RU2345802C2 - Method of treatment and prevention of nonspecific inflammatory genital diseases in animals - Google Patents

Abstract

FIELD: medicine; veterinary science.

SUBSTANCE: vaginal or rectal region or biologically active points of sacrolumbar are daily exposed to electromagnetic millimetre radiation at frequency either 65 GHz, or 129 GHz, or 300 GHz. Biologically active points are exposed during 3-5 min per each active point designated for genital activity. Rectal exposure is takes 1-2 minutes. Vaginal exposure involves neck of uterus and mucous membrane of vagina within 1-2 minutes.

EFFECT: higher rate of fertilisation after recovering, higher safety, reduced time of treatment in different kinds of animals, lower disease rate in animal yield and number of sterility days.

4 cl, 12 tbl, 3 ex

Description

The invention relates to the field of veterinary medicine and can be used for the treatment and prevention of non-specific inflammatory diseases of the genital organs in animals, such as vaginitis, vestibulovaginitis, cervicitis, uterine subinvolution, endometritis of various origins.

It is known the use of various medications for the treatment of inflammatory processes in animals, for example furapene (see RF patent No. 2139709, IPC A61K 36/00).

Known methods for treating cows with acute and chronic vestibulovaginitis, cervicitis, uterine subinvolution, endometritis, including the use of antibiotics, hormonal stimulants (Mikhailov I.M., Parshutin G.V., Kozlov N.E. Obstetrics, gynecology and artificial insemination of agricultural animals. M: Agropromizdat, 1990, p. 499-500).

However, these methods are often accompanied by side effects and low treatment effectiveness. Moreover, antibiotics and hormonal drugs enter the human body through food, which is undesirable, and sometimes unacceptable.

There is a method of treating gynecological diseases in cows by exposure to an alternating magnetic field (Auth. St. USSR 1255150, class A61N 1/32, 1986) by locally acting alternately for 3-5 minutes on the cervix and the sacral region with a value of maximum alternating magnetic intensity field in the area of the diseased organ 1-4 T at a pulse frequency of 0.25-10 Hz and a pulse duration of 0.1-1.0 milliseconds.

The disadvantages of this method are the great complexity, the possibility of additional infection of the uterus.

Closest to the proposed solution is a method of treating inflammatory processes of the productive organs of animals by high-frequency therapy, including rectal placement of the irradiator in a dielectric casing and exposure to the area of reproductive organs by a physical factor. The exposure is carried out through the wall of the rectum by a high-frequency magnetic field, and additionally, the area of the nerve plexuses of the lumbar, pelvic and spine is additionally applied (see RF patent No. 2077350, IPC A61N 5/02).

The disadvantage is the possibility of trauma and the inability to use for small cattle, pigs, dogs and cats, the lack of treatment effectiveness, the high probability of the spread of these diseases from one animal to another when prescribing these treatment procedures.

The objective of the technical solution is to create an environmentally safe drug-free antiseptic method for the treatment and prevention of non-specific inflammatory diseases of the genital organs in animals with increasing efficiency and reducing treatment time.

The problem is solved in that in the method of treatment and prevention of non-specific inflammatory diseases of the reproductive organs in animals, including exposure to a reproductive organ by the physical factor of animals, according to the solution, the effect is carried out by electromagnetic radiation of the millimeter range at one of the resonant frequencies of the molecular spectrum of atmospheric oxygen, while the effect is vaginal and / or rectal effects, and / or on BAP of the sacro-lumbar region daily for 5-7 days.

The impact on the BAT is carried out for 3-5 minutes for each AT responsible for the activity of the genital organs.

Rectal exposure is carried out for 1-2 minutes.

Vaginal effect is carried out on the cervix and / or vaginal mucosa for 1-2 minutes.

The exposure is carried out at a frequency of 65 GHz, or 129 GHz, or 300 GHz.

The method is as follows. The exposure to electromagnetic radiation of the millimeter range is carried out at the resonant frequencies of the molecular absorption spectrum and atmospheric oxygen radiation. The exposure is carried out for 1-2 minutes in each area daily. Irradiation is carried out at frequencies of 65 GHz, or 129, or 300 GHz, for example, using an EHF generator - a panoramic spectrometric complex with a quasi-optical reflectometer operating in the frequency range 118-600 GHz or Universal-M apparatus at a frequency of 65 GHz.

The choice of the irradiation frequency is due to the fact that at these frequencies the blood microcirculation in the genitals is normalized, the metabolism in the affected tissues improves, and the histostructure of the mucous membranes of the genital organs is restored, which was established by us experimentally.

Table 1
The effectiveness of the treatment of non-specific inflammatory diseases of the genital organs, depending on the time and sequential modes of vaginal and rectal effects, in% Exposure time 65 GHz 129 GHz 150 GHz 300 GHz rectally vaginally rectally vaginally rectally vaginally rectally vaginally 0.5 50,0 50,0 60.0 60.0 60.0 60.0 50,0 60.0 1,0 60.0 60.0 70.0 70.0 70.0 70.0 70.0 60.0 1,5 70.0 70.0 70.0 70.0 80.0 70.0 80.0 80.0 2.0 80.0 80.0 80.0 80.0 80.0 70.0 80.0 80.0 2.5 70.0 70.0 80.0 80.0 80.0 70.0 70.0 80.0

table 2
The effectiveness of the treatment of non-specific inflammatory diseases depending on time when exposed to the BAP of the sacro-lumbar, in% Exposure time 65 GHz 129 GHz 150 GHz 300 GHz 2.0 60.0 70.0 70.0 70.0 3.0 70.0 80.0 80.0 90.0 4.0 70.0 80.0 70.0 90.0 5,0 70.0 80.0 80.0 90.0 6.0 50,0 80.0 70.0 80.0

Table 3.
The effectiveness of the treatment of non-specific inflammatory diseases of the genital organs, depending on the time and modes of vaginal and rectal influences in combination, in% Exposure time 65 GHz 129 GHz 150 GHz 300 GHz Vaginally rectal Vaginally rectal Vaginally rectal Vaginally rectal 0.5 50,0 650 60.0 550 1,0 650 70.0 75.0 70.0 1,5 70.0 75.0 80.0 850 2.0 85.0 850 850 850 2.5 75.0 80.0 80.0 70.0

Experiments with simultaneous vaginal, rectal, and exposure to BAP of the lumbosacral at various time modes and various frequencies showed that the effectiveness of the proposed method in most animals is 65-80%.

Example. 1 In cattle.

Table 4
Hematological changes in the application of EMR EHF therapy of non-specific inflammatory diseases of the genital organs in cattle Indicators Before treatment After treatment ESR, mm / g 1.1 ± 1.19 1.2 ± 0.18 Hemoglobin, g / l 7.87 ± 0.58 8.48 ± 0.34 ^* The number of leukocytes, g / l 5.47 ± 0.41 5.87 ± 0.46 The number of red blood cells, g / l 4.56 ± 0.23 5.09 ± 0.13 ^* Leukogram,% Basophils 0.30 0.40 Eosinophils 6.20 4.21 Neurophiles: P 1.75 3.28 FROM 31,4 35.8 Lymphocytes 58.4 54.9 monocytes 1,1 2,4 Total protein, g / l 71.27 83.87 Glucose, mmol / L 1.41 ± 0.16 1.932 ± 0.17 ^* Carotene, mg /% 0.008 ± 0.02 0.235 ± 0.08 ^*** BASK,% 52,4 58.4 FAN,% 57.0 58.6 IgG, g / l 15.65 ± 1.50 23.76 ± 1.50 IgM, g / l 2.48 ± 0.22 4.07 ± 0.18 IgA, g / l 0.36 ± 0.03 0.535 ± 0.04 ^** Note ^* - hereinafter ^* p is less than 0.05, ^** p is less than 0.01 ^*** 0.001

Table 5
The effect of electromagnetic radiation of the EHF range on the contractile function of sick cows Method of treatment Uterus tone,% 3 days 6 day 0 + ++ 0 + ++ 65 GHz 15.8 26.31 57.89 5.26 10.52 84.22 129 GHz 14.2 27.91 57.89 4.6 10.1 85.3 150 GHz 10.7 29.1 60,2 4.4 9.9 85.7 300 GHz 12.49 28.3 59.21 7.3 8.9 83.8 Traditional (control = 17) 29.4 35.3 35.3 11.76 35.3 52.94 0 - atony
+ - hypotension
++ - normal uterine contractions

Table 6
The therapeutic efficacy of EHF EMR at a frequency of 129 GHz in sick cows with postpartum pathology Method of treatment Disease Recover,% Treatment time days The period from treatment to fertilization, days Insemination index Infertility days Proposed Vaginitis 95.8 5.89 16.2 ± 7.23 1,6 73.9 Cervicitis 78.5 8.65 24.3 ± 6.17 1.9 83.1 Endometritis 2.6 11.84 32.7 ± 5.08 2.2 89.4 Traditional Vaginitis 87.9 6.9 21.7 ± 6.31 1.8 85.7 Cervicitis 68.8 9.7 35.8 ± 5.27 2.1 99.3 Endometritis 57.8 15.7 45.8 ± 6.92 2.47 137.5

Table 7
EHF EMR efficiency at a frequency of 150 GHZ range for postpartum complications Groups of animals Recovery time, days Fertilization% Insemination index The number of days of infertility From ^1st insemination Total Vaginitis (n = 17) 5.4 ± 0.32 64.70 100.0 1.4 79.8 ± 2.34 Cervicitis (n = 18) 7.5 ± 0.62 61.11 94.44 1.9 91.2 ± 5.35 Uterine subinvolution (n = 19) 9.7 ± 0.82 57.89 89.47 2,3 107.5 ± 4.89 Endometritis (n = 22) 12.4 ± 0.67 50.00 77.27 2.67 113.45 ± 6.72

Example 2. In sows.

Table 8
The effectiveness of the use of EMF EHF ranges for the prevention of postpartum diseases in sows Groups Sows became ill,% Total Endometritis MMA 65 GHz 37.45 29.9 7.5 129 GHz 26.5 13.9 3.4 150 GHz 25.8 14.2 3.6 300 GHz 26.0 14.3 3.8 The control 78.6 46,4 32,2

Table 9
The therapeutic efficacy of EHF EMF at atmospheric oxygen frequencies in the treatment of sick sows with postpartum complication Therapy Method The average number of procedures The outcome of the treatment,% recovery Treatment time, days Offered (n = 19) Endometritis 7.6 84.21 8.2 MMA 10.7 73.68 11.3 Traditional (n = 17) Endometritis 10.9 76.47 12.1 MMA 15.8 64.71 17.3

Table 10
The dynamics of the gain of suckling pigs in the prevention of postpartum complications in sows when exposed to frequencies of nitric oxide Groups of animals The average number of piglets in the nest The average mass of piglets, kg The average daily weight gain, g The average mass of the nest, kg Sow offspring with EHF-therapy 1 day 9.10 1.46 - 13.28 10 day 8.36 2.81 138 23.05 20 day 7.91 4.60 182 36.38 30 day 7.27 6.52 203 47.40 Sow offspring with conventional therapy 1 day 9.18 1.36 - 10.99 10 day 7.91 2.73 134 20.84 20 day 7.54 4.40 167 32.08 30 day 7.27 6.36 196 45.03

Example 3. In bitches.

Table 11
The therapeutic efficacy of EMR of the EHF range at atmospheric oxygen frequencies in the treatment of non-specific inflammatory diseases of the genital organs in females Indicators Recover,% Number of treatment procedures Treatment time, days Fertility recovery days Vaginitis 91.85 4.7 7.8 ± 0.23 61.7 ± 6.23 Cervicitis 73.65 5.3 9.3 ± 0.17 62.9 ± 5.09 Endometritis 60,20 9.2 13.5 ± 0.35 97.9 ± 4.27 Salpengitis 69.72 10.3 15.7 ± 0.42 123.5 ± 5.99 Oophorit 70.53 9.8 15.4 ± 0.27 177.2 ± 6.25

Table 12
Dog blood counts when applying various treatment regimens when exposed to nitric oxide frequencies Indicators Study days Before treatment ^5th 10 ^th 15 ^th SoE, mm / h experience 12.86 ± 5.18 7.3 ± 0.7 2.1 ± 0.4 1.8 ± 0.3 the control 14.21 ± 1.85 11.1 ± 3.1 5.7 ± 0.6 5.0 ± 0.5 Hemoglobin, g / l 93.0 ± 5.69 107.8 ± 4.3 113.5 ± 4.9 118.6 ± 4.9 experience 104.0 ± 4.53 111.7 ± 3.5 117.6 ± 2.9 125.4 ± 3.6 the control Red blood cells g / l experience 5.3 ± 0.62 6.5 ± 0.5 6.8 ± 0.4 6.5 ± 0.2 the control 5.1 ± 0.42 5.8 ± 0.4 6.2 ± 0.3 7.5 ± 0.4 White blood cells g / l 17.2 ± 2.0 10.5 ± 1.1 8.2 ± 0.4 7.9 ± 0.3 experience 17.5 ± 1.6 16.0 ± 1.4 11.9 ± 1.4 9.4 ± 0.3 the control

Thus, the application of the method will reduce the treatment time for different types of animals, the cost of treatment, increase the percentage of fertilization after recovery of the animals, increase the safety, the incidence of offspring and reduce the number of days of infertility, which significantly increases the economic efficiency of animal husbandry.

Claims (4)

1. The method of treatment and prevention of non-specific inflammatory diseases of the genital organs in animals, including exposure to a physical factor on the genitals of animals, characterized in that the exposure is carried out by electromagnetic radiation of the millimeter range at a frequency of 65 GHz, or 129 GHz, or 300 GHz, the effect vaginal or rectal or on the BAT of the sacro-lumbar daily. 2. The method according to claim 1, characterized in that the effect on the BAT is carried out for 3-5 minutes for each AT responsible for the activity of the genital organs. 3. The method according to claim 1, characterized in that the rectal effect is carried out for 1-2 minutes. 4. The method according to claim 1, characterized in that the vaginal effect is carried out on the cervix and the mucous membrane of the vagina for 1-2 minutes.