RU2377024C1 - Method for rehabilitation of women suffering from postovariectomic syndrome - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns medicine, oncogynaecology. The method involves blood sampling, mixing thereof with oxygen-ozone gas mixture and the following reinfusion thereof. One session involves sampling of 70-120 ml of blood thereafter mixed with 200-250 ml of oxygen-ozone mixture of ozone concentration 5-10 mg/l. Blood reinfusion is followed with introduction of preparation Cernevit in amount 5 ml. Therapeutic course is 10-14 sessions.

EFFECT: method improves clinical effectiveness ensured by stimulation of antioxidant system, normalisation of metabolic processes, hormone-vegetative and immune status of an organism.

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Description

The invention relates to medicine, in particular, can be used for the rehabilitation of women with postovariectomy syndrome after radical treatment of malignant tumors of the reproductive organs.

There is a method of treating women with malignant tumors of the reproductive system, including women who have undergone cancer treatment, using hormone replacement therapy (HRT) [1]. The disadvantage of this method of treatment is the occurrence of complications in the form of a possible relapse of the malignant process, as well as in HRT there is no qualitative stimulation of metabolic processes, there is no immunomodulating effect.

Closest to the proposed invention is a method for the rehabilitation of women with malignant tumors of the organs of the reproductive system and post-varioectomy syndrome after radical cancer treatment [2], which consists in the fact that periodically during the course of six procedures (sessions) blood samples are taken from the patient every other day, mixed blood with an oxygen-ozone gas mixture and returned to the body according to the known method of ozone therapy [3].

The disadvantages of this method is the low effectiveness of the treatment, due to the fact that during the six sessions of ozone therapy, the treatment effect persists for a short time (2-3 months), and the oxygen metabolism of energy substrates and metabolic processes does not change qualitatively, there is no significant regression of the neuro-vegetative symptom complex.

The present invention is aimed at improving the effectiveness of treatment. The indicated therapeutic effect is achieved by the fact that in the method of rehabilitation of women with postovariectomy syndrome after radical treatment of cancer of the reproductive organs according to the invention, the course of treatment is carried out for 10-14 sessions. Blood sampling from the patient is carried out in a volume of 70-120 ml in one session, and the concentration of ozone in the oxygen-ozone gas mixture is selected from the interval of 5-10 mg / L. In addition, after the return of ozonated blood, the drug “Zernevit” is introduced into the body.

The appointment of a course of treatment (rehabilitation) of 10-14 procedures makes it possible to increase the effectiveness of treatment (increase the time to save the therapeutic effect) due to the fact that there is better stimulation of the antioxidant system of the body and, accordingly, immunity. Such a number of procedures (10-14) leads to a change in the metabolism of oxygen and energy substrates, which positively affects metabolic processes and the restoration of tissue trophism. At the same time, a decrease in the number of procedures below 10 leads to a noticeable decrease in the therapeutic effect, and when the number of procedures exceeds 14, the growth of the therapeutic effect is not observed.

The amount of blood taken from a sick patient in a volume of 70-120 ml per session does not lead to hemodynamic disturbances. When the volume of blood taken is less than 70 ml per session, the formation of ozonides is not sufficient and the therapeutic effect is significantly reduced, and when the volume of blood is more than 120 ml, there is a sharp surge in lipid peroxidation and a sharp inhibition of the antioxidant system of the body.

The choice of the concentration of ozone in the oxygen-ozone gas mixture from the interval of 5-10 mg / l provides a slight activation of lipid peroxidation and stimulation of the antioxidant system of the body. At a concentration of the mixture less than 5 mg / l, adequate stimulation of metabolic processes does not occur, and at a concentration greater than 10 mg / l, the treatment efficiency does not significantly increase, but the ozone-oxygen mixture can adversely affect red blood cells.

The introduction after the return of ozonated blood to the body of the drug “Zernevit” provides an increase in the effectiveness of treatment due to the fact that the antioxidant system is stimulated, the orientation of metabolic processes, hormonal-vegetative and immune status of the body are determined. The totality of these changes is metabolic adaptation, which is the basis of a stereotypically developing therapeutic effect. In addition, the simultaneous administration of a complex of vitamins in the form of the drug “Zernevit” leads to a significant reduction in the number of injections, lower economic costs, labor and the number of post-injection complications.

The proposed method is as follows. In each procedure, a blood sampling of the patient in the amount of 70-120 ml from the cubital vein through a transfusion device into a container with an anticoagulant (heparin 5000 units) is performed. Then 200-250 ml of an ozone-oxygen gas mixture with a concentration of ozone in it of 5-10 mg / l is introduced there. Further, the blood is reinfused to the patient without pressure, intravenously drip. The course of treatment is carried out in 10-14 sessions. The procedures are carried out in 1-2 days depending on the control of lipid peroxidation.

In each procedure, after administration of ozonated blood to the patient, the drug “Zernevit” in the amount of 1 bottle (5 ml) can be introduced into his body. For this, 5 ml of a 5% dextrose solution or 0.9% sodium chloride solution is injected into a vial with a lyophilisate (“Zernevit”), then the resulting solution is diluted in 250-500 ml of a 5% dextrose solution or 0.9% sodium chloride solution and intravenously drip is administered to the patient.

Examples of the method

Example 1

Patient V., 51 years old. Diagnosis: Cancer of the uterus 1 tbsp. The condition after radical surgery (2007) is post-varioectomy syndrome (neurovegetative symptom complex of moderate severity). After 12 sessions of ozone therapy, hot flashes from 25 per day decreased to episodes, sweating from 25 times a day to 1-2 times a day, intolerance to loud sounds disappeared. The urogenital syndrome, hyperemia of the vaginal mucosa has survived. This is due to the absence in the treatment regimen of "Cervneitis." The effect of the treatment lasted for 4 months.

Example 2

Patient K., 39 years old. Diagnosis: Cervical cancer 1 V Art. The condition after extended hysterectomy with appendages according to Wertheim-Gubarev (2006) is postovariectomy syndrome, mild urogenital atrophy. After 14 sessions of ozone therapy using Zernevit, hot flushes and sweating from 30 times a day decreased to 3-5 times a day, episodes of shortage of air, heart palpitations disappeared. The effect of the treatment lasted for 6 months.

Example 3

Patient R., 47 years old. Diagnosis: Cancer of the cervix 1 in Art. The condition after combined radiation therapy (2006) is a post-varioectomy syndrome (neurovegetative symptom complex of moderate severity, moderate urogenital atrophy). After 10 sessions of ozone therapy with Zernevit, hot flashes, increased sweating from 20-22 times a day decreased to 3-5 times a day, headache stopped, itching and burning in the vagina disappeared. The effect of the treatment lasted for 5 months.

Example 4

Patient M., 42 years old. Diagnosis: Breast cancer 1 tbsp. The condition after a 2-sided ovariectomy (2007) is a post-varioectomy syndrome (a neurovegetative symptom complex of weak severity, urogenital atrophy of a weak severity). After 14 sessions of ozone therapy with the use of “Zernevit”, hot flashes, excessive sweating, chills, palpitations stopped, the urethral syndrome disappeared. The effect of the treatment lasted for 6 months.

Information sources

1. Estimator V.P., Novikova O.V. The history of the use of hormone replacement therapy in women with a history of malignant tumors of the reproductive system. - Menopause, 2001, No. 4, p.3.

2. Prokopyeva T.A., Napolsky V.M., Glukhova L.S. et al. Experience in the use of ozone therapy in a rehabilitation program for the management of cancer patients with post-varioectomy syndrome. - Thes. doc. conf. “Efferent, immunocorrective and intensive therapy in clinical practice”, Izhevsk, 2004, p.108.

3. The technique of ozone therapy. Methodical recommendations of the Ministry of Health of the RSFSR, 1991

Claims (1)

A method of rehabilitation of women with post-varioectomy syndrome after radical treatment of cancer of the reproductive organs, including blood sampling, mixing it with an oxygen-ozone gas mixture and subsequent blood reinfusion, characterized in that 70-120 ml of blood is sampled in one session, which is mixed with 200- 250 ml of an ozone-oxygen mixture with an ozone concentration of 5-10 mg / l, and after blood reinfusion, 5 ml of the “Zernevit” preparation is administered, for a course of treatment of 10-14 sessions.