RU2256445C2 - Preparation for removing emotional strain in animals - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: for the purpose to decrease emotional strain, anxiety (phobia), soften both psychic and psychological state and fear in farm animals one should apply an aqueous (80 ± 5)%-α-propylene glycol solution being of efficient tranquilizing action to provide favourable adaptation aftereffect.

EFFECT: higher efficiency of application.

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Description

The invention relates to livestock, in particular, to means for reducing emotional tension and relieving fear (anxiety) and fear in farm animals, i.e. tranquilization.

Known methods and means that act soothingly on the central nervous system to make the animal calm, serene, consisting of the use of meprotan inside for diseases of the nervous system, accompanied by increased tonus of skeletal muscles, with general excitability of the animal [1, 3, 5, 11, 13] , the use of amisil with an increase in nervous excitability [1, 2, 5, 11, 13], mebicar, meprotan, phenazepam and other agents for the prevention of stress and improved adaptation [4 - 18].

The disadvantage of the above funds is the manifestation of side effects: the development of allergic phenomena (redness of the skin, itching), decreased appetite, tachycardia, dilated pupils, dry mouth (amisil), as well as allergic symptoms of dyspepsia (nozepam), contraindications during pregnancy, acute diseases liver and kidney (chlozepide), as well as the high cost of these drugs.

The technical task of this invention is to increase the efficiency and expand the range of tools to reduce emotional tension, anxiety (fear), mitigate the mental and psychological state and fear of farm animals and develop a cheap drug for veterinary medicine and animal husbandry.

The solution to the problem is achieved by using an 80 ± 5% aqueous solution of α-propylene glycol (drug “DOL”).

It is known from the literature [19] that α-propylene glycol (PG) has bactericidal properties and is used in the form of aerosols of its aqueous solutions for air purification at food industry enterprises.

α-Propylene glycol is also used as a tool for the treatment and prevention of dyspepsia in calves, mastitis and endometritis in cows (RF patent for the invention No. 2131729).

In this case, α-propylene glycol can be used in veterinary practice as a drug to reduce emotional stress, relieve fear (anxiety) and fear in farm animals, i.e. tranquilization.

A distinctive feature is the cheapness of the drug, the absence of cumulation and the absence of side effects, a long shelf life, does not freeze during storage. The therapeutic breadth of action is great.

The preferability of the upper concentration limit of an aqueous solution of α-propylene glycol (80 ± 5%) is due to technological necessity: solutions of α-propylene glycol of the indicated concentration are more technologically advanced at the stage of special purification of the drug due to the greater mobility of the solution, which is due to a decrease in viscosity to 2.0-2, 3 MPa (versus 56.0 MPa in 100% α-propylene glycol). This is the concentration of the drug "DOL" obtained according to the technological documentation.

To produce and transport purified α-propylene glycol at a concentration of less than (80 ± 5%) is not economically feasible.

The essence of the use of DOL to reduce tension, relieve fear (anxiety) and fear in farm animals is as follows: the animal is prescribed twice daily (after 12 hours) with concentrates the drug "DOL" 80 ± 5% aqueous solution in a dose of 8 -30 ml in one dose or injected intramuscularly in the same doses before veterinary and zootechnical measures: tagging cows, calf dehydration, weighing, transporting cows and calves; castration, weaning of piglets, technological movements for the formation of new groups and other technological stresses.

Example 1. Decontamination of calves.

Clinically healthy calves of both sexes of black-motley breed at the age of 2-3 months. according to the principle of analogues, they were formed in two groups (experimental and control) with 30 goals each. The conditions of feeding, care and maintenance are the same in both groups. The calves of the experimental group 2 days before stress (thermal dehydration) for two days in the morning and evening were given a solution of the drug “DOL” with food.

The calves of the control group were given chlozepide (elenium) inside.

The condition of the calves of the experimental group after thermal dehydration is satisfactory. Appetite (feed intake) is maintained, body temperature, pulse rate, respiration were maintained within the physiological norm of 38.5 ± 0.3 ° C, 129 ± 0.2 beats. in minutes, 20 ± 0.3 resp. dv. in minutes

The average daily gain in live weight of calves of the experimental group after dehydration for 30 days exceeded 8-10% compared with the control group.

Hematological and biochemical blood tests of the experimental group of animals showed no significant changes compared with the initial data. The number of red blood cells was 6.38 ± 0.10 million / μl, leukocytes 10.3 ± 0.25 thousand / μl, hemoglobin 11.9 ± 0.3 g%, total calcium 10.4 ± 0.3 mg%, inorganic phosphorus 5.0 ± 0.3 mg%, reserve alkalinity 55 ± 0.1 vol.% CO ₂ , carotene 105 ± 0.1 μg / l, total protein 5.5 ± 0.1 g%.

Example 2. Tagging cows.

Evaluation of the effectiveness of the drug “DOL” was carried out on dairy cows of black-motley breed at the age of 3-4 years. According to the principle of analogues, two groups were formed (experimental and control) of 30 goals each. The conditions of feeding, care and maintenance were the same in both groups. The cows of the experimental group 2 days before tagging, for two days in the morning and in the evening, were given with the feed a solution of DOS of 80 ± 5%. Chlozepide was administered to cows in the control group.

When examining the clinical condition of the cows of the experimental groups, no significant changes were observed. The indicators of temperature, pulse, respiration, scar reduction and chewing gum act were within the physiological norm. In the control group, animals showed a decrease in feed intake, scar reduction was reduced to 2 in 2 minutes and 2-3 ruminant cycles in 3 minutes. The temperature in the first 3-7 hours increased to 39.7 °, the heart rate increased to 82 beats / min.

The control milking showed a decrease in average daily milk yield of cows of the control group by 0.2 l and an increase in milk yield of cows of the experimental groups per day by 0.8 l.

Hematological and biochemical changes in the blood of the experimental group of animals are within the physiological norm. In cows of the control group, a decrease in carotene to 7.15 g% and a decrease in the number of leukocytes to 6.4 thousand / μl was observed, eosinopenia was observed.

Example 3. Castration of boars.

In order to prevent exposure to the above factor, a day before the castration, experimental boars were injected intramuscularly with a drug DOL of 0.5 ml / kg. Subsequently, experimental and control piglets were followed up for three months. In 10 goals from each group, the average daily gain was determined.

In the control group of 30 animals, 10 piglets (33.3%) that were stunted were registered. The initial weight of piglets averaged 5.48 kg. In the first month of observations, the average weight of piglets in this group was 13.34 kg, in the second month - 15.44 kg and in the third - 29.17 kg.

In the experimental group of those lagging behind in growth, 2 (6.6%) were registered. The initial weight was 5.32 kg, after the first month - 14.39 kg, the second - 21.05 kg, the third - 31.54 kg. The average daily gain in the first month is 262 and 302 grams, respectively, in the second month -197 and 214 and in the third month 324 and 347 grams. The decrease in weight gain in both groups in the second month is due to weaning of piglets.

Example 4. The effect of the drug on the behavioral reactions of piglets, in particular on the ratio of sleep time and wakefulness.

2 groups of piglets were formed: experimental 40 goals and control (40 goals). In turn, each of the groups was divided into 2 subgroups of 20 goals (a subgroup of piglets with their mothers and a subgroup of weaners). The experimental group a day before weaning was injected intramuscularly with 0.5 ml / kg of the drug "DOL". Then, during the day, timing of sleep and wakefulness was carried out, the pulse rate, respiration, body temperature were determined, and sensitivity studies were carried out by conventional methods.

In the control group (those who did not receive DOL), the sleep / wake ratio was: the group of piglets with their mothers was 13 hours 35 minutes (56.6%) / 10 hours 25 minutes (43.4%). In the weaning subgroup, 13 hours (54.17%) and 11 hours (45.83%).

In the experimental group, these indicators were: in piglets under the uterus 14 hours 30 minutes (60.42%) and 9 hours 30 minutes (39.58%). In weaned piglets, respectively, 14 hours 30 minutes (59.72%) and 9 hours 30 minutes (40.28%).

These studies confirm that the drug "DOL" has an effective tranquilizing effect and provides a favorable adaptive outcome, because during sleep animals are less susceptible to stressors. This conclusion is confirmed by the fact that the average daily gain of the experimental piglets exceeded the control in the first month by 14%, the second by 8% and in the third by 7%.

Production tests of the proposed tool were carried out at MTF SPH “Barmino” in the Lyskovsky district of the Nizhny Novgorod region.

Sources of information

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Claims (1)

The use of an aqueous solution of α-propylene glycol as a means to reduce emotional stress, fear (anxiety) and fear in farm animals.