RU2415141C2 - Heteroarylbenzamide derivatives applied as glk activators in diabetes treatment - Google Patents

Heteroarylbenzamide derivatives applied as glk activators in diabetes treatment Download PDF

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Publication number
RU2415141C2
RU2415141C2 RU2008101927/04A RU2008101927A RU2415141C2 RU 2415141 C2 RU2415141 C2 RU 2415141C2 RU 2008101927/04 A RU2008101927/04 A RU 2008101927/04A RU 2008101927 A RU2008101927 A RU 2008101927A RU 2415141 C2 RU2415141 C2 RU 2415141C2
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RU
Russia
Prior art keywords
oxy
heteroarylbenzamide
compound
diabetes treatment
obesity
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RU2008101927/04A
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Russian (ru)
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RU2008101927A (en
Inventor
Даррен МАККЕРРЕЧЕР (GB)
Даррен Маккерречер
Курт Гордон ПАЙК (GB)
Курт Гордон Пайк
Майкл Джеймс УОРИНГ (GB)
Майкл Джеймс УОРИНГ
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Астразенека Аб
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Priority claimed from GB0514173A external-priority patent/GB0514173D0/en
Priority claimed from GB0516297A external-priority patent/GB0516297D0/en
Priority claimed from GB0524589A external-priority patent/GB0524589D0/en
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of RU2008101927A publication Critical patent/RU2008101927A/en
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Publication of RU2415141C2 publication Critical patent/RU2415141C2/en

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  • Plural Heterocyclic Compounds (AREA)

Abstract

FIELD: medicine.
SUBSTANCE: invention refers to the compound 3-{[5-(azetidine-1-ylcarbonyl)pyrazine-2-yl] oxy}-5-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-N-(5-methylpyrazine-5-yl)benzamide or to its pharmaceutically acceptable salt. Also, it refers to a pharmaceutical composition for treating insulin-independent diabetes or obesity containing said compound.
EFFECT: there is produced and described a new compound which can be effective in treating insulin-independent diabetes and obesity.
5 cl, 64 ex

Description

Текст описания приведен в факсимильном виде.

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The text of the description is given in facsimile form.
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Claims (5)

1. Соединение 3-{[5-(азетидин-1-илкарбонил)пиразин-2-ил]окси}-5-{[(1S)-1-метил-2-(метилокси)этил]окси}-N-(5-метилпиразин-2-ил)бензамид или его фармацевтически приемлемая соль.1. Compound 3 - {[5- (azetidin-1-ylcarbonyl) pyrazin-2-yl] oxy} -5 - {[(1S) -1-methyl-2- (methyloxy) ethyl] oxy} -N- ( 5-methylpyrazin-2-yl) benzamide or a pharmaceutically acceptable salt thereof. 2. Соединение по п.1, представляющее собой 3-{[5-(азетидин-1-илкарбонил)пиразин-2-ил]окси}-5-{[(1S)-1-метил-2-(метилокси)этил]окси}-N-(5-метилпиразин-2-ил)бензамид.2. The compound according to claim 1, which is 3 - {[5- (azetidin-1-ylcarbonyl) pyrazin-2-yl] oxy} -5 - {[(1S) -1-methyl-2- (methyloxy) ethyl ] hydroxy} -N- (5-methylpyrazin-2-yl) benzamide. 3. Фармацевтическая композиция для лечения диабета 2 типа или ожирения, содержащая соединение по п.1 или 2 вместе с фармацевтически приемлемым разбавителем или носителем.3. A pharmaceutical composition for treating type 2 diabetes or obesity, comprising a compound according to claim 1 or 2 together with a pharmaceutically acceptable diluent or carrier. 4. Соединение по п.1 или 2 для применения в лечении диабета 2 типа.4. The compound according to claim 1 or 2 for use in the treatment of type 2 diabetes. 5. Соединение по п.1 или 2 для применения в лечении ожирения. 5. The compound according to claim 1 or 2 for use in the treatment of obesity.
RU2008101927/04A 2005-07-09 2006-07-03 Heteroarylbenzamide derivatives applied as glk activators in diabetes treatment RU2415141C2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0514173.4 2005-07-09
GB0514173A GB0514173D0 (en) 2005-07-09 2005-07-09 Chemical compounds
GB0516297.9 2005-08-09
GB0516297A GB0516297D0 (en) 2005-08-09 2005-08-09 Chemical compounds
GB0523862.1 2005-11-24
GB0524589A GB0524589D0 (en) 2005-12-02 2005-12-02 Chemical compounds
GB0524589.9 2005-12-02
GB0607977.6 2006-04-22

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RU2010149302/04A Division RU2010149302A (en) 2005-07-09 2010-12-03 Heteroarylbenzamide derivatives for use as GLK activators in the treatment of diabetes

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RU2008101927A RU2008101927A (en) 2009-08-20
RU2415141C2 true RU2415141C2 (en) 2011-03-27

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RU2010149302/04A RU2010149302A (en) 2005-07-09 2010-12-03 Heteroarylbenzamide derivatives for use as GLK activators in the treatment of diabetes

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RU2010149302A (en) 2012-06-10

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