JP2007246474A5 - - Google Patents

Claims (2)

The following general formula (I)

[In the formula, A is the following formula.

{Where
R ¹ and R ² are the same or different and each represents a hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, a halogen atom, a haloalkyl group, an alkyloxy group, a haloalkyloxy group, a cyano group, or a nitro group;
R ³ and R ⁴ are the same or different and represent a hydrogen atom or an alkyl group, or R ³ and R ⁴ are bonded to each other to form a cycloalkyl group;
R ⁵ represents a hydrogen atom or an alkyl group;
R ⁶ represents a hydrogen atom or an alkyl group;
R ⁷ represents an alkyl group, a haloalkyl group or an aryl group;
Q represents an oxygen atom or a sulfur atom. Of the above groups, the alkyl group and the aryl group each may have a substituent. }
n is an integer from 1 to 5;
Y is an oxygen atom, a sulfur atom, —NR ⁸ —, —CONR ⁸ —, —NR ⁸ CO— or NHCONR ⁸ — (wherein R ⁸ is a hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, a cycloalkylalkyl. A group, an arylalkyl group, an arylalkenyl group, an aryloxyalkyl group or a heteroarylalkyl group);
Z represents an aryl group, heteroaryl group, arylalkyl group, heteroarylalkyl group or cycloalkyl group.
Of the above groups, the alkyl group, aryl group, heteroaryl group, cycloalkylalkyl group, arylalkyl group, arylalkenyl group, aryloxyalkyl group or heteroarylalkyl group may each have a substituent. Good. Or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. A prophylactic and / or therapeutic drug for hyperlipidemia comprising the benzene derivative according to claim 1 or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof as an active ingredient.