RU2351350C1 - Set "predstar", its application and method of prevention of premature organism aging - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to chemical-pharmaceutical industry. Set of biologically active substances "Predstar" for prevention of premature aging of human organism includes capsules of food oil "Eiconol" and vitamin-mineral complex. Application of set for prevention of premature aging of human organism and method of prevention of premature aging of organism lying in using set 1-2 times a day, capsules of food oil "Eiconol" are taken in amount 6-8 g/day 0.5-1.0 hour after meal and capsules of vitamin-mineral complex are taken in amount 1 g/day during meal during 40-60 days with course 3 times a year. "Predstar" protects organism from heart diseases, arthritises and immune diseases.

EFFECT: can be used for prevention of premature aging of organism.

3 cl, 4 tbl

Description

The invention relates to the pharmaceutical industry and can be used to prevent premature aging of the body and its protection against heart diseases, arthritis and immune diseases. The invention can be used in enterprises producing medicines and biologically active food additives, in health facilities and as a food supplement for a population experiencing adverse factors of a hereditary and acquired nature of a predisposition to metabolic diseases.

All life processes in the body occur with the participation of enzymes. One of the most important enzymes that protect the body against aging is Δ6-desaturase. It is this enzyme that ensures the conversion of excess ω-6 fatty acids into gamma-linolenic acid (GLA) in the body, without which the production of prostaglandin E ₁ (PGE ₁ ), the most important eicosanoid responsible for protecting the body from premature aging, from heart disease, arthritis, is impossible , allergies, asthma, autoimmune and malignant diseases.

In a young healthy body, the enzyme Δ-6 desaturase is enough. However, depending on age, bad habits, diseases (for example, diabetes, hypothyroidism, viral infections and malignant diseases) or a deficiency in the body of vitamins and minerals, the amount of Δ-6 desaturase enzyme decreases.

There is a second important reason for the aging of the body associated with a deficiency of prostaglandin E ₃ eicosanoid (PGE ₃ ), for the synthesis of which omega-3 fatty acids, especially eicosapentaenoic and docosahexaenoic acids, are responsible.

A number of prostaglandins, derivatives of polyunsaturated fatty acids of various families, take part in maintaining vascular tone. Prostaglandin E ₂ (PGE ₂ ), prostacyclin I ₂ (PGI ₂ ), metabolites of arachidonic acid (AA), which belongs to omega-6 PUFAs, and prostacyclin I ₃ (PGI ₃ ), which are formed from EPA (PUFA of the omega-family), have vasodilatory properties. 3).

There are various ways to protect the body from premature aging and various diseases, the most important of which is atherosclerosis in various locations, but most of them are based on the use of synthetic drugs, the disadvantage of which is serious side effects.

Thus, for example, a biologically active compound tetrapeptide L-alanyl-L-glutamyl-L-aspartylglycine of the general formula L-Ala-L-Glu-L-Asp-Gly is provided for the preparation of a drug having geroprotective activity. A pharmacological agent containing as an active principle an effective amount of a tetrapeptide or its salt is proposed for parenteral, intranasal, oral and topical applications to prevent premature aging of the body. The method of preventing premature aging includes the prophylactic and / or therapeutic administration to the patient of a pharmacological agent in doses of 0.01-100 μg / kg body weight at least once during the period necessary to achieve a therapeutic effect [RF patent No. 2157233, class. A61K 38/07, S07K 5/10, publ. 2000.10.10].

A geroprotector based on hydrogenated pyrido- (4,3-b) -indoles is also proposed as a means for the prevention of premature aging.

A method for the prevention of premature aging consists in administering to the patient the named pharmaceutical at a dose of 0.1-10 mg / kg body weight, at least 1 time per day for the period necessary to achieve a therapeutic effect [RF patent No. 2283108, class. A61K 31/429, publ. 2005.05.20].

It is known to use an oligosaccharide selected from the group of melibiosis, stachyose or mixtures thereof, to which a hydrophobic radical is grafted, in a mixture with a pharmaceutically acceptable carrier to obtain a pharmaceutical or cosmetic composition for the prevention or for combating aging of connective tissue [RF application No. 96107214, cl. A61K 31/70, publ. 1998.06.10].

The disadvantage of the above funds is the serious side effects of the drugs.

For the prevention of premature aging of the body also use various means of natural origin.

It is known to use the drug "Vita-plant" to provide a rejuvenating effect on the human body, containing a mixture of dry extracts of the peel of dark grape varieties, olive tree leaves, rosemary leaves, grape seeds (seeds), gum arabic and aerosil [patent No. 2274469, cl . A61K 36/87, publ. 2006.04.20]. The drug increases the body's resistance to adverse external factors, slows down the aging process and stimulates the body's regenerative processes.

Known medicinal herbal remedy that helps to prevent the aging process, containing a cleaning fee and anti-aging collection, while the cleaning fee includes felt burdock root, sickle-shaped alfalfa grass and meadow clover flowers, taken in the ratio: 10: 35-40: 50-55 (wt. %). The anti-aging collection additionally includes bulbs of garlic and seeds of lemon, honeysuckle, blueberries, blueberries and lingonberries, respectively, in a ratio of 20-24: 20-24: 13-15: 13-15: 13-15: 13-15 (wt.%) [patent No. 2197256, class A61K 35/78, publ. 2003.01.27].

In 100% of cases, the rejuvenation procedure during the course of treatment improved health, patients' night sleep, promoted visible rejuvenation of the facial skin, lowered high blood pressure by 10-30 mm Hg, relieved migraine-like headaches, and increased potency in men.

It is known to use tincture of ginseng root to prevent aging of human body cells. Ginseng root tincture is prescribed 20-25 drops 3 times a day. Women are prescribed injections of a 2.5% progesterone solution once a day at a dose of 1 ml, and for men a 5% testosterone solution 2 times a day at a dose of 1 ml while eating pollen from plants and / or sex glands of animals [RF application No. 96117776 , cl. A61K 35/78, publ. 1998.12.27].

These natural preventive agents naturally strengthen the body as a whole, however, their effectiveness is not high when assessing their effect on the composition of cell membrane phospholipids fatty acids, enzymatic metabolism and the formation of lipid composition of biomembranes - the main indicators of the body's life processes that protect the body from aging.

To eliminate the deficiency of PUFAs, domestic experts have created complexes of ω-3 fatty acids from natural raw materials, of which Eikonol was the most studied and recommended as a lipid-lowering drug [RF patent No. 2039793, cl. C11B 1/10, publ. 1995].

It is with the action of this drug that the positive effects confirmed in the clinic are associated with the correction of disorders of type II diabetes, coronary heart disease, impaired tolerance to carbohydrates, fatty liver and alcoholic hepatitis, i.e. those diseases and factors that protect the body from aging, which reduce the activity of the enzyme Δ-6-desaturase.

The Eikhlofil prophylactic agent - the closest technical solution to the proposed one - contains Eikonol and biologically active substances. As the biologically active substance used copper complexes of chlorophyll in an amount of 5-15 wt.%. The tool is used as a preparation of anti-inflammatory and immunomodulatory effects and treatment of metabolic diseases. A method for the treatment and prevention of diseases includes dosing therapy for internal use at a rate of 1.2-2.5 g / day for 7-90 days with a content of copper complexes of chlorophyll of 5-10 wt.%, And for external use use an agent containing 15 wt.% Copper complexes of chlorophyll.

In order to prevent diseases, they take course doses of the drug with a concentration of chlorophyll complexes of 5.0% at 0.8-1.6 g / day for 30 days in spring and autumn.

In order to treat diseases associated with impaired lipid transport and the body’s immune systems, a tool with a concentration of copper complexes of chlorophyll of 10.0% at 1.5-2.0 g / day for 90 days is used [RF patent No. 2283108, cl. A61K 36/02, A61P 37/00, A61P 29/00, publ. 07/10/2007].

However, this tool is not effective enough to provide a rejuvenating effect on the human body, as well as the treatment and prevention of metabolic diseases,

The objective of the present invention is to expand the arsenal of tools used to increase the life of the cells of the body and provide a rejuvenating effect on the human body, as well as the treatment and prevention of metabolic diseases, enhancing the effect of polyunsaturated fatty acids.

In addition, the object of the invention is the use of the proposed tool, as a safe, affordable tool that does not contain drugs of synthetic origin, with side effects.

This problem is solved by creating a set of "Prestar" - biologically active substances to prevent premature aging of the human body, including capsules of Eikonol edible oil and a vitamin-mineral complex of the following composition per 1.0 g:

vitamin C 30-120 mg vitamin b ₃ 6-35 mg vitamin b ₆ 0.5-3.0 mg zinc 4-15 mg chromium 15-100 mcg magnesium 100-600 mg kelp powder Far Eastern rest,

the content of Eikonol edible oil and the vitamin-mineral complex is 6–8 g and 1 g, respectively.

The problem is also solved by using the Prestar kit to prevent premature aging of the human body and the way to prevent premature aging of the human body, which consists in using the Prestar kit 1-2 times a day, while the Eikonol edible oil capsules are taken in the amount of 6- 8 g / day after 0.5-1.0 hours after meals and capsules of the vitamin-mineral complex in an amount of 1 g / day with meals, for 40-60 days, 3 times a year.

The Prestar set of biologically active substances is made up of at least 2 groups and includes Eikonol edible oil, whose properties determine the lipid-lowering function of the body, and a vitamin-mineral complex that enhances the activation of the Δ-6 desaturase enzyme, each of the capsules in the kit designed for time of admission, not less than 30 minutes and not later than 60 minutes relative to meals 1-2 times a day.

Eikonol fish oil is produced from seafood on the basis of TU 400 SP "A" -1145-1-18-92 and is a product rich in (up to 30%) essential polyunsaturated acids of the Omega-3 family.

Vitamin B ₃ (niacin) helps activate the conversion of sugar and fats into energy, as well as the conversion of fats into eicosanoids - hormone-like agents that control metabolic processes in the body.

Vitamin B ₆ (pyridoxine) - like B ₃ , promotes better utilization of sugar in the body and the conversion of fats into eicosanoids.

Vitamin C is an anti-zingotic vitamin, however, it also performs other functions that make it an indispensable nutritional factor.

Chromium is an element central to sugar metabolism. Being included in the composition of enzymes, it promotes the conversion of sucrose that is not absorbed by the body into glucose and fructose, on the other hand, a lack of chromium leads to increased sugar consumption.

Chromium, along with zinc, is involved in the synthesis of the enzyme Δ6-desaturase, which is essential for the conversion of ω-6 fatty acids to gamma-linolenic acid, which is the only source of first-line prostaglandins - active eicosanoids, which reduce the aging rate of the body and protect the body from many autoimmune diseases.

Zinc is the most popular mineral for the synthesis of enzymes. This element is found in the highest concentrations in the cells of the prostate gland, and its deficiency in the body leads to such disorders that result in the appearance of diseases of the nervous system, immune system, cardiovascular system, diabetes, gastric ulcer, allergies, eating disorders and other symptoms imbalance in blood sugar.

Magnesium is the most important mineral for the heart. The formation of more than 300 enzymes in the body is associated with magnesium. At the same time, intensive land use and widespread regulation of river spills leads to an increasing deficiency of magnesium in plant foods. It is important to note that the form of magnesium is of great importance for assimilation. In combination with vitamin C, it can cause diarrhea. Large doses of magnesium oxide also cause diarrhea. High doses of magnesium are undesirable for impaired renal function.

Far Eastern laminaria is used in powder form and obtained from the laminaria of the Sea of Japan, due to its unique chemical composition containing polysaccharides (mainly salts of alginic acid), mannitol, protein substances, vitamins, iodine, mineral salts, trace elements, it additionally enriches the vitamin-mineral complex by these components, helps to reduce cholesterol in blood plasma, delays the development of atherosclerosis, improves protein assimilation, assimilation of phosphorus, calcium and iron, iruet number of enzymes. The halide group of elements (chlorine, iodine, bromine) has a disinfecting effect, under the influence of iodine, blood viscosity decreases, the tone of blood vessels and blood pressure decrease.

Hundreds of studies have been carried out with Eikonol, according to the results of which recommendations were developed on the use of 6-8 g per day as a lipid-lowering agent. It is more difficult to choose a dose for vitamins and minerals, which allows to ensure the effect of protecting the body at the lowest cost and at the same time not to allow violation of the norms of maximum allowable levels of consumption, violation of which leads to significant side effects.

Therefore, when creating a therapeutic and prophylactic agent, the composition of the components of the vitamin-mineral complex and their quantitative ratio were selected to eliminate undesirable side effects.

Considering the properties of the ingredients taken, control works were carried out, in which six variants of the formulations of the preparations “Prestar” (Table 1), consisting of eight ingredients, were considered. The first ingredient, Eikonol, was taken in all variants in a single dosage of 6 g per day based on previously performed studies.

A complex of minerals and vitamins for preserving the natural properties of minerals is preferably prepared in the form of hard gelatin capsules, at least in the form of one capsule of 500 mg or two capsules, one of which contains vitamins, and the other contains the remaining components of the vitamin-mineral complex from the fact that the mass of these compositions should be within 1 g per day.

The inventive Predstar kit is recommended for use in the form of Eikonol capsules and capsules of a complex of minerals and vitamins at the rate of 6-8 g / day of Eikonol and 1 g / day of minerals and vitamins for 40-60 days 3 times a year. Set capsules take 1-2 times a day. It is recommended to take the capsule of the vitamin-mineral complex with meals, and the Eikonol capsule after 0.5-1.0 hours after eating to exclude the aftertaste of fish oil.

Table 1 Option Eikonol g / day Means "Predstar", the content of ingredients in 1 gram Vit. C mg Vit. B ₃ mg Vit. B ₆ mg zinc mg chromium, mcg magnesium mg kelp, mg I 6 120 35 3 fifteen one hundred 600 127 II 6 120 thirty 3 fifteen one hundred 500 232 III 6 120 25 3 fifteen 60 400 377 IV 6 one hundred twenty 2 12 fifty 300 516 V 6 fifty 10 one 6 25 150 758 VI 6 thirty 6 0.5 four fifteen one hundred 844.5

Table 2 shows the results of analyzes of the fatty acid composition of erythrocyte membranes:

a) patients with coronary heart disease (CHD) before and after taking various formulations of the drug "Prestar",

a) patients with coronary heart disease (CHD) before and after taking various formulations of the drug "Prestar",

b) patients with impaired tolerance to carbohydrates (NTU) before and after taking the drug "Prestar".

Change in the level of polyunsaturated fatty acids (PUFA ω-6) in the membranes of red blood cells when using Eikonol in combination with various versions of the Prestar remedy for preventing the aging of the body and protection against diseases

table 2 Option No. Fatty acid IHD patients Patients with IHD with NTU before taking Predstar after taking Predstar before taking Predstar after taking Predstar I ω-6 24.28 22.00 27.48 25,50 ω-3 3.27 4.65 4.35 7.50 II ω-6 24.28 21,20 27.48 24.60 ω-3 3.27 5.35 4.35 8.40 III ω-6 24.28 20.60 27.48 24.00 ω-3 3.27 6.10 4.35 9.00 IV ω-6 24.28 18.70 27.48 22.10 ω-3 3.27 8.10 4.35 10.50 V ω-6 24.28 23.10 27.48 26.70 ω-3 3.27 4.30 4.35 5.10 VI ω-6 24.28 23.80 27.48 26.60 ω-3 3.27 3.60 4.35 4.80

Table 2 shows that in all cases, a decrease in the composition of erythrocyte membranes of the level of PUFA ω-6 and an increase in the content of PUFA ω-3 are observed. This effect is most pronounced both in the case of coronary heart disease and in coronary artery disease with NTU in the fourth embodiment, where in coronary artery disease, the content of PUFA ω-6 decreased by about 20%, and the level of anti-atherogenic PUFA ω-3 more than doubled from 3.27% to 8, 10%. In coronary heart disease with NTU in the fourth version of the composition, the level of PUFAs ω-6 decreased from 27.48% to 22%, and the level of anti-atherogenic PUFAs ω-3 doubled from 4.35% to 10.50%.

Table 3 identifies the effectiveness coefficients of different versions of the “Prestar” remedy by the ability of the remedy to prevent aging of the body and protect against diseases in various homeostasis disorders by reducing the level of PUFA ω-6.

Table 3 Option To the effectiveness of the means to reduce the level of PUFA ω-6 with coronary heart disease with coronary heart disease and NTU I 1.10 1,08 II 1.15 1,11 III 1.18 1.15 IV 1.31 1.24 V 1.05 1,03 VI 1,02 1,03

The highest efficiency coefficient was established with IHD 1.31 in option 4. With IHD combined with NTU, the best result was achieved using the fourth version of the Prestar tool - coefficient. eff = 1.24.

Table 4 shows the results of changes when introducing into the diet of Eikonol and the complex supplement “Prestar” in different variants of the ratio of PUFA ω-6 to PUFA ω-3 as a general indicator of anti-atherogenicity of the mixture, i.e. bringing the fatty acid mixture to a state ensuring the achievement of the task of forming hormone-like eicosanoids for the subsequent synthesis of prostaglandins of the first and third lines.

Table 4 Option IHD patients Patients with IHD with NTU before taking supplements after taking supplements Coef. eff. before taking supplements after taking supplements Coef. eff. I 7.42: 1 4.73: 1 1,57 6.32: 1 3.40: 1 1.86 II 7.42: 1 3.96: 1 1.87 6.32: 1 2.93: 1 2.16 III 7.42: 1 3.38: 1 2.19 6.32: 1 2.67: 1 2,37 IV 7.42: 1 2.31: 1 3.21 6.32: 1 2.10: 1 3.00 V 7.42: 1 5.37: 1 1.38 6.32: 1 5.24: 1 1.21 VI 7.42: 1 6.61: 1 1.12 6.32: 1 5.54: 1 1.14

Comparing the performance ratios of PUFAs ω-6 to PUFAs ω-3 before and after taking Prestar, efficacy ratios are derived. For cases of coronary heart disease, the best coefficient was 3.21 when using the fourth variant of the composition, and for cases of coronary artery disease in combination with NTU, the best coefficient of 3.00 was obtained when using the fourth variant of the mixture.

The analysis of table 4 shows that the greatest influence on the positive change in fatty acid indices is exerted by option IV of the biologically active supplement Predstar in combination with Eikonol. An increase in the level of vitamins B ₃ and B ₆ (options I and II) did not lead to an increase in the effect, as did not increase the effect of an increase in the concentration of zinc and magnesium. A decrease in the concentration of all ingredients in options V and VI reduced the effectiveness of the dietary supplement. Based on this, the indicators of options III and IV can be considered optimal.

The positive side of the proposed tool "Predstar" is its safety, accessibility, in addition, it does not contain drugs of synthetic origin with numerous side effects.

Claims (3)

1. A set of biologically active substances to prevent premature aging of the human body, including capsules of Eikonol edible oil and a vitamin-mineral complex of the following composition per 1.0 g:
vitamin C 30-120 mg vitamin b ₃ 6-35 mg vitamin B ₆ 0.5-3.0 mg zinc 4-15 mg chromium 15-100 mcg magnesium 100-600 mg Far Eastern kelp powder rest,
the content of Eikonol edible oil and the vitamin-mineral complex is 6–8 g and 1 g, respectively. 2. The use of the kit according to claim 1 for the prevention of premature aging of the human body. 3. The way to prevent premature aging of the body, which consists in using the kit according to claim 1, 1-2 times a day, while taking Eikonol edible oil capsules in an amount of 6-8 g / day after 0.5-1 , 0 hours after meals and capsules of the vitamin-mineral complex in an amount of 1 g / day with meals, for 40-60 days, 3 times a year.