RU2473675C2 - Compositions containing polymerised surfactants with low degree of polymerisation and methods of using said compositions - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: personal hygiene composition contains a polymerised surfactant selected from a group consisting of poly(sodium allyldodecyl sulphosuccinate), poly(acrylic acid co-2-acrylamidododecyl sulphonic acid) and poly(sodium allyldodecyl sulphosuccinate-co-acrylic acid) and an ingredient which is usually used in personal hygiene compositions. Preferably, the composition has TEP of about 3 or higher. The composition can additionally contain at least one monomer surfactant.

EFFECT: reduced irritant effect on the skin and eyes, increased foaming.

10 cl, 14 tbl, 27 ex, 1 dwg

Description

FIELD OF THE INVENTION

The present invention relates to compositions containing polymerized surfactants and, in particular, to compositions containing polymerized surfactants that are successful in personal care applications and have relatively low irritating properties.

DESCRIPTION OF THE PRIOR ART

Artificial detergents, such as cationic, anionic, amphoteric and nonionic surfactants, are widely used in various detergent and cleaning compositions to give them cleaning properties. Additionally, in some compositions (e.g., personal care compositions such as shampoos, cleansers, etc.) it may be necessary to use combinations and dosages of surfactants sufficient to achieve relatively high levels of foam volume and / or foam stability .

However, as is widely recognized in the art, artificial detergents tend to cause skin and eye irritation. Therefore, since the dosages of such detergents increase in an effort to improve the cleansing and foaming characteristics inherent in some compositions, the irritation associated with such compositions also tends to increase, making them undesirable for use on or in close proximity to the skin and / or eyes.

Some attempts to create mild cleansing compositions have included a combination of relatively low amounts of anionic surfactants (which tend to relatively high foaming, but also cause relatively strong irritation) with relatively less irritating surfactants, such as non-ionic and / or amphoteric surfactants active substances (see, for example, US patent No. 4726915). Another technique for creating mild cleansing compositions is a combination of anionic surfactants with amphoteric or cationic compounds to form surfactant complexes (see, for example, US Pat. Nos. 4,443,362; 4,726,915; 4,186,113; and 4,110,263). Soft cleansing compositions produced by both of these methods tend to have relatively low foaming and cleansing characteristics, which is unfavorable. Another technique described in Librizzi et. al. (in U.S. Patent Application Publication 20050075256 A1) discusses the use of a composition comprising both a hydrophobic modified polymer and a surfactant to provide a cleaning composition with low irritating properties.

Despite this, the applicants of the invention recognized the need for additional techniques to provide compositions with reduced irritating properties and methods with reduced irritating effects on the skin and / or eyes. In addition, in some embodiments, applicants have recognized the need for compositions that are not only soft for the skin and / or eyes, but additionally exhibit the required foaming properties and / or other required aesthetic characteristics.

SUMMARY OF THE INVENTION

The present invention provides personal care compositions that overcome the disadvantages of the prior art and have relatively low irritating properties associated with them. In particular, the inventors disclose that certain polymerized surfactants can be used to provide a significant advantage in creating compositions having low irritating properties, and in some embodiments combining additional beneficial aesthetic and other properties.

In accordance with one aspect, the present invention provides a personal care composition comprising a polymerized low polymerization surfactant having a PMOD% of less than 90%.

In another aspect of the invention, there is provided a composition comprising a polymerized low polymerization surfactant, compositions having a TEP value of about 3 or more.

In yet another aspect of the invention, methods are provided for manufacturing personal care compositions, comprising combining a polymerized surfactant having a PMOD% of less than about 90% with at least one other personal care component to produce a composition having a CMID% of less than approximately 90%.

In yet another aspect of the invention, Applicants provide a method for treating a skin, hair, or vaginal region, a method comprising applying to a skin, hair, or vaginal region a composition comprising a low polymerized polymerized surfactant having a PMOD% of less than about 90%.

BRIEF DESCRIPTION OF THE DRAWINGS

Figure 1 is a graphical representation of the theoretical size distribution of micelles for compositions of the present invention and compositions of the prior art.

DESCRIPTION OF PREFERRED EMBODIMENTS

All percentages listed in this document represent wt.%, Unless specifically indicated otherwise.

As used herein, the term “polymerized surfactant” means any polymer containing repeating units that are amphiphilic, i.e. the repeating units contain at least one hydrophilic part and at least one hydrophobic part.

A “repeating unit” is thus defined as the smallest combination of chemical particles (eg, ions or atoms) that are repeated periodically to create a polymer. Polymerized surfactants can be visually depicted as the number of surface active structures (i.e., amphiphilic structures) that are connected by a polymer skeleton (reference to Anton, P. Köberle, P .; Laschewsky, A. Makromol. Chem., 1993 , 194, 1-27).

As will be clearly understood by a person skilled in the art, the term "hydrophilic moiety" is any anionic, cationic, zwitterionic or nonionic group that is polar and, in general, water soluble. Non-limiting examples include anionic groups such as sulfate, sulfonate, carboxylate, phosphate, phosphonates; cationic groups such as ammonium, including mono-, di- and trialkylammonium species, pyridinium, imidazolinium, amidinium, poly (ethyleneiminium); zwitterionic groups such as ammonioalkyl sulfonate, ammonioalkyl carboxylate, amphoacetate; and nonionic groups such as hydroxyl, sulfonyl, poly (ethyleneoxy).

A “hydrophobic moiety” is thus defined as a non-polar, generally water-insoluble group containing seven or more carbon atoms. Some preferred hydrophobic moieties include moieties containing about eight or more carbon atoms, more preferably about 10 or more carbon atoms. Some particular preferred hydrophobic moieties include those moieties that have from about 8 to about 12 carbon atoms. Non-limiting examples of hydrophobic groups include any unsaturated or saturated linear, branched, cyclic or aromatic hydrocarbons containing more than five carbon atoms. Functional groups that can be included in a hydrophobic group are, for example, ethers and esters, ketone, amide, carbonate, urethane, carbamate or xanthan functional groups.

As defined herein, the term “polymerized surfactant with a low degree of polymerization” means a polymerized surfactant, as described above, which further meets the following criteria (a) and (b): (a) polymerized surfactant has at least about 7 and less than about 2000 repeating amphiphilic units per average basis weight; and (b) amphiphilic repeating units contain at least about 10 mol%. polymerized surfactant. Examples of some preferred polymerized surfactants with a low degree of polymerization include polymerized surfactants having from 7 to about 2000 amphiphilic repeating units, such as polymerized surfactants that have from 10 to about 1000 amphiphilic repeating units, and still more preferably from about 20 to about 500 amphiphilic repeating units. In some embodiments, the low polymerized polymerized surfactants of the present invention preferably contain at least about 25 mol% of amphiphilic repeating units.

As indicated above, the inventors have unexpectedly discovered that polymerized surfactants are suitable for use in the manufacture of compositions having relatively low irritating properties. In accordance with some preferred embodiments, applicants have disclosed that polymerized low polymerization surfactants having a PMOD% (measured in accordance with the procedure described hereinafter and illustrated by examples) are less than about 90%, more preferably less more than about 80%, more preferably less than about 50%, and more preferably less than about 40%, are successful in preparing the compositions, advantageously having x relatively low irritating properties associated with them.

For example, applicants indicate that the “TEP value” inherent in a single composition, which is measured by the generally accepted Trans-Epithelial Permeability Test method, as published in Invittox Protocol No. 86 (May 1994), incorporated herein by reference and described further in detail in the Examples below, has a direct correlation with skin and / or eye irritation associated with the composition. In particular, a composition with a higher TEP value tends to cause less skin and eye irritation associated with it, compared with a composition having a lower TEP value, such a composition causes higher degrees of skin and eye irritation.

Applicants have found that the present compositions have a surprisingly high TEP / lower irritation associated with them. For example, in some embodiments, the present compositions have a TEP of less than about 3, or more preferably at least about 3.5 or more. In some more preferred embodiments, the compositions prepared in accordance with the present methods exhibit a TEP of at least about 4 or more, more preferably at least about 5 or more, even more preferably at least about 6 or more. In some particular preferred embodiments, the compositions can substantially detect such an unexpected and obvious reduction in the degree of irritation that the TEP rating exceeds the measuring ability of the test, and is thus labeled “no leak”.

Applicants further disclose that two compositional parameters, (1) “average micellar hydrodynamic diameter d _n ”, an average micelle size, and in particular (2) “micelle fraction with d _n <9 nanometers (nm)” provides an estimate of the degree of irritation, which may be caused by compositions that contain surfactants. Thus, applicants have found that surfactant micelles are rarely monodisperse in size and aggregation number (i.e., the average number of surfactant molecules in a single micelle). Instead, surfactant micelles tend to exist as a population with a size and number distribution of aggregates, which determines the size distribution function of micelles, as shown by the example in FIG. 1. Figure 1 is a graph 10 showing the micelle size distribution function for a typical conventional surfactant system, a composition containing sodium laureth sulfate and cocamidopropyl betaine (curve 11 obtained by selecting the ideal normal distribution logarithm for the current data obtained by the study of Comparative Example 19) . Applicants have disclosed by comparison that the polymerized surfactants of the present invention with a low degree of polymerization are able to provide micelles distribution, which, as curve 15 illustrates, is “shifted” towards the desired larger micelles (the curve is obtained by selecting the ideal logarithm of the normal distribution for the current data obtained the study of Example 12).

Accordingly, applicants rated the fraction of relatively small micelles and the average micelle size in the compositions of the present invention and in comparative compositions as “CMID%” and “CMIDz”, respectively (both were measured in accordance with the methods described hereinafter and illustrated by the Examples). As described in detail below in tables 7, 11 and 14, applicants have indicated that the compositions of the present invention tend to consist of a fraction of small micelles, i.e. from a micelle fraction with d _H <9 nm (indicated herein as “CMID%"), which is unexpectedly low. In one embodiment, the CMID% of the composition is less than about 90%, more preferably less than about 80%, even more preferably less than about 50%, and most preferably less than about 30%.

For clarity, it is emphasized that CMID% refers to the relative irritation associated with the property of the composition (including compositions containing polymerized surfactants), while PMOD% refers to the relative irritation / relative acceptability of the polymerized surfactant for use in the composition in accordance with preferred embodiments of the invention.

Applicants further found that the present invention further allows for the manufacture of compositions that exhibit not only reduced irritating, but also desirable foaming characteristics. In particular, as described in detail in table 3, the applicants disclosed that it is not only possible to create compositions that have a low irritant effect, but these compositions also have a pronounced foaming. For example, in some embodiments, the compositions of the present methods have a foaming value of about 25 ml or more. In some more preferred embodiments, the compositions produced in accordance with the present methods exhibit foaming of at least about 50 ml or more, more preferably at least 100 ml.

Applicants further found that the present invention allows the preparation of compositions that exhibit not only reduced irritating, but also the desired rheological properties. In particular, applicants have disclosed that while some ingredients, such as hydrophobic modified polymers, tend to increase the viscosity and the yield point corresponding to the composition, more with the addition of the polymer, the polymerized surfactants of the present invention have relatively little effect on the fluidity of the compositions to which they are added. Accordingly, in some embodiments, a higher amount of the polymers of the present invention may be added to more significantly reduce irritation without obtaining a composition that is too viscous for effective personal use.

In addition, applicants further unexpectedly disclosed that while some conventional surfactants become more irritant as the concentration of surfactant in the composition increases to a certain level, the polymerized surfactants of the present invention are not likely to exhibit such an adverse increase in irritation when high concentrations. As shown in table 14, it can be seen that the concentration of the polymerized surfactant increases from 4.8% to 10%, the CMID% increases only slightly, and TEP is also quite stable, showing that the properties of these compositions are unexpectedly " not dose-dependent. ”

Any modifications to the polymerized surfactants that meet the above criteria may be suitable for the present invention. Although the applicants did not want to be bound by any particular theory, it is certain that polymerized surfactants meeting the above criteria reduce the irritation associated with the use of personal care compositions by at least partial, preferred formation of larger micelles ( which tend to be less annoying) than traditional surfactants. Polymerized surfactants suitable for use in the present invention include polymerized surfactants of various chemical classes and obtained by various synthesis routes. Examples include polymers having a skeleton that mainly contains multiple carbon-carbon bonds, preferably essentially consists or consists only of carbon-carbon bonds, and polymers have a skeleton containing multiple carbon-carbon bonds (as is known to one skilled in the art, the skeleton means, in general, a portion of the repeating units in a polymer that are covalently linked to adjacent repeating units (as opposed to “side groups"). Examples of suitable polymers having a skeleton are essentially count consisting of carbon-carbon bonds and polymers comprising carbon-heteroatom include listed below, as well as combinations of two or more thereof, etc .:

[I] Polymers having a skeleton that mainly contains carbon-carbon bonds, such as bonds that can be (1) formed by ethylene (or acetylene) unsaturated monomers or (2) polyketones (in all subclasses (A) - (D ) hereinafter, n = from 7 to 2000 and m is up to 10000).

Subclass (A): homopolymerization of pre-prepared reactive amphiphilic substances containing ethylenically unsaturated functional groups (hereinafter referred to as “EUAH”).

In which R ₁ = R ₂ = H, R ₃ = H or CH _3, and R ₄ contains an amphiphilic (Amphil) group, or

In which R ₁ = R ₂ = H, R ₃ contains a hydrophilic (Nphil) group and R ₄ contains a hydrophobic (Nphob) or

In which R ₁ , R ₃ are independently H or CH ₃ , R ₂ contains Nfil, and R ₄ contains an Nphob group, or

In which R ₁ , R ₄ are independently H or CH ₃ , R ₃ contains Nphil, and R ₄ contains an Nphob group, or

In which R ₂ , R ₃ represent independently from each other H or CH ₃ , R ₁ contains Nfil, and R ₄ contains Nfob group

to obtain a polymerized surfactant with an amphiphilic repeating unit indicated in parentheses immediately below, and having the number of repeating units n:

Examples of monomers successful in obtaining this class of polymerized surfactants include:

Anionic:

Ω-alkenoates : e.g. sodium 11-undecenoate

in which R ₁ = any linear or branched carbon chain containing more than 5 carbon atoms, and M = H ⁺ , NH ₄ ⁺ or any alkali metal cation of Group IA.

· (Meth) acrylamidoalkylcarboxylates and (meth) acryloxyalkylcarboxylates: for example sodium 11-acrylamidoundecanoate, sodium 11-methacryloyloxyundecanoate

in which R ₂ = H or CH ₃ , X = O or NH, R ₃ = any linear or branched carbon chain containing more than 5 carbon atoms and M = H ⁺ , NH ₄ ⁺ or any alkali metal cation Groups IA.

· (Meth) acrylamidoalkyl sulfonic acid: for example 2-acrylamidododecyl sulfonic acid

in which R ₄ = H or CH ₃ , X = O or NH, R ₅ = any linear or branched carbon chain containing more than 5 carbon atoms, and M = H ⁺ , NH ₄ ⁺ or any alkaline cation Group IA metal.

Allylalkyl sulfosuccinates: e.g. sodium allyldodecyl sulfosuccinate (TREM LF-40, Cognis)

in which R ₆ = any linear or branched carbon chain containing more than 5 carbon atoms and M = H ⁺ , NH ₄ ⁺ or any alkali metal cation of Group IA.

Cationic:

· Quaternized aminoalkyl (meth) acrylamides and aminoalkyl (meth) acrylates: for example (3-methacrylamidopropyl) dodecyldimethylammonium chloride, (2-methacryloyloxyethyl) dodecyldimethylammonium chloride

in which R ₇ = H or CH ₃ , X = O or NH, R ₈ = any linear or branched carbon chain containing 5 or less carbon atoms, R ₉ = H, CH ₃ , CH ₂ CH ₃ or CH ₂ CH ₂ OH, R ₁₀ = any linear or branched carbon chain containing more than 5 carbon atoms, and Z = any Group VII-A halide anion; OR, in which R ₇ = H or CH ₃ , X = O or NH, R ₈ = any linear or branched carbon chain containing more than 5 carbon atoms, R ₉ , R ₁₀ independently represent H, CH ₃ , CH ₂ CH ₃ or CH ₂ CH ₂ OH, and Z = any Group VII-A halide anion

· Quaternized vinyl pyridines: for example, (4-vinyl) dodecyl pyridine bromide

in which R ₁₁ = any linear or branched carbon chain containing more than 5 carbon atoms, and Z = any halogen anion of Group VII-A.

Alkyldiallylmethylammonium halides: e.g. diallyldiodecylmethylammonium chloride

in which R ₁₂ = H, CH ₃ or R ₁₃ , R ₁₃ = any linear or branched carbon chain containing more than 5 carbon atoms, and Z = any halogen anion of Group VII-A.

Zwitterionic:

Ammonioalkanecarboxylates: for example 2 - [(11- (N-methylacrylamidyl) undecyl) dimethylammonio] acetate

in which R ₁₄ = H or CH ₃ , X = O or N, R ₁₅ = H, CH ₃ , CH ₂ CH ₃ or CH ₂ CH ₂ OH, R ₁₆ = any linear or branched carbon chain containing more than 5 carbon atoms, R ₁₇ = any linear or branched carbon chain containing 5 or less carbon atoms, and R ₁₈ = H, CH ₃ or absent.

Ammonioalkanesulfonates: for example 3 - [(11- (methacryloyloxyundecyl) dimethylammonio] propanesulfonate

in which R ₁₉ = H or CH ₃ , X = O or N, R ₂₀ = H, CH ₃ , CH ₂ CH ₃ or CH ₂ CH ₂ OH, R ₂₁ = any linear or branched carbon chain containing more than 5 carbon atoms, R ₂₂ = any linear or branched carbon chain containing 5 or less carbon atoms, and R ₂₃ = H, CH ₃ or absent.

Nonionic:

Ω-methoxypoly (ethyleneoxy) alkyl-α- (meth) acrylates: for example, ω-methoxypoly (ethyleneoxy) undecyl -α-methacrylate

in which R ₂₄ = H or CH ₃ , X = O, R ₂₅ = any linear or branched carbon chain containing more than 5 atoms, n is an integer from about 4 to about 800, and R ₂₆ = any either a linear or branched carbon chain containing 5 or less carbon atoms

Ω-alkoxypoly (ethyleneoxy) -α- (meth) acrylates and ω-alkoxypoly (ethyleneoxy) -α-itaconates: for example, stearet-20 methacrylate, cetet-20 itaconate

in which R ₂₇ = H, CH ₃ or CH ₂ COOH, X = O, R ₂₈ = any linear or branched carbon chain containing more than 5 atoms, n is an integer from about 4 to about 800.

Subclass (B): copolymerization of one or more pre-prepared reactive amphiphilic substances containing ethylene unsaturated functional groups described above with other reactive amphiphilic substances from the above subclass (A) and / or with one or more ethylene unsaturated hydrophilic copolymers of the formula (hereinafter in this document “EUAC”):

In which R ₅ = R ₆ = H, R ₇ = H or CH ₃ and R ₈ contains an Nfil group, or

In which R ₅ , R ₆ independently represent H or CH ₃ , R ₇ contains an Nfil group, and R ₈ contains an Nfil group

In which R ₅ , R ₇ independently from each other represent H or CH ₃ , R ₆ contains Nfil group, and R ₈ contains Nfil group

In which R ₆ , R ₇ independently from each other represent H or CH ₃ , R ₅ contains Nfil group, and R ₈ contains Nfil group

to obtain a polymerized surfactant with an amphiphilic repeating unit shown in brackets immediately below and having the number of amphiphilic repeating units n and non-amphiphilic repeating units m:

Examples of pre-prepared reactive amphiphilic substances containing ethylenically unsaturated functional groups are described above with reference to (A). Examples of hydrophilic copolymers that can react with them include

i) nonionic: acrylamide, N, N-dimethylacrylamide, N-vinylformamide, hydroxyethyl (meth) acrylate, glyceryl methacrylate, sucrose mono (meth) acrylate, ω-methoxypoly (ethyleneoxy) -α- (meth) acrylate

ii) anionic: acrylic acid, 2-acrylamido-2-methylpropanesulfonic acid, 3-acrylamido-3-methylbutanoic acid

iii) cationic: N, N-dimethylaminoethyl methacrylate, N, N-dimethylpropyl (meth) acrylamide, (3- (meth) acrylamidepropyl) trimethylammonium chloride, diallyldimethylammonium chloride

iv) zwitterionic: 3 - [(3- (meth) acrylamidepropyl) dimethylammonio] propanesulfonate, 3- (3- (3- (meth) acrylamidepropyl) dimethylammonio) propionate, 3- (3- (3- (meth) acrylamidepropyldimethylammonio) acetate.

Subclass (C): polymerization of multifunctional amphiphilic molecules with multifunctional binders (e.g., stepwise polymerization of acrylic (poly) glucosides with bifunctional binders, such as dicarboxylic acids, bis (acyl halides), diisocyanates, bis (epoxide) s or epichlorohydrins, to produce polymerized a surfactant with an amphiphilic repeating unit, which is shown in brackets immediately below, and has the number of amphiphilic repeating units n (hereinafter the document "amphiphilic substances with stepwise production" or "SGA"):

Subclass (D): post-polymerization modification of the polymers described above to provide some or all of the repeating amphiphilic units; receiving a polymerized surfactant with an amphiphilic repeating unit, which is shown in brackets immediately below, and has the number of amphiphilic repeating units n and non-amphiphilic repeating units m (hereinafter referred to as "PPDA":

Examples are given below:

v) through post-polymerization modification provide repeating amphiphilic units:

(a) 1: 1 hydrolysis of alternating copolymers of maleic anhydride and long chain α-olefins or alkyl vinyl ethers;

(b) opening a 1: 1 cycle of alternating copolymers of maleic anhydride and long chain α-olefins or alkyl vinyl ethers with aminoalkyl sulfonic acids, aminoalkyl carboxylic acids or dialkylaminoalkylamines;

vi) incorporate amphiphilic repeating units through post-polymerization modification:

(a) reacting a polymer with repeating units containing hydroxyl functional groups, such as polyvinyl alcohol, hydroxyethyl cellulose or dextran, with 3-chloro-2-hydroxypropylalkyl dimethylammonium chlorides such as QUAB 342, 360 and 426 sold by Degussa AG Parsippany, NJ

(b) partial quaternization of poly (4-vinylpyridine) with alkyl bromides.

Examples of suitable polymerized surfactants with a skeleton containing carbon-heteroatom bonds include SGA and PPDA having the described skeleton, such as polyesters, including polysaccharides, polyesters, polycarbonates, polyanhydrides, polyamides, polyurethanes, polyureas, polyimides, polysulfones, polysulfides , combinations of two or more such substances, and the like.

In accordance with some preferred embodiments, the polymerized surfactant for use in the present invention comprises EUAHs such as poly (sodium allyldodecyl sulfosuccinate) and the like, EUAC such as poly (acrylic acid co-2-acrylamide dodecyl sulfonic acid), poly (sodium allyldodecyl sulfosuccinate-co-acrylic acid) and the like, PPDA polymers with a skeleton containing carbon-carbon bonds, such as octadecene / maleic anhydride copolymers, tetradecene / maleino copolymers acid anhydride, derivatives thereof (including, for example, hydrolyzed derivatives, amidated derivatives, etc.), combinations of two or more of them, and the like.

In some preferred embodiments, the polymerized surfactants for use in the present invention comprise polymers with a carbon heteroatom skeleton such as polysaccharides, polyesters, polycarbonates, polyanhydrides, polyamides, polyurethanes, polyureas, polyimides, polysulfones, polysulfides, combinations of two or more thereof substances. Some preferred carbon-heteroatom skeleton polymers include polysaccharides.

The molecular weight of the polymerized surfactant is not critical. In one embodiment, the polymerized surfactant has a molecular weight of from about 3,500 to about 500,000. In a preferred embodiment, the polymerized surfactant has a molecular weight of from about 5,000 to about 200,000, more preferably from about 7,500 to about 100,000, and most preferably from about 10,000 to about 50,000.

Any amounts of polymerized surfactants of the present invention suitable for the production of micelles with a size distribution can be combined in accordance with the present methods. In some embodiments, the polymerized surfactant is used in a concentration of more than about 0.1% to about 30% by weight of the active polymerized surfactant in the composition. Preferably, the polymerized surfactant is present in a concentration of from about 0.5 to about 20%, more preferably from about 1 to about 15%, even more preferably from about 2 to about 10% of the active polymerized surfactant in the composition. In some other preferred embodiments, the compositions of the present invention comprise from about 0.5 to about 15%, more preferably from about 1.5 to about 10%, even more preferably from about 2 to about 7%, even more preferably from about 3 to approximately 7% of the active polymerized surfactant in the composition.

The compositions used in the present invention may also include any various monomers of surfactants. "Monomeric surfactants" means any surfactants that do not meet the definition of "polymerized surfactant" above. Monomeric surfactants can be anionic, nonionic, amphoteric or cationic, examples of which are detailed below.

In accordance with some embodiments, suitable anionic surfactants include those selected from the following classes of surfactants: alkyl sulfates, esterified alkyl sulfates, ether sulfonates, alkyl arylsulfonates, alkyl sulfosulfates, ether sulfosulfates, sulfosulfonates alkyl succinates, fatty acylsar cozinates, fatty acyl amino acids, fatty acyl taurates, fatty alkyl sulfoacetates, alkyl phosphates, and mixtures of two or more thereof. Examples of some preferred anionic surfactants include:

alkyl sulfates having the formula

esterified alkyl sulfates having the formula

esterified alkyl monoglycerol sulfates having the formula

alkyl monoglyceride sulfates having the formula

alkyl monoglyceride sulfonates having the formula

alkyl sulfonates having the formula

alkylaryl sulfonates having the formula

alkyl sulfosuccinates having the formula

esterified alkyl sulfosuccinates having the formula:

alkyl sulfosuccinamates having the formula:

alkylamidosulfosuccinates having the formula:

alkyl carboxylates having the formula:

esterified alkylamide carboxylates having the formula:

alkyl succinates having the formula:

fatty acyl sarcosinates having the formula:

fatty acylamino acids having the formula:

fatty acyltaurates having the formula:

fatty alkyl sulfoacetates having the formula:

alkyl phosphates having the formula:

in which

R 'represents an alkyl group having from about 7 to about 22, and preferably from about 7 to about 16 carbon atoms,

R ₁ 'represents an alkyl group having from about 1 to about 18, and preferably from about 8 to about 14 carbon atoms,

R ₂ 'represents a substituent of a natural or synthetic l-amino acid,

X 'is selected from the group consisting of alkali metal ions, alkaline earth metal ions, ammonium ions and ammonium ions substituted with from about 1 to about 3 substituents, each of the substituents may be the same or different and selected from the group consisting of alkyl groups having from 1 to 4 carbon atoms and hydroxyalkyl groups having from about 2 to about 4 carbon atoms and

v is an integer from 1 to 6;

w is an integer from 0 to 20;

and mixtures thereof.

Any various non-ionic surfactants are suitable for use in the present invention. Examples of suitable nonionic surfactants include, but are not limited to, fatty acid alcohols or amide ethoxylates, monoglyceride ethoxylates, esterified sorbitan ethoxylates, alkyl polyglycosides, mixtures thereof, and the like. Some preferred non-ionic surfactants include polyoxyethylene ester derivatives of polyhydric alcohols in which the polyoxyethylene ester derivative of polyhydric alcohol (1) is derived from (a) a fatty acid containing from about 8 to about 22, and preferably from about 10 to about 14 carbon atoms and (b) a polyhydric alcohol is selected from sorbitol, sorbitan, glucose, α-methylglucoside, polyglucose having an average of about 1 to about 3 glucose residues per mole kulu, glycerol, pentaerythritol and mixtures thereof, (2) contains on average from about 10 to about 120 and preferably from about 20 to about 80 units of hydroxyethylene; and (3) has an average of about 1 to about 3 fatty acid residues per mole of polyoxyethylene ester of a polyhydric alcohol. Examples of such preferred polyoxyethylene ester derivatives of polyhydric alcohols include, but are not limited to, PEG-80 sorbitan laurate and Polysorbate 20. PEG-80 sorbitan laurate, which is lauric acid sorbitan monoester, ethoxylated on average with approximately 80 moles of ethylene oxide, sold by Uniqema, Chicago, I under the trade name Atlas G-4280. Polysorbate 20, which is a laurate mono-ester of a mixture of sorbitol and sorbitol anhydrides condensed with approximately 20 moles of ethylene oxide, is sold by ICI Surfactants, Wilmington, Delaware under the trade name “Tween 20”.

Another class of suitable non-ionic surfactants includes long chain alkyl glucosides or polyglucosides, which are the condensation products of (a) a long chain alcohol containing from about 6 to about 22, and preferably from about 8 to about 14 carbon atoms, with (b) glucose or glucose-containing polymer. Preferred glucosides are decyl glucosides, which are condensation products of decyl alcohol with a glucose polymer and are sold by Cognis Corporation Ambler, PA under the trade name "Plantaren 2000".

Any various amphoteric surfactants are suitable for use in the present invention. As used herein, the term “amphoteric” will mean: 1) molecules that contain both acidic and alkaline centers, such as, for example, an amino acid containing both amino (alkaline) and acidic (eg, carboxylic acid, acidic) functional groups or 2) zwitterionic molecules that have both positive and negative charges in the same molecule. The charges of the latter can be either dependent or independent of the pH of the composition. Examples of zwitterionic substances include, but are not limited to, alkyl betaines and amidoalkyl betaines. Amphoteric surfactants are disclosed herein without ion counting. The person skilled in the art clearly understands that under the pH conditions of the composition of the present invention, amphoteric surfactants are either electrically neutral, as they have positive and negative charges, or have opposite ions, such as alkali metal, alkaline earth metal or ammonium ions.

Examples of amphoteric surfactants suitable for use in the present invention include, but are not limited to, amphocarboxylates, such as alkylamphoacetates (mono or di); alkyl betaines; amidoalkyl betaines; amidoalkylsultaines; amphophosphates; phosphorylated imidazolines such as phosphobetaines pyrophosphobetaines; carboxyalkylalkylpolyamines; alkyl iminodipropionates; alkyl amphoglycinates (mono or di); alkyl amphopropionates (mono or di); N-alkyl β-aminopropionic acids; alkyl polyaminocarboxylates; and mixtures thereof.

Examples of suitable amphoteric carboxyl compounds include compounds having the formula:

A-CONH (CH ₂ ) _x N ⁺ R ₅ R ₆ R ₇

wherein

A represents an alkyl or alkenyl group with the number of carbon atoms from about 7 to about 21, for example from about 10 to about 16;

x is an integer from about 2 to about 6;

R ₅ represents hydrogen or a carboxyalkyl group containing from about 2 to about 3 carbon atoms;

R ₆ represents a hydroxyalkyl group containing from about 2 to about 3 carbon atoms or a group having the formula:

R ₈ —O— (CH ₂ ) _n CO ₂ ^-

in which R ₈ represents an alkylene group having from about 2 to about 3 carbon atoms and n is 1 or 2; and

R ₇ represents a carboxyalkyl group containing from about 2 to about 3 carbon atoms;

Examples of suitable alkyl betaines include compounds having the formula:

B-N ⁺ R ₉ R ₁₀ (CH ₂ ) _p CO ₂ ^-

wherein

B represents an alkyl or alkenyl group with carbon atoms from about 8 to about 22, for example from about 8 to about 16;

R ₉ and R ₁₀ each independently represents an alkyl or hydroxyalkyl group having from about 1 to about 4 carbon atoms; and

p represents 1 or 2.

Preferred betaines for use in the present invention are lauryl betaine sold by Albright & Wilson, Ltd. West Midlands, United Kingdom, as "Empigen BB / J".

Examples of suitable amidoalkyl betaines include compounds having the formula:

D-CO-NH (CH ₂ ) _q -N ⁺ R ₁₁ R ₁₂ (CH ₂ ) _m CO ₂ ^-

wherein

D represents an alkyl or alkenyl group with the number of carbon atoms from about 7 to about 21, for example from about 7 to about 15;

R ₁₁ and R ₁₂ , each independently of one another, is an alkyl or hydroxyalkyl group having from about 1 to about 4 carbon atoms; and

q is an integer from about 2 to about 6; and m is 1 or 2.

One amidoalkyl betaine is cocamidopropyl betaine sold by Degussa Goldschmidt Chemical Corporation Houpwell, Virginia under the trade name "Tegobetaine L7".

Examples of suitable amidoalkylsultaines include compounds having the formula

wherein

E represents an alkyl or alkenyl group with the number of carbon atoms from about 7 to about 21, for example from about 7 to about 15;

R ₁₄ and R ₁₅ each independently represents an alkyl or hydroxyalkyl group having from about 1 to about 4 carbon atoms; and

r is an integer from about 2 to about 6; and

R ₁₃ represents an alkylene or hydroxyalkylene group with a carbon number of from about 2 to about 3.

In one embodiment, the amidoalkylsulfaine is cocamidopropylhydroxysultaine sold by Rhodia Inc. Cranbury, NJ, under the trade name "Mirataine CBS".

Examples of suitable amphophosphate compounds include compounds having the formula:

in which G represents an alkyl or alkenyl group having from about 7 to about 21 carbon atoms, for example from about 7 to about 15;

s is an integer from about 2 to about 6;

R ₁₆ represents hydrogen or a carboxyalkyl group containing from about 2 to about 3 carbon atoms;

R ₁₇ represents a hydroxyalkyl group containing from about 2 to about 3 carbon atoms or a group having the formula:

R ₁₉ —O— (CH ₂ ) _t CO ₂ ^-

wherein

R ₁₉ represents an alkylene group or a hydroxyalkylene group having from about 2 to about 3 carbon atoms and

t is 1 or 2; and

R ₁₈ represents an alkylene group or a hydroxyalkylene group containing from about 2 to about 3 carbon atoms.

In one embodiment, the amphophosphate compounds are sodium lauroampho PG acetate phosphate sold by Uniqema, Chicago, Illinois under the trade name "Monateric 1023" and which is disclosed in US Pat. No. 4,380,637, incorporated herein by reference.

Examples of suitable phosphobetaines include compounds having the formula:

in which E, r, R ₁ , R ₂ and R ₃ are indicated above. In one embodiment, the phosphobetaine compounds are disclosed in US Pat. Nos. 4,215,064, 4,617,414 and 4,233,192, which are incorporated herein by reference.

Examples of suitable pyrophosphobetaines include compounds having the formula:

in which E, r, R ₁ , R ₂ and R ₃ are indicated above. In one embodiment, pyrophosphobetaine compounds are disclosed in US Pat. Nos. 4,382,036, 4,372,869 and 4,617,414, which are incorporated herein by reference.

Examples of suitable carboxyalkylalkylpolyamines include substances having the formula:

wherein

l represents an alkyl or alkenyl group having from about 8 to about 22 carbon atoms, for example from about 8 to about 16;

R ₂₂ represents a carboxyalkyl group having from about 2 to about 3 carbon atoms;

R ₂₁ represents an alkylene group having from about 2 to about 3 carbon atoms; and

u is an integer from about 1 to about 4.

Classes of cationic surfactants that are suitable for use in the present invention include quaternary alkyls (mono, di or three), quaternary benzyls, quaternary esters, quaternary ethoxylated compounds, alkyl amines and mixtures thereof, in which the alkyl groups have from about 6 to about 30 carbon atoms, preferably have from about 8 to about 22 carbon atoms.

Any amounts of a monomeric surfactant suitable for the manufacture of a composition containing a small micelle fraction can be combined in accordance with the present methods. For example, the amount of monomeric surfactants used in the present invention may be from about 0.1 to about 30%, more preferably from about 0.5 to about 20%, even more preferably from about 1 to about 15% of the total monomeric surfactants in the composition, and even more preferably from about 2% to about 10%.

Any relative amounts of polymerized surfactant and monomeric surfactant suitable for the manufacture of a composition containing a small micelle fraction can be combined in accordance with the present methods. In some embodiments, the composition comprises a polymerized surfactant in a ratio of from about 0.1: 1 to about 5: 1, and preferably from about 0.25: 1 to about 3: 1 to the sum of all monomeric surfactants .

In addition to monomeric surfactants, the compositions of the present invention may contain any other various ingredients traditionally used in personal care compositions (“personal care components”). These other ingredients include, but are not limited to, one or more pearlescent or opacifying agents, thickeners, emollients, secondary conditioners, moisturizers, chelating agents, active substances, exfoliants and additives that enhance the appearance, fill and odor compositions, such as dyes, perfumes, preservatives, pH corrective substances, etc.

Any commercially available pearlescent and opacifying agents that can suspend water-insoluble additives, such as silicon, and / or which indicate to users that the final product is a conditioning shampoo, are suitable for use in the present invention. Pearlescent and opacifying agents can be present in an amount based on the total weight of the composition, from about 1 to about 10 percent, for example from about 1.5 to about 7 percent, or from about 2 to about 5 percent. Examples of suitable pearlescent and opacifying agents include, but are not limited to, mono- and diesters of (a) fatty acids having from about 16 to about 22 carbon atoms and (b) either ethylene or propylene glycol; mono- and diesters of (a) fatty acids having from about 16 to about 22 carbon atoms and (b) a polyalkylene glycol of the formula: HO- (JO) _a —H, in which J is an alkylene group having from about 2 to about 3 carbon atoms; and a represents 2 or 3; fatty alcohols containing from about 16 to about 22 carbon atoms; fatty esters having the formula COOCOCH ₂ L, in which L and K independently from each other contain from about 15 to about 21 carbon atoms; inorganic solids insoluble in the shampoo composition, and mixtures thereof.

Pearlescent and opacifying agents can be incorporated into a mild detergent in the form of a pre-created, stabilized aqueous dispersion, such as sold by Cognis Corporation, Ambler, PA, under the trade name "Euperlan PK-3000". The specified substance is a combination of glycol distearate (ethylene glycol diester and stearic acid), Laureth-4 (CH ₃ (CH ₂ ) ₁₀ CH ₂ (OCH ₂ CH ₂ ) ₄ OH) and cocamidopropyl betaine and can be in a ratio of wt.% From approximately 25 to about 30: about 3 to about 15: about 20 to about 25, respectively.

Any commercially available thickeners that are capable of providing an appropriate viscosity to personal care compositions are suitable for use in the present invention. If thickeners are used, they can, for example, be presented in an amount sufficient to increase the viscosity of the Brookfield composition to from about 500 to about 10,000 centipoise. Examples of suitable thickeners include, but are not limited to, mono- and diesters of 1) polyethylene glycol having the formula: HO- (CH ₂ CH ₂ O) _Z H, in which z is an integer from about 3 to about 200; and 2) fatty acids containing from about 16 to about 22 carbon atoms; fatty acid esters of ethoxylated polyols; ethoxylated derivatives of mono- and diesters of fatty acids and glycerol; hydroxyalkyl cellulose; alkyl cellulose; hydroxyalkylalkyl cellulose; hydrophobically modified, alkaline, swellable emulsions (HASE); hydrophobically modified ethoxylated urethanes (HEUR); xanthan or guar gum; and mixtures thereof. Preferred thickeners include polyethylene glycol ester, and more preferably PEG-150 distearate, which is sold by Stepan Company Northfield, Illinois or Comiel, SpA. Bologna, Italy under the trade name "PEG 6000 DS".

Any of the various commercially available secondary conditioners, such as volatile silicones, which provide hair with additional properties, such as shine, are suitable for use in the present invention. Volatile silicone conditioning agent has a boiling point at atmospheric pressure of less than 220 ° C. A volatile silicone conditioner may be present in an amount of from about 0 to about 3 percent, for example, from about 0.25 to about 2.5 percent, or from about 0.5 to about 1.0 percent, based on the total weight of the composition. Examples of suitable volatile silicones include, but are not limited to, polydimethylsiloxane, polydimethylcyclosiloxane, hexamethyldisiloxane, liquid cyclomethicones such as polydimethylcyclosiloxane sold by Dow Corning Corporation, Midland, MI under the trade name "DC-345", or mixtures thereof, and preferably include liquid cycloethanes. Other suitable secondary conditioners include cationic polymers, including polyquaternium, cationic guar, and the like.

Any commercially available moisturizers that are capable of providing moisturizing and conditioning properties to personal care compositions are suitable for use in the present invention. The humectant may be present in an amount of from about 0 to about 10 percent, for example, from about 0.5 to about 5 percent, or from about 0.5 to about 3 percent, based on the total weight of the composition. Examples of suitable humectants include, but are not limited to: 1) water soluble liquid polyols selected from the group consisting of glycerol, propylene glycol, hexylene glycol, butylene glycol, dipropylene glycol, polyglycerols, and mixtures thereof; 2) a polyalkylene glycol of the formula: HO- (R ^″ O) _b -H, in which R ^″ is an alkylene group having from about 2 to about 3 carbon atoms and b is an integer from about 2 to about 10; 3) methylglucose polyethylene glycol ether having the formula CH ₃ —C ₆ H ₁₀ O ₅ - (OCH ₂ CH ₂ ) _c —OH, in which c is an integer from about 5 to about 25; 4) urea; and 5) mixtures thereof, a glycerin humectant is preferred.

Examples of suitable chelating agents include those that protect and preserve the compositions of the invention. Preferably, the chelating agent is ethylenediaminetetraacetic acid ("EDTA"), and tetrasodium EDTA sold by the Dow Corning Company, Midland, MI under the trade name "Versene 100XL" and presented in an amount of from about 0 to about 0.5 percent or from from about 0.05 to about 0.25 percent, based on the total weight of the composition.

Suitable preservatives include, for example, parabens, quaternary ammonium species, phenoxyethanol, benzoates, DMDM hydantoin and are present in the composition in an amount of from about 0 to about 1 percent, or from about 0.05 to about 0.5 percent, based on the total weight of the composition.

The polymerized surfactant, optional monomeric surfactants and optional other components of the composition can be combined in accordance with the present invention by conventional methods of combining two or more liquids or solids. For example, one or more compositions consisting mainly or consisting of at least one polymerized surfactant and one or more compositions consisting mainly or consisting of water, monomeric surfactants or acceptable ingredients may be combined by pouring by mixing, dropping, pipetting or pumping and the like, one composition containing the polymerized surfactant in or with another in any order using any conventional equipment vanie, such as mechanical mixing chopper blades, etc.

The methods of the present invention may further comprise any various steps for mixing or incorporating one or more of the optional components described hereinabove with or into a composition containing a polymerized surfactant or before, after, or simultaneously with, the combination step, described above. While in some embodiments, the mixing order is not important, it is preferable in other embodiments to pre-mix certain components, such as perfumes or non-ionic surfactants, before adding such components to the composition containing the polymerized surfactant.

The pH of the present compositions is not critical, but may be in a range that does not cause skin irritation, such as from about 5 to about 7. The viscosity of personal care compositions is not critical, although they may have the consistency of a cream, or lotion, or gel.

The present compositions can be compositions with different phases, but preferably can be aqueous solutions or, on the other hand, include an external aqueous phase (for example, the aqueous phase represents the largest external phase of the composition). Essentially, the compositions of the present invention can be oil-in-water emulsions that are shelf stable, which do not lose phase stability or do not “break” when stored under standard conditions (22 ° C., 50% relative humidity) for a week or more at manufacture.

In some embodiments, compositions made using the present invention are preferably used as or in personal care products to treat or cleanse at least a portion of the human body. Examples of some preferred personal care products include various products suitable for application to the skin, hair, and / or vaginal area of the body, such as shampoos, cleansers for the hands, face and body, bath additives, gels, lotions, creams, etc. .P. As discussed above, applicants have unexpectedly discovered that the present methods provide personal care products having reduced irritating effects on the skin and / or eyes and, in some embodiments, one or more necessary properties, such as foaming, fluidity, and potency, even at high concentrations surfactant.

The present invention provides methods of treating and / or purifying a human body, including contacting at least a portion of the body with a composition of the present invention. Some preferred methods include contacting the skin, hair and / or vaginal area with the composition of the present invention to cleanse such an area and / or treat such an area in several different conditions, including, but not limited to, acne, wrinkles, dermatitis, dryness, muscle pain, itching, etc. In some preferred embodiments, the contacting step comprises applying the composition of the present invention to human skin, hair, or a vaginal region.

The cleansing methods of the present invention may further include any various additional, optional steps associated in a conventional manner with hair and skin cleansing, including, for example, foaming, rinsing, and the like.

EXAMPLES

The following studies of skin permeability (“TET”), dynamic light reflection and foaming were used in the present methods and in the Examples listed below. In particular, as described above, the TET study was used to determine when the composition reduces irritation in accordance with the present invention; dynamic light reflection test can be used to determine the suitability of a partially polymerized surfactant (eg, PMOD%) or composition (eg CMID%); and foaming studies can be used to determine the ability of a composition to provide high levels of foam, often desirable for cleansing compositions.

Unless otherwise indicated, the amounts of ingredients in the Example and Comparative Compositions indicated in the tables are expressed in wt.% / Wt. ingredients based on the total weight of the composition.

Study of percutaneous permeability ("TET study"):

Eye and / or skin irritation is calculated for this composition in accordance with Invittox Protocol No. 86, Percutaneous Permeability Analysis (TER), as set forth in Invittox Protocol No. 86 (May 1994), incorporated herein by reference. In general, the irritation of the skin and / or eyes that the product may cause can be assessed by determining the effect on the permeability of the cell layer, as evaluated by the flow of a fluorescent substance through the layer. Monolayers of Madin-Darby dog kidney cells (MDCK) were grown to a continuous monolayer on microporous inserts in a 24-mesh plate containing medium or buffer for analysis in the underlying cells. The ability of the product to cause irritation was assessed by measuring damage to the permeability barrier in the cell monolayer after 15 minutes of exposure for dilutions of the product. Damage to the barrier was studied by the amount of fluorescein sodium that flowed into the lower cell after 30 minutes, which was determined by spectrophotometry. The flow of fluorescein sodium is displayed against the concentration of the analyte to determine the EC ₅₀ (concentration of the test substance that causes 50% of the maximum leakage of the dye, i.e. 50% damage to the permeability barrier). More accurate estimates are displayed by softness formulas.

The effect on the layer of MDCK cells grown on a microporous membrane for the test sample is a model for the initial process that occurs when the irritant comes in contact with the eyes. In vivo, the outermost layer of the corneal epithelium, forms a barrier to selective permeability due to the presence of tight contacts between cells. When exposed to an irritating substance, the dense compounds are separated, thus the permeability barrier disappears. The fluid inhibits the underlying layers of the epithelium and stroma, causing the collagen plate to separate, resulting in clouding. TEP analysis measures the effect of an irritating substance on damage to tight junctions between cells in an MDCK layer of cells grown on a microporous insert. Damage is assessed by spectrophotometry, by measuring the amount of marking dye (sodium fluorescein) that seeps through the cell layer and microporous membrane into the underlying cell.

Dynamic light scattering study (“DLS study”):

Dynamic light scattering (DLS, also known as Photon Correlation Spectroscopy or PCS) is a well-known method for determining the average micelle size (measured as the hydrodynamic diameter, d _H ) and the particle size distribution (comprehensive information about the technique can be found in ISO13321: 1996 (E)). The hydrodynamic size measured by DLS is defined as the size of a hypothetical solid sphere that diffuses in the same way as the particle being measured. In particular, micellar products are dynamic (rotating), solvated products that can be isotropic (spherical) or anisotropic (for example, ellipsoidal or cylindrical) in shape. Therefore, the diameter calculated from the diffusion properties of the micelles will show the apparent size of the dynamic hydrated / solvated particles; hence the terminology "hydrodynamic diameter". Micellar solutions for determining d n micelles are preferably obtained by diluting the compositions to 3.0% of their initial concentration with 0.1 μm-filtered deionized water obtained by the Millipore-Q filtration system. (A target dilution of up to 3.0% is selected as it falls within the usual concentration range of 1.0% -10% solutions encountered when using indelible personal care compositions. Target dilution is also in the dilution range used in TEP study). Samples are mixed in a vortex mixer at 1000 rpm for five minutes and then allowed to stand overnight before analysis. Samples are passed through a 0.2 μm Anatop-Plus syringe filter into dust-free disposable acrylic ditches of a certain size and sealed.

Samples were examined using Zetasizer Nano ZS DLS equipment (Malvern Instruments, Inc., Southborough, MA), performing an operation at 25.0 ° C. Samples must achieve a minimum count rate of 100,000 counts per second (ss) to accurately determine d n micelles and micelle size distribution. For samples with a counting rate below the specified minimum, the concentration of the sample can be gradually increased (i.e., less diluted) until a minimum counting rate is reached, or, in some cases, the sample can be used undiluted. The value of d _n micelles and the distribution of micelles by size are calculated using Dispersion Technology Software (DTS) v4.10 bundle (Malvern Instruments, Inc., Southborough, MA), which calculates the Z-average d _n micelles in accordance with ISO13321 research method. The value of the average d _n micelles is indicated herein as the Z-average d _n micelles. The indicated value of d _n micelles is the average of three separate measurements. The particle size distribution density calculated by DTS Software is a count of the micelle fraction having d _n micelles within the size limit.

Additives have a relatively large d _n (i.e., greater than approximately 200 nm) compared to micellar substances, for example, high MW polymer flow modifiers, polymer conditioners, opalescent particles, (micro) emulsions of hydrophobic softeners, silicone (micro ) emulsions, etc., typically added to personal care compositions containing micellar substances. It is obvious to DLS experts that such non-micellar substances will exhibit more light scattering intensity than the relatively smaller micellar substances in the diluted sample. The scattering intensity of such substances will suppress the scattering signal of micellar substances, thereby interfering with the accurate determination of d _n micelles. Typically, this type of interference will lead to an erroneously high measured value of d _n micelles. To avoid such interference, it is most preferable to measure the d _n micelles of the composition in the absence of additives having a d _n value greater than about 200 nm. DLS experts will confirm that additives having a large d _n value should be separated from the sample by filtration or ultracentrifugation before determining d _n micelles of the sample. Alternatively, a higher degree of DLS data analysis can also be used, using the Dispersion Technology Software (DTS) v4.10 bundle, to provide high resolution and accurate determination of d _n micelles in the presence of non-micellar reflectors.

In accordance with the above description and as shown in the Examples below, the “PMOD%” and “PMODz-average” associated with the polymerized surfactant are calculated by obtaining a model of the composition containing approximately 4.8 wt.% Of the polymerized surfactant , 0.3 wt.% A combination of sodium methyl- (and) sodium propyl- (and) sodium ethyl paraben (such as a product sold as Nipasept Sodium), 0.25 wt.% Tetrasodium EDTA (such as Versene 100 XL), with qs water, and using the DLS test to measure the fraction of micelles having a d less than _n, Th 9 nm in the final composition model (PMOD%), and z-average micelle d _n associated therewith (PMODz-average). Applicants have found that in some embodiments, the test polymerized surfactant may not be compatible with the above model composition. Therefore, if, and not only if, the preparation of the above model composition causes the formation of two separate liquid phases and / or the deposition of a polymeric surfactant, then the PMOD% and PMODz-average method involves the manufacture of a composition containing approximately 4.8 wt.% Polymerized surface -active substance, 0.5 wt.% sodium benzoate, 0.25 wt.% tetrasodium EDTA (such as Versene 100 XL), with qs of citric acid to pH 4.8 ± 0.2, with qs of water and the use of DLS analysis for measuring the fraction of micelles having d _n less than 9 nm in the final mode whether the composition (PMOD%) and z-average d _n micelles associated with it (PMODz-average).

For any other composition (including non-model compositions), the micelle fraction with d _n less than 9 nm (CMID%) and the z-average d _n micelles (CMIDz average) associated with it are measured using DLS analysis for such a composition .

Foam Volume Measurement (“Foam Study”)

The following foaming study was carried out on various personal care compositions to determine the maximum volume of foam, based on the compliance of the present invention. The procedure was performed by adding 5.0 g of a model solution, which contained a separate polymerized surfactant to be studied, to 995 g of deionized water and mixing until uniform. The mixture was then added to the Sita R-2000 Sample Tank, a foaming research apparatus (sold by Future Digital Scientific, Co., Bethpage, NY). The test parameters were found to repeat three runs (counting series = 3) of twelve shaking cycles (shaking counting = 12) 250 ml of sample (total volume = 250 ml) for 15 seconds of shaking per cycle (shaking time = 15 seconds) by rotating the rotor 1000 RPM (rotation = 1000) at a temperature of 30 ± 2 ° C. Foaming volume data was collected at each shaking cycle and the mean and standard deviation of the three runs were determined. The maximum amount of foaming is indicated for each example as the value after the twelfth cycle of shaking.

Examples E1-E8: Preparation of Model Compositions

Model compositions of Examples E1 to E8 were obtained by mixing a separate surfactant with other ingredients corresponding to the substances and amounts indicated in table 1:

Table 1 Tradename Name by INCI E1 E2 E3 E4 E5 E6 E7 E8 RA-18 hydrolyzed (26%) Hydrolyzed Octadecene / MA copolymer (relative content) 18.46 - - - - - 48.00 - RA-14 hydrolyzed (26%) Hydrolyzed tetradecene / MA copolymer (relative content) - 18.46 - - - - - 12.00 PAT-18 (17%) Tauratamide sodium octadecene / MA copolymer (relative content) - - 28.24 - - - - - PAT-14 (14%) Tauratamide sodium tetradecene / MA copolymer (relative content) - - - 34.29 - - - - Poly (acrylic acid-co-2-acrylamidododecyl sulfonic acid) (9%) Acrylates / Acryloyl Decyl Taurine Copolymer (Relative Content) - - - - 53.33 - - - Poly (sodium allyldodecyl sulfosuccinate-co-acrylic acid) (11%) Acrylates / allyldodecyl sulfosuccinate sodium copolymer (relative content) - - - - - 46.64 - - Poly (sodium allyldodecyl sulfosuccinate) (10%) Poly (sodium allyldodecyl sulfosuccinate) (relative content) - - - - - - 48 - PolySugaNate 100P (40%) Poly (decyl glucosides hydroxypropyl sulfonate) - - - - - - q.s. 12.00 Nipasept sodium Sodium methyl (i) sodium propyl (i) sodium ethyl paraben 0.30 0.30 0.30 0.30 0.30 0.30 0.30 0.30 Versene 100 XL Tetrasodium EDTA 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.25 Sodium hydroxide solution (20%) Sodium hydroxide q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. Citric Acid Solution (20%) Lemon acid q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. Purified water Water q.s. q.s. q.s. q.s. q.s. q.s. q.S. q.s. MA - maleic anhydride
qs- in the required quantity

The polymerized surfactants with a low degree of polymerization indicated in Table 1 were prepared as follows: RA-18 hydrolyzed, Example E1 was obtained by performing a 1: 1 reaction of an alternating copolymer of 1-octadecene and maleic anhydride (RA-18 low viscosity, low degree stains sold by Chevron Phillips Chemical, LLC) with sodium hydroxide in aqueous solution to produce an octadecene / MA copolymer having an average of approximately 25-75 amphiphilic repeating units per average base weight, mole fraction of amphiphilic repeats the linking units is approximately 100% and the hydrophobic group C16 in the amphiphilic repeating unit.

RA-14 hydrolyzed of Example E2 was obtained by performing a 1: 1 reaction of an alternating copolymer of 1-tetradecene and maleic anhydride (PA-14) with sodium hydroxide in an aqueous solution to produce tetradecene / MA copolymer having an average of approximately 25-75 amphiphilic repeating units , the molar fraction of amphiphilic repeating units is approximately 100% and the hydrophobic group C12 in the amphiphilic repeating unit.

PAT-18, a taurine derivative of Example E3, was prepared by a 1: 1 base-catalyzed alternating copolymer of 1-octadecene and maleic anhydride (PA-18 low viscosity, low coloration sold by Chevron Phillips Chemical, LLC The Woodlands, TX) with aminoalkyl sulfonic acid taurine in aqueous solution in accordance with the method of Grief, N., et al. (reference to international patent No. WO9716464 A1) for the preparation of octadecene tauramide / MA copolymer having an average of approximately 25-75 amphiphilic repeating units, a mole fraction of amphiphilic repeating units of approximately 100% and a hydrophobic C16 group in the amphiphilic repeating unit.

PAT-14, a taurine derivative of Example E4, was prepared by a 1: 1 base-catalyzed alternating copolymer of 1-tetradecene and maleic anhydride (PA-14) with taurine aminoalkylsulfonic acid in an aqueous solution according to the method of Grief, N., et al. (reference to international patent No. WO9716464 A1) for producing tetradecene tauramide / MA copolymer having an average of about 25-75 amphiphilic repeating units, a mole fraction of amphiphilic repeating units of about 100% and a hydrophobic C12 group in the amphiphilic repeating unit.

The poly (acrylic acid co-2-acrylamide dodecyl sulfonic acid) of Example E5 was obtained by free radical copolymerization of acrylic acid and acryloyl decyl taurine in an aqueous solution. Acryloyl decyltaurine is prepared according to Harrison, K.S. (reference to US patent No. 3544597). The final copolymer had an average weight of approximately 10-500 amphiphilic repeating units, a molar fraction of amphiphilic repeating units of approximately 50%, and a hydrophobic C12 group in the amphiphilic repeating unit.

The poly (sodium allyldodecyl sulfosuccinate-co-acrylic acid) of Example E6 was prepared by free radical copolymerization of acrylic acid and sodium allyldodecyl sulfosuccinate (TREM LF-40 sold by Cognis Corporation Ambler, PA) in an aqueous medium. The final copolymer had an average weight of approximately 10-500 amphiphilic repeating units, a molar fraction of amphiphilic repeating units of approximately 50%, and a hydrophobic C12 group in the amphiphilic repeating unit.

The poly (sodium allyldodecyl sulfosuccinate) of Example E7 was prepared by free radical polymerization of sodium allyldodecyl sulfosuccinate (TREM LF-40 sold by Cognis Corporation) in an aqueous medium. The final polymer had an average weight of approximately 10-20 amphiphilic repeating units, a mole fraction of amphiphilic repeating units of approximately 100%, and a hydrophobic C12 group in the amphiphilic repeating unit.

PolySuga ^® Nate 100P example E8 received from Solonial Chemical South Pittsburg, TN under the trade name PolySuga ^® Nate 100R. The product is found in the literature as sulfonated poly (alkylpolyglucoside).

The model compositions of table 1 were prepared as follows: water (approximately 50.0 parts) was added to a container equipped with a mechanical stirrer. Nipasept Sodium powder was added until completely dissolved. A suitable surfactant was also added at a low stirring speed to avoid aeration. Versene was added and stirring continued. Heating was provided (not more than 60 ° C) if a uniform solution was necessary. A portion, if necessary, was cooled to 25 ° C, while mixing was continued at medium speed. The pH was adjusted to 7.0 +/- 0.2 using citric acid or sodium hydroxide solution. Water added q.s. up to 100%.

Comparison of model compositions: the compositions obtained in accordance with examples E1-E8 were tested for softness in accordance with the TER study described above. Samples were also tested according to the DLS study. The results of these tests are shown below in table 2:

table 2 Etc. Polymerized Surfactant The average calculated TER (%) z-average d _H micelles (nm), PMOD z-average Micelle fraction with d _H <9 nm, (PMOD%) E1 Hydrolyzed RA-18 No leakage 15.1 10% E2 Hydrolyzed RA-14 No leakage 48.6 ^a four% E3 PAT-18, Taurine derivative RA-18 4.85 ± 1.33 17.6 13% E4 PAT-14, Taurine derivative RA-14 No leakage 13.0 ^b 34% E5 Poly (acrylic acid-co-2-acrylamidododecyl sulfonic acid) (9%) No leakage 16.7 fourteen% E6 Poly (sodium allyldodecyl sulfosuccinate-co-acrylic acid) No leakage 8.4 ^c 41% E7 Poly (sodium allyldodecyl sulfosuccinate) 3.72 ± 1.72 8.6 52% E8 PolySugaNate 100P 6.62 ± 0.77 8.8 53%

Examples E1 through E7 were also evaluated for foaming in accordance with the foaming study described above. The results of these tests are shown below in table 3:

Table 3 Example Polymerized Surfactant Maximum foaming (ml) E1 Hydrolyzed RA-18 73 E2 Hydrolyzed RA-14 - E3 PAT-18, Taurine Derivative 63 E4 PAT-14, Taurine Derivative 0 E5 Poly (acrylic acid-co-2-acrylamidododecyl sulfonic acid) (9%) 31 E6 Poly (sodium -co-acrylic acid) 225 E7 Poly (sodium 238

Comparative Examples C9-C11: Preparation of Model Compositions

Model compositions of examples C9-C11 were obtained by mixing a single surfactant with other ingredients in the same manner as described above for model compositions (see Examples E1-E8) and in accordance with the substances and amounts listed in table 4:

Table 4 Tradename Name by INCI C9 C10 C11 Tegobetaine L7-V (30%) Cocamidopropyl Betaine 24.00 - - Rhodapex ES-2 / K (26%) Sodium Laureth Sulfate - 18.46 - Cedepal TD403MFLD (30%) Sodium Tridetsulfate - - 16.00 Nipasept sodium Methyl Sodium- (and) Propyl Sodium- (and) Ethyl Paraben Sodium 0.30 0.30 0.30 Versene 100 XL Tetrasodium EDTA 0.25 0.25 0.25 Sodium hydroxide solution (20%) Sodium hydroxide q.s. q.s. q.s. Citric Acid Solution (20%) Lemon acid q.s. q.s. q.s. Purified water Water q.s. q.s. q.s. q.s.- in the required quantity

The compositions of table 4 were prepared as follows: water (50.0 parts) was added to a container equipped with a mechanical stirrer. Nipasept Sodium powder was added until completely dissolved. Monomeric surfactant was also added at low stirring speed to avoid aeration. Versene was added and stirring continued. Heating was provided (not more than 60 ° C) if a uniform solution was necessary. A portion was cooled to 25 ° C. if necessary, while mixing was continued at medium speed. The pH was adjusted to 7.0 +/- 0.2 using citric acid or sodium hydroxide solution. Water added q.s. up to 100%.

Comparison of model compositions: the compositions obtained in accordance with examples C9-C11 were tested for softness in accordance with the TER study described above. Samples were also tested according to the DLS study. The results of these tests are shown below in table 5:

Table 5 Example Surface-active substance The average calculated TER (%) z-average d _H micelles (nm), PMOD z-average Micelle fraction with d _H <9 nm, PMOD% C9 Cocamidopropyl Betaine ^a 2.55 ± 0.46 6.2 91% C10 Sodium Laureth Sulfate 3.12 ± 0.74 2.7 one hundred% C11 Sodium Tridetsulfate 1.73 ± 0.50 2.6 one hundred%

As can be seen from table 2 and table 5 for the investigated model compositions, compositions containing polymerized surfactants with a low degree of polymerization, which have a PMOD% less than about 90%, were unexpectedly generally milder and often significantly milder compared to conventional monomeric surfactants that have a PMOD% greater than or equal to approximately 90%. Also, as shown in table 3, model compositions that contain polymerized surfactants, in most cases, are also able to provide a high level of foaming, despite the absence of monomeric surfactant.

Examples E12-E18: Obtaining cleansing compositions

The cleaning compositions of Examples E12 through E18 were prepared in accordance with the substances and amounts listed in Table 6:

Table 6 Tradename Name by INCI E12 E13 E14 E15 E16 E17 E18 RA-18 hydrolyzed (26%) Hydrolyzed Octadecene / MA copolymer (relative content) 18.46 - - - - - - RA-14 hydrolyzed (26%) Hydrolyzed tetradecene / MA copolymer (relative content) - 18.46 - - - - - PAT-18 (17%) Tauratamide sodium octadecene / MA copolymer (relative content) - - 28.24 - - - - PAT-14 (14%) Tauratamide sodium tetradecene / MA copolymer (relative content) - - - 34.29 - - - Poly (sodium allyldodecyl sulfosuccinate) (10%) Poly (sodium allyldodecyl sulfosuccinate) (relative content) - - - - 48.00 - - Poly (sodium allyldodecyl sulfosuccinate-co-acrylic acid) (11%) Sodium acrylates / allyldodecyl sulfosuccinate copolymer (relative content) - - - - - 46.64 - PolySugaNate 100P (40%) Poly (decyl glucosides hydroxypropyl sulfonate) - - - - - - 12.00 Tegobetaine L7-V (30%) Cocamidopropyl Betaine 24.00 24.00 24.00 24.00 24.00 24.00 24.00 Nipasept sodium Sodium methyl (i) sodium propyl (i) sodium ethyl paraben 0.30 0.30 0.30 0.30 0.30 0.30 0.30 Versene 100 XL Tetrasodium EDTA 0.25 0.25 0.25 0.25 0.25 0.25 0.25 Sodium hydroxide solution (20%) Sodium hydroxide q.s. q.s. q.s. q.s. q.s. q.s. q.s. Citric Acid Solution (20%) Lemon acid q.s. q.s. q.s. q.s. q.s. q.s. q.s. Purified water Water q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. = in the required quantity

The composition of table 6 was obtained as follows:

water (50.0 parts) was added to a container equipped with a mechanical stirrer. Nipasept Sodium powder was added until completely dissolved. Tegobetaine was also added at a low stirring rate to avoid aeration. A suitable polymerized surfactant is then also added at a low stirring speed to avoid aeration. Versene was added and stirring continued. Heating was provided (not more than 60 ° C) if a uniform solution was necessary. A portion was cooled to 25 ° C. if necessary, while mixing was continued at medium speed. The pH was adjusted to 7.0 +/- 0.2 using citric acid or sodium hydroxide solution. Water added q.s. up to 100%.

Comparison of model compositions: the compositions obtained in accordance with examples E12-E18 were tested for softness in accordance with the TER study described above. Samples were also tested according to the DLS study. The results of these tests are shown below in table 7:

Table 7 Etc. Polymerized Surfactant TER value z-average d _H micelles (nm) (CMID-Z-AVE) Micelle fraction with d _H <9nm, (CMID%) E12 Hydrolyzed RA-18 4.76 ± 0.66 13.8 10% E13 Hydrolyzed RA-14 6.86 ± 0.51 17.3 four% E14 PAT-18, Taurine derivative RA-18 3.55 ± 0.30 12.5 23% E15 PAT-14, Taurine derivative RA-14 6.55 ± 0.07 12.3 24% E16 Poly (sodium allyldodecyl sulfosuccinate) 3.84 ± 0.28 19.0 four% E17 Poly (sodium allyldodecyl sulfosuccinate-co-acrylic acid) 4.80 ± 1.20 6.5 80% E18 PolySugaNate 100P 2.65 ± 0.26 8.5 55%

Comparative Examples C19-C20: Preparation of Cleansing Compositions

The cleaning compositions of Examples C19 and C20 were prepared according to the substances and amounts listed in Table 8.

Table 8 Tradename Name by INCI C19 C20 Rhodapex ES-2 / K (26%) Sodium Laureth Sulfate 18.46 - Cedepal TD403MFLD (30%) Sodium Tridetsulfate - 16.00 Tegobetaine L7-V (30%) Cocamidopropyl Betaine 24.00 24.00 Nipasept sodium Sodium methyl (i) sodium propyl (i) sodium ethyl paraben 0.30 0.30 Versene 100 XL Tetrasodium EDTA 0.25 0.25 Sodium hydroxide solution (20%) Sodium hydroxide q.s. q.s. Citric Acid Solution (20%) Lemon acid q.s. q.s. Purified water Water q.s. q.s. q.s. = in the required quantity

The compositions of table 8 were prepared as follows: water (50.0 parts) was added to a container equipped with a mechanical stirrer. Nipasept Sodium powder was added until completely dissolved. Tegobetaine was also added at a low stirring rate to avoid aeration. A suitable polymerized surfactant (Rhodapex or Cedepal) was then also added at a low stirring speed to avoid aeration. Versene was added and stirring continued. Heating was provided (not more than 60 ° C) if a uniform solution was necessary. A portion was cooled to 25 ° C. if necessary, while mixing was continued at medium speed. The pH was adjusted to 7.0 +/- 0.2 using citric acid or sodium hydroxide solution. Water added q.s. up to 100%.

Comparison of model compositions: the compositions obtained in accordance with examples C19-C20 were tested for softness in accordance with the TER study described above. Samples were also tested according to the DLS study. The results of these tests are shown below in table 9:

Table 9 Example Surface-active substance The average calculated TER z-average d _H micelles (nm), (CMID z-AVE) Micelle fraction with d _H <9 nm, (CMID%) C19 Sodium Laureth Sulfate 1.34 ± 0.48 5.3 94% C20 Sodium Tridetsulfate 2.75 ± 0.60 5,0 94%

As can be seen from table 7 and table 9 for the investigated compositions, various polymerized surfactants can be formed into cleaning compositions that have an unexpectedly low fraction of small micelles, as shown by CMID% (less than approximately 90%) compared to conventional monomeric surfactants -active substances. Moreover, TEP values were unexpectedly high for the compositions of the present invention.

Comparative Examples E21-E24: Preparation of Cleansing Compositions

The cleansing compositions of Examples E21 and E24 were prepared according to the substances and amounts listed in Table 10.

Table 10 Tradename Name by INCI E21 E22 E23 E24 RA-18 hydrolyzed (26%) Hydrolyzed Octadecene / MA copolymer (relative content) 18.46 18.46 18.46 18.46 Tegobetaine L7-V (30%) Cocamidopropyl Betaine 6.00 12.00 16.00 20.00 Nipasept sodium Sodium methyl (i) sodium propyl (i) sodium ethyl paraben 0.30 0.30 0.30 0.30 Versene 100 XL Tetrasodium EDTA 0.25 0.25 0.25 0.25 Sodium hydroxide solution (20%) Sodium hydroxide q.s. q.s. q.s. q.s. Citric Acid Solution (20%) Lemon acid q.s. q.s. q.s. q.s. Purified water Water q.s. q.s. q.s. q.s. q.s. = in the required quantity

The cleansing compositions from table 10 were obtained as described for E1-E9 shown in table 1. The concentration of hydrolyzed RA-18 was kept constant.

Comparison of cleaning compositions: The compositions obtained in accordance with examples E21-E24 were investigated in terms of softness in accordance with the above TER study. Samples were also tested according to the DLS study. The results of these studies are listed below in table 11 (examples E1 and E12 are also shown for comparison):

Table 11 Example SARV Ratio: RA-18 [SARV] (% wt. Active substance) TER value z-average d _H micelles (nm), (CMID z-AVE) Micelle fraction
with d _H <9 nm, (CMID%) E1 0.00 0,0 No leakage 15.1 10% E21 0.38 1.8 No leakage 19.5 3% E22 0.75 3.6 No leakage 20,2 3% E23 1.00 4.8 No leakage 18.1 5% E24 1.25 6.0 5.51 ± 0.20 16,2 9% E12 1,50 7.2 4.76 ± 0.66 13.8 eighteen%

To compare the composition with an unpolymerized surfactant (C9 formula shown in table 4) or with a monomeric surfactant (SLES), a polymerized surfactant (C19 formula listed in table 8) is replaced as shown in table 12 below .

Table 12 Example SARV Ratio: RA-18 [SARV] (% wt. Active substance) TER value z-average d _H micelles (nm), (CMID z-AVE) Micelle fraction with d _H <9 nm, (CMID%) C9 (CAPB) without PA-18 7.2 2.55 ± 0.46 6.2 91% C19 (SLES) 1.50 7.2 1.34 ± 0.48 5.3 94%

As can be seen in table 11, for the studied compositions, the polymerized surfactant hydrolyzed by RA-18 can be introduced into the composition of the cleaning composition in various relative concentrations from monomeric to polymerized surfactant. In each of the examples, the compositions have unexpectedly low fractions of small micelles, as shown by CMID% (less than about 90%), especially compared to similar compositions containing conventional surfactants shown in table 12.

Examples E25-E27: Obtaining cleansing compositions

The cleansing compositions of Examples E25 to E27 were obtained in accordance with the substances and amounts listed in Table 13.

Table 13 Tradename Name by INCI E25 E26 E27 RA-18 hydrolyzed (26%) Hydrolyzed Octadecene / MA copolymer (relative content) 23.08 30.75 38.45 Tegobetaine L7-V (30%) Cocamidopropyl Betaine 30.00 40.00 50.00 Nipasept sodium Sodium methyl (i) sodium propyl (i) sodium ethyl paraben 0.30 0.30 0.30 Versene 100 XL Tetrasodium EDTA 0.25 0.25 0.25 Sodium hydroxide solution (20%) Sodium hydroxide q.s. q.s. q.s. Citric Acid Solution (20%) Lemon acid q.s. q.s. q.s. Purified water Water q.s. q.s. q.s. q.s. = in the required quantity

The cleansing compositions from table 13 were obtained in a manner similar to that described for E1-E9 shown in table 1. The ratio of betaine to hydrolyzed RA-18 was kept constant.

Comparison of cleaning compositions: The compositions obtained in accordance with examples E25-E27, investigated in terms of softness in accordance with the above TER study. Samples were also tested according to the DLS study. The results of these studies are listed below in table 14 (example E12 is also shown for comparison):

Example [RA-18] (% wt. Active substance) [SARV] + [RA-18] (% wt. Active substance) TER value z-average d _H micelles (nm), (CMID-z-AVE) Micelle fraction with d _H <9 nm, (CMID%) E12 4.8 12.00 4.76 ± 0.66 13.8 eighteen% E25 6.0 15.00 3.20 ± 0.25 13.8 twenty% E26 8.0 20.00 4.56 ± 0.78 13.3 25% E27 10.0 25.00 4.00 ± 0.80 12.9 28%

As can be seen in table 14, for the studied compositions, the polymerized surfactant hydrolyzed by RA-18 can be incorporated into cleaning compositions with various total concentrations of surfactants (polymerized + monomeric). In each of the examples, the compositions have unexpectedly low fractions of small micelles, as shown by CMID% (less than about 90%).

Claims (10)

1. Composition for personal hygiene containing
a polymerized surfactant selected from the group consisting of poly (allyldodecyl sulfosuccinate), poly (acrylic acid co-2-acrylamidododecyl sulfonic acid) and poly (sodium allyldodecyl sulfosuccinate-co-acrylic acid); and
an ingredient traditionally used in personal care compositions. 2. The personal care composition according to claim 1, wherein said personal care composition has a TER value of about 3 or more. 3. The composition for personal care according to claim 1, in which the specified composition for personal care has a TER value of approximately 3.5 or more. 4. The composition for personal hygiene according to claim 1, in which the specified composition for personal hygiene has a TER value of at least 5 or more. 5. The personal care composition of claim 1, wherein said personal care composition has a CMID% of less than about 50%. 6. The composition for personal hygiene according to claim 1, in which the composition further comprises at least one monomeric surfactant. 7. The personal care composition of claim 1, wherein said composition further comprises at least one surfactant selected from the group consisting of anionic surfactants, amphoteric surfactants, and combinations of two or more of them. 8. The personal care composition according to claim 1, wherein said at least one surfactant contains betaine. 9. The composition for personal hygiene according to claim 1, in which the specified composition for personal hygiene is a cleanser. 10. The personal care composition according to claim 1, wherein said personal care composition is a cleanser for the skin, hair and / or vaginal area.

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