RU2382638C1 - Method of treating psoriasis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: for treatment of patients suffering from psoriasis in first 3 weeks of hospital treatment sodium chloride solution 0.9% 400 ml is introduced intravenously every second day No 3-5, sodium thiosulfate 30% 10 ml intravenously daily No 20, pyridoxine 5% 2 ml intramuscularly every second day No 10, thiamin 6% 2 ml intramuscularly every second day No 10, cyanocobalamin 500 mcg intramuscularly every second day No 10. Simultaneously on affected region protective-prophylactic preparation "Kartalin" is applied. In following 2-3 weeks of out-patient treatment patients continue applying on affected region in thin layer slightly rubbing in protective-prophylactic preparation "Kartalin" 2 times a day without further covering with film and occlusive bandage.

EFFECT: method allows to increase efficiency of psoriasis treatment essentially due to complex, optimally selected in time impact on said disease pathogenesis.

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Description

The invention relates to medicine, specifically to dermatology and is intended for the treatment of psoriasis of mild to moderate severity (PASI index up to 50 points).

The treatment of psoriasis is the most time-consuming process for the doctor and expensive for the patient (Kubanova A.A., Tikhonova L.I., 2004). The high cost of a course of treatment is due to the volume and duration of therapy (Amozov M.L., Gorbovaya T.V., Filipova N.M., 2007).

A known method of treating psoriasis (RF Patent No. 2077319). The essence of the method consists in the oral administration of drugs (biologically active substances) and application to the lesion site, against the background of a diet and normalization of the regime of work and rest, the first therapeutic ointment containing fresh egg white, bee honey, cream for children, solid oil. Then, after the disappearance of the plaques, a second therapeutic ointment is applied containing fresh egg white, baby cream, celandine grass powder. Moreover, as a biologically active substance, tincture of the temptation, or Eleutherococcus, or the golden root, or Leuzea, or Manchurian aralia is introduced in the amount of 30-40 drops 3 times a day 30 minutes before meals starting from the 11th day of the start of the treatment and at the same time the first treatment is applied ointment in which technical solidol is used, and it additionally contains ampoule vitamin E, cedar oil, medical tar in the following proportions, wt.%:

Fresh egg white - 4.0-7.0

Bee honey - 2.5-3.0

Cream for children - 1.5-2.0

Amplified Vitamin E - 0.09-0.11

Cedar Oil - 3.0-4.0

Tar tar - 1.0-5.0

Solid oil technical - rest

Then a second therapeutic ointment is applied, in which bee honey is also used, medical tar in the following proportions, wt.%:

Fresh egg white - 4.0-7.0

Cream for children - 2.0-3.0

Celandine grass powder - 0.5-1.5

Bee honey - 1.5-3.0

Tar tar - 0.3-0.8

Solid oil technical - rest

The disadvantages of this method are:

- Lack of an objective assessment of positive clinical and morphological changes in the skin in patients with psoriasis using the PASI (Psoriasis Area and Severity Index) and DICI (dermatological index of quality of life).

- Lack of data on the use in combination with other means in a hospital setting.

- Longer course treatment (9-12 weeks compared with 5-6 weeks with the proposed method).

- Lower clinical efficacy (a decrease in the PASI index in the group treated with the proposed method by 65% compared with the control group treated with the prototype method, where the PASI index decreased by 44%).

The task to which the invention is directed is to increase efficiency and reduce treatment time.

The problem is solved by using the proposed method for the treatment of psoriasis. The essence of the method lies in the fact that patients are prescribed medications and a protective and prophylactic agent (therapeutic ointment) is applied to the lesion. The novelty of the proposed method lies in the fact that in the first 3 weeks of inpatient treatment, a complex of drugs is administered, which includes a solution of sodium chloride 0.9% 400 ml intravenously every other day No. 3-5, sodium thiosulfate 30% 10 ml intravenously daily No. 20, pyridoxine 5% 2 ml intramuscularly every other day No. 10, thiamine 6% 2 ml intramuscularly every other day No. 10, cyanocobalamin 500 mcg intramuscularly every other day No. 10, at the same time, the protective agent “Kartalin” is applied to the lesion area in the next 2-3 weeks outpatient treatment for pa ienty continue to apply a protective and preventive agent "Kartalin" to the area of lesions, wherein the protective and preventive agent "Kartalin" are thin, lightly rubbing without covering film and occlusive bandage, 2 times a day.

To study the clinical effectiveness of the present invention, 80 patients with a diagnosis of psoriasis were examined and treated in a skin disease clinic of GOU VPO Roszdrav SibGMU. For all patients under observation, based on the clinical and morphological picture, the initial numbers of the PASI index were determined. In the study groups, a set of patients with psoriasis of mild to moderate severity of the disease was performed (PASI index up to 50 points). After completing the course of treatment, the proposed method recalculated the PASI index and, based on the data obtained, evaluated the effectiveness of the therapy. To assess the degree of negative impact of skin disease on various aspects of the patient’s life, characterized in general by its quality, a study was conducted at the beginning and at the end of the course of therapy of the dermatological index of life quality (DIC).

The first study group A (n = 40) received drug treatment according to the claimed method for 3 weeks in a hospital setting and topical treatment in the form of twice daily application of Kartalin protective and prophylactic agent to psoriatic papules (RF Patent No. 2124359) for 5- 6 weeks. “Kartalin” contains fresh egg white, bee honey, children's cream, solid oil and grass powder of a tripartite series.

The second group B (n = 40) received complex therapy according to the prototype method for 9-12 weeks.

Long-term results of the effectiveness of the therapy were evaluated after 5-6 months.

The studied groups were representative by age, gender, and duration of psoriasis. Statistical processing of the obtained data was carried out using the package Biostatistica 4.03, 1998. Mathematical processing of the data was carried out using Student's criterion. Differences were considered significant at p <0.05.

Based on the study, the following results were obtained:

1. The proposed method for the treatment of psoriasis is more effective, because reduces the PASI index in group A by 65% compared with control group B, where the PASI index decreased by 44%.

2. When studying long-term results (after 5-6 months) of the effectiveness of the therapy in both groups, the following results were obtained: in group A, the PASI index was 7.9 points (a decrease of 40.8%), in group B its value was 10 , 4 (decrease by 25.6%).

3. The claimed method of treatment makes the psycho-emotional state of patients with psoriasis more comfortable (a decrease in the DIC index by 40.8% in group A compared with 19% in group B).

For the first time, a method for the treatment of psoriasis has been proposed, which consists in the complex prescription of drugs and the application of a therapeutic ointment to the lesion site, which uses the protective and prophylactic agent "Kartalin". The authors clinically selected the optimal treatment time for psoriasis inpatiently and then on an outpatient basis. In addition, medicines were selected, their duration of administration and dose, as well as optimal conditions for applying the protective and prophylactic agent “Kartalin” were selected.

Studies on patent and scientific and technical sources of information showed that the proposed method is unknown and meets the criteria of "novelty" and "inventive step".

The invention is illustrated by the following examples of specific performance.

Example 1

Patient M., 28 years old (medical history No. 3828), was admitted to the clinic of skin diseases of Siberian State Medical University with a diagnosis of mild psoriasis (PASI index at admission = 21 points).

During treatment, complex therapy was used according to the proposed method: sodium chloride solution 0.9% 400 ml intravenously every other day No. 3, sodium thiosulfate 30% 10 ml intravenously every day No. 20, pyridoxine 5% 2 ml intramuscularly every other day No. 10, thiamine 6% 2 ml intramuscularly every other day No. 10, cyanocobalamin 500 μg intramuscularly every other day No. 10 and local treatment in the form of daily twice application of the protective and prophylactic drug “Kartalin” on psoriatic papules for 3 weeks in a hospital and then for 2 weeks as an outpatient patient Anosil only protective and prophylactic agent "Kartalin".

After treatment, the PASI index was 8 points. Therefore, after the treatment, the index decreased by 67%.

Example 2

Patient J., 30 years old (medical history No. 2163), was admitted to the clinic of skin diseases of Siberian State Medical University with a diagnosis of moderate psoriasis (PASI upon admission = 46 points).

During treatment, complex therapy was used according to the proposed method: sodium chloride solution 0.9% 400 ml intravenously every other day No. 5, sodium thiosulfate 30% 10 ml intravenously every day No. 20, pyridoxine 5% 2 ml intramuscularly every other day No. 10, thiamine 6% 2 ml intramuscularly every other day No. 10, cyanocobalamin 500 μg intramuscularly every other day No. 10 and local treatment in the form of a daily double application of the protective and prophylactic drug “Kartalin” on psoriatic papules for 3 weeks in a hospital and then for 3 weeks as an outpatient patient Anosil only protective and prophylactic agent "Kartalin".

After treatment, the PASI index was 13.4 points. Therefore, after treatment, the index decreased by 71%.

Thus, the proposed method for the treatment of psoriasis is more effective and less durable.

Claims (1)

A method of treating psoriasis, namely, that patients are prescribed drugs and a protective and prophylactic agent is applied to the lesion, characterized in that in the first 3 weeks of inpatient treatment, a complex of drugs is introduced, which includes 0.9% sodium chloride solution 400 ml intravenously every other day No. 3-5, sodium thiosulfate 30% 10 ml intravenously daily No. 20, pyridoxine 5% 2 ml intramuscularly every other day No. 10, thiamine 6% 2 ml intramuscularly every other day No. 10, cyanocobalamin 500 mcg intramuscularly every other day No. 1 0, at the same time, the Kartalin protective and prophylactic agent is applied to the lesion area, in the next 2-3 weeks of outpatient treatment, patients continue to apply the Kartalin protective and preventive agent to the lesion area, and the Kartalin protective and preventive agent is applied in a thin layer rubbing, not covering with a film and an occlusive dressing, 2 times a day.