RU2253669C1 - Detergent solution with disinfecting properties - Google Patents

Abstract

FIELD: detergents.

SUBSTANCE: detergent solution suitable for use in medicine, food industry, mechanical engineering, and other industries as well as in domestic practice to treat various polluted surfaces contains 10.4-18.5% surfactant composition, including nonionic surfactant (6.8-11.7%), anionic surfactant (3.1-5.8%), and cationic surfactant (0.5-1.0%), 3.0-9.8% active cleaning additive, 0.5-6.0% disinfecting agent based on polyhexamethyleneguanidine derivatives, and solvent (the balance). Active cleaning additive comprises sodium salts of phosphoric, sulfuric, and silicic acids, and sodium carboxymethylcellulose. Cationic surfactant quaternary ammonium compound, preferably alkyldimethylbenzylammonium chloride or didecyldimethylammonium chloride. Nonionic surfactant preferably consists of mixture constituted by moistening agent, sintanol, and neonol. Anionic preferably consists of sulfanol and alkyl sulfate of primary fatty acids.

EFFECT: improved detergent and anticorrosive properties, increased fungicidal activity, and achieved high antibacterial efficacy allowing detergent solution to significantly widen activity spectrum and application area.

8 cl, 4 tbl, 4 ex

Description

The invention relates to detergents with disinfecting properties used in technological processes of sanitary, hygienic, technical processing of various contaminated surfaces, and can be used in medicine, food, engineering industry and in other areas of technology, as well as in everyday life.

A number of patents are known that offer detergents containing phosphates, sulfates, percarbonates, metasilicates, alkali metal and ammonia dioxides, sodium salts of organic acids, as well as various additives, including surfactants, used depending on the material being processed surface and pollution products.

For cleaning metal surfaces from oils, emulsions, lubricants, funds are intended according to patents of the Russian Federation No. 2169175, 2001, No. 2170630, 2001, No. 2186098, 2002, No. 2182164, 2002, No. 2194748, 2002, No. 2190011, 2002, No. 2200637,2003.

Detergents for cleaning not only metal, but polymer and ceramic surfaces are protected in patents No. 2171831, 2001, No. 2187546, 2002.

There are also a number of detergents based on a mixture of primary alcohols from C ₁₁ to C ₃₆ and their sulfates, alkoxysulfates and carboxylates (RF patent No. 2198159, 1999), oleum with maleic anhydride (RF patent No. 2185626, 2002), esters sorbitan and polyelectrolytes (RF patent No. 2193592, 2002).

For conditions with increased radioactive contamination, a detergent based on organic acids — ascorbic, citric and salicylic — is proposed (RF patent No. 2196567, 2003).

To clean automobile windows, an aqueous solution based on synthetic denatured ethyl alcohol, nonionic surfactant (nonionic surfactant), disodium salt of ethylenediaminotetraacetic acid, diethyl ether of phthalic acid (RF patent No. 2167192, 2001), as well as a solution based on methyl alcohol, containing mainly methyl alcohol with the addition of surfactants, denatonium benzonate or sucrose octaacetate (RF patent No. 2171832, 2001).

For manual and automatic washing of porcelain, ceramic, metal, crystal, glassware and household appliances, a detergent containing nonionic surfactants, urea, glycerin, wheat germ oil (RF patent No. 2198207, 2003) is proposed.

The above detergents do not have disinfecting properties and are designed to treat a certain surface. In addition, the disadvantage of using organic solvents and acids as detergents is their high fire hazard and environmental hazard both for the environment and for staff.

A number of disinfecting solutions with detergent properties are also known, which contain polyhexamethylene guanidine derivatives (PHMG), quaternary ammonium compounds (QAS), and surfactants - polyoxyethylene alkyl ethers, amines, alcohols, etc. (RF patents No. 2057596, 1996; 2147032, 2000; 2173337, 2001; 2172637, 2001; 2190426, 2002).

The indicated disinfectant-detergents are not intended for widespread use and are mainly used for medical disinfection.

Closest to the proposed is a detergent with a disinfecting effect, protected by RF patent No. 2177499, C 11 D 3/48, 1/83, A 61 L 2/18, 2001, selected by the authors as a prototype. Detergent for the prototype contains, wt.%:

Disinfectant -10-20

Surfactant -10-15

Water - the rest

The surfactant consists of nonionic surfactants - polyalkylene oxide and anionic surfactants (AAS) - sodium alkylbenzenesulfonate, in particular neonols and sulfanol.

As a disinfectant in the composition, PHMG phosphate or PHMG chloride is used. In the patent, the washing qualities of the proposed products are evaluated by the magnitude of the surface tension. But, as shown by practical tests conducted by the authors, the known tool has insufficient washing ability and has a corrosive effect on the treated metal surface. In addition, with the recommended dilution, the known agent has a limited spectrum of fungicidal activity. These shortcomings narrow the scope of the tool, especially when cleaning a metal surface from organic contaminants.

The problem to which the present invention is directed, is to increase the washing ability, the exclusion of corrosive effects on metal surfaces and the expansion of the spectrum of fungicidal activity. The next tasks are to increase the range of highly effective detergents and expand the scope of their application.

To achieve a technical result in a washing solution with disinfecting properties, including a surface-active composition of a mixture of nonionic and anionic surfactants, a disinfectant based on derivatives of polyhexamethylene guanidine and a solvent, according to the invention, the surface-active composition further comprises a cationic surfactant - a quaternary the ammonium compound and the solution additionally contains an active detergent component consisting of sodium salts f Sforno, sulfuric acid, silicic acid and sodium carboxymethylcellulose in the following ratio, wt.%:

Surfactant composition - 10.4-18.5

Including nonionic surfactant

substance 6.8-11.7

Anionic Surfactant 3.1-5.8

Cationic surfactant 0.5-1.0

Active detergent component - 3.0-9.8

Disinfecting agent - 0.5-6.0

Solvent - Other

Also, according to the invention, the nonionic surfactant consists of a mixture of DB wetting agent, syntanol and neonol.

The wetting agent DB (TU 6-02-530-90) consists of a mixture of the product of the treatment of ditretic butylphenols with ethylene oxide. Structural formula

where n is the number of bound moles of ethylene oxide.

Sintanol (TU 6-14-864-88) consists of a mixture of oxidized alcohols of the general formula RO (CH ₂ CH ₃ O) _n N.

Neonol is a mixture of ethoxylated monoalkylphenols based on propylene trimers (TU 38-103625), the structural formula is RC ₆ Н ₄ O (С ₂ Н ₄ O) _n Н, where R is a branched alkyl radical, n is the number of moles of ethylene oxide per 1 mole of alkyl phenols. Nonionic surfactants - DB wetting agent, syntanol and neonol can be used as part of a washing disinfectant solution separately or together. These substances have emulsifying and stabilizing properties and bind the contaminants released on the surface of the washing liquid, preventing them from deposition back onto the surface being cleaned. Nonionic surfactants are added to the washing-disinfecting solution in the amount of 6.8-11.7 wt.%. With smaller amounts of nonionic surfactants, the washing effect of the solution is reduced, and with large quantities, foaming increases, which complicates the practical use of the solution.

The anionic surfactant according to the invention includes sodium alkylbenzenesulfonate and primary fatty alcohol alkyl sulfates. Sodium alkylbenzenesulfonate (sulfanol) (TU 6-01-1612839-34-90) corresponds to the formula RC ₆ H ₄ SO ₃ Na, where R-CH ₃ (CH ₂ ) _n CH ₃ , n = 8-12. Alkyl sulfates of primary fatty alcohols (TU 6-14-323-76) correspond to the formula CH ₃ (CH ₂ ) CH ₂ OSO ₂ ONa. The choice of these substances is due to the fact that they, having dispersing and wetting properties, destroy solid impurities and excrete them in the washing solution. The dispersion of the solid phase of contaminants in the washing solution occurs due to the adsorption of ACAS on the particles of contaminants due to the occurrence of a proppant between the particles of contaminants. Sodium alkylbenzenesulfonate is added in an amount of 2-5 wt.%, Primary sulphates alkyl sulphates - 0.3-1.1 wt.%. The total amount of ACAS is 3.1-5.8 wt.%. With smaller amounts of anionic surfactants, the washing properties of the solution deteriorate, and with large quantities the homogeneity of the solution is violated.

ACAS are not defoamers, therefore cationic substances are added to the solution. Alkyl dimethylbenzylammonium chloride or didecyldimethylammonium chloride - quaternary ammonium compounds (QUAS) are used as cationic surfactants (CASS).

Alkyldimethylbenzylammonium chloride is available as an aqueous 50% solution (TU 2482-01213164401), the general formula is [C _n H _{2n + 1} N ⁺ (CH ₃ ) ₂ CH ₂ C ₆ H ₅ ] Cl, where n = 10-18. Didecyldimethylammonium chloride is also a 50% aqueous solution (catalog of the company "Lonza", 1998). CPAS act in the inventive solution not only as defoamers, but also as corrosion protection. In addition, HOURs have antimicrobial properties and create an additional disinfecting effect. CPAS is added to the washing-disinfecting solution in an amount of 0.5-1 wt.% (In terms of dry matter). Their introduction precisely in this quantitative range provides a reduction in foaming and a decrease in the corrosion effect on the metal surface being treated. The ratio of nonionic surfactants: anionic surfactants: the surfactant is 2: 1: (0.3-0.5).

As an active detergent component according to the invention, the claimed solution contains a mixture of sodium salts of inorganic acids, preferably sodium tripolyphosphate, sodium sulfate, sodium metasilicate, and sodium carboxymethyl cellulose.

These salts increase the washing ability, enhance complexation, increase the peptization of inorganic contaminants, and increase the pH of the washing solution.

Sodium tripolyphosphate (GOST 13493-86) is added in an amount of 1.5-6.5 wt.%, Sodium sulfate (GOST 6318-77) -1-3.5 wt.%. These substances soften the aqueous solution and exhibit an inhibitory effect due to adsorption on the surface of the processed materials and the creation of protective films on it.

Sodium metasilicate (produced in the form of liquid glass according to GOST 13078-81) is added to improve the washing properties in an amount of 0.2-0.5 wt.%. The content of sodium metasilicate in a smaller amount does not affect the washing properties of the solution, and in an amount greater than 0.5 wt.%, It is impractical, since SiO ₂ is released on the surface, which prevents cleaning.

The active detergent component also contains sodium carboxymethyl cellulose (TU 6-55-40-90) in an amount of 0.1-0.3 wt.%, Since it is in this interval that the optimal washing properties of the solution are ensured.

Compounds based on polyhexamethylene guanidine hydrochloride (PHMG) are used as a disinfecting agent. In this application, PGMG hydrochloride is used, manufactured under the brand name “BIOR-1” according to TU 9392-001-36748375-2002.

Structural formula

The total formula [C ₇ H ₁₆ N ₃ Cl] _n

The molecular weight is 5000-10000.

PHMG hydrochloride is added to the washing solution in an amount of 0.5-6 wt.%. An amount of disinfecting agent of less than 0.5 wt.% Limits the spectrum of antimicrobial and fungicidal activity, and more than 6 wt.% Leads to delamination of the solution.

As a solvent, water or a mixture thereof with ethyl, isopropyl alcohols or one of these alcohols is used at their mass ratio of 1: 1 or 9: 1, or 1: 1: 1.

If necessary, fragrance and dye are added to the washing-disinfecting solution. Natural or synthetic aromatic substances are used as perfumes - perfumes for soaps and detergents (TU 64-19-137-91, TU 10-04-16-31-87 or lemon - top, ponne - top (Reunad-Sils catalog ) in an amount of 0.01-0.1 wt.%. For staining the solution, organic acid dyes of the triphenylmethane series (TU 6-14-391-76) in an amount of 0.001-0.01 wt.% are used. For ease of use, the solution may a thickener should also be added.

The inventive washing and disinfecting solution has a set of physico-chemical properties: dissolving, wetting, anti-corrosion ability and maintains a homogeneous structure during storage. The content of the above ingredients in the solution provides a synergistic effect - their combined positive effect on the treated surface and allows us to solve the tasks: increase the washing ability, eliminate the corrosive effect on the treated surface, and give the washing solution antimicrobial and fungicidal properties.

This technical solution allows you to increase the range of detergents, expand the spectrum of their action and scope.

To obtain a washing-disinfecting solution, an important operation is the mixing of the components that make up its composition in a certain sequence, with given ratios, temperature and mixing methods.

The process of preparing a washing and disinfecting solution consists of the following steps:

1. Preparation of a surfactant composition. Alkyl sulfate of primary fatty alcohols is added to sulfanol, the mixture is triturated in a porcelain mortar, then an aqueous solution of a quaternary ammonium compound (alkyldimethylbenzylammonium chloride or didecyldimethylammonium chloride) is added, the mixture is mixed again, DB wetting agent, syntanol and neonol are added, and an ABA mixture is obtained, KP is an AP mixture, NP is obtained, and NAV is obtained. in the form of a thick pasty mass.

2. Preparation of the active detergent component. Tripolyphosphate is mixed with sodium sulfate, the mixture is triturated, sodium metasilicate and sodium carboxymethyl cellulose are added, the mixture is stirred, 1/2 of the total solvent is added and triturated.

3. The mixture of surfactants and the active detergent component are combined, thoroughly mixed and 0.25 part of the total amount of solvent is added.

4. In 0.25 parts of the total amount of the solvent, PHMG hydrochloride, perfume and dye are dissolved.

5. The mixtures prepared according to claims 3 and 4 are combined, mixed thoroughly.

The resulting washing and disinfecting solution is kept at ambient temperature for 24 hours, then diluted with water until a working solution is obtained, after which the product is ready for use. The washing ability of the claimed funds was determined not by surface tension as in the prototype, but by a special method. The tests were carried out when cleaning the surface of metal and glass plates contaminated with various substances.

For testing, two types of plates were used:

a) metal plates made of steel 3 measuring 30 x 30 mm. Crude oil contamination was applied to these plates and left for 7 days;

b) glass plates of window glass measuring 45 x 45 mm, on which the contaminant was uniformly applied from linseed oil, universal medium-melting grease, sunflower oil, oleic acid, ET-2 emulsifier, egg yolk, lanolin and water.

The plates were subjected to heat treatment at a temperature of 220 ± 3 ° C for 8 min.

The plates were weighed before application of the contaminant and after, then they were immersed in a container with a solution of detergent and kept for 5-20 minutes. Then the plates were washed with water, dried and weighed.

The washing ability (degree of purification) was determined by the formula

where P0 is the initial mass of the clean plate, g;

P1 is the mass of the plate with the pollutant, g;

P2 is the mass of the plate after processing, g.

Tests for antimicrobial activity were carried out in accordance with the instructions for determining the bactericidal properties of new disinfectants No. 739-68 of the USSR Ministry of Health. The fungicidal activity of the solution was determined by the standard method. Disks of filter paper were impregnated with a certain amount of solution, which were then placed on the surface of the agarized Chapek-Doks medium in Petri dishes (GOST 9.049-91). The fungicidal activity of the solution was determined by the radius of the zone of inhibition of fungal growth. The anticorrosive properties of the solution were determined visually by the appearance of the surface of the processed plates.

The following are examples of specific applications of the proposed cleaning and disinfecting solutions for cleaning contaminated surfaces of various materials.

Example 1. Preparation of a concentrate of detergent-disinfectant:

a) preparation of a surfactant composition

2 g of sulfanol are mixed with 1.1 g of primary fatty alcohol alkyl sulfate, the mixture is triturated in a porcelain mortar, then 1 g of a 50% aqueous solution of alkyl dimethylbenzylammonium chloride is added, the mixture is stirred and 0.5 g of DB wetting agent, 7 g of syntanol, 0.6 g are added. neonol. The mixture is thoroughly mixed;

b) preparation of the active detergent component

6.5 g of Na tripolyphosphate are mixed with 3 g of Na sulfate, the mixture is triturated, 0.2 g of Na metasilicate and 0.1 g of sodium carboxymethyl cellulose are added, the mixture is stirred, 0.25 part of water is added and triturated;

C) combine the surface-active composition and the active detergent component, mix thoroughly and add 0.25 part of the total amount of water;

g) in 0.25 parts of the total amount of water, 5 g of PHMG hydrochloride is dissolved, 0.01 g of perfume, 0.001 g of dye are added, the mixture is stirred;

e) the mixtures prepared according to paragraphs “c” and “g” are combined, mixed thoroughly.

The resulting concentrate detergent-disinfectant has the following composition, wt.%:

Sulfanol - 2

Primary fatty alcohol alkyl sulphate - 1.1

DB wetting agent - 0.5

Syntanol - 7.0

Neonol - 0.6

Alkylbenzyldimethylammonium chloride - 0.5

Tripolyphosphate Na - 6.5

Sulfate Na- 3.0

Metasilicate Na - 0.2

Sodium carboxymethyl cellulose - 0.1

PHMG hydrochloride - 5

Fragrance - 0,01

Dye - 0.001

Water - the rest

The concentrate was diluted 100 times with water and the contaminated metal plates were kept in it for 20 minutes, after which the processing quality was determined:

Washing ability - 96

Corrosion is missing

Spectrum of antimicrobial activity: E. coli, St.aureus, Ps.aeroginosa, Bacillus, Subtilis, Candida albicans, K.pheumonial.

Range of fungicidal activity (types of mushrooms):

Asperdillus, Penicillium, Alternaria, Fisarium Niger.

Example 2. The composition of the solution: 5 g of sulfanol, 0.8 g of primary fatty alcohol alkyl sulfate, 0.7 g of DB wetting agent, 6 g of syntanol, 0.1 g of neonol, 0.7 g of didecyldimethylammonium chloride, 6 g of Na tripolyphosphate, 2, 5 g of Na sulfate, 0.5 g of Na metasilicate, 0.3 g of sodium carboxymethyl cellulose, 3 g of PHMG hydrochloride, the rest is a solvent consisting of water and isopropyl alcohol in a ratio of 1: 1. The solution is prepared in the same way as in example 1.

The obtained concentrated washing-disinfecting solution was diluted 90 times and in its volume, the glass plates were processed during reciprocating movement for 5 minutes, after which the processing quality was determined:

Washing ability - 98

The spectrum of antimicrobial activity is the same as in example 1.

The range of fungicidal activity is the same as in example 1, with the addition of Chactomoiumglobosum.

Example 3. The composition of the solution: 4 g of sulfanol, 0.5 g of alkyl sulfate of primary fatty alcohols, 0.6 g of a wetting agent DB, 8 g of syntanol, 0.6 g of alkylbenzyl dimethylammonium chloride, 5 g of sodium tripolyphosphate, 3.5 g of Na sulfate, 0 , 4 g of Na metasilicate, 0.2 g of sodium carboxymethyl cellulose, 0.5 g of PHMG hydrochloride, 0.01 g of dye, 0.1 g of perfume, the rest is water and ethyl alcohol denatured in a ratio of 9: 1. The solution is prepared in the same way as in example 1.

The obtained concentrated washing-disinfecting solution was diluted 80 times and the contaminated metal plates were kept in it for 20 minutes, after which the processing quality was determined:

Washing ability - 99

Corrosion is missing

The spectrum of antimicrobial and fungicidal activities is the same as in example 1.

Example 4. The composition of the solution: 5 g of sulfanol, 0.3 g of alkyl sulfate of primary fatty alcohols, 0.3 g of a wetting agent DB, 11.2 g of syntanol, 0.2 g of neonol, 1 g of alkylbenzyldimethylammonium chloride, 1.5 g of sodium tripolyphosphate, 1 g of Na sulfate, 0.3 g of Na metasilicate, 0.2 g of sodium carboxymethyl cellulose, 6 g of PHMG hydrochloride, the rest is water, isopropyl alcohol, ethyl alcohol in a 1: 1: 1 ratio. The solution is prepared in the same way as in example 1.

The obtained concentrated washing-disinfecting solution was diluted with water 120 times and processed in its volume with reciprocating movement of the glass plate for 5 minutes, after which the quality of processing was determined:

Washing ability - 100

The spectrum of antimicrobial and fungicidal activities is the same as in example 2.

The recipes of the proposed washing and disinfecting solution are shown in table 1. The main parameters of the washing and disinfecting solutions are shown in table 2. Data on fungicidal and antibacterial activity are shown in tables 3 and 4. respectively. Comparison of the data shown in tables 1-4 showed that the claimed the technical solution allows to improve the washing properties, to provide anti-corrosion effect, to increase the fungicidal activity of the detergent and to provide high antibacterial activity, which allows no widen its spectrum of action and application.

table 2
The main parameters of washing and disinfecting solutions Examples Washing ability The processed surface The presence of corrosion 1 96 metal is absent 2 98 glass - 3 99 metal is absent 4 100 glass - Prototype 70 metal traces of corrosion Table 3
Fungicidal activity of washing disinfectant solutions Examples Types of mushrooms Aspergillus Niger, Rmm Penicilliun Chrysogenun Rmm Altemaria Altemata, Rmm Fisarium moniliforme rmm Chaetomoium globosum rmm 1 2 3 3 3 - 2 4 5 5 4 5 3 5 4 6 5 5 4 4 5 5 5 5 Prototype 1 2 2 3 2 Table 4
Antibacterial activity of washing and disinfecting solutions Type of microorganism Biocidity, mg / l Examples Prototype 1 2 3 4 E.coli 10 3 5 4 8 St. aureus 4 3 4 3 3 Ps. aeroginosa 6 6 5 6 7 Bacillus subtilis 6 7 6 6 7 Candida albicans 6 6 6 6 7 K. pheumonial 3 3 3 3 4

Claims (8)

1. A washing solution with disinfecting properties, including a surface-active composition from a mixture of nonionic and anionic surfactants, a disinfecting agent based on derivatives of polyhexamethylene guanidine and a solvent, characterized in that the surface-active composition further comprises a cationic surfactant - a quaternary ammonium the compound and solution additionally contains an active detergent component, consisting of sodium salts of phosphoric, sulfuric, silicic acids and sodium ri of carboxymethyl cellulose, in the following ratio of components, wt.%: Surfactant composition 10.4 - 18.5 including Non-ionic surfactant 6.8 - 11.7 Anionic Surfactant 3.1 - 5.8 Cationic surfactant 0.5 - 1.0 Active detergent component 3.0 - 9.8 Disinfecting agent 0.5-6.0 Solvent Else 2. A washing solution according to claim 1, characterized in that the nonionic surfactant consists of a mixture of a wetting agent DB, syntanol and neonol. 3. The washing solution according to claim 1, characterized in that the anionic surfactant consists of a mixture of sulfanol and alkyl sulfate of primary fatty acids. 4. The washing solution according to claim 1, characterized in that as the cationic surfactant use alkyldimethylbenzylammonium chloride or didecyldimethylammonium chloride. 5. The washing solution according to claim 1, characterized in that sodium tripolyphosphate is preferably used as sodium salt of phosphoric acid, sodium sulfate is preferably used, sodium sulfate is used, and silicic acid is sodium metasilicate. 6. A washing solution according to claim 1, characterized in that water or its mixture with an alcohol component is used as a solvent. 7. A washing solution according to claim 6, characterized in that isopropyl alcohol, denatured ethyl alcohol or a mixture of alcohols are used as the alcohol component. 8. The washing solution according to claim 1, characterized in that the solution additionally contains perfume and dye in quantities, wt.%: Fragrance 0.01-0.1 Dye 0.001-0.01