RU2463034C1 - Composition for teeth filling - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to therapeutic and orthopedic dentistry and deals with filling and fixation materials. Composition for teeth filling contains in powder part mixture of alumofluorosilicate glass and dry polyacrylic acid, in gaye part distilled water, sodium fluoride and silver ions, obtained in electrolytic way, by diffusion from silver electrode. Composition can be used for filling milk and permanent teeth, sealing of fissures, liners in filling with composites, treatment of non-caries affections of hard tissues (wedge-shaped defects, enamel erosion), permanent fixation of dental crowns.

EFFECT: composition for teeth filling possesses prolonged antimicrobial action and good esthetic properties, which makes it possible to use it for filling front teeth.

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Description

The invention relates to medicine, namely to therapeutic and orthopedic dentistry, and relates to filling and fixing materials.

A known composition for dentistry containing calcium hydroxide, a mixture of aluminofluorosilicate glass, 1,4-di-N-oxide 2,3-bis- (oxymethyl) quinoxoline, an aqueous 40% solution of polyacrylic acid (RF patent No. 2095053). According to the patent, as a result of chemical interaction of aluminofluorosilicate glass powder with an aqueous solution of polyacrylic acid, glass ionomer cement is formed, which ensures a constant seal, and the introduction of 1,4-di-N-oxide 2,3-bis- (oxymethyl) quinoxoline into the powder gives cement bactericidal properties, which together provides a reduction in the number of relapses and complications of caries. The disadvantage of this composition is a short antimicrobial effect - up to 48 hours.

In the 1980s, the development of glass-ionomer cements began, which included metals: most often silver metal powder. These materials received the international name "cermets". The introduction of finely divided metallic silver up to 20% significantly increased the prolonged antimicrobial effect of these glass-ionomer cements. The spectrum of antimicrobial action of silver is much wider than that of many antibiotics and sulfanilamides, and the bactericidal effect is manifested with minimal (oligodynamic) doses of silver.

Silver-based preparations are widely used in dentistry.

For example, in the patent of the Russian Federation 2243775, А61К 33/38, silver nitrate is used to treat caries and disinfection of the root canal. During the chemical reduction of silver nitrate, finely dispersed silver is formed, which provides a disinfecting, therapeutic effect. The disadvantage limiting the application of this method is the aesthetic factor - finely divided silver is black, which leads to staining of the tooth in a dark color. The known composition of glass ionomer silver-containing X-ray contrast cement "Argetsem" produced by JSC "Vladmiva" (Dental program of JSC "Vladmiva", Belgorod, 2010, p. 7).

“Argetsem” refers to “cermet” -cements, that is, glass-ionomer cements modified with silver. The Argetsem cement powder is a mixture of finely ground aluminofluorosilicate glass with finely divided metallic silver 3-4 microns, a liquid is an aqueous solution of polyacrylic acid. When powder and liquid are mixed, their chemical interaction occurs with the formation of glass ionomer cement, which has chemical adhesion to dentin and enamel, low solubility, gradually releasing fluorine and silver ions, preventing the development of secondary caries.

Along with the positive qualities, “Argetsem”, like other “cermet” cements, has a drawback, namely: the presence of finely dispersed metallic silver having a black color, giving the cement a gray color, which excludes its use in the group of anterior teeth due to the possibility of them coloring (Dental program of JSC "Vladmiva", Belgorod, 2010, p. 7). The staining of the treated tooth tissue in gray is a negative property in terms of aesthetics. The high silver content in the powder part leads to a large consumption of precious metal, which in turn affects the cost and price of the finished product.

The aim of this invention is to improve the aesthetic properties of filling cement (excluding its gray color), as well as reducing silver consumption when filling with silver-containing glass-ionomer tooth cements.

The goal (technical result) is achieved by the fact that silver is introduced into the glass ionomer cement not in the piston metal form, but in the ionic form (nanosized particles) electrolytically, by diffusion from the silver electrode of the anode into water, which is used to mix the powder part of the cement.

Closest to the claimed composition (the composition was chosen as a prototype) is Aquion cement by Vladmiva CJSC (Dental program of Vladmiva CJSC, Belgorod, 2010, p.6). The Akvion glass ionomer water-cured cement powder consists of a mixture of aluminofluorosilicate glass and dry polyacrylic acid. It is mixed with distilled water (barrier fluid) with the formation of quick-hardening filling material, which provides good adhesion to enamel and dentin and a tight edge fit.

An aqueous solution with silver ions is prepared using the following technology. Distilled water is taken, in which sodium fluoride is added in an amount of 0.2-0.5 wt.% For its electro conductivity. They accumulate water with silver ions in a laboratory setup with a capacity of 2 l / h from a prepared solution of sodium fluoride on two silver electrodes of Ср 99.99 grade (current strength 10.4 MA, voltage 6.4 V). Diffusion of silver ions occurs from a positive electrode (anode) into water. The resulting water with silver ions in a concentration of 10-40 mg / liter is poured into dark dropper bottles.

The result is an aqueous solution of a barrier fluid for silver-containing glass ionomer cement of the following composition, wt.%:

sodium fluoride 0.2-0.5 silver ions (nanosilver) 0.001-0.004 water the rest is up to 100

Bacteriological tests of the modified Akvion glass ionomer cement containing ionic silver showed a high antimicrobial activity against gram-positive and gram-negative microorganisms E.coli, S. Aureus, Str. haemolyticus (table 1).

Bacteriological studies have also shown that the resulting modified Aquion silver has a pronounced, prolonged antimicrobial effect. To conduct this bacteriological test, samples of the above cement were prepared in the form of tablets in size: with a diameter of 10 mm and a height of 2 mm. Extracts from the same sample — tablets — were obtained every two weeks, they were thermostated according to the method of accelerated aging (I-42-2-82. “Temporary instructions for work to determine the shelf life of drugs based on the method of accelerated aging with increased temperature ”), followed by seeding on cups seeded with staphylococcus test culture using the in vitro cup-suspension method in accordance with the method described in MP No. 2003/17 of 03.19.2004“ Cup Method for Evaluating the Effectiveness of Disinfectants and Antiseptics ”.

As shown in Table 2, extracts from sample tablets containing ionic silver exhibit an antibacterial effect that lasts for 200 days.

Clinical trials using silver modified Aquion have shown that filling the anterior teeth does not stain them.

Filling cement "Akvion", modified by nanosilver, has a white color. This quality is due to the very low concentration of silver in the cement.

Thus, the proposed composition has a number of positive qualities: the composition has good aesthetic properties and makes it possible to use it for filling frontal teeth, as well as significantly reduce the consumption of precious metal - silver. This in turn allows you to reduce the cost of filling material.

Bacteriological tests showed that aqua-glass ionomer cement obtained by mixing with water, containing ionic silver, has a high prolonged antimicrobial effect.

Such cements have a therapeutic effect: gradually releasing fluorine and silver ions, they prevent the development of secondary caries.

Table 1 Name of samples Antimicrobial action against microorganisms Research results ND on research methods. Experience The control Aquion on distilled water E.coli solid growth solid growth GF X1 Issue 2 S.aureus solid growth solid growth Str.haemolyticus solid growth solid growth "Akvion" on water containing silver ions (Ag + = 10 mg / l) E.coli absent. growth solid growth S.aureus absent. growth solid growth Str.haemolyticus absent. growth solid growth

table 2 The silver content, wt.% Fill color Antimicrobial effect 0.0001 white No effect 0.001 white 200 day effect 0.002 white 200 day effect 0.004 white 200 day effect

Claims (1)

Composition for dental fillings, containing in the powder part a mixture of aluminofluorosilicate glass and dry polyacrylic acid, in the gate part distilled water, characterized in that the water additionally contains sodium fluoride and silver ions obtained electrolytically by diffusion from a silver electrode in the following ratio of ingredients, wt. %:
sodium fluoride 0.2-0.5 silver ions 0.001-0.004 water the rest is up to 100