1: 1: 1, respectively .

стакана 3 раза в день, за 30 минут до еды в течение 3-х недель.The fee is prescribed as an infusion of

cups 3 times a day, 30 minutes before meals for 3 weeks.

The collection includes medicinal plants that are approved for use in medical practice [State Pharmacopoeia of the USSR, eleventh edition. Vol. 2 - M., 1990, GOST 21946-76, FSP 42-0330168301, FS 42-66-87, FS 42-134-72, FS 42-3645-98, FS 42-2094-83].

стакана 3 раза в день за 30 минут до еды. Длительность лечения - 3 недели.The technology for preparing the collection is that each type of medicinal raw material that meets the requirements of the State Pharmacopoeia of the X and XI editions is ground to a particle size of not more than 7 mm, then weighed and thoroughly mixed in the appropriate parts to a uniform mixture and screened from dust through a sieve with a diameter holes 0.18 mm. To prepare the water extraction, the collection sample is poured with purified room temperature water at a ratio of 1:10, insisted in an infundir apparatus for 15 minutes, then cooled at room temperature for 45 minutes; filter, squeezing the plant material, and add water to the required volume of extraction [State Pharmacopoeia of the USSR: Iss. 2. General methods of analysis. Medicinal plant material. - 11th ed., Ext. - M .: Medicine, 1989. - S. 147-148] and consumed in a warm form according to

cups 3 times a day 30 minutes before meals. The duration of treatment is 3 weeks.

The study of acute collection toxicity was carried out by introducing 10% infusion in doses of 5000, 7500 and 10000 mg / kg of animal weight (white mongrel mice of both sexes weighing 18-20 g), calculated on the dry weight of the collection intraperitoneally and orally. The toxicity parameters were calculated using the Litchfield-Wilcoxon probit analysis method.

Example 1. The effect of collection on the restoration of the vegetative balance

стакана 3 раза в день за 30 минут до еды, длительность лечения составила 3 недели.To assess the effectiveness of individually selected phytotherapy, patients with a hypotonic-hypokinetic type of gallbladder dyskinesia were randomized into two groups: the main group (n = 24), those examined during the drug treatment received additional herbal medicine, and the comparison group (n = 24) did not receive herbal medicine . In the hypotonic-hypokinetic type of dyskinesia - a collection that enhances the tone of the gallbladder, containing corn columns with stigmas, calendula flowers, blue cornflower flowers, dandelion roots, yarrow and rose hips. Infusions from the collection were prepared according to the State Pharmacopoeia of the 11th edition, in a ratio of 1:10, all the components of the phyto-collection were taken equally according to the recipe, two tablespoons of the collection were poured with 0.5 l of water and boiled over low heat for 5 minutes. Accepted by

cups 3 times a day 30 minutes before meals, the duration of treatment was 3 weeks.

After the course of treatment with phytobarrowing, an improvement in vegetative tone was observed, the rate of heart rate variability Mod (Mo), indicating the dominance of the sinus node, increased by 16.9% and the variational range (BP) by 63.6%, and in the comparison group by 6, 8% and 18.2%; the mode amplitude (AMo), which reflects the measure of the mobilizing effect of the sympathetic part of the autonomic nervous system, decreased by 13.9% and 6.3%, and the stress index (IN), indicating the degree of heart rhythm control, by 55.1% and 25, 7%, respectively, which indicates the harmonization of the vegetative balance, and in the comparison group complete restoration of vegetative regulation was not observed.

Example 2. The effect of collection on laboratory indicators

In persons with functional gallbladder disorder, an analysis of laboratory data revealed that the most sensitive were total bilirubin and alkaline phosphatase, which were increased by 25% and 27.6%, and liver enzymes alanine aminotransferase and aspartate aminotransferase in blood serum were 30% higher and 27% in comparison with the control, but did not exceed the recommended standards. In the study group, on the background of taking individually selected herbal medicine, the level of cholestasis markers decreased by 28.4% and 24.7%, and enzyme indices by 24.3% and 23.2%, respectively.

Example 3. Acute toxicity of collection

Acute toxicity of the collection for the treatment of functional gallbladder disorder was studied when administered orally on 48 white mice weighing from 18.0 to 20.0 g. The collections were administered in the form of 10% freshly prepared infusions in doses of 5000, 7500 and 10000 mg / kg in terms of dry weight of raw materials. The animals were monitored for 14 days, noted the clinical picture of poisoning and death of animals. For statistical processing the result of the experiments, the Lichfield and Wilcoxon method was used. When introduced into collections, one of the six experimental mice died only at a dose of 10,000 mg / kg. A further increase in dose was not possible due to the large volume of infusion administered. Therefore, it is not possible to calculate LD 50 fees when administered orally. With intraperitoneal administration according to the classification of Izmerov N.F. collection refers to class 5 - practically non-toxic substances (LP ₅₀ = 10050 (6281-16080)).

Thus, the charges according to the classification of GOST 12.1.007.76 were assigned to the class of low toxic compounds, which allows us to judge their safety and makes it possible to further research.

Example 4. The effect of collection on the clinical picture

As a result of complex treatment of patients with functional gallbladder disorder with individually selected phytotherapy, a positive trend was revealed, in people with a hypotonic-hypokinetic type of gallbladder dyskinesia, pain in the right hypochondrium in the main group decreased by 42.6%, and in the comparison group by 35, 1%, belching by 25.5% and 19.2%, nausea by 19.1% and 14.1%, bitterness in the mouth by 15.9% and 11.8%, clinical signs such as vomiting and upset stool , after treatment were not noted

Thus, the proposed collection allows you to expand the arsenal of herbal medicines of multivalent action for the prevention and treatment of functional disorders of the gallbladder.

Claims (1)

A collection for the treatment of functional gallbladder disorder with a hypotonic-hypokinetic type of dyskinesia, containing dandelion roots, characterized in that it further contains columns with stigmas of corn, calendula flowers, blue cornflower flowers, yarrow grass and rose hips with an equal ratio of components.