RU2253360C2 - Method for carrying out biological tissue edema monitoring - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves measuring specific electric resistance of biological tissue using electrode device to estimate edema degree from specific electric resistance variation pattern. Canal is built before taking measurements in biological tissue to place and fix there an electrode unit. The canal is formed by creating organ wall fold and fixing the edges. The electrode unit has rope composed of four flexible current-conducting wires, each being connected in series to four biologically inert ring-shaped electrodes mounted on the rope. External wires are current-operating wires and internal ones are measuring wires. Distance between current-operating electrodes is 2-4 times as large as examination depth. Distance between measuring electrodes is not greater than 1/3 of the distance separating the current-operating ones.

EFFECT: enhanced effectiveness of monitoring.

2 cl, 3 dwg

Description

The invention relates to medicine, veterinary medicine and biology and can be used to study the course of the inflammatory process.

It is known that its specific electrical resistance depends on the degree of saturation of water (edema) of biological tissue. Thus, by measuring the electrical resistivity, one can judge the degree of edema of biological tissue.

A known method of monitoring the inflammatory process, which consists in passing an electric current through a sample of a biological fluid, measuring changes in the interelectrode potential, recording work spent on electrochemical reactions in a sample (RF Patent No. 2033606, IPC G 01 N 33/48).

The disadvantage of this method is the inability to continuously monitor the state of biological tissue. In addition, the method does not allow to determine the degree of edema of deep-lying biological tissues and internal organs.

A known method for determining the prevalence of peritonitis (RF Patent No.2006034, IPC G 01 N 33/483), in accordance with which the specific conductivity of the parietal peritoneum is measured by applying a four-electrode probe to the organ, current is passed through the extreme electrodes and the voltage drop between the middle electrodes is measured.

However, the method does not allow continuous monitoring of the state of biological tissues.

Closest to the technical nature of the present invention is a method for monitoring the resistivity of biological tissues and a device for its implementation (RF Patent No. 2056791, IPC A 61 V 5/05, A 61 H 39/02), in accordance with which the measurement of electrical resistivity carry out a matrix electrode head containing n-electrodes, on the current electrodes of which a current is supplied from a current source, stable and programmable, and information is taken from potential electrodes, and measurements are performed, the last Switch the direction of current between the electrodes carefully.

The disadvantages of this method include the need to use additional devices for pressing the matrix electrode head to the biological tissue under study, the inability to monitor the electrical resistivity of the internal organs in the depth of the tissue array.

The objective of the invention is to monitor the degree of edema of deep-lying biological tissues and internal organs.

The problem is solved in that in a method for monitoring the degree of edema of biological tissues, including measuring the electrical resistivity of biological tissue with an electrode device, and determining the degree of edema by the nature of the change in the value of specific resistance, according to the invention, a channel is formed in the biological tissue before measurement, and fix the electrode device.

In addition, to measure the degree of edema of biological tissues of hollow organs, the formation of the channel is carried out by creating a fold of the organ wall and fixing its edges.

The invention is illustrated by drawings, where figure 1, 2 shows the placement of the electrode device in the formed channel, and figure 3 is a General view of the electrode device.

The positions in the drawings indicate:

1 - array of fabrics

2 - channel

3 - electrode device

4 - nodal seam

5 - wall of a hollow organ

6 - fold

7 - harness

8, 11 - current electrodes

9, 10 - measuring electrodes

The method is as follows (figure 1): in the parenchymal organ or tissue array 1, a channel 2 is formed into which the electrode device 3 is immersed for monitoring the electrical resistivity. To prevent the electrode device from falling out, it is fixed with a nodal seam 4. In the case of measuring the electrical resistivity of the hollow organs (Fig. 2), a fold 6 is formed in the wall of the latter, into which the electrode device is immersed. The fold is fixed with interrupted sutures, thereby simultaneously fixing the latter.

To implement the method, an electrode monitoring device can be used (Fig. 3), which is a bundle 7 of four flexible current conductors, each of which is connected to ring electrodes 8-11 sequentially located on the bundle, made of a biologically inert material. The shape of the electrodes ensures their uniform contact with the studied biological tissue. External electrodes 8, 11 are current, internal 9, 10 are measuring, equidistant from current. The distance between the current electrodes, as a rule, is 2-4 times greater than the estimated depth of the study, and the distance between the measuring electrodes is not more than 1/3 of the distance between the current.

The measurements are carried out as follows. A potential electric current of 1 is applied to the electrodes 8 and 11. A potential difference ΔU is taken from the electrodes 9 and 10. The calculation of electrical resistivity is carried out according to the formula:

where ρ is the electrical resistivity,

ΔU is the potential difference at the electrodes 8 and 11,

I is the current strength on the electrodes 9 and 10,

k is the installation coefficient calculated by the formula:

where L ₈₉ is the distance between the electrodes 8 and 9,

L ₈₁₀ - the distance between the electrodes 8 and 10,

L ₉₁₀ - the distance between the electrodes 9 and 10.

The positive effect of the proposed method is the ability to monitor the degree of edema of biological tissues, including those located in hard-to-reach areas. The method simplifies the procedure for attaching the electrode device and allows you to securely fix it.

Claims (2)

1. A method for monitoring the degree of edema of biological tissues of hollow organs, including measuring the electrical resistivity of biological tissue with an electrode device and determining the degree of edema by the nature of the change in the value of resistivity, characterized in that before measurement in the biological tissue, a channel is formed in which the electrode device is placed and fixed , while the formation of the channel is carried out by creating a fold of the organ wall and fixing its edges. 2. The method according to claim 1, characterized in that the electrode device comprises a bundle of four flexible current conductors, each of which is connected in series with four ring electrodes located on the bundle made of a biologically inert material, of which the external are current and the internal are measuring while the distance between the current electrodes is 2-4 times greater than the depth of the study, and the distance between the measuring electrodes is not more than 1/3 of the distance between the current.

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