RU2463930C2 - Tobacco product filter - Google Patents

Abstract

FIELD: tobacco industry.

SUBSTANCE: invention relates to a mouthpiece-like component connected to the tobacco product. The component may be designed so that to enable alignment to the inserted end of the tobacco product so that smoke passes through the said component during smoking. The component contains a porous material made of cellulose and is impregnated with a water solution containing at least one aldehyde-binding compound with formation of an aldehyde-binding filter. The compound is chosen from cysteine, its derivates and their salts. In the said component attached to the tobacco product the material moisture content is equal to 0.1 - 10 mcl/mg of the filter material.

EFFECT: production of a component that may be attached to the tobacco product and that is able to remove a significant part of aldehydes from the tobacco smoke.

12 cl, 9 dwg, 1 ex

Description

The present invention relates to a component according to the restrictive part of paragraph 1 of the claims, intended to be attached to a tobacco product.

Smoking, like alcohol, is a risk factor for cancer of the upper digestive tract, and combined smoking and drinking increase the risk of cancer of the upper digestive tract by 150 times (Salaspuro, M. Best Pract Res Clin. Gastroenterol (2003) 17: 679-94 and Francheschi et al. Cancer Res (1990) 50: 6502-07).

The inclusion in the composition of cigarettes or filters of compounds that bind harmful substances contained in cigarette smoke is proposed in several patents. For example, in the specification of US Pat. No. 5,829,449, it is proposed to add to tobacco, cigars, pipes or filters a composition that binds harmful substances contained in cigarette smoke. The proposed composition contains L-glutathione, which is a source of selenium, for example, L-selenomethionine or L-selenocysteine. The composition may also contain L-cysteine or N-acetylcysteine. This complex of antioxidants has been proposed to disperse in tobacco or a filter in the form of a powder, a stable solution or an aqueous emulsion.

US Pat. No. 4,532,947 discloses the use of non-toxic salts of 2-mercaptoalkalenesulfonate and / or cysteine and acetylcysteine in cigarette filters or mouthpieces containing a filter.

EP 1541043 discloses a cigarette filter comprising amino acids, amino acid salts and a moisturizing agent. The specified moisturizing agent may contain glycerin, sodium propionate or sodium lactate.

The cigarette filter proposed in the specification of US Pat. No. 5,860,428 contains a porous base in which a humectant, for example sodium pyroglutamate, is dispersed. This hydrophilic humidifier absorbs moisture from cigarette smoke and releases said moisture, providing wet filtration in said porous base. This patent specification claims that the filter may contain agents that inactivate toxic smoke components. Such agents include antioxidants and radical traps, for example glutathione, cysteine, N-acetylcysteine, mesna, etc. However, this patent specification does not mention the amounts in which these substances should be used.

PCT / FI2005 / 000429 describes a separate preparation or composition which is added to a tobacco product, filter or mouthpiece and which binds aldehydes entering saliva during smoking. Compounds containing free sulfhydryl and / or amino groups, for example cysteine, are used to bind aldehydes.

In order to reduce the effects of harmful free radical compounds generated by the use of tobacco products, oral resorption or chewing preparations have been proposed containing amino acids such as L-cysteine, selenomethionine, taurine or arginine, ascorbic acid, vitamins A and E, and use specified drugs. Amino acids are believed to have effects on various tissues after absorption (Hersch, US Pat. No. 5,922,346, Hersch, PCT / US98 / 12617).

The present invention is directed to solving at least some of the problems existing in the art.

An object of the present invention is to provide a component that can be attached to a tobacco product and which is capable of removing a significant portion of the aldehydes from smoke from a tobacco product.

In particular, the composition in accordance with the present invention is characterized by the features indicated in the characterizing part of paragraph 1 of the claims.

A problem inherent in prior art filter solutions or other solutions for binding harmful substances contained in smoke is that the filter dries or is too dry from the very beginning, as a result of which the filter does not properly bond harmful compounds. The present invention is based on the fact that the material inside the component attached to the tobacco product must be sufficiently moist at the beginning of the smoking process, so that the compounds capable of binding aldehydes contained in said material are active.

According to the present invention, compounds capable of binding aldehydes are absorbed by the material in the form of an aqueous solution or are otherwise associated with said material, which is packed into a component intended to be attached to a tobacco product. When the indicated component is firmly attached to the insertion end of the tobacco product, cigarette smoke passes through the component, while the material inside the component containing compounds capable of binding aldehydes binds the aldehydes contained in the cigarette smoke so that the aldehyde content in the mouth and saliva cannot reach a dangerous level level. Since compounds capable of binding aldehydes bind aldehydes in the aqueous phase, the material containing said aldehyde-binding compounds must be sufficiently moist at the beginning of the smoking process so that a binding reaction proceeds.

An objective of one of the preferred embodiments of the present invention is, in particular, to provide a solution whereby the ability of a component to be attached to a tobacco product to bind harmful aldehydes is maintained during storage of said product.

According to a preferred embodiment of the compound, the compounds capable of binding aldehydes are absorbed by the porous material in the form of an aqueous solution in order to keep the moisture content of the material high enough until a filter containing the material is used. As used herein, “sufficiently high moisture content” means that the aldehyde-binding compounds contained in the material remain active, i.e. they are able to bind aldehydes in a form that is harmless to health.

According to a preferred embodiment of the present invention, the moisture in the material contained in the component attached to the tobacco product is held by waterproofing pads. Waterproofing pads are used to fully or partially protect the component attached to the tobacco product.

According to another preferred embodiment of the invention, the filter material containing the aldehyde-binding compounds is packed in a sleeve that can be inserted into a component attached to the tobacco product. The sleeve can be fully or partially protected with waterproofing pads.

Using the filter of the present invention capable of binding aldehydes, at least 60%, usually at least 80%, preferably at least 85%, more preferably at least 90% and most preferably at least 95% aldehydes can be bound contained in the smoke of tobacco, cigars, pipes or other tobacco products.

Aldehyde-binding filter is easy to apply. The component containing the filter material is attached to the tobacco product in the same manner as commercially available tips and cigarette mouthpieces. According to a preferred embodiment of the invention, said component is fully or partially protected by waterproofing pads. Waterproofing pads are removed from the ends of the specified component, or the component is removed from the package, which acts as a waterproofing pads, immediately after which the filter is ready for use. In embodiments where the filter material contained in the component contains a sufficient amount of aldehyde-binding compounds, the component can be used during more than one use (while smoking) of the tobacco product.

In accordance with another preferred embodiment of the invention, a cartridge containing an aldehyde-binding filter material is added to a component, such as a tip or cigarette holder. Preferably, the sleeve is partially or fully protected by a waterproofing pad. Before use, the waterproofing pads are removed and the sleeve is inserted into the component attached to the tobacco product.

DESCRIPTION OF DRAWINGS

Figure 1 shows the filtering effect of a filter moistened with a water-cysteine solution on the content of carcinogenic aldehydes and acetaldehydes contained in cigarette smoke. The use of a cysteine filter reduces the acetaldehyde content in saliva, measured during smoking, making it significantly lower than the internationally established carcinogenic limit for these compounds.

FIGS. 2A-C show a top view of a tobacco product and component (cigarette mouthpiece) that can be attached to the specified tobacco product (FIG. 2A), and a cross-sectional side view when the component is separated from the tobacco product (FIG. 2B) or attached to tobacco product (Figure 2).

Figure 3 shows a cross-sectional view of a component (cigarette mouthpiece) when viewed from the end of the mouthpiece (Figure 3A) and from the side (Figure 3B). 3C shows a cigarette mouthpiece from its end.

Figure 4 shows a side view of the tobacco product and the component, which can be attached to the tobacco product attached between the fastening means of the specified component.

FIG. 5 shows a packaging cartridge in which components attached to a tobacco product are packaged.

Further, the present invention is described in more detail using the detailed description and application examples.

The term “tobacco product” refers to any tobacco product, such as a cigarette, cigar or pipe. The tobacco product may already contain a conventional filter, or the product may be without a filter. However, it is preferable that said filter does not interfere with the passage of smoke through said component (cigarette holder, aldehyde-binding filter) containing the aldehyde-binding material in accordance with the present invention.

The term "smoking" refers to the use of a tobacco product, such as a cigarette, cigar or other tobacco product.

A “component that can be attached to a tobacco product” may also be called a cigarette mouthpiece or filter. In this case, the term refers to a filter that binds aldehydes, unlike traditional filters that are used in tobacco products.

Typically, the component attached to the tobacco product is in the form of a cigarette mouthpiece or tip.

Consider the solutions proposed in the present invention, with reference to Fig.2-5.

Figure 2 shows the component 1 in accordance with the present invention, attached to the tobacco product, and the tobacco product 2. In Fig.2A and 2B, the component 1 and the tobacco product 2 are separated, and in Fig.2C are attached to each other. In FIG. 2A, component 1 and tobacco product 2 are shown from above, and in FIGS. 2B and 2C, in cross section, on the side. The component 1 intended to be attached to the tobacco product comprises a cylindrical region 13 that is open at both ends and substantially hollow inside, said component being able to fit snugly against the insertion end 12 of the tobacco product 2. When fitting to the tobacco product, component 1 should be open at both ends so that smoke passes through the specified component while smoking. Component 1 may also be called a cigarette mouthpiece or filter. The tobacco product shown in FIG. 2 also contains a conventional filter 14.

The region 13 within the component 1 intended to be attached to the tobacco product contains a porous material 3 impregnated with an aqueous solution containing at least one aldehyde-binding compound, or otherwise connected to at least one aldehyde-binding compound. The material containing the aldehyde-binding compound may also be called filter material. At the end of component 1, adapted to fit the insertion end 12 of the tobacco product, there is an empty space 15 free of material 3. When fitting component 1 to the tobacco product 2, the insertion end 12 of the tobacco product extends into the empty space 15 at the end of component 1 in this way that the edge 16 of the fitting area covers the end 12 of the tobacco product.

After manufacturing the filter part of the component, the material 3 should be wetted. It is preferable that the material is moistened with 20-500 μl, more preferably 20-400 μl, most preferably 50-250 μl of water or, if the aqueous solution contains aldehyde-binding compounds, the indicated amount of aqueous solution, containing an aldehyde binding substance. Obviously, the amount of aqueous solution required to moisten the specified material depends on the length of the specified component (cigarette mouthpiece) and the amount of material. The moisture content of material 3 in component 1 can be maintained substantially unchanged with waterproofing pads 4, 5, which can be opened or removed before smoking.

According to another embodiment of the invention, the filter material is moistened before use. However, it must be ensured that the aldehyde-binding compounds in the filter material are able to maintain their ability to interact with aldehydes even when dried. According to a preferred embodiment, the aldehyde-binding compounds are attached to the filter material in the form of an aqueous solution, wherein the moisture content of said filter material is kept substantially constant until the use of the tobacco product and the component containing the filter material intended to be attached to said tobacco product.

Figure 3 shows the waterproofing strip 4, 5 in accordance with one of the solutions proposed in the present invention. Said gasket is made of a substantially airtight material, for example, aluminum foil. A waterproofing pad 4, 5 covers both ends of component 1.

In accordance with one of the preferred solutions proposed in the present invention, shown in Figure 4, component 1 can be equipped with additional means 8, 9 containing protrusions 10, 11, which pierce the waterproofing pads 4, 5, when these additional means stand on your place. These additional funds can be placed on the inserted end 12 of the tobacco product 2 so that component 1 remains between the additional means 8 and 9, made with the possibility of tight fitting to each other. When the waterproofing pads 4, 5 are opened by piercing with the protrusions 10, 11, smoke can pass through the tobacco product 2 and component 1.

5 shows a packaging cassette 16 for packaging components 1 in accordance with a preferred embodiment. Component 1 is packaged in a recess 6 of the packaging cassette 16, which is made of a moldable material, such as plastic. Said recess preferably has a shape corresponding to the shape of component 1. The recess 6 can be covered with a waterproofing pad 17, while component 1 remains in the airtight space of the recess 6. Component 1 can be pushed out of the recess 6 so that the waterproofing pad 17 is torn, or can be disconnected waterproofing strip 17 from the upper part of the specified component. One packaging cassette 16 may contain several components 1, packed in respective recesses 6.

Porous material 3, which is impregnated with an aldehyde-binding compound or to which the compound is otherwise attached, is packed inside component 1 so that as much surface as possible comes into contact with smoke. Figure 3 shows a packing method in accordance with a preferred embodiment of the present invention. According to this embodiment, the material 7 is rolled up and stuffed into the component 1. In this case, smoke is allowed to pass between the slightly spaced layers 18 of the material 7, while the aldehyde-binding compound in the material comes into contact with the aldehydes contained in the smoke. In accordance with another preferred embodiment of the invention, cellulose can be loaded into the component 1 as the packing mass.

Typically, the component attached to the tobacco product has an elongated shape of a cigarette mouthpiece / tip.

Inside component 1, a sleeve 19 is preferably contained within which the porous material 3 and aldehyde-binding compounds are packed. Preferably, said sleeve comprises a material similar to plastic. The sleeve preferably has a shape and size corresponding to the shape and size of the inner part of component 1. The outer dimensions of said sleeve may be, for example, 6-10 mm × 30-40 mm, typically 8 mm × 35 mm.

According to a preferred embodiment of the invention, the sleeve 19 is packed with a porous material and is independently partially or fully protected by waterproofing pads. The sleeve can be inserted into component 1, for example, into a cigarette mouthpiece or tip attached to a tobacco product before smoking.

The porous material inside the component, such as a cigarette mouthpiece or sleeve, which can be attached to the tobacco product, may contain, for example, cellulose. The cellulose may be, for example, padded cellulose wool or filter paper, or other material having suitable properties. The amount of material per cigarette mouthpiece or sleeve inside the mouthpiece may be 50-200 mg, preferably 70-150 mg, usually 90-120 mg. The amount of porous material depends on the size of the tip or cigarette mouthpiece or sleeve inside the specified tip or mouthpiece, and also on how large the amount of aldehyde-binding compounds that need to be attached to the material.

The amount of aqueous solution per component, for example, a cigarette mouthpiece or sleeve inside said mouthpiece, is preferably 20-500 μl, more preferably 20-400 μl, usually 50-250 μl. The amount of water should be sufficient to maintain the activity of the aldehyde-binding compounds.

The amount of water (or a solution, usually an aqueous solution containing an aldehyde-binding compound) in the porous material contained in the indicated component, for example, a cigarette mouthpiece or sleeve inside the mouthpiece, is preferably 0.1-10 μl of water or an aqueous solution / mg of porous material ( 20-500 μl / 50-200 mg), more preferably 0.1-5.7 μl / mg (20-400 μl / 70-150 mg), usually 0.4-2.7 μl / mg (50-250 μl / 90-120 mg) of water or aqueous solution / mg of porous material. Said water is usually distilled water.

A component, such as a cigarette mouthpiece or sleeve inside said mouthpiece, intended to be attached to a tobacco product, preferably contains an aldehyde-binding compound in an amount sufficient to bind the aldehydes contained in the smoke of at least one tobacco product. This amount is preferably 0.5 mg to 100 mg, usually 10-50 mg. A larger amount is preferred, especially when the specified component, such as a cigarette mouthpiece or sleeve, is used repeatedly.

The amount of aldehyde-binding compounds in an aqueous solution containing aldehyde-binding compounds is preferably 1-5000 mg / ml of solution (0.5 mg - 100 mg / 20-500 μl of solution), more preferably 25-2500 mg / ml of solution (10- 50 mg / 20-400 μl of solution), usually 40-1000 mg / ml of solution (10-50 mg / 50-250 μl of solution), generally 40-400 mg / ml (10-100 mg / 250 μl of solution) aqueous solution, in most cases 40-200 mg / ml aqueous solution (10-50 mg / 250 μl of solution).

An aqueous solution containing an aldehyde-binding compound also refers to aqueous solutions containing a buffering agent whose acid content is adjusted and / or to which salts are added. The binding of aldehydes and their filtration from cigarette smoke can be improved, for example, by adding buffers or by adjusting the acid content to provide slightly alkaline or slightly acidic values by adding a small amount of salts to the aqueous solution.

The term “aldehydes” refers to C ₁ -C ₇ aldehydes, which may be hydrocarbon chains with a linear, branched or cyclic structure. In addition to the aldehyde group, these compounds may also contain other reactive groups, as well as double or triple bonds between atoms. Low molecular weight aldehydes include formaldehyde (C ₁ ), acetaldehyde (C ₂ ), acrolein (C ₃ ) and cretone aldehyde (C ₄ ), with the last two of these compounds containing a double bond. Among these compounds, acetaldehyde is particularly important. As used herein, the term “aldehydes” refers to aldehydes contained in the smoke of tobacco products. Despite the fact that further references are given, in particular, to acetaldehyde, the present invention also relates to other aldehydes contained in cigarette smoke.

According to the present invention, compounds obtained from aldehydes, acetaldehyde, in particular by chemical bonding, are harmless to health.

The term “aldehyde binding” refers to a chemical reaction between an aldehyde and a compound containing a free sulfhydryl and / or amino group, wherein the aldehyde forms a larger molecule together with the “aldehyde-binding substance” during the reaction, and water may also form during the reaction . Accordingly, “acetaldehyde binding” refers to a chemical reaction between acetaldehyde and a compound containing a free amino group and / or sulfhydryl or sulfo group, while acetaldehyde forms a larger molecule together with the “acetaldehyde-binding substance” during the reaction, while it is also possible during this reaction water formation. An “acetal binding agent” preferably refers to a compound containing one or more free amino groups and sulfhydryl groups or sulfo groups. The term “compound” may refer to one or more compounds.

For example, during the reaction with cysteine, acetaldehyde binds to both sulfhydryl and amino groups to form 2-methyl-L-thiazolidine-4-carboxylic acid and water. Acetaldehyde can bind to the amino group of almost any protein, with the formation of a Schiff base or a 2-methylimidazole ring.

Cysteine and its derivatives are particularly suitable for the purposes of the present invention. The most suitable amino acids for use in accordance with the present invention include L- and D-cysteine, acetylcystsine, N-penicillamine or cysteine derivatives that have the same effect as L- or D-cysteine. The most suitable compound is L-cysteine.

Compounds suitable for binding acetaldehyde in the body also include compounds of formula (I):

Where

R ¹ represents hydrogen or an acyl group containing 1-4 carbon atoms;

R ² represents a sulfhydryl or sulfo group;

n represents 1, 2, 3 or 4.

Amino acids or other compounds that suitably bind acetaldehyde and contain a free sulfhydryl (SH) and / or amino (NH ₂ ) group include

L-cysteine;

D-cysteine

cysteic acid

cysteine glycine,

threo or erythro-β-phenyl-DL-cysteine,

β-tetramethylene-DL-cysteine,

methionine

D-penicillamine and its N-terminal dipeptides,

semicarbazide

reduced glutathione,

β-mercaptoethylamine

D, L-homocysteine,

N-acetylcysteine

L-cysteinyl-L-valine,

β-β-tetramethylene-DL-cysteine,

cysteinyl glycine,

mercaptoethyl glycine,

thiamine hydrochloride,

sodium metabisulfite

mercaptans.

However, only those aldehyde-binding compounds that are not harmful to the health in the dosages used are suitable for the purposes of the present invention.

Compounds suitable for use in the present invention also include salts of aldehyde-binding compounds.

“The acetaldehyde content that is harmful / causes cancer” in a person’s mouth, esophagus, stomach and colon is 20-800 μmol / L in saliva or intestinal contents.

In the present description, the term "in connection with smoking" refers to the period of time that begins from the moment smoking begins and ends when smoking is completed.

EXAMPLES

Example 1

Humidified Cysteine Filter

Test Materials

Tobacco

Marlboro Red, Amer Tupakka North State Plain, BAT

The Marlboro Red filter was removed entirely or, in some tests, 2-3 mm of the original filter was left in the cigarette.

Cigarette holder

In these tests, commercially available serial cigarette mouthpieces / tips from Denicotea, www.denicotea.de, were used. In these cigarette mouthpieces / tips, plastic “sleeves” of cylindrical shape were used in which the filter material was stuffed. The original contents (intended for nicotine removal) of the cartridges were removed and replaced with the material used in this study. The liner had the following external dimensions: diameter 8 mm and length 35 mm.

Filter material

Cellulose wool (p. 100 mg), filter paper (Whattman),

Serial filters: Smart (importer: Altadia Finland Oy) and Ventti (Philip Morris Finland Oy),

Cysteine

Cysteine was dissolved in distilled water, 30-180 mg L-cysteine / 1 ml. Manufacturer: Fluka, 30089.

Test Procedure

The filter material stuffed into plastic cylinders was moistened with a water-cysteine solution (50-250 μl); the filter cartridge thus obtained was placed in a Denicotea cigarette holder. After that, the test participants smoked cigarettes inserted into these mouthpieces. While smoking, saliva samples were taken from test participants and the salde acetaldehyde content was analyzed by gas chromatography, Perkin-Elmer, HS40, headspace Gas Chromatograph.

results

Similar results were obtained for both tobacco brands.

- The filter material, which was moistened with a water-cysteine solution, provided for the removal from saliva of almost the entire content of acetaldehyde (95%), Figure 1

- The acetaldehyde content measured in saliva with the use of a cysteine filter decreased to a value that is significantly lower than the internationally established carcinogenicity limit for acetaldehyde of 100 μM.

- The filtering ability depended on the amount of cysteine; figure 1 shows the effect of a moistened cysteine filter on the content of acetaldehyde in saliva during smoking.

The results obtained showed that:

- The filter material, taken separately, does not filter out acetaldehyde.

- The filter moistened with water does not filter out acetaldehyde.

- The filter and cysteine in the solid state do not filter out acetaldehyde.

- The results can be summarized for different tobacco brands, with or without filter.

- Serial filters do not bind water; therefore, they are not suitable for use as a filter material.

- It is preferable not to use a cysteine filter in conjunction with the original filter of the cigarette, since in this case normal, without difficulty, the passage of smoke through the two specified filters is not ensured. You can leave a small portion of the original filter if the cysteine filter material is sufficiently porous.

Claims (12)

1. Component intended to be attached to a tobacco product, containing
the cylindrical component (1) is essentially hollow inside, and the specified component can be adapted to fit the inserted end (12) of the tobacco product (2) so that smoke passes through the specified component during smoking,
characterized in that the space (13) inside the component (1) contains a porous material (3) which is made of cellulose and impregnated with an aqueous solution containing at least one aldehyde-binding compound selected from cysteine, its derivatives and their salts, or which otherwise connected to at least one aldehyde-binding compound to form an aldehyde-binding filter,
at the same time, at the beginning of smoking, the moisture content of the material (3) contained in component (1), which is attached to the tobacco product, is from 0.1 to 10 μl / mg of filter material, whereby these aldehyde-binding compounds interact with the aldehydes contained in the smoke . 2. A component according to claim 1, characterized in that after obtaining the specified filter, the moisture content of the material (3) can be maintained substantially constant using one or more waterproofing gaskets (4, 5, 17), which can be opened or removed. 3. The component according to claim 2, characterized in that the waterproofing gasket is made of an airtight material, such as aluminum foil. 4. A component according to claim 2 or 3, characterized in that the waterproofing gasket (4, 5, 17) partially or fully covers component (1). 5. A component according to any one of claims 1 to 3, characterized in that the amount of aldehyde-binding compound in the filter material contained in component (1) is from 0.5 to 100 mg. 6. A component according to any one of claims 1 to 3, characterized in that component (1) contains a sleeve (19), inside of which a filter material is packed. 7. The component according to claim 6, characterized in that the sleeve (19) can be placed inside the component (1). 8. The component according to claim 6, characterized in that before using the sleeve (19) is partially or fully protected with waterproofing pads made with the possibility of opening or removal. 9. A component according to any one of claims 1 to 3, 7 or 8, characterized in that said aldehyde-binding compound contains one or more free sulfhydryl and amino groups or sulfo groups. 10. A component according to any one of claims 1 to 3, 7 or 8, characterized in that the said aldehyde-binding compound comprises one or more compounds of the formula (I)

,
where R ¹ represents hydrogen or an acyl group containing from 1 to 4 carbon atoms,
R ² represents a sulfhydryl or sulfo group, and
n represents 1, 2, 3 or 4,
or a salt of said compounds. 11. A component according to any one of claims 1 to 3, 7 or 8, characterized in that said aldehyde-binding compound is selected from the group consisting of L-cysteine, D-cysteine, cysteic acid, cysteine-glycine, cystine, threo or erythro β-phenyl-DL-cysteine, β-tetramethylene-DL-cysteine, methionine, serine, D-penicillamine or the N-terminal D-penicillamine dipeptide, semicarbazide, glutathione, reduced glutathione, β-mercaptoethylslamine, DL-homocysteine, DL homocysteic acid, N-acetylcysteine, L-cysteinyl-L-valine, β-β-tetramethylene-DL-cysteine, cysteinyl glycine, mercaptoe ilglitsin, cysteine hydrochloride, thiamine hydrochloride, sodium metabisulphite, arginine, glycine, lycine, ammonium chloride, 1,4-dithiothreitol, mercaptane, or a salt of any of these compounds. 12. A component according to any one of claims 1 to 3, 7 or 8 for use to reduce the amount of aldehydes contained in cigarette smoke, in the mouth and in saliva.

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