RU2276986C2 - Curative-prophylactic composition possessing with general tonic and rejuvenating effect - Google Patents

Abstract

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to the development of a curative-prophylactic preparation based on vegetable and animal components with broad spectrum of the pharmacological effect. The curative-prophylactic composition possessing with the general tonic and rejuvenating effect comprises sea urchin sublimated roe, brown algae sublimated fragments from sea urchin cavities, sea urchin sublimated intracavitary liquid and sublimated laminaria chosen in the definite ratio of components. The curative-prophylactic composition is prepared in the form of powder, capsule or tablet. The preparation normalizes the metabolic processes under extreme metabolic conditions.

EFFECT: valuable medicinal properties of composition.

2 cl, 2 ex

Description

The invention relates to the creation of a therapeutic product based on plant and animal components with a wide range of pharmacological effects.

Our health is threatened by the combined effect of many factors:

environmental pollution;

the use of antibiotics;

high levels of stress;

use of alcohol, drugs;

aging etc.

Thus, it is quite obvious that it is necessary to use therapeutic and prophylactic agents that contribute to improving well-being, increasing physical and mental performance, increasing the body to adverse environmental conditions.

Recently, more and more are using products based on substances of natural origin.

Known composition (French patent No. 2676648), which includes extracts of the heart and liver of a duck. The composition is a Barbari for the prevention and treatment of infectious diseases.

Known drug from the tissues of marine aquatic organisms "Orbitar" (RF patent No. 2053779) to increase human resistance to adverse factors.

Known therapeutic and prophylactic balm Vitagen (TU 9169-010-20785204-94) containing 37 components of plant and animal origin, including ginseng, eleutherococcus, preparations from kelp, salmon milk, mummy. This tool is used in the rehabilitation of patients after various diseases, a decrease in the functions of the central nervous system, and a decrease in muscle and mental performance.

Known composition "Tinrostim-S" (RF patent No. 2105504), which contains peptides from squid ganglia, ascorbic acid and glucose. Tinrostim-C is recommended to be taken as a general strengthening and immunostimulating composition.

The known composition "ENERGOLAM PLUS" (RF patent No. 2219806) containing dried seaweed, freeze-dried caviar of sea urchins, calcium stearate and lactose. "ENERGOLAM PLUS" has a restorative and anti-aging effect, helps to restore strength after illness and previous operations, increases the body's resistance to various infections.

The objective of the present invention is to develop a new complex drug based on the biologically active substances of the sea urchin and kelp with the manifestation of an immunomodulating effect when exposed to various adverse factors on the human body.

This problem is solved as follows.

A therapeutic and prophylactic composition is proposed that has a general strengthening and rejuvenating effect, containing sublimated caviar of sea urchins, sublimated fragments of brown algae from the cavity of sea urchins, sublimated intracavitary fluid of sea urchins and sublimated sea kale in the following ratio of components, in wt.%:

freeze-dried sea urchin caviar 24-25 sublimated brown fragments seaweed from the cavity of sea urchins 24-25 sublimated intracavitary sea urchin fluid 0.3-0.4 freeze dried sea kale rest.

The treatment and prophylactic composition may be in the form of powder, capsules, tablets.

It has now been established that the main cause of many diseases is an overabundance of free oxidizing radicals. The same process occurs with the aging of the body. Free radicals primarily damage cell membranes, their lipid structures, causing a violation of homeostasis. The uncontrolled formation of free radicals is opposed by the body's defenses, as well as a number of food components: biologically valuable proteins, polyunsaturated fatty acids, vitamins A, E, C, etc., as well as a number of minerals - Ca, K, Mg, Fe, Se , Zn, J, etc.

The seafood of both plant and animal origin in terms of their chemical composition is not only unique food products, but also serves as a source of various medical and therapeutic drugs.

One of the representatives of echinoderms is a sea urchin. As a food product, it is not of interest due to its specific taste, but its caviar is very much appreciated. Sea urchin caviar is a high-quality therapeutic product. Depending on the production season, it contains 12-20% protein, 10-35% fat and up to 3.5% of minerals that have a tonic effect on the body.

Of the huge variety of macrophytes, brown algae from the kelp family are of the greatest practical interest. In Russia, two kinds of kelp are of commercial importance - Japanese kelp and sugar kelp. They are better known as sea kale. Both types of kelp are allowed and recommended for food and medical use. Seaweed tissue contains from 75 to 88% moisture and 12-25% dry matter, represented by a whole complex of various macro- and microelements, nitrogen-containing components, lipids, pigments, polysaccharides, mannitol, fiber. Of the micronutrients found in seaweed, the most interesting are iodine and selenium. Of particular interest is alginic acid present in seaweed. It is proved that she and her salts are effective enterosorbents that can bind and remove radionuclides, heavy metals and some toxins from the body.

All the ingredients that make up the composition are freeze-dried.

Freeze-drying is the drying of objects in a frozen state in a deep vacuum. With this drying method, there is no contact of the material with oxygen. Freeze-drying allows you to maximize the preservation of biologically active substances in the object.

Sublimation drying exposes caviar of sea urchins, fragments of brown algae from the cavity of sea urchins, intracavitary fluid of sea urchins and sea kale.

The invention is illustrated by examples.

All components after freeze-drying are crushed and mixed in the following ratio:

Example 1. The composition for capsules, in mg:

freeze-dried sea urchin caviar fifty sublimated brown fragments seaweed from the cavity of sea urchins fifty sublimated intracavitary sea urchin fluid 0.6 freeze dried sea kale one hundred.

Example 2. The composition for tablet, in mg:

sublimated sea urchin caviar fifty sublimated brown fragments seaweed from the cavity of sea urchins fifty sublimated intracavitary sea urchin fluid 0.6 freeze dried sea kale one hundred lactose and calcium stearate to obtain tablets weight 300 mg

Studies on volunteers made it possible to establish that this composition, unlike Energolam plus, due to the content of sublimated fragments of brown algae from the cavity of sea urchins and sublimated intracavitary fluid of sea urchins, is a much more powerful biologically active drug.

Thanks to the above new substances, the composition is able to penetrate into human cells and helps to maintain the cellular equilibrium state. It has a strong immunomodulatory effect compared with the preparation of caviar of sea urchins "Energolam plus". The immunomodulating effect of the composition is due to the ability to activate and restore the restructuring of the immune forces, the gene-binding activity of the immune system, stimulation of the B-link of lymphocytes, activation of T-hellers, etc. Activation of cells of the monocytic-macrophage system leads to an increase in the ability of phagocytes to absorb and kill microbes. At the same time, cellular immunity is activated, the ability of natural killers and antigen-specific T-killers to kill cells infected with various viruses increases.

The composition has a more powerful antioxidant property, unlike Energolam Plus, which manifests itself in the ability to remove various free radicals from the body, which reduces their negative effect on organs and tissues. The growth rate of tumors, including malignant ones, is slowing down.

The composition significantly reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs and radiotherapy, which is manifested in a decrease in cardio- and myelotoxicity of cancer patients and the stability of the therapeutic effect of the repeated course of treatment of cancer patients. Oncoprotective properties are determined by the content of the natural polysaccharide fucoidan contained in the above substances.

The proposed composition has been tested in cardiology. The intracavitary substances of sea urchins contain echinochrome, which stops the chain reactions of lipid peroxidation in cells in several ways. The drug can intercept free radicals, chelate peroxidation metal catalysts, inhibit lipoxygenase enzymes, the oxidative status of cells largely depends on their activity, and it can also be synergistically activated by plasma membrane phospholipids. All this creates an echinochrome high rating among the well-known bioantioxidants. He showed high cardiotropic properties, which served as the basis for the creation of this drug. The drug has a pronounced cardioprotective effect in acute heart failure, affects the peri-infarction zone, and in chronic coronary insufficiency, it eliminates ischemic myocardial hypocenisia.

When using the drug, the scar zone after myocardial infarction is significantly reduced. Favorably affects the walls of the vessel. The distinct therapeutic effect of the drug is universal in nature, consisting in the normalization of metabolic processes in tissues under extreme metabolic conditions.

The proposed composition has high regenerative and reparative properties, is distributed in all organs and tissues, has no side effects.

Claims (2)

1. Therapeutic and prophylactic composition having a restorative and anti-aging effect, including freeze-dried sea urchin caviar and sea kale, characterized in that it additionally contains freeze-dried brown algae fragments from the sea urchin cavity, freeze-dried intracavitary sea urchin fluid and freeze-dried sea kale in the following ratio components, wt.%: Sublimated sea urchin caviar 24-25 Sublimated fragments of brown algae from the cavity of sea urchins 24-25 Sublimated intracavitary fluid of sea urchins 0.3-0.4 Sublimated Sea Kale Rest 2. The treatment and prophylactic composition according to claim 1, characterized in that it is made in the form of powder, capsules, tablets.