RU2283120C1 - Method for treating intestinal dysbacteriosis in peritonitis cases - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves administering Splenopid at a dose containing in standard flask of this preparation. The dose is diluted in 50 ml of isotonic sodium chloride solution and introduced into small intestine once a day. The total treatment course is 5 days long.

EFFECT: significant pathogenous strains and stimulating saprophyte flora without administering antibiotics.

Description

The invention relates to medicine and is intended for the treatment of intestinal dysbiosis that occurs with peritonitis.

A known method of treating intestinal dysbiosis, which consists in taking drugs containing lyophilized cultures of bifido and lactobacilli. (Okorokov A.N. Guidelines for the treatment of diseases of internal organs. Volume 1, p.338-339.)

The disadvantage of this method is the lack of bactericidal action of drugs against pathogenic strains. A significant portion of vegetative forms die in the acidic environment of the stomach.

There is a method of treating intestinal dysbiosis, which consists in the oral administration of broad-spectrum antibiotics (A. Okorokov, Guide to the treatment of diseases of internal organs. Volume 1, p.336-337).

The disadvantage of this method, taken as a prototype, is the development of repeated dysbiosis associated with the bactericidal action of antibiotics not only on pathogenic microorganisms but also on strains of physiological intestinal microflora, in addition, with peritonitis in patients with impaired motor activity of the gastrointestinal tract, taking drugs os os not effective enough.

The objective of the claimed invention is to provide a more effective method of treating intestinal dysbiosis with peritonitis.

The problem is solved due to the fact that according to the method of treating intestinal dysbiosis with peritonitis, including the introduction of the drug, Splenopid, a standard bottle with a dry matter content of 0.230 g, which is diluted in 50 ml of an isotonic sodium chloride solution and through a probe is used as the drug injected into the small intestine once a day for 5 days.

The advantages of this method are that not only the suppression of pathogenic strains colonizing the gastrointestinal tract occurs, but also the growth of saprophytic microflora is stimulated. The introduction of the drug through a probe prevents it from entering the stomach and contact with acidic contents. The specified method is carried out without the additional use of antibiotics, which eliminates their toxic effects. The method allows to stimulate the growth of its own saprophytic intestinal microflora, which has advantages over artificial, which is not always able to take root in the intestine with peritonitis.

Our proposed method is as follows. During the operation, the probe is carried out into the small intestine at a distance of not less than 50 cm from the ligament of Traits. Subsequently, in the postoperative period, the drug “Splenopid” is administered via a syringe using a syringe (Developed by the Research Institute of Transplantology and Artificial Organs (Moscow) A. B. Tsypin) For this, a standard bottle of the drug is diluted in 50 ml of isotonic sodium chloride solution, then injected into the probe through a syringe. The procedure is performed once a day for 5 days.

Example 1. Patient S. was admitted to the hospital with a diagnosis of Perforated ulcer of the duodenal bulb, diffuse purulent-purulent peritonitis. Operation: suturing perforation, sanitation drainage of the abdominal cavity, nasointestinal intubation. Sowing intestinal contents. An increase in staphylococcal flora was detected in an amount of 10 ¹⁴ in 1 ml of intestinal contents. The treatment was supplemented with the introduction of Splenopid. A standard bottle of the Splenopid preparation containing 0.230 g of dry matter was diluted in 50 ml of an isotonic sodium chloride solution and injected through the probe once a day for 5 days. On the second day, the restoration of peristalsis, the disappearance of bloating. The patient was transferred to enteral nutrition. The feces were taken on day 3, the growth of pathogenic microflora was not detected. The growth of bifidobacteria is determined in an amount of 10 ⁸ in 1 ml of intestinal contents.

Example 2. Patient P was admitted to the hospital with a diagnosis of Gangrenous-perforated cholecystitis, diffuse biliary peritonitis. Operation: median laparotomy, cholecystectomy debridement, nasointestinal intubation. Sowing of intestinal contents on microflora was taken; growth of protea in the amount of 10 ⁹ in 1 ml was detected. Splenopid was added to the treatment, the first standard bottle of which, containing 0.140 g of dry matter, was diluted in 43.5 ml of an isotonic sodium chloride solution, 10 ml of an isotonic sodium chloride solution was introduced into a second similar bottle, uniformly mixed and taken with a 6.5 syringe ml, then this amount of solution was added to the volume in which the first vial was diluted until a total volume of 50 ml was obtained and was administered once a day through a probe for 5 days. On the fourth day, the disappearance of nausea, vomiting, active motility was noted, there was an independent chair. Sowing feces on pathogenic microflora is negative. The growth of bifidobacteria in the amount of 10 ^{6 is} determined.

Clinical example 3

Example 3. Patient P was admitted to the hospital with a diagnosis of Gangrenous-perforated cholecystitis, diffuse biliary peritonitis. Operation: median laparotomy, cholecystectomy debridement, nasointestinal intubation. Sowing of intestinal contents on microflora was taken; growth of protea in the amount of 10 ⁹ in 1 ml was detected. In treatment, the drug "Splenopid" was used. 0.140 g of "Splenopid" contained in a standard vial was diluted in 50 ml of isotonic sodium chloride solution and was administered through the probe into the small intestine once a day for 5 days. On the fourth day, the disappearance of nausea, vomiting, active motility was noted, there was an independent chair. Sowing feces on pathogenic microflora is negative. The growth of bifidobacteria in the amount of 10 ^{6 is} determined.

Claims (1)

A method of treating intestinal dysbiosis with peritonitis, comprising administering a preparation, characterized in that "Splenopid" is used as the preparation, which is contained in a standard vial of this preparation, which is diluted in 50 ml of an isotonic sodium chloride solution and is administered once a day through the probe into the small intestine within 5 days.