RU2491909C1 - Removable denture - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents a removable denture containing an acrylic basis and a basis liner formed of a siloxane rubber composition, differing by the fact that composition used to form the basis liner contains, weight portions: polydimethyl methylvinyl siloxane rubber - 100, exipient - 16.2÷25.8, silica hydrogel - 1÷3, platinum catalyst - 5·10^-4-5·10^-6, chlorhexidine -1÷3.

EFFECT: invention provides creating the liner possessing high elasticity and high adhesion to the denture basis, the prolonged antibacterial effect with the higher hardening speed of the composition and the reduced amount of the platinum catalyst.

2 cl, 1 ex, 2 tbl

Description

The invention relates to medicine, in particular to orthopedic dentistry, and can be used in the manufacture of dentures.

Under unfavorable anatomical and topographic conditions of the prosthetic bed (atrophy of the alveolar ridge, the presence of acute oblique protrusions and exostases, a thinned, malleable mucous membrane, and increased pain sensitivity), using prostheses with plastic bases becomes difficult or completely impossible.

In these cases, the use of two-layer bases with an elastic lining in contact with the tissues of the prosthetic bed is indicated.

Known removable dentures, including an elastic lining based on silicone rubber (RU No. 2187286, AK 6/093, 2002).

The disadvantage of this solution is the low adhesion of the lining to the base and low strength indicators of the lining.

Also known is a composition for forming an elastic lining for a removable denture based on silicone rubber, including a filler (metal oxide), a pigment and a crosslinking agent (SU copyright certificate No. 427706, A6 / C 9/00, 1974).

The composition allows to obtain an elastic lining, but has a low viability and low adhesion to the acrylic base, which negatively affects the operational properties of the denture.

The closest analogue of the invention is a removable denture containing an acrylic base and a backing layer under the base, formed from a composition comprising polydimethylvinylsiloxane rubber, filler, silicon hydride, catalyst and modifier (RU No. 2261698, A61K 6/08, 2004).

The disadvantage of this technical solution is the lack of softness of the lining. In addition, when using prostheses under the base, an area with a constant temperature and humidity is created in which self-cleaning of the mucous membrane from food residues is impaired, which contributes to the rapid development of the microbial film.

Due to trauma to the soft tissues adjacent to the prosthetic bed, bacterial and fungal infection leads to candidiasis and other diseases.

The problem solved by the claimed invention is the creation of a removable denture with a lining layer having high physical and mechanical properties and providing long-term surface and volume antibacterial action.

The problem is solved in that in a removable denture containing an acrylic base and a lining layer under the basis, the lining layer is formed from a composition based on siloxane rubber, including, by weight:

polydimethylmethylvinylsiloxane rubber one hundred filler 16.2 ÷ 25.8 silica 1 ÷ 3 platinum catalyst 5 · 10 ^-4 -5 · 10 ^-6 chlorhexidine 1 ÷ 3

In addition, the composition for forming the lining layer may further contain a dye in an amount of 0.1 ... 0.3 parts by weight

The technical result from the use of the invention is to create a lining, which along with high elasticity and high adhesion to the prosthesis base has a prolonged antibacterial effect while providing a high curing rate of the composition and at the same time reducing the amount of platinum catalyst.

The introduction of chlorhexidine in the specified amount, in addition to a long antimicrobial effect, does not adversely affect the function performed by the catalyst, namely, the rapid hardening of the composition, while the presence of chlorhexidine in the composition gives an additional, previously unknown effect - reducing the amount of catalyst while maintaining a minimum hardening time composition.

As rubber, the composition may contain polydimethylmethylvinylsiloxane rubber with a viscosity of 14 · 10 ³ ÷ 30 · 10 ³ centipoise (cP).

Modified aerosil, quartz sand, diatomite can be used as a filler.

As a catalyst, Pt complexes (platinum-1,3-divinyl tetemethyl disoloxane) can be used.

Organohydrosiloxanes may be used as silica hydride.

The invention is illustrated by the examples shown in table 1.

Example (corresponds to composition No. 5 from table 1).

Polydimethylmethylvinylsiloxane rubber with a viscosity of 23 · 10 ³ cP is loaded into a laboratory mixer. In an amount of 100 parts by mass, modified aerosil with a specific surface of 50 m ² / g — 25.8 parts by mass; polyethylhydridesiloxane - 3 parts by weight and chlorhexidine 1 parts by weight The components are mixed at a temperature of 25 ° C for 30 minutes, after which the resulting mixture is discharged into a container.

Then a mixture of the following composition is prepared: polydimethylmethylvinylsiloxane rubber 23 · 10 ³ cP - 100 parts by weight; modified aerosil with a specific surface of 50 m ² / g - 25.8 mass.h; the catalyst is platinum-1,3-divinyltetramethyldisiloxane - 5 · 10 ^-5 parts by weight All ingredients are mixed for 30 minutes, after which the resulting mixture is discharged from the mixer. The resulting two compositions are mixed in a ratio of 1: 1 to the resulting homogeneous mass for 23 minutes.

The composition is ready to form an elastic lining. Curing occurs in the patient’s oral cavity.

Similarly prepare the composition according to examples 1-4 and 6 of table 1.

The determination of the basic physical and mechanical parameters was carried out on 2 mm thick plates in accordance with standard methods.

The determination of antimicrobial activity was carried out using the following methods: “agar plates” and drop-by-drop application of test microorganisms on test samples from the obtained materials in accordance with guidance Р4.2.2643-10 “Methods of laboratory research and testing of disinfectants to assess their effectiveness and safety”.

The material properties of the resulting backing layer are shown in table 2.

As can be seen from the examples presented in table 2, the introduction of chlorhexidine in the composition does not inhibit the activity of the catalyst (curing time 5 min) compared with control example No. 7, in which chlorhexidine is absent in the composition, does not worsen the basic physical and mechanical properties, but It has a noticeable antibacterial effect.

When the content of chlorhexidine is less than 1 mass.h. its effect is insufficient to provide a noticeable antibacterial effect. And when the content of chlorhexidine is above 3 parts by weight there is a decrease in the cure rate of the composition.

Table 1 Composition Ingredients Conventional song numbers one 2 3 four 5 6 7 1. Viscous Polydimethylmethyl Vinyl Siloxane Rubber 14000 cp one hundred - - - - - - 23000 cp - one hundred - - - one hundred one hundred 30000 cp - - one hundred one hundred - - - 2. Modified Aerosil 16,2 - - 22 25.8 - 22 3. Quartz sand - 15.8 - - - - - 4. Diatomaceous earth - - 10 - - 25.8 - 5. Cremhydride HO [Si (H) C ₂ H ₅ ] n ^-H one - 1,5 3 - - 1,5 HO [Si (H) CH ₃ ] n ^-H - 2 - - 2 1,5 - 6. Platinum 1,3 divinyltetramethyldisiloxane 5 · 10 ^-4 5 · 10 ^-4 5 · 10 ^-6 5 · 10 ^-4 5 · 10 ^-5 5 · 10 ^-4 5 · 10 ^-4 7. Chlorhexidine one 2 3 2 2 2 -

table 2 Properties of the resulting materials Indicators Conditional numbers one 2 3 four 5 6 7 1. The curing time of the mixture, min 5 5 5 5 5 5 5 2. Conditional tensile strength, MPa 3.8 3.6 4.2 4.0 3,7 3,5 3.2 3. Shore hardness, A twenty fifteen fifteen twenty twenty fifteen thirty 4. The force of separation from the acrylic substrate, kg / cm 8.6 7.9 8.2 9.0 9.2 8.9 7.8 5. Relative elongation,% 620 700 740 650 720 710 580 6. Shrinkage,% 0,025 0.02 0.02 0,025 0,025 0.02 0,03 7. The size of the zone of inhibition of bacterial growth, mm 4.0 7.6 7.0 7.0 5,0 7.0 0

Claims (2)

1. A removable denture containing an acrylic base and a backing layer under the basis, formed from a composition based on siloxane rubber, characterized in that the composition for forming the backing layer under the basis includes, by weight:
Polydimethylmethylvinylsiloxane rubber one hundred Filler 16.2 ÷ 25.8 Silica hydride 1 ÷ 3 Platinum catalyst 5 · 10 ^-4 -5 · 10 ^-6 Chlorhexidine 1 ÷ 3 2. A removable denture according to claim 1, characterized in that the composition for forming a lining layer under the base further includes a dye in an amount of 0.1 ÷ 0.3 wt.h.