RU2245676C1 - Method for predicting human functional cerebral asymmetry pattern - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: method involves determining prognostic parameter values like those of lung ventilation function after spoken rational and irrational test texts. Three values are calculated from the obtained data using linear classification functions. They are compared and functional cerebral asymmetry pattern is to be predicted from their values.

EFFECT: high accuracy and reliability of prognosis.

Description

The invention relates to the field of physiology, namely to psychophysiology, and is intended to objectify an individual profile of the functional asymmetry of the human brain.

Under the profile of functional asymmetry of the brain, we understand the combination of many signs of functional inequality of the arms, legs, and also the right and left halves of the body and face in the formation of the overall motor activity of a person, as well as the uneven perception of objects located to the right and left of the middle plane of the body. Functional asymmetry is one of the internal determinants of human brain activity, reflecting the process of bilateral regulation - the functional specialization of the hemispheres of the human brain. Distinguish between left hemisphere, right hemisphere and equisymmetric profiles of the functional asymmetry of the brain.

A known method for determining the profile of functional asymmetry of the human brain using tests to determine the leading right (left) eye, ear, leading right (left) arm, leg or their sensory and motor symmetry, followed by calculation of the coefficient of functional asymmetry according to the formula (according to N.N. Bragin and T.A. Dobrokhotova).

The main disadvantages of this method are the subjective nature of the assessment of various parameters in the absence of clear objective criteria. This circumstance is the reason for the low accuracy of the forecast profile of the functional asymmetry.

The aim of the invention is to increase the objectivity and accuracy of forecasting the profile of the functional asymmetry of a person.

This goal is achieved by determining the values of the prognostic parameters of the ventilation function of the lungs after pronouncing rational and irrational text tests, using the obtained values of the indicators to calculate the three integral indicators Y1, Y2 and Y3 by linear classification functions, comparing them with each other and predicting the profile by their value functional asymmetry of the brain.

The method of the invention is implemented in a certain sequence of actions in two stages. At the first stage, the necessary quantitative information about the object under study is obtained, at the second stage, calculations are carried out according to the test data obtained (according to linear classification functions) of the modules of integral indicators characterizing the state of the brain as a single functional system.

Each profile of functional asymmetry of the brain is characterized by its own value of the modulus of the integral indicator. The degree of functional asymmetry of the brain is directly dependent on this value.

The prognosis of the profile of functional asymmetry of the human brain is based on the values of the parameters of the ventilation function of the lungs, recorded, for example, on the Eton apparatus (Russia) after the subjects spoke text tests (rational and irrational) that most significantly reflect the phenomenon being studied (test texts in Appendix 1) . The parameters of the ventilation function of the lungs are recorded in subjects immediately after reading aloud the texts, first rational, then irrational (on average, 1 minute each). Between the stages of pronouncing both texts, a pause of 5 minutes is made in order to exclude the trace “layering” of the previous study on the next.

For men, such parameters recorded after pronouncing a rational text are: the maximum volumetric rate at the time of exhalation of the first 25% of the volume of the FVC in l / s (V1); maximum volumetric velocity at the time of exhalation of the first 50% of the volume of FVC in l / s (V3); the average volumetric velocity at the time of exhalation between 75% and 85% of the volume of FVC in l / s (V5); total time for exhalation of FVC in s (V7); time required to reach peak expiratory flow rate in s (V9); maximum volumetric velocity at the time of inspiration of the first 50% of the volume of FVC in l / s (V12); tidal volume in l (V14) and after speaking an irrational text: maximum volumetric velocity at the time of exhalation of the first 25% of the volume of the FVC in l / s (V2); the average volumetric velocity at the time of exhalation between 25 and 75% of the volume of FVC in l / s (V4); the average volumetric velocity at the time of exhalation between 75 and 85% of the volume of FVC in l / s (V6); total time for exhalation of FVC in s (V8); time required to reach peak volume expiratory flow rate in s (V10); peak inspiratory volumetric rate in l / s (V11); maximum volumetric velocity at the time of inspiration of the first 50% of the volume of FVC in l / s (V13); tidal volume in l (V15).

For women, such parameters recorded after pronouncing a rational text are: maximum volumetric velocity at the time of exhalation of the first 25% of the volume of the VFJ in l / s (V2); maximum volumetric velocity at the time of exhalation of the first 75% of the volume of FVC in l / s (V4); average volumetric velocity at the time of exhalation between 25 and 75% of the volume of FVC in l / s (V6); the average volumetric velocity at the time of exhalation between 75 and 85% of the volume of FVC in l / s (V8); time required to reach peak volume expiratory flow rate in s (V10); peak volume inspiratory velocity in l / s (V12) and after speaking an irrational text: peak volume exhalation velocity in l / s (V1); maximum volumetric velocity at the time of exhalation of the first 25% of the volume of FVC in l / s (V3); maximum volumetric velocity at the time of exhalation of the first 75% of the volume of FVC in l / s (V5); average volumetric velocity at the time of exhalation between 25 and 75% of the volume of FVC in l / s (V7); the average volumetric velocity at the time of exhalation between 75 and 85% of the volume of FVC in l / s 0/9); time required to reach peak volume expiratory flow rate in s (V11); peak inspiratory volumetric rate in l / s (V13); maximum volumetric velocity at the time of inspiration of the first 50% of the volume of FVC in l / s (V14); tidal volume in l (V15).

According to the obtained indicators, three integral indicators Y1, Y2 and Y3 are calculated according to linear classification functions:

- for men

Y1 = -540 + 26.03V1 + 28.55V2-42.42V3-5.80V4 = 59.67V5 = 22.31V6 = 193.06

V7 + 135.26V8-90.41V9 + 472.97V10 ++ 309.72V11 + 11.90V12-301.61V13-

68.20 V14 + 154.26 V15;

Y2 = -581.46 + 31.97V1 + 24.36V2-52.74V3-1.83V4 + 65.76V5 + 21.03V6 + 209.95V7 + 132 08V8-

50.78V9 + 476.38V10 + 301.50V11 + 16.07V12-294.31V13-68.90V14 + 154.30V15-

-10.2 V16 + 11.8 V17-5.9 V18;

Y3 = -637.99 + 18.31V1 + 35.57V2-32.52V3-

11.62V4 + 62.88V5 + 24.14V6 + 177.01V7 + 180.05V8-

111.65V9 + 446.66V10 ++ 344.65V11 + 3.52V11 + 3.52V12-329.26V13-79.34V14 + 167.43V15.

- for women

Y1 = -30.10 + 3.97V1 + 14.75V2-2.71V3 + 12.44V4-5.86V5-

17.65V6 + 2.77V7 + 0.58V8 + 0.64V9 + 103.52V10 + 3.02V11-388V12 + 6.31V13-2.56V14- 7.07 V15;

Y2 = -50.63 + 20.93V1 + 24.68V2-20.63V3 + 25.56V4-11.65V5-

38.79V6 + 17.13V7-6.29V8-1.58V9 + 256.63V10-35.17V11-

13.59; V12-30.82; V13 + 43.67; V14-12.56; V15;

Y3 = -39.45 + 19.74V1 + 20.56V2-19.32V3 + 20.96V4-18.61V5-

51.53 V6 + 15.61 V7-1.08 V8 + 1.32 V9 + 173.60 V10-26.44 V11-

5.65V12 + 10.77V13-5.79V14-11.26V15.

When evaluating each subject, a comparison is made of the obtained values of Y1, Y2 and Y3. For example, if the value of Y1 is the largest, then the test subject is assigned to the left hemisphere, if the value of Y2 is the largest, to the right hemisphere, if Y3 is to the equisymmetric profile of the functional asymmetry of the brain.

Example 1. Test V-v, 23 years. The parameters of the ventilation function of the lungs were recorded on the Eton apparatus (Russia) after speaking text tests (rational and irrational) to determine the profile of the functional asymmetry of the brain using a mathematical model. The calculations established the values of the integral indicators: Y1 = 446.84: Y2 = 423.63; Y3 = 439.69. The integral index Y1 was of maximum value, which corresponded to the left hemisphere profile of the functional asymmetry of the brain.

Example 2. The test R-va, 24 years. The parameters of the ventilation function of the lungs were recorded on the Eton apparatus (Russia) after speaking text tests (rational and irrational) to determine the profile of the functional asymmetry of the brain using a mathematical model. The calculations established the values of the integral indicators: Y1 = 35.07; Y2 = 29.29; Y3 = 48.19. The integral value Y3 was of maximum value, which corresponded to the equisymmetric profile of the functional asymmetry of the brain.

The proposed method allows you to objectively predict the profile of the functional asymmetry of the brain and can be recommended for use in practical psychophysiology.

Annex 1

Text 1

The macro and microworld are two specific areas of objective reality, differing in the level of structural organization of matter. The sphere of macroscopic phenomena is the ordinary world in which a person lives and acts (planets, earthly bodies, crystals, etc.). A qualitatively different region is represented by the microworld (atoms, nuclei, elementary particles, etc.), where the size of objects is less than billionths of a centimeter, and time intervals of the order of billionths of a second, i.e. not directly observable. Each of these worlds is characterized by a peculiar structure of matter, spatio-temporal and causal relationships, patterns of motion. So, in the macrocosm, material objects have a pronounced discontinuous, corpuscular, or continuous, wave nature, and their movement obeys the dynamic law of classical mechanics. The phenomena of the microworld, on the contrary, are characterized by a close relationship between the particle and wave properties, which finds its expression in the statistical laws of quantum mechanics.

Text 2

The irreplaceable modality of the visible. At least, if not more, my eyes speak my mind. I am here to read the marks of the essence of things: all these algae, fry, incoming tide, that rusty boot. Green, silver blue, rusty, colored marks. The limits of transparency. But he adds - in bodies. It means that the body, he learned before that color. How? And having hit a head about them, as yet. Caution. He was bald and a millionaire, the teacher of those who know. The limit of transparent c. Why in? Transparent, opaque. Where the whole five crawls through, this is the gate; where not, the door. Close your eyes and watch. Open your eyes. Not. Lord If I fall off a formidable cliff hanging over the sea, I will fall irrevocably. I move well in the dark. An ash sword is on its side. Tap it - they do it. My legs in his shoes and his trousers are one after another. The sound is solid - hammered by the hammer of the demiurge of Los. Do I walk along the shore of Sandimount for eternity? Crupcrack, creak creak. Seashells, natives money. Now open your eyes. I open it. Wait a minute. What if everything disappeared during this time? I will open everything and end up forever in the opaque black. Pipes! I can see - I will see. Well, look. It was in place and without you; and abides.

Sources of information

1. Bragin NN, Dobrokhotova T.A. Functional asymmetries of a person. - M.: Medicine. - 1988.

2. Lavrova OV, Pyatin V.F. Guide to practical exercises in psychophysiology. - Samara., IWF “SMS”. - 1999.

Claims (1)

A method for determining the profile of functional asymmetry of the brain, including calculating according to test studies, characterized in that they determine the values of the parameters of the ventilation function of the lungs after pronouncing rational and irrational texts, while after pronouncing a rational text for men, they determine: - the maximum space velocity at the time of exhalation of the first 25% of the volume of FVC in l / s (VI), - the maximum space velocity at the time of exhalation of the first 50% of the volume of the FVC in l / s (V3), - the average space velocity at the time of exhalation between 75% and 85% of the volume of the FVC in l / s (V5), - total time for exhalation of FVC in s (V7), - the time required to achieve the peak volume expiratory flow rate in s (V9), - the maximum volumetric velocity at the time of inspiration of the first 50% of the volume of FVC in l / s (V12), - tidal volume in l (V14); for women: - the maximum space velocity at the time of exhalation of the first 25% of the volume of the FVC in l / s (V2), - the maximum space velocity at the time of exhalation of the first 75% of the volume of the FVC in l / s (V4), - the average space velocity at the time of exhalation between 25% and 75% of the volume of the FVC in l / s (V6), - the average space velocity at the time of exhalation between 75% and 85% of the volume of the FVC in l / s (V8), - the time required to reach the peak volume expiratory flow rate in s (V10), - peak volumetric inspiratory velocity in l / s (V12); after pronouncing an irrational text is determined for men: - the maximum space velocity at the time of exhalation of the first 25% of the volume of the FVC in l / s (V2), - the average space velocity at the time of exhalation between 25% and 75% of the volume of the FVC in l / s (V4), - the average space velocity at the time of exhalation between 75% and 85% of the volume of the FVC in l / s (V6), - total time for exhalation of FVC in s (V8), - the time required to reach the peak volume expiratory flow rate in s (V10), - peak volumetric inspiratory velocity in l / s (V11), - the maximum volumetric velocity at the time of inspiration of the first 50% of the volume of FVC in l / s (V13), - tidal volume in l (V15); for women: - peak volume expiratory flow rate in l / s (V1), - the maximum space velocity at the time of exhalation of the first 25% of the volume of FVC in l / s (V3), - the maximum volumetric velocity at the time of exhalation of the first 75% of the volume of FVC in l / s (V5), - the average space velocity at the time of exhalation between 25% and 75% of the volume of the FVC in l / s (V7), - the average space velocity at the time of exhalation between 75% and 85% of the volume of the FVC in l / s (V9), - the time required to reach the peak volumetric expiratory flow rate in s (V11), - peak volumetric inspiratory velocity in l / s (V13), - the maximum volumetric velocity at the time of inspiration of the first 50% of the volume of FVC in l / s (V14), - tidal volume in l (V15); according to the obtained indicators, three integral indicators Y1, Y2 and Y3 are calculated according to linear classification functions, for men: Y1 = -540 + 26.03V1 + 28.55V2-42.42V3-5.80V4 = 59.67V5 = = 22.31 V6 = 193.06 V7 + 135.26 V8-90.41 V9 + 472.97 V10 + + 309.72 · V11 + 11.90 · V12-301.61 · V13-68.20 · V14 + 154.26 · V15; Y2 = -581.46 + 31.97V1 + 24.36V2-52.74V3 = 1.83V4 + 65.76V5 + + 21.03 V6 + 209.95 V7 + 132.08 V8-50.78 V9 + 476.38 V10 + + 301.50V11 + 16.07V12-294.31V13-68.90V14 + 154.30V15- -10.2 V16 + 11.8 V17-5.9 V18; Y3 = -637.99 + 18.31V1 + 35.57V2-32.52V3-11.62V4 + 62.88V5 + 24.14 V6 + 177.01 V7 + 180.05 V8-111.65 V9 + 446.66 V10 + + 344.65V11 + 3.52V11 + 3.52V12- -329.26V13-79.34V14 + 167.43V15. for women: Y1 = -30.10 + 3.9V1 + 14.75V2-2.71.3 + 12.44V4-5.86V5- 17.65V6 + 2.77V7 + 0.58V8 + 0.64.9 + 103.52V10 + 3.02V11 -388 V12 + 6.31 V13-2.56 V14-7.07 V15; Y2 = -50.63 + 20.93V1 + 24.68V2-20.63V3 + 25.56 = V4-11.65V5- -38.79V6 + 17.13V7-6.29V8.58V9 + 256.63V10-35.17V11- -13.59 V12-30.82 V13 + 43.67 V14-12.56 V15; Y3 = -39.45 + 19.74V1 + 20.56V2-19.32V3 + 20.96V4-18.61V5- -51.53V6 + 15.61V7-1.08V8 + 1.32V9 + 173.60V10-26.44V11- -5.65V12 + 10.77V13-5.79V14-11.26V15 and at the highest value of Y1, the left hemisphere is determined, at the highest value of Y2, the right hemisphere, and at the highest value of Y3, an equal-symmetric profile of the functional asymmetry of the brain.