RU2475875C2 - Method of depositing radioisotope on concave metal surface of substrate of sealed radiation source - Google Patents

Abstract

FIELD: physics.

SUBSTANCE: method of depositing a radioisotope in the concave metal surface of a substrate of a sealed radiation source involves preparing the concave metal surface of the substrate for deposition of the radioisotope, preparing a salt solution of the radioisotope in a viscous organic fluid which wets the metal surface of the substrate by evaporating the aqueous salt solution of the radioisotope to wet salt and dissolving the obtained salt with prolonged mixing in the required amount of glycerol, filling the substrate with the prepared salt solution of the radioisotope in glycerol and evaporating the solution therefrom.

EFFECT: method enables uniform deposition of a radioisotope on the concave surface of a device with full extraction of the radioisotope from the solution.

1 dwg, 2 cl

Description

The invention relates to radiochemistry and the production of medical equipment and can be used to deposit ruthenium-106 on a concave metal surface of an ophthalmic applicator substrate.

A known method of preparing preparations for measuring activity, including the selection of an aliquot of a solution of the salt of a radioisotope in a measuring flat cup and evaporating the solution without overheating it under a lamp to dryness (Lukyanov V.B., Berdonosov S.S., Bogatyrev I.O., Zaborenko , BZ Iofa "Radioactive indicators in chemistry. Conducting an experiment and processing the results." Textbook for universities. M., Higher School, 1977).

The disadvantage of this method is that it cannot be applied when applying a radioisotope to the concave metal surface of the substrate of a closed radiation source. The radioisotope salt solution will drain down a concave surface and the application will be uneven.

Closest to the technical nature of the claimed technical solution is a method of applying ruthenium-106 on a concave metal surface of an ophthalmic applicator substrate, including preparing a solution of a salt of a radioisotope and electrochemical non-current reduction of a radioisotope on a metal surface of a substrate (S.P. Razdrokina, V.V. Gromov "Production of beta sources of ruthenium-106 for ophthalmology ”, Material Science No. 4, 2001).

According to the known method, for applying ruthenium-106 to the concave metal surface of the ophthalmic applicator substrate, the substrate is completely immersed in a solution of ruthenium-106 salt and the solution is mixed, while ruthenium-106 is restored on both the concave and convex surfaces of the substrate.

The disadvantages of this method:

- the window for beta radiation of the ophthalmic applicator is its cover adjacent to the concave surface of the substrate, and ruthenium-106 is advisable to be applied only to the concave surface of the substrate. According to the known method, ruthenium-106 is applied both to a concave surface and to a convex one. For this reason, the consumption of ruthenium increases, since the radiation of ruthenium deposited on a convex surface is significantly shielded by the substrate material;

- according to the known method, the extraction of ruthenium-106 from a solution of its salt is only 50%, the remaining 50% remain in solution.

The technical result of the invention is to save the radioisotope due to its deposition only on the concave surface of the substrate and complete extraction from the solution. To achieve a technical result in a method for applying a radioisotope to a concave metal surface of a substrate of a closed radiation source, including preparing a concave metal surface of a substrate for applying a radioisotope and preparing a solution of the salt of the radioisotope, it is proposed:

- the preparation of the salt solution of the radioisotope is carried out by evaporating an aqueous solution of the salt of the radioisotope to a wet salt and dissolving the obtained salt by prolonged stirring in the required volume of glycerol;

- fill the substrate with the prepared solution of the salt of the radioisotope in glycerol and evaporate the solution from it.

In particular cases of application of the method it is proposed:

- prolonged mixing of the salt solution of the radioisotope by shaking for 12 hours.

The invention is illustrated in the drawing, a flowchart of a method of applying a radioisotope on a concave metal surface of a substrate of a closed radiation source.

The method is as follows.

Preparation of a concave metal surface of a substrate for applying a radioisotope.

The concave metal surface of the substrate of the closed radiation source is prepared by etching in concentrated acid, electrochemical polishing and subsequent washing in distilled water. Preparation of a solution of the salt of the radioisotope. To prepare a solution of the salt of the radioisotope:

- select an aliquot of the initial aqueous solution of the radioisotope in a penicillin vial;

- evaporate the solution in the bottle to wet salt;

- add the required volume of glycerin to the bottle;

- dissolve the salt of the radioisotope in glycerin by means of prolonged stirring;

- the prepared solution of the salt of the radioisotope fill the substrate and the solution is evaporated from it.

The substrate is filled with a solution of the salt of the radioisotope to the upper boundary of its concave metal surface and placed in a heating device installed in a fume hood. Exhaust ventilation is turned on, the heater is turned on, and the solution is evaporated from the substrate. When the solution is evaporated, the radioisotope is chemically reduced on the metal surface of the substrate.

After application, the substrate is washed in acetone, the applied layer of the radioisotope is coated with varnish and the varnish is dried for the required time.

An example of a specific implementation of the method.

As an example of a specific implementation of the method, deposition of 1.25 mCi of ruthenium-106 on the concave surface of a copper substrate of an ophthalmic applicator having the shape of a spherical segment is taken.

Preparation of the concave surface of the copper substrate of the ophthalmic applicator for the application of the radioisotope.

The concave surface of the copper substrate of the ophthalmic applicator is prepared by etching in 12 molar hydrochloric acid, electrochemical polishing and subsequent washing in distilled water.

A solution of ruthenium-106 salt in glycerin is prepared for which:

0.5 ml of the initial solution of ruthenium-106 chloride with a volumetric activity of 2.5 mCi / ml is selected in a penicillin vial;

a solution of ruthenium-106 chloride in a bottle is evaporated to a wet salt;

add the required volume of glycerin to the bottle;

dissolve the ruthenium-106 salt in glycerin by shaking the vial for 12 hours.

The ophthalmic applicator substrate is filled with a solution of ruthenium-106 salt in glycerin to the upper boundary of the concave surface and the solution is evaporated from it. Upon evaporation of the solution, ruthenium-106 is uniformly chemically reduced on the copper concave surface of the ophthalmic applicator substrate. After evaporation of the solution, the substrate is washed in acetone, its concave surface is varnished and dried.

When implementing the method, the loss of ruthenium is excluded and it is applied only on the concave surface of the substrate adjacent to the lid of the ophthalmic applicator. The surface of the ophthalmic applicator cap opposite the substrate is the radiation exit window.

The technical result of the invention is achieved, which consists in saving the radioisotope due to its complete extraction from the solution and applying only to the concave surface of the substrate.

Claims (2)

1. A method of applying a radioisotope to a concave metal surface of a substrate of a closed radiation source, comprising preparing a concave metal surface of a substrate for applying a radioisotope and preparing a solution of the salt of the radioisotope, characterized in that the preparation of a solution of the salt of the radioisotope is carried out by evaporating an aqueous solution of the salt of the radioisotope to a wet salt and dissolving the resulting salt by prolonged stirring in the required volume of glycerin, a prepared solution of the salt of the radioisotope in glycerin fill the substrate and evaporate the solution from it. 2. The method according to claim 1, characterized in that the long-term mixing of the salt solution of the radioisotope is carried out by shaking for 12 hours