RU2368383C1 - "prometey" dietic food product having rehabilitation action on patients who suffered acute cerebrovascular diseases and traumatic injuries of central nervous system long ago - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine and namely to dietology, neurology, neurorehabilitology as well as to food industry. Food products are prepared from muscular and other tissues obtained during butchering of cattle (pigs) by which acute stroke has been pre-caused. Those products have not only nutritional value but also neurorehabilitation action on the organism of the patients who suffered acute ischemic or apoplectic blood-stroke (primary or repeated), and hypoxic or traumatic brain damages. The product is recommended to be used once a day in quantity of approximately 0.5 gram per 1 kg of the mass. The course lasts 2 weeks to 1.5 months.

EFFECT: product use speeds up recovery of central nervous system functions at the above pathology.

1 tbl, 2 ex, 4 cl

Description

Field of technology: medicine, dietetics, neurology, neurorehabilitation, food industry.

The use of diet in many areas of medicine gives tangible results in the comprehensive treatment and rehabilitation of patients. The use of chemically modified products for this purpose is one of the most significant achievements in the field of dietetics of the last decade, however, this approach does not allow to accelerate the processes of post-stroke and post-traumatic neurorehabilitation.

Currently, there are known drugs for drug therapy used to accelerate the course of neurorehabilitation processes after cerebrovascular diseases (CEH): growth hormone (STH), insulin with preparations of the thymus gland (thymus), cerebrolysin, etc. In particular, the drug is used for this purpose cerebrolysin (Ebewe Austria) obtained by enzymatic hydrolysis from the brain of intact female pigs. Cerebrolysin is administered by parenteral administration of 10-20 ml daily for 1-1.5 months, intravenously in a dose of 0.1-0.2 ml / kg body weight (Vidal Handbook, 2004. Medications in Russia. - Edition 10 - B. 930-931; Windish M. Cerebrolysin - the latest results confirming the versatile effect of the drug // in the book: Third International Symposium on Cerebrolysin. M. - 1991. - P.81-106). However, this approach has several disadvantages, given the length of the recovery period in patients and the need for a continuous course of rehabilitation treatment. Such therapy is not physiological enough, as it requires intravenous infusion. At the same time, it was found that it is impossible to solve the problem of increasing the effectiveness of neurorehabilitation treatment of the body after acute acute respiratory failure and traumatic injuries of the central nervous system by changing the dose of the drug Cerebrolysin. Reducing the administered dose of the drug sharply reduces its therapeutic effectiveness, that is, makes the use of this substance ineffective, and increasing the dose leads to a sharp increase in the cost of treatment with constant efficacy above the dose. In addition, an increase in the dose of the drug may be accompanied by a neurotoxic effect as a result of the direct effect of free excitatory neuroamino acids (HLR and ASP) on the neurons of a number of brain formations.

Currently, a number of food products are used to accelerate the neurorehabilitation processes in patients. The closest to the proposed product are modified foods made from animal muscle tissue, pre-saturated with certain micro and macro elements, such as selenium, zinc and other substances (Balym Yu.P., Belyaev V.I. Effect of selenium preparations on cattle productivity and meat quality. All about meat. - 2007. - No. 2. - S.36-37).

The use of these foods designed to increase the nonspecific resistance of the body, the activity of metabolic processes, has been very effective in some functional disorders of the central nervous system. However, the use of these products in acute and chronic cerebrovascular diseases, neurodegenerative processes, and brain diseases in patients after a traumatic brain disease is ineffective. This is due to the fact that the use of such modified food products does not specifically affect the pathogenesis of these diseases, and therefore this approach is ineffective for solving practical issues of neurorehabilitation.

The aim of the present invention is the creation of specific dietary products to increase the effectiveness of neurorehabilitation treatment. The goal is achieved in that for the restorative and neurorehabilitation effect in patients after acute cerebrovascular diseases and traumatic injuries of the central nervous system, the food product Prometheus, obtained from the meat and brain of animals that reproduced acute stroke, is used. To create such a product, female pigs aged 11-13 months are used, whose weight is 90-120 kg. In animals, acute stroke is pre-modeled. Two months later, these animals are slaughtered. Meat is taken along with other organs. In particular, mechanical and thermal processing of meat for the preparation of a food product is carried out. The meat used, obtained from animal convalescents, fundamentally differs from the meat of intact animals by the features of the chemical composition.

The amount of the used Prometheus food product used in the form of a paste containing 50.0 g of meat per 100 g of the finished food product ¹ ( ¹ except fatty pork, the paste also contains liver up to 22 g, brain - 25 g, flour - 2 , 97 g, other additives - 0.03 g), in total is 40 g of the product, that is, 0.5 g / kg body weight of an adult patient for 2-6 weeks. This product for dietary nutrition "Prometheus" is used once a day alone or in conjunction with other food products.

Thus, the task is achieved by the fact that the Prometheus dietetic food product used for neurorehabilitation treatment of patients after CEH and traumatic brain injuries is obtained from meat, as well as other pig tissues and organs containing a complex of amino acids, peptides and proteins, the ratio which determines the specificity of its action. The complex includes substances that determine the therapeutic and neurostimulating properties of the claimed product for dietetic nutrition. Its amino acid composition is represented by 17 amino acids, among which the following dominate: GLU, ALA, LYS, SER and LEU. Table 1 shows the amino acid composition of the food product "Prometheus" (after preliminary hydrolytic digestion), a control sample and the well-known drug "Cerebrolysin".

The use of the proposed food product provides the body with therapeutic factors that accelerate the body's rehabilitation processes after a stroke and brain injury, and the use case used (orally, at the rate of about 0.5 g per 1 kg of body weight, once a day, together with others food products for a period of 2 weeks to 1.5 months) allows you to create optimal conditions in the body to accelerate the course of recovery processes, increase nonspecific resistance of the body and nnogo restoration of impaired functions of the central nervous system.

Table 1
The amino acid composition of the claimed food product "Prometheus", a control sample and "Cerebrolysin" (% mm). No. p / p Amino acids Food product "Prometheus" Meat control sample Cerebrolysin one Lysine 8.30-8.88 5.53-8.89 14.63 2 Histidine 2.29-2.70 2.41-1.11 1.45 3 Arginine 3.92-4.38 0.51-0.29 0.91 four Aspartic acid 7.12-7.02 19.26-17.00 8.94 5 Threonine 7.11-6.63 5.71-4.91 1,64 6 Serine 7.77-6.76 13.75-6.32 2.03 7 Glutamic acid 15.36-15.93 26.17-18.24 13.09 8 Proline 5.16-5.62 1.67-0.96 3.60 9 Glycine 6.32-4.86 0.88-2.01 8.81 10 Alanine 9.46-10.38 2.14-3.54 12.37 eleven Cysteine 3.25-3.53 4.56-4.90 0.00 12 Valine 6.54-6.09 5.30-5.53 7.51 13 Methionine 0.50-0.54 0.97-0.56 0.54 fourteen Isoleucine 1.42-1.31 1.04-6.0 5.70 fifteen Leucine 7.64-7.81 9.63-11.05 14.08 16 Tyrosine 3,59-3,37 0.36-1.55 0.43 17 Phenylalanine 3.96-4.20 0.13-7.18 4.25 eighteen Gamma Aminobutyric Acid / GABA / 0.00-0.00 0,00-0,000 0.00 Note. The food product Prometheus was prepared from pig meat, which reproduced acute stroke, as indicated in the text. A control image of meat was obtained in intact animals.

The fundamental difference between the proposed method for the accelerated restoration of impaired functions of the central nervous system, which developed during acute cerebrovascular and neurotraumatic diseases, from known types of treatment and diet therapy in the long-term period of cerebrovascular disease and neurotrauma, lies in the fact that the Prometey food product contains specific substances that are formed within two months before the slaughter of animals after modeling their acute stroke.

Using the proposed method for the accelerated restoration of impaired functions of the central nervous system that developed during acute cerebrovascular and neurotraumatic diseases provides (compared with existing treatment methods and dietary nutrition) the following advantage - this product is more physiological, it can be used with other food products in various combinations for a long time, it does not cause complications and side effects.

Example No. 1. Patient Leonid K., 69 years old. Disabled person of the first group. Before the development of the disease, he worked as a store director. Suffers from the effects of ischemic cerebral infarction. Partial carotid syndrome. He suffered a stroke about nine months ago. So far, left-side hemiparesis has been noted, in neurological status: left-sided spastic hemiparesis, muscle strength in the left arm 2 points, in the left leg - 3 points, sensitive ataxia is noted. Central paresis of the seventh pair of cranial nerves. Tongue deviation to the left, painful hyposthesia on the face. Tendon periosteal reflexes are elevated, S> D. Sensitive area: pain hyposthesia on the left. Coordination sphere: the finger-bearing and knee-calcaneal tests are performed with intention and mimicry. Pathological reflexes: to the left of Babinsky, Oppenheim, Chedok, Rossolimo, Ankylosing spondylitis. Symptoms of oral automatism are positive. Abdominal reflexes live D = S. In the Romberg position is unstable, shakiness without sideness. Astheno-depressive syndrome and hypochondria are noted.

The patient independently moves with the help of a cane, hesitancy in the gait is noted. Stride length approx. 20 cm.

After a two-week intake of the dietary product "Prometheus" once a day in a daily portion of 40-50 g, signs of astheno-depressive syndrome were reduced, and sleep was normalized. The patient began to walk without a cane, stride length increased by 15 cm, appetite and body weight increased, flexion-extensor movements in the left hand resumed. Muscle strength in the left hand - 3 points, in the left leg - 4 points. The manifestations of spasticity decreased, the signs of paresis of 7.12 pairs of cranial nerves decreased. The manifestations of dizziness and shakiness during walking decreased. The patient began to cook food on his own, which was not previously noted.

Example No. 2. Patient Nikolai V., 27 years old, worked as a driver before the disease. About 4.5 months ago, he was in a car accident. He received a severe head injury and concussion. He was treated in the Oryol Regional Clinical Hospital in the neurological department. After discharge from the hospital, I could not begin professional activity, neurosis of obsessive states, astheno-depressive syndrome and severe cephalgic syndrome developed. The latter was stopped by a systematic administration of analgesics. The patient became aggressive towards others and relatives, irritable, inadequately reacted to a loud sound, bright light, tearfulness appeared, sleep was sharply disturbed. The patient developed apathy, decreased appetite, the patient became asocial. The patient developed residual disorders of the central nervous system after suffering a traumatic brain injury, which manifested itself as a central paresis of 5, 7 and 12 pairs of cranial nerves. The phenomena of monoparesis in the right hand and sensitive ataxia differed.

After a three-week use of the proposed dietary food product "Prometheus" by patients, a marked decrease in cephalgic syndrome was noted, the structure and duration of night sleep was restored. The patient leveled out manifestations of a neurosis of obsessive states, interest in his own professional activity was restored. The patient returned to work. The manifestations of monoparesis of the right hand and lesions of 5 and 7 pairs of cranial nerves decreased. In his free time, the patient began to read a lot of fiction and historical literature. The patient became resocialized, began to communicate with family members, work employees, answer phone calls, participate in family TV shows, take an interest in the academic performance of his younger brothers and sisters at school, and work actively in a personal plot.

Claims (4)

1. A product to accelerate the restoration of the functions of the central nervous system and the body as a whole in the long-term period of acute cerebrovascular and traumatic injuries, characterized in that it is a food product from tissues and organs of animals-convalescents who successfully underwent a stroke, which was previously modeled. 2. The product according to claim 1, characterized in that it is a food product from meat and brain of pigs. 3. The product according to claim 1, characterized in that the amount of product used is 0.5 g per 1 kg of patient body weight per day for 2-6 weeks. 4. The product according to claim 1, characterized in that it is intended for use in conjunction with other food products.