RU2312857C2 - Фосфатные производные фтороксиндолов и способ лечения с их использованием - Google Patents
Фосфатные производные фтороксиндолов и способ лечения с их использованием Download PDFInfo
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- RU2312857C2 RU2312857C2 RU2004131201/04A RU2004131201A RU2312857C2 RU 2312857 C2 RU2312857 C2 RU 2312857C2 RU 2004131201/04 A RU2004131201/04 A RU 2004131201/04A RU 2004131201 A RU2004131201 A RU 2004131201A RU 2312857 C2 RU2312857 C2 RU 2312857C2
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- Russia
- Prior art keywords
- methoxyphenyl
- fluoro
- chloro
- trifluoromethyl
- oxo
- Prior art date
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Classifications
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Landscapes
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- Vascular Medicine (AREA)
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- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36601002P | 2002-03-20 | 2002-03-20 | |
| US60/366,010 | 2002-03-20 |
Publications (2)
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| RU2004131201A RU2004131201A (ru) | 2005-05-10 |
| RU2312857C2 true RU2312857C2 (ru) | 2007-12-20 |
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| RU2004131201/04A RU2312857C2 (ru) | 2002-03-20 | 2003-03-20 | Фосфатные производные фтороксиндолов и способ лечения с их использованием |
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| EP (1) | EP1485085A4 (enExample) |
| JP (1) | JP4359150B2 (enExample) |
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| CN (1) | CN100384820C (enExample) |
| BR (1) | BR0308737A (enExample) |
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| CO (1) | CO5611143A2 (enExample) |
| GE (1) | GEP20074230B (enExample) |
| HR (1) | HRP20040853A2 (enExample) |
| IL (2) | IL164022A0 (enExample) |
| IS (1) | IS7456A (enExample) |
| MX (1) | MXPA04008999A (enExample) |
| NO (1) | NO20044442L (enExample) |
| NZ (1) | NZ535365A (enExample) |
| PL (1) | PL372413A1 (enExample) |
| RS (1) | RS81904A (enExample) |
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| UA (1) | UA77296C2 (enExample) |
| WO (1) | WO2003080047A1 (enExample) |
| ZA (1) | ZA200407337B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CN103169708B (zh) | 2002-07-29 | 2018-02-02 | 里格尔药品股份有限公司 | 用2,4‑嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
| US6916937B2 (en) * | 2003-02-03 | 2005-07-12 | Bristol-Myers Squibb Company | Carbohydrate prodrugs of fluorooxindoles |
| US7122542B2 (en) | 2003-07-30 | 2006-10-17 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
| US7169803B2 (en) * | 2004-03-15 | 2007-01-30 | Bristol-Myers Squibb Company | N-substituted prodrugs of fluorooxindoles |
| US7253167B2 (en) | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
| US7449458B2 (en) | 2005-01-19 | 2008-11-11 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| US8227455B2 (en) | 2005-04-18 | 2012-07-24 | Rigel Pharmaceuticals, Inc. | Methods of treating cell proliferative disorders |
| US20090114877A1 (en) * | 2005-09-13 | 2009-05-07 | Eisai R&D Management Co., Ltd. | Composition Containing Stability-Improved Chloromethyl Phosphate Derivatve and Process for Producing Same |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| TW200841879A (en) | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| US8513287B2 (en) * | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| CA2722536A1 (en) * | 2008-02-05 | 2009-08-13 | Merck & Co., Inc. | Prodrugs of cgrp receptor antagonist |
| US8188119B2 (en) * | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| ES2639065T5 (es) | 2009-06-25 | 2023-01-30 | Alkermes Pharma Ireland Ltd | Compuestos heterocíclicos para el tratamiento de trastornos neurológicos y psicológicos |
| AU2010266040B2 (en) * | 2009-06-25 | 2015-01-15 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds |
| EP2585066B1 (en) | 2010-06-24 | 2018-09-26 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| CN109879859B (zh) | 2015-07-06 | 2022-01-25 | 吉利德科学公司 | Cot调节剂及其使用方法 |
| US10933069B2 (en) | 2018-01-05 | 2021-03-02 | Cybrexa 1, Inc. | Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues |
| EP3762386B1 (en) * | 2018-03-05 | 2024-01-24 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| AU2019230014B2 (en) | 2018-03-05 | 2024-11-28 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| PH12022550037A1 (en) | 2019-07-10 | 2023-04-12 | Cybrexa 3 Inc | Peptide conjugates of microtubule-targeting agents as therapeutics |
| EP3997093A1 (en) | 2019-07-10 | 2022-05-18 | Cybrexa 2, Inc. | Peptide conjugates of cytotoxins as therapeutics |
| EP4126231A1 (en) | 2020-03-30 | 2023-02-08 | Gilead Sciences, Inc. | Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
| CN115397824B (zh) | 2020-04-02 | 2024-10-22 | 吉利德科学公司 | 用于制备cot抑制剂化合物的方法 |
| EP3912625A1 (en) | 2020-05-20 | 2021-11-24 | Kaerus Bioscience Limited | Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders |
| WO2025233532A1 (en) | 2024-05-10 | 2025-11-13 | Les Laboratoires Servier | Maxi-k potassium channel openers and therapeutic applications thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5187173A (en) * | 1991-12-27 | 1993-02-16 | Sterling Winthrop Inc. | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| SU749063A1 (ru) * | 1979-01-29 | 1996-09-10 | Военно-медицинская академия им.С.М.Кирова | 3-(4-карбэтокси)-фенилимино-2-оксоиндолин, повышающий устойчивость организма к повторной черепно-мозговой травме |
| US5602169A (en) * | 1995-06-07 | 1997-02-11 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| US5939405A (en) * | 1998-01-29 | 1999-08-17 | Bristol-Myers Squibb Company | Phosphate derivatives of diaryl 1,3,4-oxadiazolone |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234947A (en) | 1991-11-07 | 1993-08-10 | New York University | Potassium channel activating compounds and methods of use thereof |
| ATE261730T1 (de) | 1997-12-31 | 2004-04-15 | Univ Kansas | Wasserlösliche medikamentenvorstufen tertiärer amine enthaltender medikamente und verfahren zu ihrer herstellung |
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2003
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- 2003-03-20 BR BR0308737-9A patent/BR0308737A/pt not_active IP Right Cessation
- 2003-03-20 MX MXPA04008999A patent/MXPA04008999A/es active IP Right Grant
- 2003-03-20 PL PL03372413A patent/PL372413A1/xx not_active Application Discontinuation
- 2003-03-20 HR HRP20040853 patent/HRP20040853A2/xx not_active Application Discontinuation
- 2003-03-20 CN CNB038109778A patent/CN100384820C/zh not_active Expired - Fee Related
- 2003-03-20 GE GEAP8458A patent/GEP20074230B/en unknown
- 2003-03-20 CA CA002479256A patent/CA2479256A1/en not_active Abandoned
- 2003-03-20 RU RU2004131201/04A patent/RU2312857C2/ru not_active IP Right Cessation
- 2003-03-20 UA UA20041109513A patent/UA77296C2/uk unknown
- 2003-03-20 JP JP2003577875A patent/JP4359150B2/ja not_active Expired - Fee Related
- 2003-03-20 KR KR1020047014626A patent/KR100951499B1/ko not_active Expired - Fee Related
- 2003-03-20 IL IL16402203A patent/IL164022A0/xx active IP Right Grant
- 2003-03-20 US US10/393,031 patent/US6930100B2/en not_active Expired - Lifetime
- 2003-03-20 WO PCT/US2003/008613 patent/WO2003080047A1/en not_active Ceased
- 2003-03-20 RS YUP-819/04A patent/RS81904A/sr unknown
- 2003-03-20 EP EP03711659A patent/EP1485085A4/en not_active Withdrawn
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2004
- 2004-09-12 IL IL164022A patent/IL164022A/en not_active IP Right Cessation
- 2004-09-13 ZA ZA200407337A patent/ZA200407337B/en unknown
- 2004-09-17 IS IS7456A patent/IS7456A/is unknown
- 2004-09-20 CO CO04093294A patent/CO5611143A2/es not_active Application Discontinuation
- 2004-10-19 NO NO20044442A patent/NO20044442L/no not_active Application Discontinuation
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU749063A1 (ru) * | 1979-01-29 | 1996-09-10 | Военно-медицинская академия им.С.М.Кирова | 3-(4-карбэтокси)-фенилимино-2-оксоиндолин, повышающий устойчивость организма к повторной черепно-мозговой травме |
| US5187173A (en) * | 1991-12-27 | 1993-02-16 | Sterling Winthrop Inc. | 2-saccharinylmethyl and 4,5,6,7-tetrahydro-2-saccharinylmethyl phosphates, phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5602169A (en) * | 1995-06-07 | 1997-02-11 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
| RU2165925C2 (ru) * | 1995-06-07 | 2001-04-27 | Бристоль Мейерз Сквибб Компани | 3-замещенные оксиндольные производные в качестве модуляторов калийных каналов, фармацевтическая композиция, способ лечения |
| US5939405A (en) * | 1998-01-29 | 1999-08-17 | Bristol-Myers Squibb Company | Phosphate derivatives of diaryl 1,3,4-oxadiazolone |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003215017A1 (en) | 2003-10-08 |
| US6930100B2 (en) | 2005-08-16 |
| JP2005526097A (ja) | 2005-09-02 |
| EP1485085A4 (en) | 2007-03-14 |
| BR0308737A (pt) | 2005-01-11 |
| RU2004131201A (ru) | 2005-05-10 |
| IL164022A0 (en) | 2005-12-18 |
| HRP20040853A2 (en) | 2004-12-31 |
| MXPA04008999A (es) | 2004-12-07 |
| UA77296C2 (en) | 2006-11-15 |
| IL164022A (en) | 2008-04-13 |
| NZ535365A (en) | 2006-07-28 |
| CO5611143A2 (es) | 2006-02-28 |
| JP4359150B2 (ja) | 2009-11-04 |
| IS7456A (is) | 2004-09-17 |
| EP1485085A1 (en) | 2004-12-15 |
| KR20040106293A (ko) | 2004-12-17 |
| RS81904A (sr) | 2007-02-05 |
| PL372413A1 (en) | 2005-07-25 |
| KR100951499B1 (ko) | 2010-04-07 |
| GEP20074230B (en) | 2007-11-12 |
| ZA200407337B (en) | 2006-02-22 |
| CN100384820C (zh) | 2008-04-30 |
| WO2003080047A1 (en) | 2003-10-02 |
| CN1652769A (zh) | 2005-08-10 |
| US20030195169A1 (en) | 2003-10-16 |
| NO20044442L (no) | 2004-10-19 |
| CA2479256A1 (en) | 2003-10-02 |
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