RU2410386C2 - Novel compounds possessing antibacterial activity - Google Patents

Novel compounds possessing antibacterial activity Download PDF

Info

Publication number
RU2410386C2
RU2410386C2 RU2007105995/04A RU2007105995A RU2410386C2 RU 2410386 C2 RU2410386 C2 RU 2410386C2 RU 2007105995/04 A RU2007105995/04 A RU 2007105995/04A RU 2007105995 A RU2007105995 A RU 2007105995A RU 2410386 C2 RU2410386 C2 RU 2410386C2
Authority
RU
Russia
Prior art keywords
group
formula
compounds
halogen
alkyl
Prior art date
Application number
RU2007105995/04A
Other languages
Russian (ru)
Other versions
RU2007105995A (en
Inventor
Забине ПИРАУ (DE)
Забине ПИРАУ
Гленн ДАЛЕ (CH)
Гленн ДАЛЕ
Михаэль В. КАППИ (DE)
Михаэль В. КАППИ
Корнелия ЦУМБРУНН (CH)
Корнелия ЦУМБРУНН
Кристиан ХУБШВЕРЛЕН (FR)
Кристиан ХУБШВЕРЛЕН
Жан-Филипп СЮРИВЕ (FR)
Жан-Филипп СЮРИВЕ
Original Assignee
Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми filed Critical Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми
Publication of RU2007105995A publication Critical patent/RU2007105995A/en
Application granted granted Critical
Publication of RU2410386C2 publication Critical patent/RU2410386C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to novel antibacterial compounds of formula (I). Compounds of formula (I) Q-NH-CO-R3, where Q stands for group of the following structure
Figure 00000164
, R1 represents hydrogen, halogen, hydroxy, amino, mercapto, alkyl, heteroalkyl, alkeloxy, heteroalkyloxy, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, cycloalkyloxy, alkylcycloalkyloxy, heterocycloalkyloxy or heteroalkylcycloalkyloxy, X1, X2, X3, X4, X5 and X6 each independently on each other represent nitrogen atom or group of formula CR2, R2 represents hydrogen, halogen or hydroxy, amino, alkyl, alkenyl, alkinyl or heteroalkyl group, R3 is selected from the following groups
Figure 00000165
Figure 00000166
Figure 00000167
Figure 00000168
R5 represents group of formula -B-Y, where B represents alkylene, alkenylene, alkinylene, -NH- or heteroalkylene, and Y represents aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl or heteroalkylcycloalkyl, or their pharmaceutically acceptable salt, solvate, hydrate or pharmaceutically acceptable composition, as well as to pharmaceutical composition, which possesses antibacterial activity, based on said compounds and to their application for preparation of medication, intended for treatment of bacterial infections.
EFFECT: obtained and described are compounds, which can be useful in medicine.
9 cl, 147 ex

Description

Текст описания приведен в факсимильном виде.

Figure 00000001
Figure 00000002
Figure 00000003
Figure 00000004
Figure 00000005
Figure 00000006
Figure 00000007
Figure 00000008
Figure 00000009
Figure 00000010
Figure 00000011
Figure 00000012
Figure 00000013
Figure 00000014
Figure 00000015
Figure 00000016
Figure 00000017
Figure 00000018
Figure 00000019
Figure 00000020
Figure 00000021
Figure 00000022
Figure 00000023
Figure 00000024
Figure 00000025
Figure 00000026
Figure 00000027
Figure 00000028
Figure 00000029
Figure 00000030
Figure 00000031
Figure 00000032
Figure 00000033
Figure 00000034
Figure 00000035
Figure 00000036
Figure 00000037
Figure 00000038
Figure 00000039
Figure 00000040
Figure 00000041
Figure 00000042
Figure 00000043
Figure 00000044
Figure 00000045
Figure 00000046
Figure 00000047
Figure 00000048
Figure 00000049
Figure 00000050
Figure 00000051
Figure 00000052
Figure 00000053
Figure 00000054
Figure 00000055
Figure 00000056
Figure 00000057
Figure 00000058
Figure 00000059
Figure 00000060
Figure 00000061
Figure 00000062
Figure 00000063
Figure 00000064
Figure 00000065
Figure 00000066
Figure 00000067
Figure 00000068
Figure 00000069
Figure 00000070
Figure 00000071
Figure 00000072
Figure 00000073
Figure 00000074
Figure 00000075
Figure 00000076
Figure 00000077
Figure 00000078
Figure 00000079
Figure 00000080
Figure 00000081
Figure 00000082
Figure 00000083
Figure 00000084
Figure 00000085
Figure 00000086
Figure 00000087
Figure 00000088
Figure 00000089
Figure 00000090
Figure 00000091
Figure 00000092
Figure 00000093
Figure 00000094
Figure 00000095
Figure 00000096
Figure 00000097
Figure 00000098
Figure 00000099
Figure 00000100
Figure 00000101
Figure 00000102
Figure 00000103
Figure 00000104
Figure 00000105
Figure 00000106
Figure 00000107
Figure 00000108
Figure 00000109
Figure 00000110
Figure 00000111
Figure 00000112
Figure 00000113
Figure 00000114
Figure 00000115
Figure 00000116
Figure 00000117
Figure 00000118
Figure 00000119
Figure 00000120
Figure 00000121
Figure 00000122
Figure 00000123
The text of the description is given in facsimile form.
Figure 00000001
Figure 00000002
Figure 00000003
Figure 00000004
Figure 00000005
Figure 00000006
Figure 00000007
Figure 00000008
Figure 00000009
Figure 00000010
Figure 00000011
Figure 00000012
Figure 00000013
Figure 00000014
Figure 00000015
Figure 00000016
Figure 00000017
Figure 00000018
Figure 00000019
Figure 00000020
Figure 00000021
Figure 00000022
Figure 00000023
Figure 00000024
Figure 00000025
Figure 00000026
Figure 00000027
Figure 00000028
Figure 00000029
Figure 00000030
Figure 00000031
Figure 00000032
Figure 00000033
Figure 00000034
Figure 00000035
Figure 00000036
Figure 00000037
Figure 00000038
Figure 00000039
Figure 00000040
Figure 00000041
Figure 00000042
Figure 00000043
Figure 00000044
Figure 00000045
Figure 00000046
Figure 00000047
Figure 00000048
Figure 00000049
Figure 00000050
Figure 00000051
Figure 00000052
Figure 00000053
Figure 00000054
Figure 00000055
Figure 00000056
Figure 00000057
Figure 00000058
Figure 00000059
Figure 00000060
Figure 00000061
Figure 00000062
Figure 00000063
Figure 00000064
Figure 00000065
Figure 00000066
Figure 00000067
Figure 00000068
Figure 00000069
Figure 00000070
Figure 00000071
Figure 00000072
Figure 00000073
Figure 00000074
Figure 00000075
Figure 00000076
Figure 00000077
Figure 00000078
Figure 00000079
Figure 00000080
Figure 00000081
Figure 00000082
Figure 00000083
Figure 00000084
Figure 00000085
Figure 00000086
Figure 00000087
Figure 00000088
Figure 00000089
Figure 00000090
Figure 00000091
Figure 00000092
Figure 00000093
Figure 00000094
Figure 00000095
Figure 00000096
Figure 00000097
Figure 00000098
Figure 00000099
Figure 00000100
Figure 00000101
Figure 00000102
Figure 00000103
Figure 00000104
Figure 00000105
Figure 00000106
Figure 00000107
Figure 00000108
Figure 00000109
Figure 00000110
Figure 00000111
Figure 00000112
Figure 00000113
Figure 00000114
Figure 00000115
Figure 00000116
Figure 00000117
Figure 00000118
Figure 00000119
Figure 00000120
Figure 00000121
Figure 00000122
Figure 00000123

Claims (9)

1. Соединения формулы (I)
Figure 00000124

где Q означает группу следующей структуры:
Figure 00000125

R1 означает водород, галоген, гидрокси, амино, меркапто, алкил, гетероалкил, алкилокси, гетероалкилокси, циклоалкил, гетероциклоалкил, алкилциклоалкил, гетероалкилциклоалкил, циклоалкилокси, алкилциклоалкилокси, гетероциклоалкилокси или гетероадкилциклоалкилокси,
X1, X2, X3, X4, X5 и X6 каждый независимо друг от друга означает атом азота или группу формулы CR2,
R2 означает водород, галоген или гидрокси, амино, алкильную, алкенильную, алкинильную или гетероалкильную группу,
R3 выбран из следующих групп:
Figure 00000126
Figure 00000127
Figure 00000128
Figure 00000129

R5 означает группу формулы -B-Y, где В означает алкилен, алкенилен, алкинилен, -NH- или гетероалкилен, a Y означает арил, гетероарил, аралкил, гетероаралкил, циклоалкил, гетероциклоалкил, алкилциклоалкил или гетероалкилциклоалкил,
или их фармацевтически приемлемая соль, сольват, гидрат или фармацевтически приемлемая композиция.1. The compounds of formula (I)
Figure 00000124

where Q means a group of the following structure:
Figure 00000125

R 1 means hydrogen, halogen, hydroxy, amino, mercapto, alkyl, heteroalkyl, alkyloxy, heteroalkyloxy, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, cycloalkyloxy, alkylcycloalkyloxy, heterocycloalkyloxy or heteroalkylcycloalkyl
X 1 , X 2 , X 3 , X 4 , X 5 and X 6 each independently of one another means a nitrogen atom or a group of the formula CR 2 ,
R 2 means hydrogen, halogen or hydroxy, amino, alkyl, alkenyl, alkynyl or heteroalkyl group,
R 3 is selected from the following groups:
Figure 00000126
Figure 00000127
Figure 00000128
Figure 00000129

R 5 means a group of formula —BY, where B is alkylene, alkenylene, alkynylene, —NH— or heteroalkylene, and Y is aryl, heteroaryl, aralkyl, heteroaralkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl or heteroalkylcycloalkyl,
or a pharmaceutically acceptable salt, solvate, hydrate or pharmaceutically acceptable composition thereof. 2. Соединения по п.1, где Q выбран из следующих групп:
Figure 00000130
Figure 00000131
Figure 00000132

Figure 00000133
Figure 00000134
2. The compound according to claim 1, where Q is selected from the following groups:
Figure 00000130
Figure 00000131
Figure 00000132

Figure 00000133
Figure 00000134
 3. Соединения по п.1, где R1 означает метоксигруппу.3. The compound according to claim 1, where R 1 means a methoxy group. 4. Соединения по п.1, где R2 означает водород или галоген.4. The compounds according to claim 1, where R 2 means hydrogen or halogen. 5. Соединения по пп.1-4, где В означает группу формулы -CH2CH(ОН)-,
-CH2NHCH2-, -NHCH2CH2-, -NH-, -CH2NHCH2CH2-, -СН2СО- или -NHCH2-.5. The compounds of claims 1 to 4, where B is a group of the formula —CH 2 CH (OH) -,
-CH 2 NHCH 2 -, -NHCH 2 CH 2 -, -NH-, -CH 2 NHCH 2 CH 2 -, -CH 2 CO- or -NHCH 2 -. 6. Соединения по пп.1-5, где Y означает одну из следующих структур:
Figure 00000135
Figure 00000136

Figure 00000137
Figure 00000138

Figure 00000139
или
Figure 00000140
или
Figure 00000141
или
Figure 00000142

Figure 00000143
или
Figure 00000144
или
Figure 00000145
или
Figure 00000146

Figure 00000147
или
Figure 00000148
или
Figure 00000149
или
Figure 00000150

Figure 00000151
или
Figure 00000152
или
Figure 00000153

где X7, X8 и X9 каждый независимо друг от друга означает атом азота или группу формулы CR21, X10 и X11 каждый независимо друг от друга означает атом кислорода или серы или группу формулы NR22, о равно 0, 1 или 2, R15, R16, R17, R18, R20 и R21 каждый независимо друг от друга означает водород, галоген, гидрокси, алкил, алкенил, алкинил или гетероалкил и R19 и R22 каждый независимо друг от друга означает водород, алкил, алкенил, алкинил или гетероалкил.6. Compounds according to claims 1-5, where Y means one of the following structures:
Figure 00000135
Figure 00000136

Figure 00000137
Figure 00000138

Figure 00000139
or
Figure 00000140
or
Figure 00000141
or
Figure 00000142

Figure 00000143
or
Figure 00000144
or
Figure 00000145
or
Figure 00000146

Figure 00000147
or
Figure 00000148
or
Figure 00000149
or
Figure 00000150

Figure 00000151
or
Figure 00000152
or
Figure 00000153

where X 7 , X 8 and X 9 each independently from each other means a nitrogen atom or a group of formula CR 21 , X 10 and X 11 each independently from each other means an oxygen or sulfur atom or a group of formula NR 22 , o is 0, 1 or 2, R 15 , R 16 , R 17 , R 18 , R 20 and R 21 each independently of each other means hydrogen, halogen, hydroxy, alkyl, alkenyl, alkynyl or heteroalkyl and R 19 and R 22 each independently of one another hydrogen, alkyl, alkenyl, alkynyl or heteroalkyl. 7. Соединения по пп.1-5, где Y означает одну из следующих структур:
Figure 00000154
или
Figure 00000155
или
Figure 00000156

Figure 00000157
или
Figure 00000158
или
Figure 00000159

Figure 00000139
или
Figure 00000144
или
Figure 00000160

Figure 00000143
или
Figure 00000161
или
Figure 00000162
7. Compounds according to claims 1-5, where Y means one of the following structures:
Figure 00000154
or
Figure 00000155
or
Figure 00000156

Figure 00000157
or
Figure 00000158
or
Figure 00000159

Figure 00000139
or
Figure 00000144
or
Figure 00000160

Figure 00000143
or
Figure 00000161
or
Figure 00000162
 8. Фармацевтические композиции, обладающие антибактериальной активностью, включающие соединение по любому из пп.1-7 и необязательно носители и/или адъюванты.8. Pharmaceutical compositions having antibacterial activity, comprising a compound according to any one of claims 1 to 7 and optionally carriers and / or adjuvants. 9. Применение соединения или фармацевтической композиции по пп.1-8 для приготовления лекарственного средства, предназначенного для лечения бактериальных инфекций. 9. The use of a compound or pharmaceutical composition according to claims 1-8 for the preparation of a medicinal product intended for the treatment of bacterial infections.
RU2007105995/04A 2004-08-25 2005-08-25 Novel compounds possessing antibacterial activity RU2410386C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004041163.8 2004-08-25
DE102004041163A DE102004041163A1 (en) 2004-08-25 2004-08-25 New compounds with antibacterial activity

Publications (2)

Publication Number Publication Date
RU2007105995A RU2007105995A (en) 2008-10-10
RU2410386C2 true RU2410386C2 (en) 2011-01-27

Family

ID=35431960

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007105995/04A RU2410386C2 (en) 2004-08-25 2005-08-25 Novel compounds possessing antibacterial activity

Country Status (14)

Country Link
US (1) US20070244103A1 (en)
EP (1) EP1781650A1 (en)
JP (1) JP2008510762A (en)
KR (1) KR20070045152A (en)
CN (1) CN101035785A (en)
AU (1) AU2005276576A1 (en)
BR (1) BRPI0514665A2 (en)
CA (1) CA2571132A1 (en)
DE (1) DE102004041163A1 (en)
IL (1) IL179837A0 (en)
MX (1) MX2007002097A (en)
NZ (1) NZ552036A (en)
RU (1) RU2410386C2 (en)
WO (1) WO2006021448A1 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1796466A4 (en) 2004-06-15 2009-09-02 Glaxo Group Ltd Antibacterial agents
JP4887297B2 (en) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド New bicyclic antibiotics
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
KR20080064953A (en) * 2005-10-13 2008-07-10 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 Antibacterial active 5-quinoline derivative
EP1790342A1 (en) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazine derivatives and their use as signal transduction modulators
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
UY30183A1 (en) 2006-03-02 2007-10-31 Astrazeneca Ab QUINOLINE DERIVATIVES
WO2007115947A1 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
GB0608263D0 (en) * 2006-04-26 2006-06-07 Glaxo Group Ltd Compounds
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
TW200819457A (en) 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
CL2007003693A1 (en) 2006-12-22 2008-06-27 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM PIRIDO [3,2-B] [1,4] THIAZINE; PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPOUNDS; AND ITS USE IN THE TREATMENT OF BACTERIAL INFECTIONS.
CL2008001003A1 (en) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION.
AU2008240764C1 (en) * 2007-04-20 2011-10-20 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
EP2182950B8 (en) * 2007-05-17 2017-08-23 Helperby Therapeutics Limited Use of 4-(pyrrolidin-1-yl)quinoline compounds to kill clinically latent microorganisms
ATE520687T1 (en) * 2007-06-15 2011-09-15 Actelion Pharmaceuticals Ltd 3-AMINO-6-(1-AMINO-ETHYL)-TETRAHYDROPYRANDERIVA E
EP2245028B1 (en) 2007-12-18 2012-02-22 Actelion Pharmaceuticals Ltd. 5-aminocyclylmethyl-oxazolidin-2-one derivatives
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
BRPI0906598A2 (en) 2008-02-01 2015-07-07 Takeda Pharmaceutical Oxim derivatives as hsp90 inhibitors
MX2010008922A (en) 2008-02-20 2010-09-07 Actelion Pharmaceuticals Ltd Azatricyclic antibiotic compounds.
TW200944529A (en) 2008-04-15 2009-11-01 Actelion Pharmaceuticals Ltd Tricyclic antibiotics
BRPI0920895A8 (en) 2008-10-07 2017-12-26 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS
WO2010043714A1 (en) 2008-10-17 2010-04-22 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
EP2379554B1 (en) 2009-01-15 2015-11-11 Glaxo Group Limited Naphthyridin-2(1h)-one compounds useful as antibacterials
CN102361863B (en) * 2009-01-21 2014-12-03 巴斯利尔药物股份公司 Novel bicyclic antibiotics
EP2332939A1 (en) 2009-11-26 2011-06-15 Æterna Zentaris GmbH Novel Naphthyridine derivatives and the use thereof as kinase inhibitors
JP5697685B2 (en) 2009-12-18 2015-04-08 バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ Tricyclic antibiotics
ES2596369T3 (en) 2011-06-17 2017-01-09 Basilea Pharmaceutica Ag N-heterotricyclic antibiotics
JP2014533747A (en) 2011-11-30 2014-12-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 3,7-Disubstituted octahydro-2H-pyrido [4,3-e] [1,3] oxazin-2-one antibiotic
AR090844A1 (en) * 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd PROCESS TO MANUFACTURE DERIVATIVES OF NAFTIRIDINE
CN104803913B (en) * 2014-01-24 2019-02-12 浙江省化工研究院有限公司 A kind of carbonic acid benzylquinolin base ester type compound, preparation method and application
EA031589B1 (en) 2014-08-22 2019-01-31 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
MA41168A (en) 2014-12-17 2017-10-24 Acraf NEW ANTIBACTERIAL COMPOUNDS
MA41169A (en) 2014-12-17 2017-10-24 Acraf WIDE-SPECTRUM ANTIBACTERIAL COMPOUNDS
UY36851A (en) * 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS
HUE049547T2 (en) 2016-06-08 2020-10-28 Acraf New antibacterial compounds
CN109311897B (en) 2017-03-20 2021-07-20 福马治疗股份有限公司 Pyrrolopyrrole compositions as Pyruvate Kinase (PKR) activators
US20230055923A1 (en) 2018-09-19 2023-02-23 Forma Therapeutics, Inc. Activating pyruvate kinase r
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
MX2023000056A (en) 2020-07-02 2023-04-12 Incyte Corp Tricyclic urea compounds as jak2 v617f inhibitors.
WO2022006456A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic pyridone compounds as jak2 v617f inhibitors
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
TW202302589A (en) 2021-02-25 2023-01-16 美商英塞特公司 Spirocyclic lactams as jak2 v617f inhibitors
CA3237199A1 (en) 2021-11-02 2023-05-11 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
EP2181996A1 (en) * 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidine derivatives
AR040335A1 (en) * 2002-06-26 2005-03-30 Glaxo Group Ltd CYCLLOHEXAN OR CYCLHEXENE COMPOUND, USE OF THE SAME TO PREPARE A MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, PROCEDURE AND INTERMEDIATE COMPOUNDS OF UTILITY TO PREPARE SUCH COMPOUND
CA2500320A1 (en) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Novel compounds with antibacterial activity
DE10256405A1 (en) * 2002-12-02 2004-06-17 Morphochem Aktiengesellschaft für kombinatorische Chemie New 4-substituted quinoline derivatives, useful for treating bacterial infections, optionally including additional ring nitrogens
DE10247233A1 (en) * 2002-10-10 2004-06-17 Morphochem AG Aktiengesellschaft für kombinatorische Chemie New 4-substituted quinoline derivatives, useful for treating bacterial infections, optionally including additional ring nitrogens
AR042486A1 (en) * 2002-12-18 2005-06-22 Glaxo Group Ltd QUINOLINE AND NAFTIRIDINE COMPOSITE HALOSUSTITUDED IN POSITION 3, PROCEDURE TO PREPARE THE COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE SUCH COMPOSITION.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TERENT'EW; GURWITSCH. SB.STATEI OBSHCH.KHIM, 1953, p.404-407 PROFFT; BIEDERMANN. J.PRAKT. CHEM, vol.15, 1962, p 54-61. *

Also Published As

Publication number Publication date
NZ552036A (en) 2010-08-27
MX2007002097A (en) 2007-04-24
US20070244103A1 (en) 2007-10-18
DE102004041163A1 (en) 2006-03-02
BRPI0514665A2 (en) 2009-03-24
CA2571132A1 (en) 2006-03-02
KR20070045152A (en) 2007-05-02
JP2008510762A (en) 2008-04-10
AU2005276576A1 (en) 2006-03-02
CN101035785A (en) 2007-09-12
RU2007105995A (en) 2008-10-10
WO2006021448A1 (en) 2006-03-02
IL179837A0 (en) 2007-05-15
EP1781650A1 (en) 2007-05-09

Similar Documents

Publication Publication Date Title
RU2410386C2 (en) Novel compounds possessing antibacterial activity
RU2403258C2 (en) Thiazolyldihydroindazoles
RU2327701C2 (en) Nucleoside derivatives and pharmaceutical composition, with antiviral activity to hcv
HUP0401889A2 (en) 1,8-naphthyridine derivatives as antidiabetics and pharmaceutical compositions containing them
MXPA06011194A (en) Thiadiazolidinones as gsk-3 inhibitors.
BRPI0509377A (en) alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1 receptor antagonists
EA200600225A1 (en) DERIVATIVES OF PIPERAZINE FOR THE TREATMENT OF HIV INFECTIONS
EP1609798A4 (en) Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof
CY1107422T1 (en) FURAZANOBENZIMIDAZOLES
CA2634005A1 (en) N-hydroxyamide derivatives possessing antibacterial activity
MY145031A (en) N-(aminoheteroaryl)-1h-indole-2carboxamide derivatives, and preparation and therapeutic application thereof
JP2007246474A5 (en)
HUP0500457A2 (en) Polyalkylene polymer compounds, compositions containing the same and uses thereof
SE0302192D0 (en) Novel compounds
TW200621694A (en) Substituted n-sulfonylaminobenzyl-2-phenoxyacetamide compounds
RU2019122815A (en) HISTONACETYLASE INHIBITORS
CA2441309A1 (en) Biguanide derivatives
JP2000026494A5 (en)
WO2006021833A3 (en) Bisbenzamidines for the treatment of pneumonia
MA28325A1 (en) NOVEL PHENYLPYRIDINYLPIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO323556B1 (en) Compounds, pharmaceutical compositions comprising the compounds, and the use of the compounds in the preparation of antibacterial drugs.
RU2004130284A (en) ANTI-PARASITIC ARTEMISININ DERIVATIVES (ENDOPEROXIDES)
IL169577A0 (en) Oligosaccharide derivatives and pharmaceutical compostions containing the same
PT1175429E (en) HALO 9-DEOXO-9A-AZA-9A-HOMOERITHROMYCIN A HALO DERIVATIVES
RU2002118708A (en) HETEROCYCLIC DERIVATIVES AND MEDICINES

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20110826