RU2426452C2 - Composition for preparation of biologically active food additive - Google Patents

Abstract

FIELD: food industry.

SUBSTANCE: invention relates to food industry. The composition for preparation of biologically active food additive contains wt %: cedar sap - 0.1-15.0, the rest is oily base. The oily base may be represented by cedar nut oil and/or linseed oil and/or a sea-buckthorn fruits oil concentrate in any combination. The composition containing cedar nut oil as the oily base includes a functional component represented by cedar sap in an amount of 0.1 - 5.0 wt % or more than 12.5 but up to 15.0 wt % inclusive.

EFFECT: invention allows to produce a new food additive with enhanced biologically activity due to enhancement and optimisation of the content of polyunsaturated fatty acids, sterines and terpenes as well as due to the resorptive properties of terpenes with regard to the biologically active composition components.

6 tbl, 4 ex

Description

The invention relates to the food industry, in particular to the production of dietetic and prophylactic products, and can be used as an independent biologically active food supplement (BAA) and in the enrichment of combined foods containing a fatty phase - mayonnaise, sauces, milk and creamy vegetable oils, margarines and pastes, ice cream and others.

At present, a great deal of positive experience has been gained in the use of dietary supplements in nutrition correction, prophylaxis and complex treatment of many diseases, but the development of products containing biologically active components in their composition remains valid. The insufficient content of biologically active substances in the diet, such as vitamins, polyunsaturated fatty acids and others, leads to various metabolic disorders. Prolonged or systematic consumption of food products with a low content of these components leads to deviations in the physiological state of the body, the activity of the circulatory, cardiovascular and central nervous system is disrupted, the body's immune resistance to infections is reduced, and life expectancy is reduced.

Characteristic features of dietary supplements are the gentle effect on the body, the absence of adverse reactions and intolerance, the possibility of complex effects, which is especially important in the presence of several diseases. Additives of this kind implement the mechanism of a non-pharmacological, safe way of regulating and supporting the functions of individual organs and systems of the human body, which ensures an increase in the level of health and a decrease in the incidence of disease.

Known biologically active product (RU 2137401, 6 A23L 1/30, publ. 09/20/1999), including sea buckthorn concentrate and cedar oil with a volume ratio of components (1-8) :( 1-2), respectively. The disadvantage of this product is the high content in the composition of sea buckthorn concentrate, which can cause irritation of the gastric and intestinal mucosa, moreover, the ratio of product components does not allow to achieve the required amount and ratio of polyunsaturated fatty acids. A significant drawback is the preparation of sea buckthorn concentrate and cedar oil by extraction with an organic solvent, which significantly reduces the food safety of the finished biologically active product, since it will always retain trace amounts of the organic solvent.

A known composition of biologically active substances (RU 2353107, A23L 1/30, publ. 04/27/2009), which is a solution or suspension of betulin in edible oil in the following ratio of components, wt.%: Betulin 0.1-74.9, food oil 25.0-99.8, other additives 0.1-74.9. The disadvantages of the composition are the use of non-nutritional mineral and silicone oils, as well as the presence of physiologically non-functional additives (0.1-74.9 wt.%), Including surfactants and emulsifiers.

For the closest analogue, a composition for the preparation of dosage forms and enrichment of food products was adopted, which contributes to the correction of lipid metabolism disorders, the prevention and treatment of atherosclerosis (RU 2211043, 7 A61K 35/78; A23L 1/303, publ. 10.05.2002), containing any of lipophilic vitamins A, D, E, K or beta-carotene, or any combination thereof, and an oil base, which is used as a pine nut oil (pine nut oil). The main disadvantage of the proposed composition is the use of a non-natural complex of vitamins, and the use of their synthetic analogues, as is known, in complex compositions, synthetic analogues exhibit less synergistic effect than natural ones. It is also known that when preparing complex compositions of lipophilic components, it is not recommended to administer all fat-soluble vitamins at once, since they can interact with each other, which leads to a deterioration in their digestibility. In addition, the analogue incorrectly solves the problem of correcting lipid metabolism disorders due to PUFA of cedar oil, since it is assumed that up to 30% of cedar oil is formed by acids of the ω-3 family. The highly active isomer of linolenic acid Δ-5, 9, 12 by the mechanism of physiological action refers to acids ω-6 / Deineka V.I., Deineka L.A. Cedar oil (Pi-nus sibirica seed oil): analysis and determination of falsification by HPLC // Chemistry of plant raw materials. 2006. No. 3 /, which means that the task set in the patent analogue cannot be solved only at the expense of cedar oil.

The technical problem solved by this invention is to expand the biological value and the spectrum of the preventive action of biologically active food additives by increasing and optimizing the content of polyunsaturated fatty acids, a complex of vitamins, phospholipids, sterols and terpenes, as well as by the resorptive properties of terpenes with respect to biologically active components of the composition.

The stated technical problem is solved by the fact that a composition is proposed for preparing dietary supplements for food, containing an oil-based functional component - cedar gum with a ratio of components, wt.%: Pine gum cinnamon 0.1-15.0 and oil base - pine nut oil and / or linseed oil, and / or sea buckthorn fruit oil concentrate in any combination thereof - the rest; at the same time, when flaxseed oil is used as the oil base, the content of cedar resin in the composition. from 0.1 to 5.0 or more than 12.5 to 15.0 wt.%.

The proposed dietary supplement is a liquid oily fraction with a pleasant taste and aromatic characteristics and increased biological activity, a wide range of effects of which is ensured by the synergistic action of biologically active components of the resin of cedar and oil base - a composition of vegetable oils, the composition and amount of which varies depending on the need adjust one or another function of the body. Cedar resin is a valuable raw material for the pharmaceutical industry; it is used for kidney diseases, urolithiasis, stomach and duodenal ulcers, pulmonary tuberculosis, and pneumonia. From the pharmaceutical level, drugs are known that include cedar gum: cosmetic creams, balms, balms for internal use, and oral hygiene products. The use of cedar resin in the production of multicomponent biologically active food additives and enriched (functional) food products has not been identified.

A feature of cedar resin from resins of other conifers is that it does not crystallize for a long time and does not lose its bactericidal qualities. The resin contains from 22.5 to 28% terpenes, differing in quantitative content (table 1), from 3.5 to 6.5% of fatty acids (oleic, linoleic, linolenic), the rest (more than 60%) are resin acids showing anti-inflammatory, bactericidal and wound healing properties.

Gum turpens have a variety of pharmacological activity: they exhibit antispasmodic, bactericidal and wound healing properties, help to reduce the manifestation of chronic fatigue syndrome and increase mental and physical performance.

Table 1 Composition of turpentine gum * Terpene Concentration,% of terpenes α-pinene 45.7-62.9 α-fenhen 0.8-1.1 Kampen 0.4-0.6 β-pinene 5.5-7.7 Δ ³ 11.7-12.3 α-fellandren 0.9-1.0 Mirzen Up to 0.7 Limonene + β-fellandren 0.8-0.9 Cineol 1.0-1.2 Terpinen 0.6-0.9 Terpinolen 0.6-0.9 Camphor 0.8-0.9 Bornyl acetate 0.7-0.9 Terpineol 1.0-2.3 Menthol 0.5-0.7 Borneol 0.5-0.9 Tsimol 0.6-0.9 ^* Determined using a Crystal-5000.1 gas-liquid chromatograph; standards of terpenes of firms Merk, Fluka, Aldrich.

Many of the terpenes (α-pinene, β-pinene, Δ ³ -arene, α-fellandren, terpinene, limonene, camphene, etc.) stimulate respiration and blood circulation, and have a diuretic and expectorant effect. Oxygen-containing terpenes (menthol, linalool, terpineol, borneol, bornyl acetate, cineole, cimol, camphor) exhibit anti-inflammatory, antispasmodic and antimicrobial effects. Menthol has a calming effect and antiseptic properties, exhibits a mild local anesthetic effect, is used for inflammatory diseases of the upper respiratory tract, cimol and its derivatives are used as anesthetics. Borneol and borne acetate suppress infections, viruses, slow down the growth of bacteria, have a diuretic, stimulating, tonic effect, stimulate the immune system and promote sputum separation. Borneol and camphor stimulate respiration and heart function, normalize carbohydrate-phosphorus metabolism and blood circulation. Camphor improves myocardial function, under the action of camphor, peripheral blood vessels narrow, used in acute and chronic heart failure, hypotension; in connection with the inhibition of platelet aggregation, camphor is recommended for use to improve microcirculation. Borneol and camphor are used as anesthetics, against stress, in the treatment of central nervous system diseases, such as Alzheimer's syndrome, Parkinson's disease and others. Cineol is used in medicine as an antiseptic and expectorant, and has a bactericidal effect. In addition, terpenes exhibit a general resorptive effect, affect regulatory processes, including neurotransmitter and immune responses. The irritation of receptors of the mucous membranes (for example, the stomach) caused by them is accompanied by stimulation of the synthesis and release of enkephalins, endorphins and other substances that play an important role in the regulation of pain and vascular permeability, stimulating immunological processes. Terpenes are natural antioxidants, which makes it possible to give dietary supplements not only antioxidant activity, but also the ability to stimulate the production of detoxifying enzymes by the liver. Limonene and menthol are included in the list of biologically active substances for which the recommended level of consumption is established / MP 2.3.1.19150-04. Recommended levels of intake of food and biologically active substances: guidelines. M.: State Research Institute of Nutrition RAMS, 2004 /.

Therefore, the biological value of cedar gum is determined by the high content of terpenes differing in action, affecting the regulation of metabolism and the gastrointestinal tract, stimulating respiration and circulation, regulating the activity of the cardiovascular and central nervous system, contributing to the acceleration of healing of damaged tissues. Thus, the physiological effect of the proposed composition for the preparation of dietary supplements is due to the presence of terpenes in it, and their effect is manifested both in the properties of individual terpenes and in the manifestation by these terpenes of resorptive properties with respect to other biologically active components of the composition. The use of cedar resin in the composition in amounts less than 0.1 wt.% Does not significantly increase the biological and physiological value of dietary supplements, and the use of amounts greater than 15.0 wt.% Leads to a decrease in the activity of the composition due to an increase in the dissolution time cedar resin in the components of the oil base and the resulting increase in oxidative damage.

The oil base is used not only as a solvent for the functional component - cedar resin, but also participates in the dietary supplement as an independent physiologically functional component. The combination of cedar resin with an oil base, including pine nut oil and / or linseed oil, and / or sea buckthorn fruit oil concentrate, allows to increase the biological value of the claimed dietary supplement due to polyunsaturated fatty acids (PUFAs), a complex of fat-soluble vitamins (tocopherols and carotenoids), phosphol and sterols.

Linoleic and linolenic acids (PUFAs ω-3 and ω-6, vitamin F) are involved in the synthesis of prostaglandins, enhance the effectiveness of the body's antioxidant systems, normalize lipid transport processes in the bloodstream, participate in the restoration of cell membranes, activate the functions of immunocompetent cells, and enhance the body's stability to infections and colds. They are necessary in a comprehensive therapeutic and preventive nutrition for hyperlipidemia, hypertension, thrombosis, diabetes mellitus, bronchial asthma, skin diseases, immunodeficiency states. Acids ω-3 show a pronounced anti-inflammatory effect; α-linolenic acid, as a representative of the ω-3 fatty acid group, in addition to the anti-inflammatory effect caused by the formation of prostaglandins, as a result of preventing blood cell aggregation and blood clots, helps to prevent atherosclerosis, strengthen the walls of blood vessels, increase their elasticity, reduce permeability and restore microcirculation.

Depending on the direction of the dietary supplement, the ratio of fatty acids ω-6: ω-3 in the diet of a healthy and relatively healthy person should be from 10: 1 to 12: 1, in therapeutic and preventive nutrition - from 5: 1 to 1: 1 / Poznyakovsky V.M., Austrievskikh A.N., Vekovtsev A.A. Nutritional and dietary supplements. Moscow; Kemerovo: Russian Universities, 2004 /. Individually, none of the vegetable oils included in the oil base, except for sea buckthorn fruit oil, is characterized by the required ratio of fatty acids (table 2). But the main drawback of sea buckthorn fruit oil is its high acidity, leading to heartburn (or its intensification), as a result of which contraindications to the use of sea buckthorn fruit oil are gallstone disease, chronic cholecystitis, pancreatitis. The formation of dense scars during epithelialization of the tissue in conditions of the use of sea buckthorn fruit oil is also associated with increased acidity. In this regard, there are recommendations to use sea buckthorn fruit oil previously neutralized, or in combination with alkaline mineral water, or previously diluted in another, inert, vegetable oil, such as olive or sunflower. The latter leads to a significant slowdown in reparative processes.

table 2 The composition and content of fatty acids in oils - components of the oil base Fatty acid Mass fraction of fatty acids,% / Oil pine nut flaxseed sea buckthorn fruit Palmitic 3.0-7.3 5.4-11.3 29.0-35.5 Palmitoleic up to 1.2 up to 0.1 31.2-37.0 Stearin 1.8-4.9 2.5-8.0 1.9-3.3 Oleic 19.9-24.9 13.0-36.0 11.0-12.6 Linoleic (ω-6) 38.8-46.6 8.3-30.0 12.5-15.7 Linolenic (ω-6) 18.0-24.3 - - Linolenic (ω-3) 0.3-1.2 30.0-67.0 2.4-5.8 The composition of fatty acids is determined in accordance with GOST R 51483.

Tocopherols (vitamin E) are direct-acting antioxidants, they perform the functions of stabilization and protection of lipids of cell membranes from free-radical processes of peroxidation, regulate the metabolism of proteins, fats and carbohydrates. With a lack of tocopherols in the diet, disturbances in the work of many systems and organs begin: the fat balance is disturbed, the permeability and fragility of capillaries increases, degenerative changes in nerve cells and endocrine glands occur, and the liver parenchyma is affected.

One of the main functions of carotenoids in the body is the synthesis of vitamin A, the absorption of which is positively influenced by α-tocopherol. As antioxidants, carotenoids are involved in the inhibition of lipid peroxidation in the human body.

Phospholipids contribute to better absorption of fats and PUFAs. Entering the human body, phospholipids are included in the boundary layer of cells and are one of the main regulators of membrane permeability. The functions of phospholipids in the body are structural and function, aimed at stimulating the activity of various enzyme systems, participation in the processes of molecular transport, division, maturation and differentiation of cells. Being part of the protein-lipid complexes of cells, phospholipids are involved in antioxidant processes in the body. Consumption of phospholipids helps to lower blood pressure, the content of total cholesterol in the blood. It is plant phospholipids that are used in prophylactic nutrition for the restoration of liver hepatocyte membranes: when phospholipids are ingested, substances are incorporated directly into the membrane structure of damaged hepatocytes, increasing their fluidity and flexibility, which contributes to the activation of membrane-dependent metabolic processes in the liver. Plant phospholipids contribute to the restoration and maintenance of the structure of organs and phospholipid-dependent enzymatic systems, normalization of lipid and protein metabolism, the conversion of neutral fats and cholesterol into forms that facilitate their metabolism, stabilization of the physicochemical properties of bile, normalization of functions and a decrease in the level of energy expenditure of the liver, and slowdown of growth in liver connective tissue in case of cirrhosis.

Sterols have the ability to form insoluble complexes with cholesterol, showing an active hypocholesterolemic effect and reducing the risk of coronary heart disease. Sterols have an additive effect on the composition of the diet, showing a more pronounced effect in lowering cholesterol when introduced into the diet against a background of low saturated fat content. Additivity is also manifested in relation to drug methods of lowering cholesterol, and therefore combination treatment gives better results in lowering blood cholesterol. Other biologically active properties of sterols is participation in reparative processes both for internal and external use; active anti-inflammatory properties; participation in the synthesis of steroid hormones.

The biological value of pine nut oil is determined by the high content of PUFA ω-6 (up to 70% in total), vitamin E (from 40 to 65 mg / 100 g, with an approximately equal ratio of α- and γ-forms), especially high in comparison with other types vegetable oils - the content of phospholipids (up to 0.6%). As a source of PUFA and tocopherols, pine nut oil is recommended for prophylactic and complex therapeutic and prophylactic nutrition in immunodeficiency states, hypertension, diabetes mellitus, predisposition to blood clots, dermatological and some other diseases. The use of pine nut oil for ulcerative erosive lesions and burns leads to faster than using sea buckthorn oil, cleansing wounds, shortening the time of epithelization and the formation of granulation tissue. Pine nut oil allows you to optimize the course of the recovery process and change the structure and biomechanical properties of scar tissue both due to higher collagen production and as a result of more advanced remodeling of the scar and more optimal orientation of collagen bundles in it than when using sea buckthorn oil.

The biological value of flaxseed oil is due to the high content of PUFAs (which are dominated by the essential fatty acid ω-3 - up to 67%, and also contain up to 30% of the essential fatty acid ω-6) and vitamin E (at least 40 mg / 100 g), the composition of which is dominated by the γ-form of tocopherols, which has the highest antioxidant activity. Flaxseed oil has pronounced prophylactic properties against metabolic disorders causing vascular atherosclerosis, diabetes mellitus, and oncological diseases. Flaxseed oil is recommended for impaired fat metabolism, reduces high blood cholesterol, it reduces the risk of stroke, and therefore plays an important role in the prevention of cardiovascular disease; has a positive effect on the function of the liver, thyroid gland, intestines, stomach. There are no contraindications to the use of 100% pine nut oil and flaxseed oil.

The biological value of the sea buckthorn fruit oil concentrate is due to the high content of carotenoids (from 320 to 700 mg / 100 g), sterols (1.2-5.2%), vitamin E (from 180 to 520 mg / 100 g, a pronounced predominance of α-tocopherols with the highest E-vitamin activity), to a certain extent - PUFA (2.4-5.8% ω-3 and 12.5-15.7% ω-6). Sea buckthorn fruit oil exhibits a high adaptogenic and vitamin effect, which helps to increase the body's resistance to aggressive factors. This product has been used for a long time as a pharmaceutical product and dietary supplement for food, promotes the healing of external and internal wounds and burns (accelerates processes and improves the quality of epithelization), has anti-inflammatory, some antibacterial and antitumor properties, is recommended for use with ulcerative erosive lesions of the stomach and duodenum intestines, biliary dyskinesia and in the complex treatment of cancer of the esophagus (to reduce degenerative changes in the mucous membrane).

Despite the fact that sea buckthorn fruit oil is recommended for prophylactic nutrition in atherosclerosis, as it causes noticeable positive changes in the lipid spectrum of blood serum, there are no such broad and unambiguous recommendations for use in preventive nutrition as for flaxseed oil and cedar oil walnut.

A study of the dynamics of the oxidation of dietary supplements to food of the proposed composition shows that cedar gum can have an inhibitory effect on oxidative spoilage processes: the introduction of gum in oil reduces its oxidation rate (the growth rate of the peroxide number decreases by 1.2-1 , 5 times).

The combination of pine resin with an oil base, including pine nut oil and / or linseed oil, and / or sea buckthorn fruit oil concentrate, can further increase the consumer value of the proposed dietary supplement with other active substances, expanding the range of its functional properties due to:

- increasing and optimizing the content of polyunsaturated fatty acids, improving the ratio of fatty acids ω-6 and ω-3 and bringing this ratio closer to that recommended for consumers with different health conditions;

- expansion of the qualitative composition of biologically active components involved in the formation of nutritional value of dietary supplements and with pronounced antioxidant, capillary-strengthening, cholesterol-lowering and hypolipidemic properties;

- a synergistic combination of carotenoids, tocopherols, phospholipids and sterols with antioxidant properties and contributing to the prevention of atherosclerosis and cardiovascular diseases involved in the normal functioning of organs and tissues of the human body;

- the presence of terpenes, which enhance the motor and secretory functions of the intestine and stimulate the work of the gastrointestinal tract, kidneys and gall bladder; regulating the work of the nervous and cardiovascular systems;

- increase the efficiency of metabolization of all these components, due to the combination of a complex of fat-soluble vitamins with PUFA and terpenes;

- changes in the rate of oxidative damage processes (in the direction of their inhibition), which helps to prolong the conservation of consumer value, and, as a consequence, the biological activity of dietary supplements.

Thus, an inexpensive and affordable composition has been developed to obtain a biologically active food supplement containing PUFA, a complex of fat-soluble vitamins (tocopherols + carotenoids), phospholipids, sterols and terpenes.

A biologically active food supplement is a natural physiologically valuable product of plant origin and can be recommended for direct consumption as an independent prophylactic or against the background of general diet therapy, as well as for inclusion in the composition of functional foods containing the fat phase - mayonnaise, sauces, dairy and creamy vegetable oils, margarines and pastes, ice cream and others.

The use of cedar resin in combination with an oil base - a composition of vegetable oils - leads to an increase in the digestibility of all components, an increase in the biological activity of the product due to the synergistic action of the dietary supplement components and the intensification of the process of their absorption in the gastrointestinal mucosa. All components are used taking into account their physiological significance, and in each case the properties of each input component are taken into account due to an empirically selected effective amount. Obtaining dietary supplements is as follows.

The starting components are added to each other in a specific sequence. At the first stage, cedar resin is melted in a water bath for 2-3 minutes at a temperature of no more than 60 ° C, followed by filtration and cooling to room temperature. Next, cedar gum is dissolved in the prescribed amount of pine nut oil; complete dissolution of the resin and its uniform distribution in the oil is achieved by keeping the mixture of these components in a water bath at a temperature of not more than 60 ° C for 10-20 minutes.

To obtain a dietary supplement of a given composition, pine nut oil with resin coated in it is mixed in established proportions with another (and) prescribed) vegetable (s) formulation (s).

Obtaining dietary supplements precisely in the indicated sequence is due to the fact that in the list of used oils, pine nut oil has the lowest oxidation rate, and therefore, the product with the lowest values of oxidative deterioration is obtained, i.e. with the highest possible consumer value.

The prior art is not known biologically active additive in which the proposed combination of components would take place. However, it was this combination of components that made it possible to obtain a new biologically active food supplement with a wide range of biological effects, properties of a corrector for carbohydrate, protein and fat metabolism, and an action that strengthens and enhances immunity, and widens the range of additives.

The invention is further illustrated by examples of specific implementation, which should not serve as a basis for limiting the claims of the applicant, but should be considered solely as examples confirming the possibility of carrying out the invention with the achievement of the above technical result.

Example No. 1. To obtain dietary supplements, cedar gum melt is introduced into pine nut oil, obtained by heating gum in a water bath at a temperature of not more than 60 ° C for 2-3 minutes and then filtering and cooling. Dissolution of pine resin in pine nut oil is carried out by keeping these components in a water bath at a temperature of not more than 60 ° C for 10-20 minutes. Next, pine nut oil with gum dissolved in it is mixed with linseed oil and sea buckthorn fruit oil in the following ratio of the components of the formulation, wt.%:

cedar resin 15.0,

pine nut oil 45.0,

linseed oil 5.0,

Sea buckthorn fruit oil concentrate 35.0.

BAA is a liquid oily fraction of a saturated orange color with the taste and smell of sea buckthorn oil against a background of pronounced smell and smack of resin. The composition of the active components of dietary supplements is shown in table 3.

Table 3 BAA characteristics The name of indicators The composition of dietary supplements PUFA ω-3,% 3,5-3,8 PUFA ω-6,% 33.0-34.3 Ω-3 ratio: ω-6 1: 8.8-1: 9.5 Tocopherols (Vitamin E), mg / 100 g, 142.5-177.5 including α-tocopherol 84.3-109.3 Carotenoids, mg / 100 g 175.0-227.5 Phospholipids (for stearoleolecithin),% 0.4-0.5 Sterols,% 1.3-1.4 Terpenes,%: α-pinene 1,576-2,169 α-fenhen 0.027-0.037 Kampen 0.013-0.021 β-pinene 0.189-0.265 Δ ³ 0.403-0.424 α-fellandren 0,031-0,034 Mirzen 0.018-0.024 Limonene + β-fellandren 0.027-0.031 Cineol 0,034-0,042 Terpinen 0,021-0,031 Terpinolen 0,021-0,031 Camphor 0.027-0.031 Bornyl acetate 0.024-0.031 Terpineol 0,034-0,079 Menthol 0.016-0.024 Borneol 0.016-0.031 Tsimol 0,021-0,031

For better preservation of the active components, ease of consumption and dosing accuracy, the production of dietary supplements can be carried out in soft gelatin capsules with a standard net weight of 0.2 g with recommendations for adults to take 4-8 capsules 2-3 times a day during meals for 2 -3 weeks.

The component composition is selected in such a way as to expand and enhance the adaptogenic and immunostimulating activity of dietary supplements. As a result, as a prophylactic and restorative agent, dietary supplement is effective in the period of exacerbation of infectious diseases of the upper respiratory tract, increases the nonspecific resistance of the body due to the manifestation of vitamin, antioxidant, immunocorrective effects and activation of all metabolic processes.

Example No. 2. Getting dietary supplements is carried out analogously to example No. 1, but in the following ratio of the components of the formulation, wt.%:

cedar resin 10.0,

pine nut oil 60.0,

linseed oil 10.0,

Sea buckthorn fruit oil concentrate 20.0.

BAA is a liquid oily fraction of a saturated orange color with the taste and smell of sea buckthorn oil against a background of pronounced smell and smack of resin. The composition of the active components of dietary supplements is shown in table 4.

Table 4 BAA characteristics The name of indicators The composition of dietary supplements one 2 PUFA ω-3,% 5.7-6.4 PUFA ω-6,% 41.3-43.5 Ω-3 ratio: ω-6 1: 6.5-1: 7.6 Tocopherols (Vitamin E), mg / 100 g, 89.5-110.4 including α-tocopherol 63.5-74.5 Carotenoids, mg / 100 g 100.0-130.0 Phospholipids (for stearoleolecithin),% 0.5-0.6 Sterols,% 1.0-1.2 Terpenes,%: α-pinene 1,051-1,446 α-fenhen 0.018-0.025 Kampen 0.009-0.014 β-pinene 0.126-0.177 Δ ³ 0.269-0.283 α-fellandren 0.021-0.023

Continuation of table 4 one 2 Mirzen 0.012-0.016 Limonene + β-fellandren 0.018-0.021 Cineol 0,023-0,028 Terpinen 0.014-0.021 Terpinolen 0.014-0.021 Camphor 0.018-0.021 Bornyl acetate 0.016-0.021 Terpineol 0,023-0,053 Menthol 0.011-0.016 Borneol 0.011-0.021 Tsimol 0.014-0.021

For the best preservation of active components, ease of consumption and dosing accuracy, the production of dietary supplements can be carried out in soft gelatin capsules with a standard net weight of 0.2 g each, with recommendations for adults to take 6-12 capsules 2-3 times a day during meals for 3 -4 weeks.

The component composition is selected in such a way as to expand and enhance the vitamin and immunostimulating activity of dietary supplements. As a result, dietary supplements can be used for the prevention and in the complex therapy of diseases associated with immunodeficiency, hypo- and vitamin deficiencies, and exhibits a multivitamin, antioxidant, capillary-strengthening, immunocorrecting and pronounced hypocholesterolemic effect, contributes to the regulation of carbohydrate-fat metabolism and improve cardiovascular and central nervous system. Carotenoids of sea buckthorn fruit oil in combination with tocopherols orient dietary supplements to improve the permeability of the vascular walls and microcirculation processes, regulate the blood supply to the retina of the eye and, in general, normalize the function of vision. Terpenes of resin of cedar and phospholipids of the composition of vegetable oils contribute to a synergistic enhancement of the antioxidant and capillary-protective properties of dietary supplements, normalize the processes of respiration and blood circulation, causing an increase in mental and physical performance.

Example No. 3. Obtaining dietary supplements is carried out analogously to example No. 1, but after dissolving the pine resin in pine oil, the latter is mixed with linseed oil

in the following ratio of components of the formulation, wt.%:

cedar resin, 2.5,

pine nut oil 30,0,

linseed oil 67.5.

Dietary supplement is a golden-yellow liquid oily fraction with a pronounced aroma and taste of pine nut oil and a light gummy aftertaste. The composition of the active components of dietary supplements is shown in table 5.

Table 5 BAA characteristics The name of indicators The composition of dietary supplements PUFA ω-3,% 30.8-34.0 PUFA ω-6,% 30.4-33.2 Ω-3 ratio: ω-6 1: 1 Tocopherols (Vitamin E), mg / 100 g, 46.2-58.7 including α-tocopherol 24.7-31.2 Carotenoids, mg / 100 g 0.3-0.4 Phospholipids (for stearoleolecithin),% 0.5-0.6 Sterols (in terms of β-sitosterol),% 0.4-0.6 Terpenes,%: α-pinene 0.260-0.360 α-fenhen 0.005-0.006 Kampen 0.002-0.003 β-pinene 0.032-0.044 Δ ³ 0,067-0,071 α-fellandren 0.005-0.006 Mirzen 0.003-0.004 Limonene + β-fellandren 0.004-0.005 Cineol 0.006-0.007 Terpinen 0.003-0.005 Terpinolen 0.003-0.005 Camphor 0.004-0.005 Bornyl acetate 0.004-0.005 Terpineol 0.006-0.013 Menthol 0.003-0.004 Borneol 0.003-0.005 Tsimol 0.003-0.005

For better preservation of the active components, ease of consumption and dosing accuracy, the production of dietary supplements can be carried out in soft gelatin capsules with a standard net weight of 0.2 g each, with recommendations for adults to take 6-12 capsules 3-4 times a day during meals for 3 -4 weeks.

The component composition is selected in such a way as to give the dietary supplement a functional orientation, focused on the prevention and complex therapy of cardiovascular diseases and arterial hypertension.

Due to the optimized ratio of polyunsaturated fatty acids ω-3 and ω-6, dietary supplement components determine its properties of lowering blood cholesterol, improving blood circulation in the vessels of the heart and brain, normalizing the rhythm of cardiac activity, which allows the composition to be oriented toward the prevention of atherosclerotic phenomena, hypertension and other cardiovascular disease. Acceleration of the manifestation of the hypocholesterolemic and lipotropic properties of biologically active substances in the composition of vegetable oils is due to the general resorption effect of terpene turpentine.

Example No. 4. Obtaining dietary supplements is carried out analogously to example No. 1, but in the following ratio of the components of the formulation, wt.%: Pine pine gum 0.1, pine nut oil 52.4, linseed oil 27.5, sea buckthorn fruit oil concentrate 20.0.

BAA is a liquid oily fraction of a saturated orange color with the taste and smell of sea buckthorn oil. The composition of the active components of dietary supplements is shown in table 6.

Table 6 BAA characteristics The name of indicators The composition of dietary supplements PUFA ω-3,% 14.5-16.1 PUFA ω-6,% 39.6-42.0 Ω-3 ratio: ω-6 1: 2.5-1: 2.9 Tocopherols (Vitamin E), mg / 100 g, 100.0-115.2 including α-tocopherol 56.6-63.6 Carotenoids, mg / 100 g 100.0-130.0 Phospholipids (for stearoleolecithin),% 0.5-0.6 Sterols,% 1.1-1.3 Terpenes,%: α-pinene 0.011-0.015 β-pinene 0.001-0.002 Δ ³ 0.002-0.003

For better preservation of the active components, ease of consumption and dosing accuracy, the production of dietary supplements can be carried out in soft gelatin capsules with a standard net weight of 0.2 g each, with recommendations for adults to take 6-12 capsules 3-4 times a day during meals for 3 -4 weeks.

The component composition is selected in such a way as to give the dietary supplement a metabolic orientation focused on therapeutic and prophylactic nutrition in case of hyperacid gastritis, gastric and duodenal ulcer, and also on the improvement of postoperative reparative processes in the gastrointestinal tract. Supplements have general strengthening, anti-inflammatory and wound healing properties, have the activity of a corrector of carbohydrate-fat metabolism, and stimulate the functioning of the gastrointestinal tract.

It is very important in the proposed dietary supplement that the biologically active substances contained in it of the individual components of the formulation are balanced in action. So, if the terpenes included in it, which stimulate the secretion of gastric juice, have an undesirable effect in peptic ulcer and gastritis, then with such a low concentration of resin in the composition of dietary supplements, they manifest themselves mainly as catalysts of immune reactions, and their bactericidal effect is mitigated by the properties of PUFAs and lipophilic vitamins of the composition of vegetable oils that reduce the acidity of gastric juice and have a normalizing effect in chronic gastritis and ulcerative erosive lesions.

For better preservation of the active components, ease of consumption and dosing accuracy, the production of dietary supplements can be carried out in soft gelatin capsules with a standard net weight of 0.2 g each, with recommendations for adults to take 6-12 capsules 3-4 times a day during meals for 3 -4 weeks.

The component composition is selected in such a way as to give the dietary supplement a metabolic orientation focused on therapeutic and prophylactic nutrition in diseases of the liver, gastrointestinal tract, to improve fat metabolism, lower blood cholesterol and prevent obesity.

The physiological function of dietary supplements is aimed at improving metabolism, enhancing the secretory and motor functions of the gastrointestinal tract, and regulating the functional activity of the pancreas, liver and gall bladder. Due to terpenes of turpentine, cedar dietary supplement provides relief of the development of pain and inflammation, prophylaxis of diseases of the gastrointestinal tract, stimulates immunological processes and the production of liver enzymes that provide detoxification.

Claims (1)

Composition for the preparation of a biologically active food supplement containing a functional component and an oil base, characterized in that it contains pine gum as a functional component, and pine nut oil and / or linseed oil and / or fruit oil concentrate as an oil base sea buckthorn in any combination of them in the following ratio of components, wt.%:
cedar resin - 0.1-15.0 oil base - pine nut oil and / or linseed oil, and / or sea buckthorn fruit oil concentrate - the rest,
wherein the composition containing cedar nut oil as an oil base contains cedar gum in the amount of, wt.%, from 0.1 to 5.0 or more than 12.5 to 15.0 inclusive.