RU2283590C1 - Insecticide and acaricide formulation for mammalian - Google Patents

Abstract

FIELD: veterinary, in particular formulation for controlling of mammalian skin pests.

SUBSTANCE: claimed formulation contains (mass %): fipronil 0.3-5; methopren up to 1 %; benzylbenzoate 5-40 and balance: alcohol solvent. Formulation of present invention is useful in agriculture and treatment of domestic and wild animals, as well as treatment of apartments.

EFFECT: effective formulation for controlling of mammalian skin pests with prolonged storage time.

4 cl, 5 ex

Description

The invention relates to the field of veterinary medicine, and can be used to treat skin parasites of mammals.

The aim of the invention is an effective fight against skin parasites of mammals, especially cats and dogs. In this regard, an effective composition has been developed that acts, in particular, on such parasites as:

- cat and dog fleas (Ctenocephalides felis, Ctenocephalides sp. and others),

- ticks (Rhipicephalus sp., Ixodes sp., Dermacentor sp., Amblyomma sp. and others),

- galls (Demodex sp., Sarcoptes sp., Octodectes sp. and others).

Insects parasitizing in dogs and cats are ubiquitous. Flea-infected animals are stressed because parasite bites cause severe skin itching. At the same time, a dog or cat combes itchy areas of the skin, as a result of which abrasions, scratches appear on these places, which open the "gate" of infection. In addition, fleas are carriers of helminths - Dipylidium caninum, which parasitizes in animals and in humans.

Ectoparasites, such as ticks, cause great harm to the body of the animal. They are carriers of pathogenic factors that can affect both animals and humans. Among the main diseases that must be avoided are borreliosis (Lim disease caused by Borellia burgdorferi), and babesiellosis (or pyroplasmosis caused by Babesia sp.) And racketeziosis (called the English term "Rocky Mountain Spotted Fever"). The toxins that secrete parasites have paralyzing and inflammatory properties, causing skin damage, swelling and inflammation. Often diseases caused by ticks can be fatal. Finally, with galls, ticks that cause otodectosis, demadecosis, sarcoptosis, it is especially difficult to fight, since there are very few active substances that act on these parasites, and they require frequent treatments.

A known composition for the treatment of arachnoentomiasis containing fipronil, esfenvalerate, citric acid, polyethylene glycol and isopropyl alcohol as a solvent (patent RU 2181243 C1, published on 04/20/2002).

As a prototype, the patent of the Russian Federation 97110663 C2, published on 12/20/2000, an antiparasitic composition for the treatment and protection of animal companions of humans, containing an active insecticidal principle, a crystallization inhibitor, an organic solvent and an additional organic solvent, was selected.

In contrast to the compositions described above, the proposed insect-acaricidal composition contains fipronil, optionally metoprene, benzyl benzoate and an organic solvent, in particular polyethylene glycol. The use of benzyl benzoate in the insect-acaricidal composition, which exhibits insect-acaricidal activity and at the same time is an effective antioxidant, can significantly reduce the amount of the active insecticidal component - fipronil, as well as metoprene in a private embodiment of the invention. Benzyl benzoate is toxic to scabies mites (Acarus scabiei) and is used to treat scabies, head and scabies lice. It was unexpectedly found that benzyl benzoate, being an antioxidant, exhibits effective properties of the preservative against fipronil and metoprene, which allows for a rather long time to store the insect-acaricidal agent made on the basis of the proposed composition both in the package and during use.

In addition, a decrease in the amount of fipronil and metoprene in the proposed insect-acaricidal composition can reduce the possible adverse reactions of the body to fipronil and metoprene.

The objective of the invention is the creation of insect-acaricidal composition, which is a universal remedy against known skin parasites of mammals, cheap and effective (up to 95% are destroyed after the first application). In addition, the composition should be practical, i.e. the shelf life during storage and use of the composition is extended through the use of an antioxidant.

This problem was solved by selecting components for a composition that meets the above requirements. As an insect-acaricidal agent for mammals, a composition was developed with the following ratio of components in 100 wt.%:

Fipronil 0.3-5 wt.% Optional methoprene 0-1 wt.% Benzyl benzoate 5-40 wt.% Alcohol solvent rest.

In a private embodiment of the invention, the composition may include metoprene, which effectively acts on the larvae and prolongs the action of the composition for at least 3 months. In addition, without limiting the scope of claims, polyethylene glycol can be used as an alcohol solvent.

Examples of carrying out the invention.

Example 1. Mix 0.3 mg of fipronil, 0.25 mg of metoprene, 5 mg of benzyl benzoate, 94.45 mg of polyethylene glycol in the following ratio, wt.%:

Fipronil 0.3 Metoprene 0.25 Benzyl benzoate 5 Polyethylene glycol rest

1 ml of the composition is dripped onto the withers of a cat infected with an itch mite. After 24 hours, the veterinarian did not show signs of scabies mite on the skin of the cat. The procedure can be repeated after a week to obtain 100% of the result.

Example 2. Mix 5 mg of fipronil, 1 mg of metoprene, 40 mg of benzyl benzoate, 54 mg of polyethylene glycol in the following ratio, wt.%:

Fipronil 5 Metoprene one Benzyl benzoate 40 Polyethylene glycol rest

1 ml of the composition is dripped onto the withers of a dog infected with Ctenocephalides sp. (dog fleas). After 24 hours, the veterinarian did not find fleas on the hairline of the dog. In addition, the dog can be treated with a spray containing the specified composition.

1 ml of the composition according to the patent of the Russian Federation 97110663 dripped on the withers of a dog infected with dog fleas. The complete absence of fleas was recorded by a veterinarian after 48 hours. In addition, the secondary appearance of fleas was detected after 20 days, whereas after treatment with the claimed composition, fleas were detected only after 45-60 days.

Example 3. Mix 3 mg of fipronil, 20 mg of benzyl benzoate, 77 mg of polyethylene glycol in the following ratio, wt.%:

Fipronil 3 Benzyl benzoate twenty Polyethylene glycol rest

A spray is used to treat the skin of a horse in which mites are found. After 24 hours, there were no signs on the horse's skin indicating infection with its ticks.

Example 4. Mix 3 mg of fipronil, 20 mg of benzyl benzoate, 77 mg of isopropyl alcohol in the following ratio, wt.%:

Fipronil 3 Benzyl benzoate twenty Isopropyl alcohol rest

Spray process the skin of a dog in which ticks have been found. After 24 hours, the dog’s skin showed no signs of infection with its ticks.

Example 5. Mix 0.5 mg of fipronil, 0.03 mg of metoprene, 20 mg of benzyl benzoate, 79.47 mg of ethyl alcohol in the following ratio, wt.%:

Fipronil 0.5 Metoprene 0,03 Benzyl benzoate twenty Ethanol rest

Spray process the habitat of animals, living quarters, woolen products, carpets, etc. The presence of fleas for two months was not detected.

The technical result of the invention is to increase the effectiveness of the composition while reducing the concentration of active substances and prolonging its action. The shelf life of the drug is more than 3 years.

The presented examples cannot serve as a basis for limiting the scope of claims of the claimed invention and are only special cases of the invention.

Claims (4)

1. Insecticide and acaricidal composition for a mammal containing fipronil and an alcohol solvent, characterized in that it further contains benzyl benzoate in the following ratios of components, wt.%: Fipronil 0.3-5 Benzyl benzoate 5-40 Alcohol solvent Rest 2. Insecticide and acaricidal composition according to claim 1, characterized in that it additionally contains metoprene in an amount of up to 1 wt.%. 3. The insect acaricidal composition according to claim 1, characterized in that the benzyl benzoate in the composition is an antioxidant and an insect acaricide. 4. Insect acaricidal composition according to claim 1, characterized in that the alcohol solvent contains polyethylene glycol.