RU2550929C2 - Method of obtaining rosemary microcapsules - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining rosemary microcapsules. Claimed method is characterised by the fact that mixture of rosemary and dimethylsulphoxide is dispersed in suspension of carrageenan in ethanol in presence of preparation E472c, with the following addition of toluene and water, obtained suspension of microcapsules is filtered and dried, with ratio core/envelope in microcapsules constituting 1:1 or 1:3.

EFFECT: method by invention ensures simplification and acceleration of process of obtaining microcapsules, as well as increase of output by weight.

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Description

The invention relates to the field of encapsulation.

Previously known methods for producing microcapsules.

In the patent of the Russian Federation 2173140, IPC A61K 009/50, A61K 009/127, publ. 09/10/2001, a method for producing silicon organolipid microcapsules using a rotary-cavitation unit with high shear forces and powerful sonar phenomena of sound and ultrasonic range for dispersion is proposed.

The disadvantage of this method is the use of special equipment - a rotary cavitation unit, which has an ultrasonic effect, which affects the formation of microcapsules and can cause adverse reactions due to the fact that ultrasound destructively affects polymers of a protein nature, therefore, the proposed method is applicable when work with polymers of synthetic origin

In the patent of the Russian Federation 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00, publ. 06/27/2009, a method is proposed for producing sodium chloride microcapsules using spray cooling in a Niro spray tower under the following conditions: inlet air temperature 10 ° C, outlet air temperature 28 ° C, spray drum rotation speed of 10,000 rpm. The microcapsules of the invention have improved stability and provide controlled and / or prolonged release of the active ingredient.

The disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of certain conditions (air temperature at the inlet 10 ° C, air temperature at the outlet 28 ° C, rotation speed of the spray drum 10,000 rpm).

The closest method is the method proposed in the patent of the Russian Federation 2134967, IPC A01N 53/00, A01N 25/28, publ. 08/27/1999. A solution of a mixture of natural lipids and a pyrethroid insecticide in a weight ratio of 2-4: 1 in an organic solvent is dispersed in water, which simplifies the microencapsulation method.

The disadvantage of this method is dispersion in an aqueous medium, which makes the proposed method inapplicable for producing microcapsules of water-soluble preparations in water-soluble polymers.

The technical task is to simplify and accelerate the process of obtaining microcapsules, reducing losses when receiving microcapsules (increase in yield by mass).

The solution to the technical problem is achieved by the method of producing rosemary microcapsules, characterized in that carrageenan is used as the shell of the microcapsules, and rosemary is used as the core in the preparation of encapsulated particles by the non-solvent precipitation method using ethanol and toluene as precipitants, the microcapsule production process is carried out without special equipment.

A distinctive feature of the proposed method is the preparation of microcapsules by non-solvent precipitation using ethanol and toluene as precipitants, as well as the use of carrageenan as a particle shell and rosemary as a core.

EXAMPLE 1 Obtaining microcapsules of rosemary in carrageenan in the ratio of core: shell 1: 1

100 mg of rosemary is dissolved in 1 ml of dimethyl sulfoxide and the resulting mixture is dispersed into a suspension of carrageenan in ethanol containing 100 mg of the indicated polymer in the presence of 0.01 g of the preparation. Е472с (glycerol ester with one or two molecules of food fatty acids and one or two molecules of citric acid, moreover, citric acid, as tribasic, can be esterified with other glycerides and other acids as fatty acids. Free acid groups can be neutralized with sodium) with stirring 1300 rpm Then pour 2 ml of toluene and 0.5 ml of water. The resulting suspension is filtered and dried at room temperature.

0.198 g of microcapsule powder obtained. The yield was 99%.

Example 2 Obtaining microcapsules of rosemary in carrageenan in the ratio of core: shell 1: 3

100 mg of rosemary is dissolved in 1 ml of dimethyl sulfoxide and the resulting mixture is dispersed into a suspension of carrageenan in ethanol containing 300 mg of the indicated 300 mg of polymer in the presence of 0.01 g of the preparation E472c (glycerol ester with one or two food-grade fatty acids and one or two molecules of citric acid, and citric acid as tribasic, can be esterified with other glycerides and as an acid with other fatty acids. Free acid groups can be neutralized with sodium) with stirring 1300 r / sec. Then pour 2 ml of toluene and 1 ml of water. The resulting suspension is filtered and dried at room temperature.

0.392 g of microcapsule powder obtained. The yield was 98%.

Claims (1)

A method of producing rosemary microcapsules, characterized in that the mixture of rosemary and dimethyl sulfoxide is dispersed in a suspension of carrageenan in ethanol in the presence of the preparation E472c with stirring, toluene and water are added, the resulting suspension of microcapsules is filtered and dried, while the ratio of core / shell to microcapsule is 1: 1 or 1: 3.