RU2514542C1 - Method of treating threatening miscarriage in 2-3 trimester of pregnancy - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics. A method involves acupuncture. An ultrasonography is used to pre-determine a side of the placenta. A standard drug-induced therapy is added with the exposure on biologically active points MC-7, RP-6, TR-5, R-6 on the side of the placenta by needle entry. The needles are introduced perpendicularly to the skin surface at an angle on approximation to 90° for 30 minutes. The course of acupuncture is 7 sessions. The first session involves the exposure on the points MC-7, RP-6; the second session - on the point R-6; the third session - on the point TR-5; the fourth session - on the points MC-7, RP-6; the fifth session - on the point TR-5; the sixth session - on the point R-6; the seventh session - on the point TR-5.

EFFECT: method reduces a probability of recurrent threatening miscarriage, providing a stable clinical effect ensured by alternating the specified combination of the exposure points.

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Description

The invention relates to medicine, specifically to obstetrics, gynecology and reflexology, and can be used in the complex treatment and prevention of miscarriage.

Miscarriage contributes significantly to maintaining indicators of perinatal morbidity and mortality, which significantly affects the increase in the number of premature babies (Savelyeva G.M., 2006; Peresada O.A., 2009; Sidelnikova V.M. et al., 2010), 60% -75% of which die in the first month of life, and the rest have various deviations in indicators of somatic health in subsequent periods of development (Serov V.N., 2008; Ailamazyan E.K., 2009). The third trimester accounts for 25.6% to 30% of miscarriage (Ailamazyan E.K., 2009; Sidelnikova V.M. et al., 2010).

For the treatment of threatening preterm labor, numerous drug correction methods are used, often of an excessive nature. There are no convincing data in the literature about the long-term consequences of drug therapy (Zharky A.F. et al., 1988; Radzinsky V.E., 2007).

A known method of conducting acupuncture in corporal points TR-S, E-36, F-2 using steel microneedles / G.M. Vorontsova. Acupuncture in the inhibition of contractile activity of the uterus with threatening

premature birth. - Obstetrics and gynecology, 1979, N 4, p.15-17 /.

The disadvantages of this method are the need for periodic permutation of the needles, a relatively short exposure period with a small number of activated points, and the impossibility of a constant preventive effect on the mother's body.

A known method of treating miscarriage (RF patent No. 2132671, 07/10/1999), including the acupuncture effect of microneedles at points F-2, E-36, TR-5, characterized in that microneedles are additionally installed at points R-3, RP-6 , BM-160 for a period of 2 to 36 weeks of pregnancy.

The disadvantages of this method is the lack of a pathogenetic orientation of exposure, a short effect on uterine relaxation (short-term tocolysis), and therefore repeated relapses of the threat of termination of pregnancy are likely.

There is a method of correcting the condition of pregnant women with gestosis of the first and second half of pregnancy and the threat of its termination (RF patent No. 2162681, 02/10/2001) - carry out a manual action aimed at restoring the position of the vertebrae along the axis of the spine, and carry it out at levels L2-S3, C4 -T1, T9-T12, which prevents the threat of premature birth.

The disadvantages of this method is the high probability of provocation of generalized uterine activity in the process of restoring the position of the vertebrae, as well as the lack of effectiveness of this method with the threat of miscarriage of immunological, infectious and endocrine etiology.

A known method of treatment and prevention of preterm birth (RF patent No. 2264213, 11/20/2005) by the appointment of ginipral, characterized in that for 2-5 days 1 time per day, ginipral is administered 2.0 ml intravenously, after 30-40 minutes instenon 2.0 ml intravenously, and in the evening - 1 dragee instenon, and then continue to take only oral instenon 1 dragee 3 times a day with meals and ginipral 1 tablet 4 times a day after meals until the symptoms of the threat of termination of pregnancy disappear .

The disadvantage of this method is the suppression of any form of uterine activity, some of which (for example, local ones) are adaptive in nature and are aimed at stabilizing blood flow in the uteroplacental-fetal complex (Theodorescu-Exarka I. Physiology and pathophysiology of human reproduction. // Transl. Romanian Bucharest. - 1981. - 846 p.) If they are suppressed, the fetus may deteriorate.

There is a method of treating miscarriage (patent RF №2283653, 09/20/2006), in which the level of CD 56 + lymphocytes in the peripheral blood is determined and if they are higher than normal, courses of lymphocytimmunotherapy (LIT) are carried out by donor lymphocytes, and LIT is performed on days 5-6 the fertile cycle until normal levels of CD 56 + lymphocytes are restored, and from the moment pregnancy is established, LIT is performed according to the results of ultrasound, moreover, in the presence of chorionic hypoplasia - every 2 weeks, and if the chorion thickness corresponds to gestational age - every 3-4 weeks to 12-14 weeks of pregnancy.

The disadvantage of this method is the possibility of its use only in pregnant women with an immunological etiology of miscarriage. With the ideopathic form of miscarriage, with a violation in the hemostatic system and abnormalities in the development of the internal genital organs as an etiological factor for the threat of abortion, the effectiveness of this method decreases sharply.

There is a method of preventing and treating the threat of termination of pregnancy in women with uterine fibroids according to a new look at its etiopathogenesis (RF patent No. 2424817, 07.27.2011), the patient is prescribed prophylactically wearing Polish Pyokal inserts for 8-15 hours a day. With the onset of pregnancy for 5-7 hours daily. At the same time, “Dienai” is prescribed 1 capsule for 3 days before pregnancy. Then 2 capsules for another 3 days and on subsequent days 2 capsules 2 times a day for 3 weeks. After a 7-10-day break, take "Neurostim" 2 capsules in the morning and 1 capsule in the evening 30 minutes before meals for a course of 3-4 weeks. During pregnancy, “Lohelan" is additionally prescribed - 20-30 minutes before a meal, a quarter cup 2 times a day, a course of treatment of 20 days, during pregnancy 2-3 courses, and "MIGI" - 1 tablespoon without dilution 3 times a day for 15 days, 1-2 courses for the entire period of pregnancy.

The disadvantage of this method is its effectiveness mainly in infectious etiology of miscarriage.

There is a method of treating patients with habitual miscarriage in the first trimester (RF patent No. 2452481, June 10, 2012), which consists in the fact that the patient is prescribed an aqueous solution of the drug "Immunal" at a dosimeter, 2 times a day, nicotinic acid tablets at 50 mg 2 times a day, rectal enemas with - 5.0 ml of a 30% solution of sodium thiosulfate and 15.0 ml of a 0.25% solution of novocaine once a day, and Rekitsen RD on a dessert spoon 2 times a day, course 30 days.

The disadvantage of this method is the achievement of short-term tocolysis, the absence of the pathogenetic orientation of this type of therapy and the likelihood of worsening the symptoms of the threat of interruption during rectal enemas.

Acupuncture is one of the effective methods of treating the threat of termination of pregnancy officially recognized in the “Industry Standards for the volume of examination and treatment in obstetrics, gynecology and neonatology” (2001). Reflex therapy involves the normalization of regulatory processes in the nervous system and, indirectly, through it, the restoration of homeostasis of the whole organism (Zharky A.F. et al., 1988; Orlov V.I., 1989; Gavaa Luvsan, 2000; Pesonina S.P. et al. , 2000; Linde, V.A., 2004; Hecker, H.U., 2009).

However, traditional studies on acupuncture did not take into account the paired dominantly asymmetric principle of the organization of the female reproductive system, which mediates the formation of adaptive and resistance mechanisms of the female body and affects the nature of the course of pregnancy (Orlov V.I. et al., 1989; Khloponina A.V., 1998; Botasheva T.L. 1999; Orlov A.V., 2006; Avrutskaya V.V., 2008; Gamaeva R.A., 2010; Gudz E.B., 2012).

The prototype of the claimed invention, we have chosen a method for the treatment of miscarriage according to A.F. Zharkin and N.A. Zharkin (Zharky A.F., Zharky N.A. Reflexotherapy in obstetrics and gynecology. - L .: Medicine, 1988. - 158 p. ) Acupuncture course includes 12 sessions.

1st session: MS-7, RP-6; 2nd session: MS-6, R-6, P-7; 3rd session: VG-14, V-11, E-14; 4th session: VG-4, V-23, VB-26; 5th session: TR-5, VB-13; 6th session: MS-7, RP-6; 7th session: TR-5, V-12; 8th session: VG-4, V-23, VB-26; 9th session: R-6, R-7; 10th session: VG-14, V-l 1, GI-14; 11 session: V-43, F-13; Session 12: MS-7, RP-6.

The disadvantage of this method is the complexity, as well as the likelihood of relapse, because the method does not take into account the stereofunctional specifics of the mother-placenta-fetus system and performs a symmetric (right and left) effect on the acupuncture points responsible for the functional processes in the uteroplacental complex located asymmetrically, which reduces the therapeutic effectiveness of the method due to the mismatch of the exposure side and "Target organ."

The objective of the invention to develop a new simpler and more effective method of complex treatment of threatening abortion by correcting the functions of organs and systems involved in this complex process? using acupuncture taking into account the stereofunctional specifics of the mother-placenta-fetus system.

Pregnant women with a threatening termination of pregnancy are preliminarily determined by the ultrasound method the location of the placenta and, in addition to the standard drug therapy, influence the biologically active points MS-7, RP-6, TR-5, R-6 on the side of the placenta with an exposure of needles of 30 minutes, the needle injected perpendicular to the skin surface at an angle close to 90 ^about .

EFFECT: reducing the likelihood of recurrence of the threat of termination of pregnancy, and therefore, the number of repeated hospitalizations and repeated courses of therapy, provides a stable clinical effect due to the alternation of pathogenetically substantiated and correctly selected point formulations, the effect of leveling bilateral and maintaining one-sided “useful” uterine activity is achieved .

The experimental and clinical data of recent years show that the resistance of the female reproductive system both outside and during pregnancy is largely determined by the severity, orientation, and most importantly - the spatial consistency of morphofunctional asymmetries of the brain and the reproductive apparatus. Features of the paired morphofunctional organization of the female reproductive system, in particular the inadequate ratio of the initial and gestational asymmetries in the process of the formation of the functional mother-placenta-fetus system with the subsequent occurrence of centro-peripheral disintegration, determines a low level of resistance and increases the risk of threatening termination of pregnancy (Orlov V .I., 1989; Chernositov A.V., 2000; Botasheva T.L., 2012).

Based on the concept of three types of stereofunctional organization of the mother-placenta-fetus system (dextral, sinistral and combined), it is of considerable interest to study the adaptation features of various parts of this system during acupuncture, since it is the predominant participation of subcortical brain formations (hypothalamus, limbus, diencephalic reticular formation, etc.) in the integrative system of vegetative-endocrine regulation allows us to consider pathogenetically substantiated Anna acupuncture at various obstetric and gynecological diseases (Hot AF et al, 1988;. Pesonina SP et al, 2000; Linde VA, 2004).

The obstetric problem of threatening abortion posed for consideration and the fundamental problem of stereoisomerism of reproductive processes when using acupuncture requires a systematic and multicenter approach.

According to the results of the log-linear and analysis of variance, we found that when the vectors of the initial and gestational asymmetries coincided, the one-sided uterine activity was most often recorded both during physiological pregnancy and in pregnant women with the threat of premature birth (private connection criterion: X = 3.51036; df = 1; p = 0.06098).

We have studied the frequency of occurrence of various patterns of a cardiotachogram of a fetus of medium periodicity depending on uterine activity and the location of the placenta.

It was found that in response to an increase in the tone of the myometrium and the appearance of uterine contractions with the threat of premature birth, the fetus naturally responds by increasing the basal rhythm by an average of 5 ± 7 beats. per minute. In addition, there was an increase in the number of pathological patterns of fetal cardiac rhythm in the form of pronounced oscillation variability.

When using traditional drug therapy, there was no significant decrease in the frequency of detection of pathological patterns of fetal cardiac rhythm with a change in the level of uterine activity, and in 12% of cases an increase in the number of pathological patterns of fetal cardiac rhythm was recorded, which indicated a deterioration in its condition (p = 0.04863).

After a course of acupuncture according to the standard method, a significant decrease in the frequency of decelerations and an increase in the frequency of accelerations on the cardiotachogram of the fetus was revealed, which indicated an improvement in its condition, regardless of placental lateralization. However, the complete disappearance of pathological patterns of fetal cardiac rhythm did not occur, which indicated the manifestations of distress.

Cardiorespiratory reactions of the fetus, both before and after the course of all treatment methods used in the study / according to the prototype and drug / significantly correlated with the contractile activity of the right uterus (p = 0.04232). With the right-sided location of the placenta, this dependence was most pronounced (p = 0.01712).

Thus, on the basis of our studies, it was revealed that both during the physiological course of pregnancy and when there is a threat of its termination, stereofunctional processes occur that determine the localization of the dominant pregnancy and affect the developmental conditions of the fetus. Conducting maintenance therapy with the threat of preterm birth without taking these features into account does not provide the desired result, as evidenced by the indicators of contractile activity of the uterus, blood flow in the uterine and fetal-placental arteries, and cardiotachogram of the fetus.

In this regard, we have developed a new method for the treatment of miscarriage, which takes into account the revealed functional asymmetry and is based on acupuncture effects taking into account lateralization of the placenta.

Practical application of the proposed method for the treatment of patients showed that by the end of the second session, against the background of a decrease in the basal tone of the myometrium, right-sided uterine contractions dominated. When the placenta was ambilateral, a functional “behavior” of the myometrium was found, which was characteristic mainly for the right-sided type of the mother-placenta-fetus system.

Lower values of the blood flow velocity curve in the umbilical cord and middle cerebral arteries of the fetus in 93% of cases were observed in the ipsilateral relative to the placenta of the uterine artery.

During the treatment of threatening abortion, a decrease in the level of bilateral (isometric) uterine activity was observed in 90% of patients. When using medical treatment and the standard method of acupuncture, suppression of all forms of uterine activity was recorded, which was accompanied by the preservation of hemodynamic processes in the uteroplacental-fetal complex and the presence of pathological patterns on the cardiotachogram in 89% of the fetuses.

Acupuncture taking into account placental lateralization contributed to the normalization of hemodynamic processes in the uteroplacental-fetal complex in 98% of pregnant women, which is due to increased asymmetry of blood flow in the right and left parts of the uterus, an increase in blood flow in the uterine artery on the side of the placenta by 25%, and an improvement in curve performance blood flow rates in the umbilical cord and middle cerebral arteries of the fetus an average of 20%.

Acupuncture taking into account placental lateralization in women with the threat of termination of pregnancy provides a decrease in the number of pregnant women with manifestations of vegetative lability by 35%, vegetative-vascular dystonia by 43%, contributes to the manifestation of normal adaptation in all treated pregnant women, and reduces their anxiety level by 2.3 times.

The results obtained indicate the existence of a reliable relationship between the nature of the course of pregnancy and the processes of lateralization of uterine activity. It is proved that during lateral stimulation of biologically active acupuncture points, taking into account the placental lateralization factor in the uteroplacental-fetal complex, functional processes are initiated, accompanied by increased right-sided asymmetry of the uteroplacental blood flow and contractile activity of the uterus, as well as an improvement in the fetus.

Detailed description of the method

The formation of clinical groups “threatening termination of pregnancy” included the use of the following inclusion criteria (Arias F., 1984; Sidelnikova V.M., 2001):

1) the presence of contractile activity of the right and left parts of the uterus, detected by mechano-hysterographic and ultrasound examinations;

2) the condition of the cervix with transvaginal ultrasound: the length of the cervical canal is at least 3 cm with a closed internal pharynx;

3) a change in the state of the cervix during bimanual examination and examination of the cervix in the mirrors (length, consistency, position, condition of the external and internal pharynx) - shortening of the cervix (not more than 2.5 cm);

4. subjective complaints of regular pain in the lower abdomen and back. The exclusion criteria were isthmic-cervical insufficiency,

multiple pregnancy, decompensation of concomitant extragenital pathology, as well as abnormalities in the development of internal genital organs, benign tumors of the female reproductive system.

Ultrasound examination, assessment of the functional state of the blood flow in the uteroplacental-fetal complex, the study of fetometric indicators and the study of placental lateralization was carried out using two-dimensional ultrasound and Dopplerometric methods of investigation on the Toshiba (Essose) SSA-340 (Japan), 3, 3, 5 MHz with color Doppler mapping (FS registration certificate No. 2005/1686).

The patient lies on the couch in a special darkened room with an air temperature of 24 ° C at atmospheric pressure of 98.4-102.4 kPa (740-770 mmHg) and a relative humidity of 50-85%, the procedure takes 9-10 in the morning, 1 session per day. The procedure is carried out no earlier than an hour after eating. A woman takes a comfortable position on her back, she should be relaxed, calm and motionless throughout the procedure. Sessions are carried out once a day.

The search for acupuncture points is carried out according to the principle of their topographic relationship to the musculoskeletal and tendon landmarks and the distribution of the skin surface of the body parts (trunk, head, arms and legs) into the so-called proportional segments (tsuni). Zun is the division of a certain distance between areas of the body into a standard number of equal parts (regardless of height and age). The angle of the needle is vertical, the needle is inserted perpendicular to the skin surface at an angle close to 90 ^about . The depth of needle insertion for each particular point is individual, until the appearance of the intended sensations - the so-called “needle phenomenon”. The “needle phenomenon” appears gradually or suddenly, felt in some cases at the beginning while the needle is being promoted, in others it remains until the end of the procedure, and in some cases even after removing the needle.

After that, an acupuncture lateral effect on the biologically active points of MC-7, RP-6, TR-5, R-6 is performed on the right or left, depending on the lateralization of the placenta with an exposure of needles of 30 minutes.

The course of acupuncture included 7 sessions: 1st session: MS-7, RP-6; 2nd session: R-6; 3rd session: TR-5; 4th session: MS-7, RP-6; 5th session: TR-5; 6th session: R-6; 7th session: TR-5.

At the end of the procedure, the pregnant woman rests on the couch for 30 minutes.

Acupuncture points for the modified acupuncture method were selected based on the most pronounced hemodynamic and contractile reactions from the uterine-placental-fetal complex.

The scheme of drug therapy was developed on the basis of "Industry standards for the volumes of examination and treatment in obstetrics, gynecology and neonatology" (2001). According to the recommendations of the Industry Treatment Standards, as well as the recommendations of leading obstetrician-gynecologists in the treatment of threatening preterm birth, in addition to acupuncture, the following groups of drugs were used:

- β-mimetics (intravenous ginipral 5 ml + 400 ml NaCl, starting from 8 drops and bringing to 15-20, No. 3 15-20 minutes before the end of the infusion therapy, ginipral 1 tablet, reducing the dosage to ¼ tab .

- Gestogens (Utrozhestan 400-600 mg for 5-7 days) in order to desensitize uterine receptors.

If there are contraindications to the use of β-mimetics, magnesium sulfate is at least 2 g per hour (according to indications).

- Calcium channel blockers (nifedipine 1 t (10 mg)).

- Prevention of fetal RDS (up to 34 weeks of gestation).

- Antispasmodics (no-shpa 2.0 ml v / m No. 10).

- Metabolic therapy (chimes 1 t × 3 r. Per day).

- Sedatives (sebazone or relanium 2 ml / m). The performance of the proposed method is confirmed by the following clinical examples.

Example 1

Pregnant Belozerova V.V., 32 years old. Case history No. 1908. Examination March 29, 2011, 35 weeks of gestation, OAP.

By the method of two-dimensional ultrasound scanning, the side of the placenta is determined - left-sided. During a Doppler study, a violation of feto- and utero-placental hemodynamics was recorded. Cardiotocographic examination showed signs of fetal distress.

In addition to standard drug therapy, biologically active points of MC-7, RP-6, TR-5, and R-6 were exposed to the left (on the side of the placenta). Conducted 7 sessions of acupuncture with an exposure of needles of 30 minutes. Evaluation of the effectiveness of the treatment was carried out on the basis of control ultrasound, Doppler and cardiotocographic studies. When registering a fetal heart rate, there is an improvement in patterns of short-term, medium periodicity and long-term variability: stabilization of the basal rhythm, an increase in the amplitude of instantaneous oscillations, an increase in the frequency of detection of acceleration and the disappearance of pathological forms of deceleration, indicating a decrease in the manifestation of signs of fetal distress (V.L. Voskresensky, 2004) . According to the results of a Doppler study, an improvement in blood flow in the vessels of the uteroplacental-fetal complex was found, consisting in a decrease in the systolodiastolic ratio (by 19% -22%) in the uterine, middle cerebral and umbilical arteries of the fetus.

Delivery is urgent. A fetus weighing 3 kg., Growth 49 cm., With a rating on the APGAR scale of 8-9 points.

Example 2

Pregnant Kiseleva I.A., 32 years old. Case history No. 1825. Survey August 24, 2010, 33-34 weeks of gestation, OAP.

By the method of two-dimensional ultrasound scanning, the side of the placenta location is determined - right-side. During a Doppler study, a violation of feto- and utero-placental hemodynamics was recorded. Cardiotocographic examination showed signs of fetal distress.

In addition to standard drug therapy, biologically active points MS-7, RP-6, TR-5, R-6 were exposed to the right (on the side of the placenta). Conducted 7 sessions of acupuncture with an exposure of needles of 30 minutes. Evaluation of the effectiveness of the treatment was carried out on the basis of control ultrasound, Doppler and cardiotocographic studies. When registering a fetal heart rate, there is an improvement in patterns of short-term, medium periodicity and long-term variability: stabilization of the basal rhythm, an increase in the amplitude of instantaneous oscillations, an increase in the frequency of detection of acceleration and the disappearance of pathological forms of deceleration, indicating a decrease in the manifestation of signs of fetal distress (V.L. Voskresensky, 2004) . According to the results of a Doppler study, an improvement in blood flow in the vessels of the uteroplacental-fetal complex was found, consisting in a decrease in the systolodiastolic ratio (by 20% -25%) in the uterine, middle cerebral and umbilical arteries of the fetus.

Delivery is urgent. A fruit weighing 3 kg 200 g, height 52 cm, with a rating on the APGAR scale of 8-9 points.

Example 3

Pregnant Dudkina N.Y., 33 years old. Case history No. 1824. Examination 09.09.2010, 30 weeks of pregnancy, OAP.

By the method of two-dimensional ultrasound scanning, the side of the placenta location is determined - ambilateral. During a Doppler study, a violation of feto- and utero-placental hemodynamics was recorded. Cardiotocographic examination showed signs of fetal distress.

In addition to standard drug therapy, the biologically active points of MS-7, RP-6, TR-5, and R-6 were exposed to the right, since in the case of the ambiguous location of the placenta, the functional processes in the uterine-placental-fetal complex proceed in the same number of cases, as with the right-sided location of the placenta (T.L. Botasheva, 1999). Conducted 7 sessions of acupuncture with an exposure of needles of 30 minutes. Evaluation of the effectiveness of the treatment was carried out on the basis of control ultrasound, Doppler and cardiotocographic studies. When registering a fetal heart rate, there is an improvement in patterns of short-term, medium periodicity and long-term variability: stabilization of the basal rhythm, an increase in the amplitude of instantaneous oscillations, an increase in the frequency of detection of acceleration and the disappearance of pathological forms of decelerations, indicating a decrease in manifestations of fetal distress (V.L. Voskresensky, 2004). According to the results of a Doppler study, an improvement in blood flow in the vessels of the uteroplacental-fetal complex was found, consisting in a decrease in the systolodiastolic ratio (15% -19%) in the uterine, middle cerebral and umbilical arteries of the fetus.

Delivery is urgent. A fetus weighing 2 kg 750 g, height 47 cm, with a rating on the APGAR scale of 7-8 points.

We examined 299 pre-pregnant women who underwent routine examinations in the department of pregnancy pathology and the outpatient department of the Federal State Budgetary Institution RNIIAP of the Ministry of Health of the Russian Federation, observed in the framework of the Obstetric Monitoring program. Based on the data of hormonal, biochemical, ultrasound and dopplerometric studies, four main clinical groups were formed. Clinical group I included 78 women with the threat of termination of pregnancy who received combination therapy according to the prototype - standard medication and acupuncture (Zharky A.F. et al., 1988). In II, there were 76 patients who received combined drug and acupuncture according to our improved technique, in which the impact on acupuncture points MS-7, RP-6, TR-5, R-6 was carried out on the ipsilateral (eponymous) side of the placenta. Clinical group III comprised 71 women with a threat of termination of pregnancy who received only standard drug therapy. In IV (control group) included 74 pregnant women with a physiological course of the gestational period. Analysis of the results of the therapy in each clinical group was evaluated taking into account the placenta location side (right, left, and ambilateral).

All studies were carried out after obtaining the informed consent of the patient to conduct additional research and treatment methods, as well as the conclusion of the Ethics Committee.

Verification of the treatment results was carried out with a comprehensive analysis of the ultrasound, Dopplerometric studies available for the pregnant woman, analysis of the outcome of the birth and the condition of the newborn.

When processing the results, we used log-linear, multivariate analysis of variance, and analysis tools for multidimensional tables (Bailey N., 1970; Afifi A., Eisen S, 1982; Dvoirin V.V., Klimenkov, A.A., 2004). Comparison of shares was carried out using the Yates correction for continuity. Data processing was carried out using STATISTICA packages version 6.0, EXCEL 2003 with the AtteStat add-in, MedCalc and the Deductor Studio Pro package version 5.2. The reliability of the results was calculated with a confidence level of 0.95 and an accuracy of 0.05.

The inventive method of treatment of threatening abortion in the 2-3 trimester of pregnancy based on the stereofunctional specifics of the mother-placenta-fetus system is an effective and safe treatment method that provides the maximum therapeutic effect when the placental lateralization and lateralization of acupuncture points coincide.

Application of the method is accompanied by a change in the stereofunctional specificity of contractile activity of the uterus and blood flow in the uteroplacental complex. Conducting lateral acupuncture exposure provides a significant improvement in the psychoemotional and hormonal status, the activity of the autonomic nervous system in pregnant women with menacing premature births, which is accompanied by an increase in the adaptive potential of the mother’s body, especially in the conditions of the right-oriented type of functional system “mother-placenta-fetus”.

Claims (1)

A method of treating threatened abortion in the 2-3 trimester of pregnancy by means of acupuncture, characterized in that pregnant women with threatened abortion preliminarily determine the side of the placenta by ultrasound and, in addition to standard drug therapy, influence biologically active points MS-7, RP-6 , TR-5, R-6 on the side of the location of the placenta with exposure of 30 minutes needles, the needle is introduced perpendicular to the skin surface at an angle approximate to ^90, igloreflekso rate erapii performed in 7 sessions: 1st session - MC-7, RP-6; 2nd session - R-6; 3rd session - TR-5; 4th session - MS-7, RP-6; 5th session - TR-5; 6th session - R-6; 7th session - TR-5.