RU2340284C1 - Method of predicting of preclinical manifestation of multiple sclerosis at patients with optical neuritis - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: define the content of trace substances: aluminium, lead, copper and manganese in hair of patients with an optical neuritis. At value of indicators of microelement structure of hair: aluminium - over 10.0 mkg/g, lead - over 5.0 mkg/g, copper - less than 10.0 mkg/g and manganese - less than 1.5 mkg/g it is possible to assume development of a multiple sclerosis at a stage of preclinical manifestation.

EFFECT: possibility of manifestation prediction of a multiple sclerosis on a preclinical disease stages.

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Description

The invention relates to medicine, in particular to ophthalmology, and can be used to predict the preclinical manifestation of multiple sclerosis (PC).

There are methods for determining the occurrence of PC, which only state the fact of the presence of this disease, its severity by determining the patient’s magnetic resonance imaging, visually evoked potentials, HLA typing, antibodies to myelin substance [Modern methods for the diagnosis of multiple sclerosis [Text] / G .N. Bisaga, V.I. Golovkin, S.A. Lytayev [et al.] // Journal. neurology and psychiatry. - 1996. - No. 6. - S.40-43].

There is a relationship between the incidence of multiple sclerosis and micronutrient deficiencies - copper, manganese and an excess of lead and aluminum.

A number of patients with optic neuritis (OH) subsequently develop PC [Zavalishin, I.A. Multiple sclerosis. Selected Issues of Theory and Practice [Text] / I.A. Zavalishin, V.I. Golovkin. - M .: TEVA Pharmaceutical Enterprises Ltd., 2000. - 639 p.].

The task is to propose a method for predicting preclinical manifestation of PC in patients with OH.

EFFECT: possibility of predicting the occurrence of preclinical manifestation of PC by determining the microelement composition of hair in patients with OH.

The technical result is achieved by the fact that in the hair of patients with optical neuritis (OH) determine the content of Al, Pb, Cu, Mn. With an excess of aluminum and lead in excess of 10.0 μg / g and 5.0 μg / g, respectively, and copper deficiency of less than 10.0 μg / g and manganese of less than 1.5 μg / g, it is possible to predict the possibility of development of stage PC in patients preclinical manifestation.

The main group was 40 people. At admission, the content of trace elements in the hair roots was determined for all patients. In retrospect, after 3 years, all patients were divided into 2 groups depending on the occurrence of their PC.

Table number 1. Groups Copper Manganese Aluminum Lead PC 1 group (28 people) 11.23 mcg / g 1.76 mcg / g 19.38 mcg / g 3.75 mcg / g - 2 group (12 people) 6.47 mcg / g 0.27 mcg / g 37.79 mcg / g 12.83 mcg / g 12 pax Control (20 people) 12.59 mcg / g 3.75 mcg / g 7.82 mcg / g 1.95 mcg / g -

The advantages of the proposed method:

- convenient, since only hair is taken for analysis;

- the analysis is atraumatic;

- the analysis is informative, as it allows to judge by the microelement composition about the possibility of PC occurrence;

Example No. 1.

Patient V., 32 years old, complained of complaints of pain during eye movement, fog in front of the eyes, decreased vision in both eyes. From the anamnesis it is known that he fell ill 2 days ago. On the eve of the disease noted the phenomenon of influenza, an increase in temperature to 38.5 ° C. In ophthalmostatus: visual acuity of the right eye - 0.3 n / a, left - 0.5 n / a. The central scotoma is in sight. The microelement composition of the hair: aluminum - 19.38 μg / g, lead - 3.57 μg / g, copper - 11.23 μg / g and manganese - 1.76 μg / g. After 3 years, the manifestation of PC in the patient was not observed.

Example No. 2.

Patient P., 37 years old, complained about newly arising complaints of decreased vision, narrowing of the field of view, the appearance of a veil in front of her eyes for a week. From the anamnesis it is known that 6 months ago I was treated in a clinic with a diagnosis of Optic neuritis in both eyes (against the background of exacerbation of chronic sinusitis from 2 sides). Visual acuity is - 0.3 n / a in the right eye and 0.5 n / a in the left eye. The micronutrient composition of the hair was as follows: aluminum - 37.79 μg / g, lead - 12.83 μg / g, copper - 6.47 μg / g and manganese - 0.27 μg / g. After 10 days, the patient was diagnosed : Multiple sclerosis, primarily a progressive course. After 1 year 6 months, she was again admitted to the hospital with a diagnosis of Relapse of optic neuritis in both eyes against the background of multiple sclerosis.

Example No. 3.

Patient I., 42 years old, complained of complaints of decreased vision, pain when moving behind the eyeballs. From the anamnesis it became known that for the first time this disease was 2 years 4 months ago. The last relapse of optic neuritis was 1.5 years ago. Currently, visual acuity was 0.4 n / a in the right eye and 0.09 n / a in the left eye. An analysis of the microelement composition of the hair was taken - aluminum - 25.44 μg / g, lead - 9.53 μg / g, copper - 9.31 μg / g and manganese - 0.68 μg / g. After 11 months, a diagnosis of multiple sclerosis was made.

Claims (1)

A method for predicting the preclinical manifestation of multiple sclerosis, which consists in determining the microelement composition of hair in individuals with optical neuritis, characterized in that when the aluminum content is more than 10.0 μg / g, lead more than 5.0 μg / g, copper less than 10.0 μg / g and manganese less than 1.5 μg / g predict the possibility of developing multiple sclerosis in patients.