RU2308880C2 - Method for investigating radiation emitted by living organism for diagnosing cancerogenesis processes - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves placing device having single-crystal circular Z-slice quartz wafer on facial head region. Electromagnetic signals are recorded. Pulses or pulse groups, which amplitudes exceed noise amplitude level, being detected, preliminary diagnosis of cancerogenesis process availability is to be set. The abovementioned operations are repeated at the second investigation stage on skin region adjacent to organ under study. Pulses, which amplitudes exceed noise amplitude level, being detected several times, preliminary conclusion is to be drawn concerning malignant tumor disease of the organ under study.

EFFECT: wide range of functional applications in diagnosing oncological diseases.

10 dwg

Description

The invention relates to medicine and is intended for the early detection of malignant oncological diseases, including before the formation of conditions providing the possibility of detecting the fact of the formation of a malignant tumor using currently accepted diagnostic methods.

There is a method of studying the radiation of a living organism in order to diagnose carcinogenesis processes, including the reception of thermal radiation of the human body emanating from atoms of polymerized, oncological cell molecules, while the presence of cancer is judged by the excess of radiation intensity from the background (see ed. St. USSR No. 1363996, 1996).

The disadvantage of this solution is the difficulty in recognizing cancer against the background of other pathologies.

In recent years, in physiology, an informational approach to the analysis of various human functions has been increasingly used. Considering only physical and chemical factors, it is not always possible to explain the processes occurring in the human body. From the point of view of the information approach, along with physicochemical processes in the human body, information processes are formed and closely interact, transmitted, stored and analyzed. Moreover, the informational assessment in the functional systems of the homeostatic level acts as informational signals that control processes in the human body. Research in microbiology in the field of redox systems: excited molecules and key signal-transmitting proteins of electron acceptors (Science Journal 1998, No. 5, v.280, p.1723) confirmed the leading role of information processes in the regulation of homeostasis. As a rule, living organisms objectively and quantitatively evaluate the results of activities of functional systems that determine various indicators of homeostasis. Thus, information and / or energy-information processes that are organically inherent in any living organism, appearing in the external environment in the form of radiations of various physical nature, can be used to diagnose the state of the human body and its individual organs.

Thus, it seems possible to use the body's own radiation for diagnostic purposes.

This idea is realized by the invention that we used as a prototype (see Pat. RF No. 2144781, class A61B 5/00, 2000), while the method for studying the radiation of a living organism in order to diagnose carcinogenesis involves fixing its own radiation from organs and / or tissues human and subsequent processing and analysis of the measurement results, with the allocation of the diagnostic signs of the disease.

The disadvantages of the method include the multioperational nature of both the directly measuring process and the mathematical processing of the results. In addition, the diagnosed organ itself is used as a signal source and the energy-informational characteristics of the carcinogenesis process that is already occurring in the diagnosed organ are “taken off”, i.e. there is no possibility of early diagnosis of the disease (i.e., the initial stage - before the formation of a malignant tumor).

The task to which the proposed technical solution is directed is to provide the possibility of diagnosing a cancer, including early, at the initial stage before the formation of a malignant tumor, simplifying the diagnostic procedure.

The technical result that is achieved when solving the problem is expressed in ensuring high reliability of diagnosis at the earliest stage of the carcinogenesis process, providing the ability to diagnose a wide range of cancer diseases. In the future, with the accumulation of statistical material, accurate differentiation and localization of oncopathology at any stage of its development will be possible.

To solve this problem, a method for studying the radiation of a living organism in order to diagnose carcinogenesis is characterized in that a device containing a single-crystal quartz round Z-slice plate is positioned on the front of the head, records electromagnetic signals, and when pulses or groups of pulses appear, the amplitude of which exceeds the level the amplitudes of the noise track, make a preliminary conclusion about the presence of carcinogenesis in the body, then repeating in the second stage of the study m described operations at the site of the skin closest to the examinee body and repeated fixation of pulses whose amplitude exceeds the level of the noise paths, specify a preliminary conclusion about the malignant disease of the subject body.

A comparative analysis of the totality of the features of the proposed solution and the totality of the features of analogues and prototype indicate that the proposed technical solution meets the criterion of "novelty."

In this case, the distinctive features of the formula solve the following functional tasks.

Signs indicating the use of a device containing a single-crystal quartz round Z-slice plate provide the possibility of converting a portion of the total spectrum of natural emissions of organs and / or human tissues of radiation corresponding to energy-information processes of the body during carcinogenesis into an information electromagnetic signal suitable for processing to form diagnostic signs.

Signs “position on the front of the head, record electromagnetic signals” provide maximum binding of the recorded signal to carcinogenesis processes and reduce the attenuation of this signal by body tissues. In addition, it is possible to fix the carcinogenesis process at the earliest stages even before the formation of cancer cells (even before the appearance of malignant cancer cells, the radiation of which is used to solve diagnostic problems) - at the stage when the nervous system only "gives a command" for the formation of such molecules. In this case, the amount of malignant formation becomes insignificant (from the point of view of the reliability of the diagnosis), since the signals generated by a powerful radiation source - the brain, are received.

The sign “record electromagnetic signals” provides the possibility of their subsequent electronic processing and analysis using computer technology, which allows to speed up and simplify the diagnostic procedure.

The signs “in the second stage of the study repeat the described operations on the site of the skin closest to the organ under examination, and with repeated fixation of pulses whose amplitude exceeds the level of the noise path, clarify the preliminary conclusion about the malignant disease of the organ under examination” provide an increase in the reliability of the diagnosis.

The claimed invention is illustrated by graphic materials, while figure 1 shows a functional diagram of the installation, providing the implementation of the method; figure 2 schematically shows a radiation receiver; figure 3 - placement of the radiation receiver in the process, for example, the fixation of brain signals; figure 4 shows a fragment of the examination of a patient with a diagnosis of breast adenocarcinoma (the upper graph on the left is the impulse recorded in the radiation of the brain characteristic of the diagnosis of breast adenocarcinoma, the lower graph on the left is a dashed line fragment of the same impulse, extended in time, the upper graph on the right is the impulse recorded in the radiations of the diseased organ, characteristic of the diagnosis of mammary adenocarcinoma, below on the right is a fragment of the same pulse highlighted by a dashed line, stretched over time eni); figure 5 is a fragment of the examination of a patient with a diagnosis of uterine endometrial adenocarcinoma (the upper graph on the left is the impulse recorded in brain radiation characteristic of an oncological patient, the lower on the left is a dashed line fragment of the same impulse stretched in time, the upper graph on the right is the impulse fixed in the projection of a surgical suture in the region of a distant diseased organ, characteristic of an oncological patient, below on the right is a fragment of the same pulse highlighted by a dashed line, stretched over time); Fig.6 is a fragment of the examination of a patient with a diagnosis of breast adenocarcinoma (the upper graph on the left is the impulse recorded in the brain radiation characteristic of the diagnosis of mammary adenocarcinoma, the lower on the left is a dashed line fragment of the same impulse, extended in time, the upper graph on the right is the impulse recorded in the radiations of the diseased organ, characteristic of the diagnosis of breast adenocarcinoma, below on the right is a fragment of the same impulse highlighted by a dashed line, stretched over time); Fig.7 is a fragment of the examination of a patient with a diagnosis of uterine fibroids (the upper graphs on the left and on the right are the pulses recorded in the radiation of the brain, characteristic of malignant cancer, lower left and right are the selected fragments of the same pulses, enlarged and extended in time), signals diagnosing signs of malignant cancer directly from the organ at this stage are not fixed; Fig. 8 is a fragment of an examination of a patient diagnosed with localized mastopathy against the background of diffuse fibrocystic mastopathy, presumably the initial stage of malignancy (the upper graph on the left shows the impulse recorded in brain radiation typical of an oncological patient, and the fragment of the same highlighted by a dashed line on the left) pulse extended in time, the upper graph on the right is the pulse recorded in the radiation of the diseased organ, characteristic of the diagnosis of breast adenocarcinoma, below the right is the highlighted line hovoy fragment of the same line pulse stretched over time); figure 9 is a fragment of the examination of a patient with a diagnosis of uterine fibroids, polyposis, presumably the initial stage of malignancy of the tumor (the upper graph on the left is the impulse recorded in the radiation of the brain characteristic of a cancer patient, below the left is a fragment of the same impulse highlighted by a dashed line stretched along time, the upper graph on the right is the impulse recorded in the radiations of the diseased organ, characteristic of the diagnosis of uterine cancer, lower on the right is the dashed line fragment of the same impulse, stretched over time); figure 10 is a fragment of the examination of a healthy patient (the upper graph is a record of only the noise track, below is a fragment of the same pulse highlighted by a dashed line, stretched over time).

The method is based on the effect established by the authors, namely, that single-crystal quartz round Z-slice plates placed in the radiation field of a living organism having a malignant disease (confirmed by known diagnostic methods) are able to detect specific signals induced by the brain in a certain frequency range the patient, while in the patients examined by us who do not have a diagnosis of malignant neoplasm, these signals are absent.

To implement the method, a device developed by the authors is used, the main element of which is a radiation receiver made in the form of a single-crystal round plate, which is a thin quartz plate 1 Z-section, on both sides 2 of which a thin coating 3 of silver is applied (thickness not more than 0 , 1 mm). The plate is installed in the cavity of the confuser reflector 4, the axis of symmetry 5 of which passes through the center 6 of the quartz plate 1. In this case, the confuser reflector 4 or its inner surface 7 is made of silver (in the second case, the reflector case is made of non-magnetic material coated with silver on the inner surface) . In addition, the coating of the quartz plate 1 is electrically connected to the input of the signal preamplifier 8, the output of which is connected through an analog-to-digital converter 9 to the computer 10.

Known means are used as elements 8-10 of the device, the operating characteristics of which correspond to the operating parameters of the device, while the signal preamplifier 8 is made according to the known scheme, a 12-bit ADC is used as analog-to-digital converter 9, to ensure an acceptable processing speed of the measurement results, it is desirable so that the computer processor is at least Pentium-4.

The device is used as follows: it is positioned so that the wide base of the cone of the reflector 1 falls on the front of the head or (in the second stage of the study) - on the area of the skin closest to the examined organ (not shown in the drawing). In this case, the potential difference is constantly removed from the silver-plated surfaces of the quartz round plate 2. When a malignant carcinogenesis process takes place (forming or developed), a potential difference arises from the silver coatings 3 of the quartz round plate 2, in the presence of which it is concluded that there is a malignant cancer .

The claimed method is implemented in the following order.

Survey Process:

1. The patient removes all metal jewelry and parts from the examined area (head, neck and / or the corresponding part of the body) and is located on the examination couch, lying on his back in the most comfortable position. The head is thrown back a little through the soft cushion-pillow.

2. The sensor is positioned on the front of the head (orienting its longitudinal axis to the central region of the brain) at a distance of 3-9 mm from the skin integument or to the area of the skin integument of the patient’s body closest to the organ being examined (if we are talking about the second stage of the examination).

3. Start recording signals from the receiving sensor to the computer.

4. After registration, recording stops for 20-30 minutes.

Deciphering the results:

1. The process resembles the interpretation of the results of a standard ECG or EEG. All fragments of the record are viewed page by page. Currently, decoding one study takes up to 20-30 minutes.

2. If the pulses and (or) their sequences are repeatedly fixed from the area of the brain, a preliminary diagnosis is made - the presence of carcinogenesis, after which, stretching the pulses in time, they fix their configuration characteristics, comparing them with the configuration characteristics of similarly processed electromagnetic signals recorded in patients with reliably established diagnoses of malignant cancer, make a conclusion about the type of malignant pathology.

3. If there are no pulses in the region of the brain exceeding the amplitude level of the noise track, they proceed to the second stage of the examination, repeating the operations described above at the site of the skin of the patient’s body closest to the organ being examined (clothes are removed from this area).

4. With repeated fixation at the second stage of the examination of the patient’s organs, the impulses and (or) their sequences make a conclusion about the type of malignant pathology.

5. If there are no pulses in the region of the examined organ exceeding the amplitude level of the noise track, a conclusion is drawn about the absence of carcinogenesis processes in the body.

Recorded Signals.

The recorded “oncological signals” look like relatively short burst sequences of various configurations. The duration of these packets can be from tens of microseconds to milliseconds. As the experience of examining patients shows, during its conduct (20-30 minutes), these signal packets appear repeatedly (up to 10 or more), although there have been cases when only one impulse was recorded for the indicated time. In this connection, to increase the reliability of the diagnosis, the duration of the examination is set within the above limits.

Example 1 (figure 4). Patient S., woman, 51 years old. Examined on an infiltrate of the right breast. When examining our method from the brain, repeated pulse packets were recorded, indicating the presence of a malignant cancer. During examination in the projection of the affected organ, impulses characteristic of the malignant disease were also recorded. The above fragments of the study indicate the orderliness and repeatability of individual amplitude-frequency characteristics of the signals corresponding to a malignant disease with a diagnosis of breast adenocarcinoma. The diagnosis was made on the basis of a puncture of an infiltrate - breast adenocarcinoma.

Example 2 (figure 5). Patient B., woman, 43 years old. Surveyed inpatiently and operated on in the amount of uterine extirpation with appendages for uterine endometrial adenocarcinoma. The diagnosis is histologically confirmed. When examining our method from the brain, repeated pulse packets were recorded, indicating the presence of a malignant cancer. When examining a projection of a surgical suture in the area of a distant diseased organ, weak impulses characteristic of a malignant disease were also recorded. The given fragments of the study indicate the orderliness and repeatability of individual amplitude-frequency characteristics of the signals corresponding to a malignant disease with a diagnosis of uterine cancer.

Example 3 (Fig.6). Patient Z., woman, 39 years old. Breast adenocarcinoma. When examining our method from the brain, repeated pulse packets were recorded, indicating the presence of a malignant cancer. During examination in the projection of the affected organ, impulses characteristic of the malignant disease were also recorded. The above fragments of the study indicate the orderliness and repeatability of individual amplitude-frequency characteristics of the signals corresponding to a malignant disease with a diagnosis of breast adenocarcinoma. The diagnosis is confirmed by histological studies.

Example 4 (Fig.7). Patient B., female, 52 years old. Uterine fibroids. When examining our method from the brain, repeated pulse packets were recorded, indicating the presence of a malignant cancer. In the projection of the affected organ, the signals characteristic of the malignant disease are not yet recorded, which presumably indicates the earliest stage of the disease, when a benign formation has not yet begun degeneration into a malignant tumor. The given fragments of the study indicate the orderliness and repeatability of individual amplitude-frequency characteristics of the signals corresponding to a malignant disease with a diagnosis of uterine cancer.

Example 5 (Fig. 8). Patient B., female, 31 years old. Localized mastopathy on the background of diffuse fibrocystic mastopathy. Mammography revealed a nodular formation in the upper external quadrant of the left breast. When examining our method from the brain, repeated pulse packets were recorded, indicating the presence of a malignant cancer. During examination in the projection of the affected organ, impulses characteristic of the malignant disease were also recorded. The above fragments of the study indicate the orderliness and repeatability of individual amplitude-frequency characteristics of the signals corresponding to a malignant disease with a diagnosis of breast adenocarcinoma, which indicates an early stage of malignancy of a benign formation.

Example 6 (Fig.9). Patient Z., female, 48 years old. Uterine fibroids 7.5 cm, polyposis. According to the results of histological examination - glandular endometrial hyperplasia. When examining our method from the brain, repeated pulse packets were recorded, indicating the presence of a malignant cancer. During examination in the projection of the affected organ, impulses characteristic of the malignant disease were also recorded. The given fragments of the study indicate the orderliness and repeatability of individual amplitude-frequency characteristics of the signals corresponding to a malignant disease with a diagnosis of uterine cancer, which indicates an early stage of malignancy of a benign formation.

In healthy patients, these impulse groups are absent (Fig. 10). The survey results look like a solid line, due to the noise of the equipment.

To date, over 300 patients have been examined, of which about 90 people with a diagnosis of malignant cancer have been identified (the rest are either healthy or have a non-cancerous pathology). The reliability of the diagnosis is currently about 87%, and this figure has a tendency to increase, since our diagnosis (which we initially assigned to negative statistics) over time (from one month to years) is nevertheless confirmed.

Claims (1)

A method for studying the radiation of a living organism in order to diagnose carcinogenesis processes, which consists in positioning a device containing a single crystal quartz, a circular Z-slice plate on the front of the head, recording electromagnetic signals and when pulses or groups of pulses appear, the amplitude of which exceeds the amplitude level noise path, make a preliminary conclusion about the presence of the process of concertogenesis in the body, then in the second stage of the study repeat the described operations on An examination of the skin closest to the organ under examination and with repeated fixation of pulses whose amplitude exceeds the level of the noise path, clarifies the preliminary conclusion on the malignant disease of the organ under examination.

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