RU2284813C1 - Method for treating ocular lesions - Google Patents

Abstract

FIELD: medicine, ophthalmology.

SUBSTANCE: the present innovation deals with treating ocular lesions of different etiology. One should perform ocular instillation of preparation consisted of retinal acetate 0.01-0.001 g, ecdisterone 0.01-0.001 g, olive oil - up to 100.0 g, by 2 drops four times daily. The innovation provides stimulation of reparative processes in ocular tissues in combination with decreased inflammation and corneal edema due to optimal qualitative and quantitative composition of the preparation applied.

EFFECT: higher efficiency of therapy.

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Description

The invention relates to medicine, namely to ophthalmology.

There are many methods for treating eye lesions and the accompanying complications, including using various drugs, such as actovegin, solcoseryl, cornegel, acetone, dexamethasone, retinol, and others (1, 2), but the problem of treating such a pathology remains very relevant . The drugs used have a limited range of therapeutic effects, can cause allergic reactions, which in turn requires treatment, their reparative activity is limited, in most cases they are imported and expensive.

The purpose of the invention: the treatment of eye lesions of various etiologies by using an original preparation containing ecdysterone.

The goal is achieved by installing in the affected eyes 2 drops 4 times a day of the drug we created (ophthalmic), which has the following composition, in mass parts:

retinol acetate - 0.01-0.001 g

ecdysterone - 0.01-0.001 g

olive oil - up to 100.0 g.

To prepare the preparation, retinol acetate and ecdysterone were dissolved in aseptic conditions in sterile olive oil under heating to 50-60 ° C. The drug is slightly yellowish, odorless, neutral. Ecdysterone was obtained from the plants of the genera Smolevka, Blister, Coronaria, Tar, Lychnis, Oberna, Smolevochka and other clove families (3).

The proposed method of treatment was carried out in the form of monotherapy and complex treatment for eye burns, damage to them with chemicals, mechanical injuries and acquired keratopathies.

The drug was used in 20 patients aged 40 to 75 years.

The implementation of the method is detailed in the following examples.

Example 1. Patient P., 39 years old. Was admitted to the hospital on November 3, 2004 with complaints of low vision, photophobia, redness, and lacrimation of the right eye.

From the anamnesis:

On August 28, 2004, the patient received a burn with acetic acid of the right eye. In hospital arrived an hour from the onset of injury. Visual acuity of the right eye is 0.1 n / a, left 0.3-3d = 1.0. It was treated stationary, received anti-burn therapy. Against the background of treatment, positive dynamics were noted. At discharge, visual acuity of the right eye 0.2 n / K. Moderate mixed injection. The cornea is smooth, without defects in the epithelium.

An objective study revealed that the visual acuity of the right eye is 0.02 n / a, left 0.3-3d = 1.0. Ciliary soreness on the right, palpebral fissure narrowed, lacrimation, marked mixed injection. The cornea is thickened, swollen, dull, the surface is uneven, extensive central erosion (diameter 3 mm), newly formed vessels at the limb at 18 o'clock, going to the center, folding of the descemet shell.

Diagnosis: chemical burn of the cornea 3 degrees, uveitis, keratitis of the right eye. Epithelizing, anti-inflammatory, antibacterial therapy was prescribed (chloramphenicol, diclof, actovegin, retinol).

12 days (November 15, 2004) after the start of therapy, weak ciliary soreness, mixed injection, corneal epithelial defect (2.5 mm), edema decreased, and the folding of the Descemet sheath remains. Visual acuity of the right eye is 0.02 n / a.

Since November 16, we used ophthalmic drops 4 times a day, 2 drops each. On the 20th day of treatment, there is no ciliary soreness, a slight mixed injection, no corneal epithelium defect. In the optical zone, a gentle clouding is formed. Visual acuity of the right eye 0.04 n / a.

The patient was discharged on December 8, 2004. visual acuity of the right eye 0.04 n / a. The eye is calm, in the optical zone is blurred.

Example 2. Patient M., 70 years old. Complaints about the low vision of the left eye. Visual acuity 1 / ∞ p. 1.s. left and 0.7 right eye.

Diagnosis: mature age-related cataract of the left eye, immature cataract of the right eye. The patient underwent extracapsular cataract extraction with implantation of a posterior chamber lens on the left eye. The next day after surgery, the patient on the operated eye noted: moderate injection, the cornea is thickened, swollen. Visual acuity 0.09n / k. The patient is prescribed ophthalmic 4 times a day, 2 drops in the left eye. A day after the start of the use of the drug ophthalmic, there is an improvement in visual acuity to 02 without correction. Mixed injection less, corneal edema decreased. After 7 days of conjunctiva of normal color, the cornea is transparent, shiny, of normal thickness.

The patient was discharged 10 days after the operation, the left eye is calm, the cornea is transparent, the sharpness of the left eye is 0.7 N / K.

Example 3. Patient K., 67 years old. Complaints of low vision, more on the left eye. Visual acuity 0.2-3.5d = 0.5 right and 1 / ∞ p. 1.s. left eye.

Diagnosis: mature cataract of the left eye, immature cataract of the right eye.

The patient underwent extracapsular cataract extraction with implantation of a posterior chamber lens on the left eye. The next day after surgery, the patient on the operated eye noted: weak mixed injection, the cornea is swollen, thickened. Visual acuity 0.1 n / a. The patient was given anti-inflammatory therapy (naklof, dexazone). After two days, no positive dynamics were observed. The patient is prescribed ophthalmic 4 times a day, 2 drops in the left eye. After two days, a minor injection, corneal edema decreased. Visual acuity of the left eye 0.2 n / a.

The patient was discharged nine days after the operation, the operated eye is calm, the cornea is transparent, the visual acuity of the left eye is 0.3 N / K.

Thus, the proposed method for the treatment of eye lesions of various etiologies with ophthalmovitis allows in a short time to achieve a significant improvement in the condition of the eyes by stimulating the processes of epithelialization and repair of eye tissue, reducing inflammation and swelling of the cornea, improving its nutrition and respiration, which ultimately leads to a favorable outcome diseases, reduction of hospitalization, reduction of complications. In no case were undesirable adverse reactions detected.

Literature

1. Mashkovsky M.D. Medicines, vol. 1, 2. - M .: Medicine, 1987.

2. Reference Vidal. Medicines in Russia: A Handbook. 10th ed., Revised., Isp., Ext .- M: AstraFarmServis, 2004 .-- 1448 p.

3. Darmogray V.N. Ecdysteroids of some plant species of the family. cloves. // Resource and pharmacological study of the medicinal flora of the USSR: Scientific. tr VNIIF. - M., 1987. - T. 25. - S.111-113.

Claims (1)

A method of treating eye lesions by instilling in them 2 drops 4 times a day of a drug having the following composition, parts by weight: Retinol Acetate  0.01-0.001 g Ecdysterone  0.01-0.001 g Olive oil  up to 100.0 g