RU2306919C1 - Method for treating hypothalamic syndrome in girls and women - Google Patents

Abstract

FIELD: medicine, gynecology, endocrinology, homeopathy.

SUBSTANCE: one should introduce complex homeopathic preparations into acupuncture points - cerebrum-compositum, tonsilla-compositum and placenta-compositum. Moreover, injections of cerebrum-compositum should be carried out for points T14, PN45 (din-chuan'), VB21 (2), and injections of tonsilla-compositum - for points T14, VB21 (2), GI4 (2). Injections of each preparation should be carried out once-twice weekly during menstrual cycle. Injections of placenta-compositum should be carried out for points E36 (2), Rp6 (2) twice-thrice weekly during the second phase of menstrual cycle. Therapeutic course should be started on the 5^th-7^th d of menstrual cycle, each point should be injected with 0.2-0.5 ml preparation. In case of anovulatory cycles and amenorrhea it is necessary to carry out additional injections of ovarium-compositum preparation during the first phase of menstrual cycle for points E36 (2), Rp6 (2) once-twice weekly. The innovation enables to correct hormonal disorders.

EFFECT: higher efficiency of therapy.

2 cl, 2 ex

Description

The invention relates to medicine, namely to gynecology, endocrinology and homeopathy, and can be used to treat hypothalamic syndrome in women.

Hypothalamic syndrome (HS) is the most common form of endocrine-metabolic pathology, which mainly debuts in the teenage period. The average age of patients with HS is 15-17 years (Artymuk N.V., Ushakova G.A. Hypothalamic syndrome and women's reproductive health: Overview. // Obstetrics and Gynecology, 1997. - No. 4. - P.3-6 .; Kokolina V.F., Artyukova O.V., Balabanova V.A., Maksimova N.V. Diagnosis and treatment of hypothalamic syndrome in adolescent girls // Pediatrics, 1995. - No. 6. - P.50-52.) .

The urgency of the problem of hypothalamic syndromes is determined not only by its high prevalence, expressed metabolic disorders, reproductive dysfunction, but also by the complexity of therapy. Applied therapy is not always pathogenetic, well-known treatment methods do not always allow for persistent correction of hormonal and metabolic disorders, and for obesity, a stable decrease in body weight (V.F.Kokolina. Gynecological endocrinology of children and adolescents. - M., 2001. - C .89-105). This encourages the continued search for optimal treatments.

There is a method of treating HS by prescribing complex drug therapy and physiotherapy. In this case, drugs that improve microcirculation, regeneration processes, trophic processes in the cellular structures of the brain, vitamins are used, dehydrating and desensitizing therapy is carried out. From physiotherapeutic procedures, methods are used that improve blood circulation, trophic processes in the brain. To treat obesity, use fasting, exercise. To eliminate reproductive dysfunction, hormone therapy is used (Yu.I. Stroev, L.P. Churilov et al. Obesity in adolescents. - St. Petersburg, 2003. - P.161-173). This therapy requires the simultaneous administration of a sufficiently large number of medications, each of which has only a specific therapeutic effect, while the drugs generally do not have a clear etiopathogenetic focus in HS.

Drug therapy has to be carried out in long courses, which significantly increases the possibility of side effects of the drugs used. The use of hormones to eliminate menstrual dysfunction is not justified, since the reason lies in the violation of cerebral functions, and dysfunction of the ovaries - a second time. In addition, the appointment of hormone therapy increases the risk of ovarian hyperstimulation and the development of osteoporosis. The use of diet and exercise to treat obesity does not eliminate obesity in patients with HS, and without pathogenetic therapy it can even lead to a worsening of this syndrome.

Closest to the proposed is a method of treating HS, which includes the introduction of a 20% solution of piracetam at acupuncture points (AT). The course of treatment consists of 3-5 sessions of pharmacopuncture (Vogralik V.G., Runov G.P., Runova A.A. et al. Effect of pharmacopuncture on the activity of the sympathoadrenal system in patients with hypothalamic syndrome of puberty // Materials of the I European Congress on Acupuncture - Chisinau, 1994 .-- p.150).

However, this method has the following disadvantages: in the literature available to us there is information about the effectiveness of this method only for vegetative-vascular disorders. In the description of the method there is no information about the effect on the hormonal status of patients, the correction of which is most important for girls in the pubertal period, suffering from hypothalamic dysfunction with reproductive disorders. The mechanism of therapeutic effect of piracetam is to improve the blood supply to the brain and the energy processes in it, increasing the resistance of the central nervous system to hypoxia. In the pathogenesis of GS, the deterioration of the blood supply to the brain is only one of the links. In addition, piracetam can have side effects - cause irritability, increased emotional irritability, anxiety, poor sleep, dyspeptic symptoms, and sometimes distal tremor. But all these symptoms often accompany HS, and with a vegetovascular form, HS are the main complaints. Therefore, the use of piracetam is limited by the dose and number of sessions, and as you know, treatment courses for GS should be long. In connection with the above, treatment with this method of HS is not effective enough.

The aim of the invention is to increase the effectiveness of treatment.

This goal is achieved by the fact that patients with GS carry out pharmacopuncture of complex homeopathic (antihomotoxic) preparations of the Heel company (Germany). The impact is carried out on AT. They use placenta-compositum, tonsilla-compositum, cerebrum-compositum, ovarium-compositum. Injections of drugs are carried out in the following AT: T14, PN45 (Ding Chuan), VB21 (2), E36 (2), Rp6 (2), GI4 (2).

Comparative analysis with the prototype showed that the proposed method differs from the known one in that complex homeopathic preparations are used - placenta-compositum, tonsilla-compositum, cerebrum-compositum, ovarianium-compositum, which are introduced according to the proposed scheme into the proposed AT.

Thus, this method meets the criteria of the invention of "novelty."

The analysis of patent and specialized literature showed that the proposed technical solution has features that distinguish it not only from the prototype, but also from other technical solutions in this and related fields. So, the authors did not find a way to treat HS, which would include the introduction of the proposed drugs in the proposed AT. Namely, the proposed modes of the method — the combination of drugs and the regimen for their administration — made it possible to increase the effectiveness of the treatment of HS by normalizing hormonal and vegetative status, and, consequently, normalizing reproductive function.

The noted multimineral effect of the pharmacopuncture of complex homeopathic preparations can be explained from the standpoint of the unique mechanism of action of the proposed drugs and their combination, different from the known methods. The central nervous system, peripheral nervous system, protective and regulatory systems of the body take part in the implementation of the therapeutic effect. Homeopathic medicines are characterized by high therapeutic efficacy and a low level of undesirable side effects. Homeopathic medicines do not cause allergic reactions, do not lead to drug dependence.

All of the above leads to an improvement in the condition of patients with HS and the regulation of reproductive function.

This method is simple to implement, does not require any equipment and can be used in the treatment of patients with HS both in stationary conditions (in physiotherapeutic and reflexotherapy departments), and in outpatient conditions (in physiotherapy, reflexotherapy departments (offices) of clinics).

Therefore, the method meets the criteria of "inventive step" and "industrial applicability".

The method is as follows. The procedure is carried out in a prone position. Pharmacopuncture is carried out with complex homeopathic preparations of the Heel company (Germany). The course of treatment begins on the 5-7th day of the menstrual cycle, lasts 3.5-4 weeks (during the menstrual cycle). During the course of treatment, injections of the drug cerebrum-compositum in AT T14, PN45 (Ding Chuan), VB21 (2) 1-2 times a week and the preparation of tonsill-compositum in AT T14, VB21 (2), GI4 (2) 1 -2 times per week. Injections of these drugs can be carried out both simultaneously and with an interval of 1-3 days. In the second phase of the menstrual cycle, injections are made with the placenta-compositum preparation in AT E36 (2), Rp6 (2) 2-3 times a week.

With anovulatory cycles and amenorrhea, the ovarium-compositum preparation is additionally included in the course of treatment, which is administered in the first phase of the cycle (with anovulatory cycles) or the treatment course is started with this drug (with amenorrhea). The drug is administered at points E36 (2), Rp6 (2) 1-2 times a week.

Injections are performed using an insulin syringe, 0.2-0.5 ml of the drug is injected into each AT, the canonical depth of administration is before the sensations (bursting, heat, current flow) appear.

Before and after treatment, the hormonal background, indicators of vegetovascular status (CIT, EEG), and clinical symptoms were determined in patients.

Example 1. Patient Rkh Sveta, 19 years old. I was on outpatient treatment with a diagnosis of hypothalamic syndrome.

Clinically: complaints of fatigue, poor sleep, excessive sweating, general ill health, striae on the skin of the mammary glands, hips, irregular menstrual cycle (at the time of examination, the absence of menstruation for 4 months).

On examination: EEG is moderately disorganized by the slow-wave activity of the theta range. Bilateral synchronous flashes of sharp waves up to 100 mV in amplitude are recorded: Moderate diffuse changes with signs of dysfunction of the stem-diencephalic structures.

Cardiointervalography (CIT) - lying down - vagotonia, standing - aytonia. Vegetative reactivity is asymptaticotonic.

Prolactin - 920 mU / ml (norm 72-480 mU / ml); cortisol - 520 nM / l (normal 155-660 nM / l); LH - 3.3 mU / ml (normal 0.5-5 mU / ml); FSH - 7.2 mU / ml (norm 1.8-10.5 mU / ml).

A course of pharmacopuncture was carried out according to the method described above: the course of treatment lasted 4 weeks. During the course of treatment, Cerebrum-compositum was injected with AT T14, PN45 (Ding Chuan), VB21 (2) 2 times a week, and tonsill-compositum was injected with AT T14, VB21 (2), GI4 (2) 2 times a week. Injections of these drugs were performed at intervals of 1 day. During the 3rd and 4th week of the course of treatment, the placenta-compositum was injected with AT E36 (2), Rp6 (2) 3 times a week.

In connection with amenorrhea, during the first two weeks of the course of treatment, the preparation ovarium-compositum was additionally administered 2 times a week in AT E36 (2), Rp6 (2).

Injections were performed using an insulin syringe, 0.2 ml of the drug was injected into each AT, the depth of administration was canonical until a feeling of bursting, heat, and current flow appeared.

During the control examination after the end of the course of treatment:

EEG - an increase in the alpha-rhythm severity index: Light diffuse changes in the bioelectric activity of the brain.

KIT - lying, standing - eitonia, autonomic reactivity is normal.

Prolactin - 95 mU / ml; cortisol - 421 nM / l; LH - 4.8 mU / ml; FSH - 6.9 ppm / ml.

Thus, after the treatment, the patient returned to normal hormonal levels, vegetative status indicators improved, overall health improved significantly, sleep returned to normal, striae turned pale. The next menstruation came after 28 days.

After 3 months, a second course of pharmacopuncture therapy was carried out, while the course of treatment was started on the 7th day of the menstrual cycle and lasted 3.5 weeks. During the course of treatment, Cerebrum-compositum is injected with AT T14, PN45 (Ding Chuan), VB21 (2) once a week and tonsill-compositum is injected with AT T14, VB21 (2), GI4 (2) 1 time per a week. Injections of these drugs were carried out with an interval of 3 days. During the second phase of the menstrual cycle, the placenta-compositum is injected with AT E36 (2), Rp6 (2) 2 times a week.

During injection, 0.5 ml of the drug was injected into each AT, the depth of administration is canonical.

6 months after the end of the second course, you feel good, there are no pathologies detected in hormonal analyzes, a regular menstrual cycle has been established.

Example 2. Patient X-Len, 35 years old. I was hospitalized in the gynecological department of the clinic with a diagnosis of hypothalamic syndrome.

From the anamnesis: after childbirth (13 years ago) - an increase in body weight, bright pink striae on the buttocks, hips, abdomen, opsomenorrhea, and the absence of pregnancy over the past 12 years.

Clinically: excess hair growth on the body, striae, body mass index - 27, 8, according to ultrasound - anovulatory cycle.

EEG is a low-amplitude desynchronous curve with a predominance of fast rhythms. Zonal differences are smoothed: Moderately pronounced cerebral changes. Signs of dysfunction of nonspecific median brain structures.

KIT - lying - sympathicotonia, standing - sympathicotonia. Hypersympathicotonic autonomic reactivity.

Prolactin - 558 mU / ml (norm 72 - 480 mU / ml); cortisol - 423 nM / L (normal 155-660 nM / L); LH - 3.7 mU / ml (normal 0.5-5 mU / ml); FSH - 8.2 mU / ml (norm 1.8-10.5 mU / ml).

The treatment was carried out according to the method described above, while the course of treatment began on the 5th day of the menstrual cycle and lasted 3.5 weeks. Throughout the course of treatment, Cerebrum-compositum was injected with AT T14, PN45 (Ding Chuan), VB21 (2) once a week, and tonsill-compositum was injected with AT T14, VB21 (2), GI4 (2) 1 time in Week. Injections of these drugs were carried out simultaneously. During the second phase of the menstrual cycle, the placenta-compositum is injected with AT E36 (2), Rp6 (2) 3 times a week.

Additionally, during the first phase of the menstrual cycle, the preparation ovarium-compositum was used, which was introduced into AT E36 (2), Rp6 (2) once a week.

During injection, 0.5 ml of the drug was injected into each AT, the depth of administration is canonical.

During the control examination after the end of the course of treatment: overall health is satisfactory, the striae are pale.

EEG - alpha rhythm of 9-10 Hz, modulated. Zonal differences are expressed: EEG variant of the norm.

KIT - lying - eitonia, standing - sympathicotonia. Vegetative reactivity is normal.

Prolactin - 390 mU / ml; cortisol - 376 nM / l; LH - 2.8 mU / ml; FSH - 7.3 ppm / ml.

After 6 months, a second course of treatment was carried out as described above, while the course of treatment began on the 7th day of the menstrual cycle and lasted 3.5 weeks. Throughout the course of treatment, Cerebrum-compositum was injected with AT T14, PN45 (Ding Chuan), VB21 (2) 2 times a week, and tonsill-compositum was injected with AT T14, VB21 (2), GI4 (2) 2 times in Week. Injections of these drugs were carried out after 2 days. In the second phase of the menstrual cycle, injections are made with the placenta-compositum preparation in AT E36 (2), Rp6 (2) 2 times a week.

At injection, 0.3 ml of the drug was injected into each AT, the depth of administration is canonical.

On the control examination after treatment: body weight decreased by 6 kg, regular menstruation, satisfactory general condition. According to ultrasound and hormonal analyzes, no pathology was detected.

On examination after 6 months: overall health is satisfactory. Pregnancy, term 16 weeks.

This method was used to treat HS in 17 patients.

All patients achieved a therapeutic effect (improvement). Moreover, a significant improvement, i.e. complete normalization of laboratory parameters, including hormonal levels, disappearance of clinical symptoms (blanching or disappearance of striae, normalization of body temperature, decrease in body mass index, etc.), normalization of vegetative-vascular status (according to EEG, CIT) was achieved in 70.6% of patients. The duration of remission was more than 1 year. According to the prototype method, the effectiveness of the treatment consisted only of improving vegetative indicators.

The proposed method is simple to implement, does not require special equipment, can be used both monotherapy and in the complex treatment of HS. The proposed drugs do not have any side effects. The proposed method allows to increase the effectiveness of the treatment of HS, to normalize reproductive function.

Claims (3)

1. A method of treating hypothalamic syndrome in girls and women, comprising administering the drug to acupuncture points, characterized in that complex homeopathic preparations — cerebrum-compositum, tonsilla-compositum and placenta-compositum — are used as medicines, with cerebrum-compositum injections carried out at points T14, PN45 (ding-chuan), VB21 (2), and tonsill-composite injections at points T14, VB21 (2), GI4 (2), with each drug being injected 1-2 times a week for menstrual cycle, and inject placenta-compositum cells are carried out at points E36 (2), Rp6 (2) 2-3 times a week during the second phase of the menstrual cycle, with the course of treatment starting on the 5-7th day of the menstrual cycle. 2. The method according to claim 1, characterized in that, in addition, during the first phase of the menstrual cycle, ovarian-compositum is injected, which is administered at points E36 (2), Rp6 (2) 1-2 times a week. 3. The method according to claim 1 or 2, characterized in that 0.2-0.5 ml of the drug is administered at each point.