RU2243152C2 - Xenon hexafluoride-boron trifluoride complex preparation method and utilization thereof - Google Patents

Abstract

FIELD: inorganic synthesis.

SUBSTANCE: xenon hexafluoride-boron trifluoride complex is prepared by fluorination of xenon difluoride in anhydrous hydrogen fluoride with gaseous fluorine at 298-373K into xenon hexafluoride, which is then complexed with boron trifluoride at 298K and molar ratio 1:2.2:1, respectively. Xenon hexafluoride-boron trifluoride complex can also be prepared in xenon tetrafluoride/anhydrous hydrogen fluoride system via fluorination with gaseous fluorine at 298-373K into xenon hexafluoride, which is then complexed at 298K and molar ratio 1:1.2:1, respectively. Complexation of xenon hexafluoride with boron trifluoride is further possible in anhydrous hydrogen fluoride at 298K and molar ratio 1:1. Above-indicated complex and compositions based thereon are used for preparing disinfection, sterilization, and detoxification agents, in sanitary and industrial hygiene, as food additives, in cosmetics, in broad-spectrum pharmaceutical compositions as well as for assisting in reuse of wastes. Pharmaceutical compositions contain xenon hexafluoride-boron trifluoride complex in the form of aqueous solution and are administered orally, by irrigation, inhalation, or application on damaged sites. When in use, all agents do not emit toxic gases and do not form toxic degradation products in disposal of venomous and especially toxic substances, in particular in reuse and detoxification of toxic emissions.

EFFECT: extended assortment of useful various-purpose inorganic agents, especially in disinfection, sterilization, and detoxification fields.

12 cl, 4 tbl

Description

The invention relates to methods for producing a complex of xenon hexafluoride with boron trifluoride; using it and compositions based on it as a means for disinfecting, sterilizing detoxification, with the aim of destroying pathogenic and conditionally pathogenic microorganisms, chemical toxic substances and poisons of organic and inorganic origin in the environment, as an antiseptic, for destroying or suppressing the life of potentially dangerous for the health of humans and animal microorganisms in wounds, on the skin, in the mucous membranes and cavities, in order to treat and prevent the development of infection ny processes; the use of the aforementioned agents and, based on them, various compositions as means for the disposal of waste and therapeutic agents of a wide spectrum of action.

The prior art.

A method of obtaining a complex of xenon hexafluoride with boron trifluoride

A known method of synthesis of a complex of xenon hexafluoride with boron trifluoride (XeF ₆ · BF ₃ ) in high pressure autoclaves at 50-100 atm in systems Xe-F ₂ -BF ₃ , XeF ₂ -F ₂ -BF ₃ and XeF ₆ -BF ₃ in temperature ranges 298-573 K (the Dissertation of candidate of chemical science Krasulina SV Synthesis of complex inorganic fluorine-containing oxidizing agents. Moscow, 1997, p.90-105). The limiting stage of the process is the stage of xenon hexafluoride formation. XeF ₆ · BF ₃ complex or XeF ionic compound $\genfrac{}{}{0ex}{}{\text{+}}{\text{5}}$ Bf $\genfrac{}{}{0ex}{}{\text{-}}{\text{4}}$ formed during the cooling of the reactor with the yield of the target product 55-92%. The disadvantage of the existing method for the synthesis of compounds XeF ₅ ⁺ BF $\genfrac{}{}{0ex}{}{\text{-}}{\text{4}}$ are high pressure and temperature synthesis.

Disinfectants and sterilizers.

Known chemical disinfectant and sterilizing halogen-containing compounds, which in their composition as the active active substance (ADV) have chlorine, bromine, iodine. For example: Chloramines B, HB, D (Russia), Technical calcium hypochlorite (Russia), Dibasic salt of calcium hypochlorite (Russia), Chloric lime (Russia), Lidos-20, 25 (Russia), Givelles (France), Maranon X ( Finland), Sporox (Russia), Trichlorol (Germany), Aquatabs (Ireland), Deochlor - tablets (France), Javelion (France), Clor-Clip (Ireland), Clorcept 7, 17, 87 (Ireland), Presept (USA) ), Purgevel - tablets (France) and others (The team of authors. Handbook of a practical doctor. Bacterial, serum and viral therapeutic and prophylactic drugs. Al disinfection and sterilization regimes of polyclinics - St. Petersburg: Foliant, 1998, pp. 424-424 [1]. These drugs have the widest spectrum of antimicrobial activity, relatively quick action, are inexpensive, but some of their properties make it difficult to limit the use of these drugs For example: corrosion of instruments, irritating effect on the mucous membranes of the respiratory system and eyes, sharp unpleasant odor, discoloration of tissues. Solutions, for example sodium hypochlorite, are stable for 1-7 days and receive them on special non-diaphragm units. When working with Sporox, Clorcept, THCC (trichloroisocyanuric acid), chloramines, mandatory use of rubber gloves, airtight goggles and respirators is required. The shelf life of almost all drugs rarely exceeds more than 3 years.

Chemical disinfecting and sterilizing oxygen-containing substances are known. This group of drugs, the active substance (ADV) of which is oxygen in the composition of hydrogen peroxide, peroxide compounds and peroxyacids. For example: Peroximed (Russia), Peramin (Russia), Desoxon 1,4 (Russia), Orotol Ultra (Austria), Perform (Germany), Secusept-Pulver (Finland), Dismozon pur (Germany) and others [1]. These drugs have a wide spectrum of antimicrobial action, do not have pungent odors, and are environmentally friendly. Some preparations have sporocidal properties, but their use as sterilants is limited by the corrosive effect on metals (6% solution of H ₂ O ₂ ). The disadvantages of some preparations of this group include the need to observe special precautions when preparing working solutions from a concentrate. When disinfecting and sterilizing by irrigation, rubber gloves, airtight goggles and a respirator should be used. Veks Side (USA), Dytsid 4, 5 (USA), Germasept plus (England), Viamond U 40 K (Poland), Microbic Forte (Germany), Septodor (Israel), Sokrena (Germany), Dulbak DTB / L ( France), Septabic (Israel) and others [1]. All preparations have good detergent properties and are intended for disinfection in case of bacterial infections, the preparations lack pungent odors, they have a low level of toxicity. The disadvantages of drugs of this group include the complete absence of a sporocidal effect and the fact that with prolonged use, the resistance of microorganisms to them can be developed.

Chemical disinfecting and sterilizing agents (guanidines) are known, the active principle of which are complex organic compounds such as chlorophenyldiguanidohexane or cocospropylene diamine guanidine acetate. Guanidines are active against gram-positive and gram-negative microorganisms, with the exception of mycobacterium tuberculosis. Guanidines do not show activity against viruses, spores. The expansion of the spectrum of antimicrobial activity occurs with the combination of guanidines with surface-active substances (surfactants). On this basis, drugs Demos (Russia), Katasept (Russia), Lysoformin special (Germany), Lysetol AF (Germany), Plivacept 5% with surfactants (Germany), Plivacept 5% without surfactants (Germany) and others are produced [1].

Of interest are the preparations Fogucid and Polisept (Russia), which on the treated areas create a film that provides a long bactericidal effect from 3 to 7 days. However, due to the formation of a film, these drugs cannot be used to disinfect instruments, utensils, and can be used as aerosols.

Chemical disinfectants and sterilizing aldehyde-containing agents are known whose active ingredient is glutaral or succinic aldehyde.

Known chemical disinfectants and sterilizing agents based on glutaraldehyde, for example, an aqueous composition containing glutaraldehyde, as well as sodium bicarbonate and sodium hydrogen phosphate, are used to create a pH 7-9 buffer in the initial solution (EP 66759, 1982). These products are used for disinfection and sterilization of laboratory equipment, hospital walls, surgical or dental instruments and have complex compositions. Solutions containing 2% glutaraldehyde at pH 5.6-9.0 are a universal disinfectant and sterilizing agent that destroys spores, viruses, fungi and bacteria (RU 2036664). Preparations of this group have a wide spectrum of antimicrobial action: bactericidal, tuberculocidal, virucidal, fungicidal, and in concentrations of 2% and higher on glutaraldehyde - and sporocidal action. Known drugs: Bianol (Russia), Glutaral, N (Russia), Aldezan-2000 (Germany), Gigasept FF (Germany), Deconex-50 FF (Switzerland), Soluble Dulback (France), Coldspor (USA), Sidex (USA) ), Microcid (Germany), Septodor forte (Israel), Secusept forte (Finland) and others [1]. The positive qualities of aldehyde-containing preparations are: the absence and low corrosion against metals, the absence of pungent odors (with the exception of formalin).

The disadvantages of this group of drugs are the need to work with them in the absence of patients and a pronounced ability to fix organic pollution: blood, mucus, pus, etc.

Known chemical disinfectant and sterilizing agents based on ethanol, propanol, isopropanol (alcohols). For example, for the disinfection of medical devices and endoscopes, ethyl alcohol of 70% (Russia) is used, which has a bactericidal (except for mycobacterium tuberculosis), virucidal effect. Known drugs: Atmosteril aerosol (France), Bacillol plus (Germany), Grotanat (Germany), Incidurspray (Finland), FD-322 (Germany), Deconex Solarsept (Switzerland) and others [1]. These preparations are widely used for disinfecting various surfaces and tools and, as a rule, are ready for use in the form of solutions or in the form of aerosol cans. The disadvantage of this group of drugs is the ability to fix organic contaminants, which, ultimately, requires preliminary washing of surfaces and products in water with the help of various tampons.

Known chemical disinfectants and sterilizing phenol-containing agents. These include Lizol (Russia), Chlorbetanaphthal (Russia), Amocid (Germany), Amocid-2000 and others [1]. The drugs have bactericidal, tuberculocidal, virucidal and fungicidal properties. However, phenol-containing agents are not widely used in disinfection practice, since phenol is banned as a disinfectant for use due to its high toxicity and persistent smell.

It is known to use for disinfecting surfaces contaminated with a vegetative or spore form of microorganisms in the medical, microbiological or food industry means based on an aqueous solution of sodium perxenonate (SU 1755801). However, the use of these funds according to the developed methods, at high concentrations of sodium perxenonate, is largely limited due to their toxicity (at concentrations of 5% and above).

Antiseptic agents.

It is known that the chemical structure of all antiseptics are classified into: 1. Halogens and their organic and inorganic derivatives. 2. Inorganic and organic acids and their derivatives. 3. Hydrogen peroxide and potassium permanganate. 4. Aldehydes. 5. Alcohols. 6. Heavy metals and their organic and inorganic salts. 7. Dyes. 8. Phenol and its derivatives. 9. 8-hydroxyquinolines. 10. 4-quinolones, quinoxalines, naphthyridines. 11. Nitrofuran antiseptics. 12. Sulfanilamide antiseptics. 13. Imidazole antiseptics. 14. Quaternary ammonium compounds and their analogues. 15. Derivatives of aryl and alkyl sulfones and their analogues. 16. Higher fatty acids. 17. Antiseptics of plant and animal origin. 18. Antibiotics of antiseptic origin. 19. Immobilized antiseptics (Krasilnikov A.P. Handbook of antiseptics. - Minsk: Higher school, p.67 [2].

Among antiseptics, hydrogen peroxide, potassium permanganate and halogens have an oxidizing mechanism of action. The oxidation of the organic substances of a microbial cell by antiseptics obeys the general laws explained by the peroxide theory of oxidation. At the first stage of the chain reaction, oxygen is disconnected from the antiseptic, its activation, as well as the formation of intermediate peroxide products: • OH, • O ₂ H and others that carry a higher electrochemical potential than oxygen. At the second stage, activated oxygen and intermediate oxidizing agents interact with reactive groups of chemical compounds of the microbial cell, as a result of which complete destruction of the molecules occurs or salt-forming or non-salt-forming target analogs are formed that are not capable of performing the functions inherent in the initial compound. The change in the target, as a rule, is of a slightly specific and irreversible nature, therefore, the antiseptic oxidizing agents are characterized by a microbicidal effect. All types of microbes contain a significant amount of macromolecules that easily react with oxidizing agents, which determines a wide range of their antimicrobial effects.

One of the most popular antiseptics of this group is hydrogen peroxide. Hydrogen peroxide introduced into living tissues quickly decomposes under the influence of tissue catalase into water, molecular oxygen and peroxide ions. In inflamed, infected tissues, this process is already very intense (a catalase molecule decomposes 10 ⁵ H ₂ O ₂ molecules in 1 second at pH 6-8) and is enhanced by microbial catalases, phonols, iron, copper, manganese and their bivalents present in the exudate ions, ascorbic acid released into the exudate during the breakdown of red blood cells, white blood cells, microbes, or contained in lymph and blood plasma. In the presence of ascorbic acid and phenols, as well as other hydrogen donors, catalase manifests itself as peroxidase, that is, it breaks down H ₂ O ₂ into water and atomic oxygen, which has a higher redox potential than O ₂ .

The negative sides of H ₂ O ₂ are the instability of aqueous solutions, short duration of action, decrease or loss of activity at pH above 10 and below 4 in the presence of cyanides, azides, sulfites, thiosol and its analogues.

Potassium permanganate has an even more pronounced oxidative activity. In the presence of oxidizable organic substances in an acidic environment, manganese passes from heptavalent to divalent (at alkaline pH to tetravalent) with the release of atomic oxygen, which oxidizes the compounds that make up the surface structures of the microbial cell, and sometimes the patient’s tissues.

High oxidizing properties have antiseptics of a halogen nature. Their activity decreases with increasing molecular weight: fluorine, chlorine, bromine, iodine.

When combined with hydrogen, halogens form hydrogen halides, with metals - halides. Halogens do not directly combine with oxygen; during indirect reactions, they form unstable oxides (HClO ₃ , HClO ₄ , HBrO ₃ , HJO ₃ , HJO ₄ · 2H ₂ O and others) and their salts. All of these compounds are strong oxidizing agents, since free halogens and oxygen are easily released. Halogen ions and compounds that do not release free halogen do not possess oxidizing properties.

The mechanism of oxidation of organic substances by halogens proceeds in the form of the following chain reaction (for example, chlorine):

Cl ₂ + H ₂ O → HCl + Hcl; 2CHlO → 2CHl + O ₂ .

In approximately the same way, oxygen is released from hypochlorites of potassium, sodium and chloramines. The oxidation of organic substances by liberated oxygen occurs according to the same scheme as the oxidation by oxygen of H ₂ O ₂ .

The release of oxygen by inorganic halogen compounds occurs quickly, which causes damage not only to microbes, but also to the patient’s tissues. Therefore, organic chlorine compounds (chloramines) and hypochlorous acid salts (chlorites), which release oxygen more slowly, are used as antiseptics. In iodine and its complex salts with polymers (iodophors), oxygen is released even more slowly and over a long period. Therefore, while maintaining the high oxidizing properties of iodophors, their side effect on the human body is weaker, which makes iodophors one of the most effective antiseptics available.

The following antiseptics are known: Alinaderm (Austria), Alinoman (Austria), Aseptinol (France), AXO-2000-Special (Germany), Gibitan 2.5 alcohol (England), Degimicide (Russia), Decosept (Switzerland), Kutasept G ( Germany), Kutasept F (Germany), Manopronto (USA), ND-410 (Germany), Octeniman (Germany), Plivacept 5% concentrate with surfactant (Croatia), Plivacept 5% concentrate without surfactant (Croatia), Sagrosept (Germany) , Softamon (Germany), Ethyl alcohol 70% (Russia), Spitaderm (Finland), Tincture painted dodecept (USA), Colorless dodecept tincture (USA) and others (2), adjo Life 25.

A well-known drug, boric acid (Acidum boricum), which is used as an antiseptic in the form of ear drops (3% boric alcohol), 5-10% ointments, powders, 0.5-5% aqueous solutions. Boric acid preparations are used for dermatitis, diaper rash, shallow burns, acute otitis media, chronic tonsillitis, purulent conjunctivitis, etc. Recently, a critical attitude to boric acid has been growing. Some pharmacopoeias excluded it from the list of drugs recommended for use in medicine (p. 86) [2].

Known drug based on sodium hypochlorite (Natrii hypochloritum), aqueous solutions of which at a concentration of 2-5% are recommended for washing the vagina, oral cavity, nose and pharynx with bacterial, viral and fungal diseases. Sodium hypochlorite accumulates in the skin and causes irritation of the mucous membranes and skin (p. 96) [2].

Known drugs based on hydrogen peroxide, which are available in the form of three drugs:

1. A solution of hydrogen peroxide concentrated 27.5-31% aqueous solution.

2. A solution of hydrogen peroxide 3% (contains 10 g perhydrol, 0.05 g antifebrin - stabilizer, up to 100 ml of water).

3. Hydropyrite.

Hydrogen peroxide has an almost universal antimicrobial effect, is well tolerated by the skin and mucous membranes, does not accumulate in the body with prolonged use, does not have toxic and allergenic effects, has additional therapeutic effects, such as mechanical cleaning of the application site, deodation, stimulation of blood supply and tissue regeneration. At the same time, a preparation based on hydrogen peroxide quickly decomposes in the light when interacting with metals, organic substances, and alkalis. In addition, there has recently been a decrease in the background sensitivity of microorganisms to hydrogen peroxide and the appearance of bacterial variants resistant to this drug. This is due to the selection of active producers of catalase (p. 104-105) [2].

A known drug based on peracetic acid, which has a microbicidal effect on gram-positive and gram-negative bacteria, mycobacteria, bacterial spores, fungi, some viruses, including hepatitis C pathogens. In the form of soap 2% or solutions 0.3-0.5% is recommended for preventive antiseptics in surgery, dentistry, urology, dermatology. However, the antimicrobial activity of the drug is significantly reduced in the presence of proteins, blood. In experiments on animals revealed a general toxic, mutagenic and teratogenic effects (p. 105-106) [2].

Known drug antiformin (Antiforminum), consisting of a mixture of equal volumes of sodium hypochlorite solution and 15% potassium hydroxide solution. Due to the content of free chlorine (about 5%) it has a microbicidal effect on a wide range of microorganisms. Antiformin is used as an antiseptic in the form of 1-50% solutions for the treatment of local pathological processes, especially in dentistry (with ulcerative stomatitis and gingivitis). The mechanism of action and toxicity is similar to chlorine (p. 70) [2].

The well-known drug Hydroperitum (Hydroperitum), consisting of hydrogen peroxide and urea, is available in tablets of 1.5 g, which has a wide spectrum of antimicrobial action. Apply instead of hydrogen peroxide in the form of a 3% freshly prepared solution for rinsing the mouth, pharynx, flushing cavities, wounds. The antimicrobial effect of 0.25-1.0% solutions is doubtful, hygienic - doubtless (p. 76) [2].

Inorganic iodine preparations are known:

1) 5% alcohol solution of iodine;

2) 10% alcohol solution of iodine.

Solutions are used as an antiseptic in the hygienic and surgical treatment of hands, the surgical field, to prevent infection of minor damage to the integrity of the skin, as well as an irritating and distracting agent. Both solutions in repeated applications can cause toxic or allergic skin damage (p. 83) [2].

A known solution of lugol (Solutio Lugoli), which is used in chronic inflammatory processes of the nose, nasopharynx, larynx (p. 83) [2].

(2). Organic iodine preparations are known which are less toxic and allergenic. These drugs include iodotrichloride, iodotribrom, diiodhydroxypropane, iodoform, as well as a large group of iodophors.

The antimicrobial activity of iodophors is associated with the presence of ionized (I $\genfrac{}{}{0ex}{}{\text{-}}{\text{3}}$ ), not molecular iodine. In contrast to molecular ionized iodine does not have a general toxic effect, while preserving antiseptic. The disadvantages of iodophore preparations are the possible emergence of resistant forms of bacteria and microbial contamination of finished dosage forms (p. 83) [2].

The known drug is potassium permanganate (Permanganas kalii), which is used as an antiseptic in the form of aqueous solutions for washing wounds (0.1-0.5%), for lubricating ulcerative and burn surfaces (2-5%), rinsing the mouth and pharynx (0 , 01-0.1%), antiseptic baths for newborns. Disadvantages: potassium permanganate solutions stain linen and dressings, absorption into the blood causes methemoglobinopathy (p. 85) [2].

The general toxic effect is found in a large number of antiseptics. It usually develops as a result of prolonged use of antiseptics and is in the nature of a chronic lesion. Here are some examples of the general toxic effects of antiseptics borrowed from the works (Kramer A., Gruschel D., Heeg P. Mutary. Acute Toxizitdt von Antiseptika, Berlin, 1985, Bd. 1/5, S.211-278).

Mercury, lead, and bismuth preparations are toxic to the liver and kidneys. Boron and its compounds, especially boric acid, have the properties of cumulation, cause reversible and irreversible lesions, up to death. The use of boric acid is contraindicated in newborns. With prolonged use of quinolines, reversible and irreversible dysfunctions of the nervous system are possible. Chlorhexidine is a non-toxic drug, but when large quantities enter the blood, damage to the vestibular apparatus is possible. Furazolidone when administered orally can cause agranulocytosis. Prolonged intake of iodine causes resorptive intoxication, iodoform - psychasthenic phenomena, potassium permanganate - psychological and neurological disorders. This medication is contraindicated in pregnancy. Menthol may cause the development of methemoglobinemia. Nalidixic acid is potentially neurotoxic; nausea, vomiting, insomnia, and leukemia are also possible. In experimental studies, weak mutogenic activity was found in hydrogen peroxide, hypochlorides. In experiments, teratogenic activity was established in iodine, carcinogenic activity of high doses was detected in formaldehyde.

When using a solution of furatsilin for prolonged washing with extensive wounds, resorptive lesions in the form of polyneuropathies, allergic lesions were observed.

Biologically active additives.

Known biologically active substances used in cosmetics for preserving food, for storing transplants in medicine, as well as as food additives.

So, to increase the shelf life of bran, it is known to use a natural antibiotic, propolis water, as a biologically active substance (RU 2065272).

A known composition for preserving fruits, vegetables and other food products during transportation and storage, made on the basis of alkali metal pyrosulphates. To prevent oxidation, an inhibitor from the class of alcohols, for example, methol or hydroquinone, is added to the composition in an amount of 0.01-0.05 wt.% (RU 93013746).

It is known to introduce as a preservative into sausages a concentrate of microbiologically hydrolyzed fermented milk whey enriched with sodium and / or ammonium lactates (RU 96114818).

A biologically active substance with antimicrobial, phagocytic, mitotic and antioxidant activity is known, which is obtained by extraction of the corresponding plant materials with oil and distilled water, followed by the combination of extracts (RU 2008913).

A biologically active substance with antimicrobial, phagocytic, mitotic and antioxidant activity is known, which is a collection of herbs (in%): wormwood, St. John's wort, thyme, yarrow, celandine, licorice root, pine buds, mint leaf, marigold flowers (RU 2115425 )

Known food biologically active additive, which as an immunobiological preparation contains recombinant α ₂ -interferon and acidophilus bacteria as bacteria of normal microflora (RU 2144294).

Known biologically active additive that contains silver ions dissolved in alcohol-containing solutions, and which can be used in the manufacture of food products, therapeutic drugs, alcoholic, low alcohol and non-alcoholic products, as well as perfumes and cosmetics. The additive has an antiseptic, wound healing, antiviral effect, improves hematopoietic and metabolic processes (RU 2138183).

A well-known cosmetic cream is an emulsion gerontological cream containing a base and, as a biologically active substance, the sodium salt of DNA obtained from sturgeon milk. In addition, it has antiherpetic, anti-inflammatory, hydrant, photoprotective and antioxidant effects (RU 2032397).

Known hair balm, including a biologically active substance - chitosan and flozalizin and structure-forming substances (RU 2034532).

A preventive hygienic antiherpetic cream is known in which sodium foscarnet and calendula or celandine oil extract are used as the biologically active substance (RU 95118080).

It is known to use coumarinquinolone carboxylic acids of biologically active substances as antimicrobial, antitumor and antiviral agents (RU 97113254).

It is known to use indenoilguanidine for the preservation and storage of transplants for surgical procedures (RU 96107258).

It is known to use amniotic fluid of women in labor for the preservation of transplants (RU 2053671).

Disposal and detoxification of toxic organic and inorganic substances and industrial waste.

Known treatment of domestic wastewater containing toxic impurities in an amount significantly higher than the MPC, chemical reagents (RU 2019529).

It is known to use nitrogen, sulfur, carbon oxides and organic toxic substances for cleaning liquid, gas, and granular media, oxidizing toxicants with ultraviolet radiation in the presence of a chemical agent in an excited state (RU 2115463).

Known utilization of nitrogen-containing liquid rocket fuels by introducing them into the builder (RU 93043275).

Effective chemical methods of water purification are known: methods of chlorination, ozonation and fluorination (Orlov V.A. Ozonation of water. - M .: Stroyizdat, 1984; Magaro Yasumoto, RZhKhim, 1989, N9, I 309; Zisk J. Water Eng. And Manag 1988, v. 135, N5, p. 28). However, when water is chlorinated, noticeable amounts of chlorohydrocarbons are formed (including dioxin derivatives, which are very harmful to public health. MPC = 10 ^-13 mg / l). It would seem that the methods of ozonation and fluorination are promising, because their use destroys harmful impurities in industrial wastewater (Naidenko V.V., Kulakova A.P., Sherenkov I.A. Optimization of the treatment of natural and wastewater. - M .: Stroyizdat, 1984), destroys toxic dyes (Krasnoborodko I .G. Destructive wastewater treatment from dyes. - L .: Chemistry, 1988]. At the same time, ozone is unstable and easily decomposes during storage, and fluorine is extremely reactive (toxic and dangerous to use), often reacts with water and organic substances with an explosion, both oxidizing agents are toxic (MPC = 0.1 mg / l) and an explosion dangerous (gas mixtures of ozone and fluorine should be used in concentrations of less than 15% (vol.). Diluted gas mixtures of ozone with air are unstable, and the ozone content in them decreases during storage (for example, at a temperature of 20 ° C it decomposes by 40% in 10 hours ). The bottleneck in the process of ozonation and fluoridation of water is the hardware design of the unit for mixing ozone and fluorine with water. A large difference in the specific gravities of water and air leads to rapid separation, high surface tension of the water creates an obstacle for a sufficiently fine dispersion rgirovaniya gas (Razumovskiy SD, ZHVHO, 1990, T.35, N1, str.77-88) that does not provide a sufficiently complete and efficient use of ozone and fluorine.

Pharmaceutical Compositions

Chemicals are known - oxidizing agents and superoxidizing agents, which are used as modern therapeutic agents in modern medicine. For example, hydrogen peroxide (H ₂ O ₂ ), sodium hypochloride (NaClO), ozone (O ₃ ), potassium permanganate.

Hydrogen peroxide (Н ₂ О ₂ ) at the beginning of the century was actively used as an antiseptic and a therapeutic agent with a wide spectrum of action (Ulyam Douglas. The healing properties of hydrogen peroxide. Piter Publishing House, 1998). Currently, hydrogen peroxide is used to sterilize the skin of the hands of medical staff (RU 2021820), to treat trophic ulcers complicated by microbial eczema (RU 2065304), to treat chronic pyococcal leg ulcers (RU 94016146), as well as to obtain physiologically activating water (RU 94003510). In the United States, hydrogen peroxide is used mainly as a component of contact lens disinfectants, skin and hair care products, and is part of toothpastes, as well as contraceptives to prevent infection of a woman from a sexual partner. Ingestion of hydrogen peroxide-containing products is used to accelerate the removal of ethanol from the body (US 5759539). The limited use of hydrogen peroxide as a therapeutic agent with a wide spectrum of action is explained by the fact that superoxide radicals (• О ₂ Н) appear during its dissociation, the action of which leads to the loss of blood ferrooxidase activity (A. Kozlov et al. Bulletin of experimental biology and medicine , 1984, No. 12, pp. 669-671). In experimental studies (E. Gebhard, Mutagenildt von Antiseptika. Berlin, 1985, Bd. 1/5, S. 279-326), mutagenic activity of hydrogen peroxide was established.

An aqueous solution of sodium hypochlorite (NaClO) is another oxidizing agent that is used in medical practice as a therapeutic agent for a wide range. It is used to treat patients with obesity (RU 2008905), purulent sinusitis (RU 2014816), rosacea and acne vulgaris (RU 2014838, RU 2019192), obliterating diseases of the lower extremities (RU 2014848), pyoderma (RU 2029552), chronic purulent endobronchitis (RU 2070045), non-specific lung diseases (RU 2071774, RU 2085196), meningococcal infection (RU 2077330), chronic generalized viral infection (RU 2089194), surgical infection (2091078), peritonitis (RU 2123361), acute cholangitis (RU 94001617), endometritis after cesarean section (RU 94007071), inflammatory diseases of the internal sex female organs (RU 96100310), pre- and proliferative diabetic retinopathy (RU 96117517). Sodium hypochlorite is also used as an immunosuppressive agent (RU 2058146), for the prevention of non-inhalation anesthesia complications (RU 2043125), correction of blood gas composition (RU 2062101), plasma regeneration after plasmapheresis (RU 2033190), and purification of the dialysis solution in artificial kidney devices ( RU 93046072). In the United States, sodium hypochlorite is used moderately enough to rinse the mouth and treat the bad smell (US 5738840), purify water from infection (US 5688515), and also deactivate HIV infection in the blood and deactivate anticancer drugs (US 5811113). The use of sodium hypochlorite as a therapeutic agent of a wide spectrum of action is more convenient, however, this salt is chemically unstable and should be used immediately after it is received in the electrolyzer. In addition, sodium hypochlorite can lead to chlorination of amino groups, amino acids with the formation of unstable chloramines, which are then spontaneously decarboxylated and deaminated.

Ozone (O ₃ ), as a medicine, is actively used in medicine for the ozonation of drugs, blood plasma, donated blood and the patient’s blood itself for the treatment of various diseases. Ozonation of drugs is used to treat fungal and viral skin diseases (RU 2008898), purulent wounds (RU 2068263), pulmonary tuberculosis (RU 2085218), gastric and duodenal ulcers (RU 2098099), diphtheria (RU 2099110), inflammatory periodontal diseases ( RU 2123319), bronchial asthma (RU 93014294), sepsis (RU 94002980), diabetes mellitus (RU 94005363), neurodermatitis (RU 94026137), toxic diphtheria (RU 95109747), gunshot wounds (RU 95121676) and flu (RU 97103156). Saline ozonation is used to treat critical ischemia of the lower extremities (RU 2085218), OPT - gestosis of pregnant women (RU 2110228), autonomic dystonia syndrome (RU 2124356), non-gestational pregnancy (RU 93033734), trophic ulcers (RU 96122385) and malignant neoplasms ( RU 96124167). Ozone is also used: as a stimulator of liver regeneration (RU 94008835), to increase the health of the body (RU 94008836), detoxify the body (RU 94017960, RU 96100223) and correct its condition (RU 96122812). In the United States, ozone is widely used as a broad-based therapeutic agent for treating skin diseases (US 4196726, US 5834031), purifying blood from microbial infections (US 4632980, US 5622848, US 5674537, US 5731008), as well as protecting platelets from aggregation and stimulation of the immune system of the human body (US 5591457). The use of ozone as a therapeutic agent with a wide spectrum of action has a significant drawback, which requires the use of special equipment for ozonizers and oxygen generators, as well as equipment for the Clip (Ireland), Clorsept 7, 17, 87 (Ireland), Presept (USA), Purgevel - tablets (France) and others (Handbook of a practical doctor. Bacterial, serum and viral therapeutic and prophylactic drugs. Allergens. Disinfection and sterilization regimes of polyclinics. Authors. - St. Petersburg: Foul ant, 1998, str.423-424 [1]). These drugs have the widest spectrum of antimicrobial activity, relatively quick action, inexpensive. But some of their properties force to limit the use of these drugs. For example: corrosion of instruments, irritating effect on the mucous membranes of the respiratory system and eyes, a sharp unpleasant odor, and discoloration of tissues. Solutions, for example sodium hypochlorite, are stable for 1-7 days and receive them on special non-diaphragm units. When working with Sporox, Clorcept, THCC (trichloroisocyanuric acid), chloramines, mandatory use of rubber gloves, airtight goggles and respirators is required. The shelf life of almost all drugs rarely exceeds more than 3 years.

Chemical disinfecting and sterilizing oxygen-containing substances are known. This group of drugs, the active substance (ADV) of which is oxygen in the composition of hydrogen peroxide, peroxide compounds and peroxyacids. For example: Peroximed (Russia), Peramin (Russia), Desoxon 1,4 (Russia), Orotol Ultra (Austria), Perform (Germany), Secusept-Pulver (Finland), Dismozon pur (Germany) and others [1]. These drugs have a wide spectrum of antimicrobial action, do not have pungent odors, and are environmentally friendly. Some drugs have sporocidal properties, but their use as sterilants is limited by the corrosive effect on metals (6% solution of H ₂ O ₂ ). The disadvantages of some preparations of this group include the need to observe special precautions when preparing working solutions from a concentrate. When disinfecting and sterilizing by irrigation, rubber gloves, airtight goggles and a respirator should be used.

Known chemical disinfectants and sterilizing agents based on quaternary ammonium compounds (QAC) and amphoteric surface-active compounds (surfactants). For example: Catamine A6 (Russia), Veltolen (Russia), Alaminol (Russia), Amfolan (Russia), Vex-Side (USA), Daytsid 4, 5 (USA), Germasept plus (England), Viamond U 40 K (Poland ), Mikrobik Forte (Germany), Septodor (Israel), Sokrena (Germany), Dyulbak DTB / L (France), Septabik (Israel) and others [1]. All preparations have good detergent properties and are intended for disinfection in case of bacterial infections, the preparations lack pungent odors, they have a low level of toxicity. The disadvantages of drugs of this group include the complete absence of a sporocidal effect and the fact that with prolonged use, the resistance of microorganisms to them can be developed.

Chemical disinfecting and sterilizing agents (guanidines) are known, the active principle of which are complex organic compounds such as chlorophenyldiguanidohexane or cocospropylene diamine guanidine acetate. Guanidines are active against gram-positive and gram-negative microorganisms, with the exception of mycobacterium tuberculosis. Guanidines do not show activity against viruses, spores. The expansion of the spectrum of antimicrobial activity occurs with the combination of guanidines with surface-active substances (surfactants). On this basis, drugs Demos (Russia), Katasept (Russia), Lysoformin special (Germany), Lysetol AF (Germany), Plivacept 5% with surfactants (Germany), Plivacept 5% without surfactants (Germany) and others are produced [1].

Of interest are the preparations Fogucid and Polisept (Russia), which on the treated areas create a film that provides a long bactericidal effect from 3 to 7 days. However, due to the formation of a film, these drugs cannot be used to disinfect instruments, utensils, and can be used as aerosols.

Chemical disinfectants and sterilizing aldehyde-containing agents are known whose active ingredient is glutaral or succinic aldehyde.

Known chemical disinfectants and sterilizing agents based on glutaraldehyde, for example, an aqueous composition containing glutaraldehyde, as well as sodium bicarbonate and sodium hydrogen phosphate, are used to create a pH 7-9 buffer in the initial solution (EP 66759, 1982). These products are used for disinfection and sterilization of laboratory equipment, hospital walls, surgical or dental instruments and have complex compositions. Solutions containing 2% glutaraldehyde at pH 5.6-9.0 are a universal disinfectant and sterilizing agent that destroys spores, viruses, fungi and bacteria (RU 2036664).

Preparations of this group have a wide spectrum of antimicrobial action: bactericidal, tuberculocidal, virucidal, fungicidal, and in concentrations of 2% and higher on glutaraldehyde - and sporocidal action. Known drugs: Bianol (Russia), Glutaral, N (Russia), Aldezan-2000 (Germany), Gigasept FF (Germany), Deconex-50 FF (Switzerland), Soluble Dulback (France), Coldspor (USA), Sidex (USA) ), Microcid (Germany), Septodor forte (Israel), Secusept forte (Finland) and others (1). The positive qualities of aldehyde-containing preparations are: the absence and low corrosion against metals, the absence of pungent odors (with the exception of formalin).

The disadvantages of this group of drugs are the need to work with them in the absence of patients and a pronounced ability to fix organic pollution: blood, mucus, pus, etc.

Known chemical disinfectant and sterilizing agents based on ethanol, propanol, isopropanol (alcohols). For example, for the disinfection of medical devices and endoscopes, ethyl alcohol of 70% (Russia) is used, which has a bactericidal (except for mycobacterium tuberculosis), virucidal effect. Known drugs: Atmosteril aerosol (France), Bacillol plus (Germany), Grotanat (Germany), Incidurspray (Finland), FD-322 (Germany), Deconex Solarsept (Switzerland) and others [1]. These preparations are widely used for disinfecting various surfaces and tools and, as a rule, are ready for use in the form of solutions or in the form of aerosol cans. The disadvantage of this group of drugs is the ability to fix organic contaminants, which, ultimately, requires preliminary washing of surfaces and products in water with the help of various tampons.

Known chemical disinfectants and sterilizing phenol-containing agents. These include Lizol (Russia), Chlorbetanaphthal (Russia), Amocid (Germany), Amocid-2000 and others [1]. The drugs have bactericidal, tuberculocidal, virucidal and fungicidal properties. However, phenol-containing agents are not widely used in disinfection practice, since phenol is banned as a disinfectant for use due to its high toxicity and persistent smell.

It is known to use for disinfecting surfaces contaminated with a vegetative or spore form of microorganisms in the medical, microbiological or food industry means based on an aqueous solution of sodium perxenonate (SU 1755801). However, the use of these funds according to the developed methods, at high concentrations of sodium perxenonate, is largely limited due to their toxicity (at concentrations of 5% and above).

Disclosure of invention

A method of obtaining a complex of xenon hexafluoride with boron trifluoride

The technical result in terms of a method for producing a complex of xenon hexafluoride with boron trifluoride is to simplify the process.

The indicated technical result is achieved in a method for producing a complex of xenon hexafluoride with boron trifluoride, including fluorination of Xenon difluoride in anhydrous hydrogen fluoride system XeF ₂ -F ₂ -BF ₃ at a temperature of 298-473 K to xenon hexafluoride and complexing with boron trifluoride at a temperature of 298 K and a molar ratio of reactants 1: 2.2: 1.

The specified technical result is also achieved in the method of obtaining a complex of xenon hexafluoride with boron trifluoride, including fluorination in the XeF ₄ -F ₂ -BF _{3 system of} xenon tetrafluoride in anhydrous hydrogen fluoride with fluorine gas at a temperature of 298-473 K to xenon hexafluoride and complexing with boron trifluoride at a temperature of 298 K and a molar ratio of reactants of 1: 1.2: 1.

The specified technical result is also achieved in the method of obtaining a complex of xenon hexafluoride with boron trifluoride, including the reaction of xenon hexafluoride with boron trifluoride in anhydrous hydrogen fluoride at 298 K and a molar ratio of reactants 1: 1.

Means for disinfection, sterilization, antiseptics and detoxification.

The technical result in terms of means for disinfection, sterilization, antiseptics and detoxification is to develop a simple composition based on xenon compounds, less toxic and more effective than used.

The essence of the invention is to achieve the mentioned technical result and is achieved by a means for disinfection, sterilization, antiseptics and detoxification based on xenon compounds, characterized in that for especially dangerous infections it is a complex of xenon hexafluoride with boron trifluoride in concentrations up to 1.5% and a filler.

The same technical result is achieved by a means for disinfection, sterilization, antiseptics and detoxification based on xenon compounds, which for especially dangerous infections contains an aqueous solution of a complex of xenon hexafluoride and boron trifluoride in concentrations up to 1.5%.

The same technical result is achieved by a means for disinfection, sterilization, antiseptics and detoxification based on xenon compounds, which for especially dangerous infections is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 1.5% with the addition of hydrogen peroxide in concentrations up to 0, 3%

The same technical result is achieved by a means for disinfection and sterilization of contact lenses, which is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of not more than 0.05%.

The same technical result is achieved by a disinfectant and sterilizer based on xenon compounds, which for dental and microsurgical instruments is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 0.03% or with the addition of hydrogen peroxide in concentrations up to 0.03% .

The same technical result is achieved by a means for disinfection, sterilization, antiseptics and detoxification based on xenon compounds, which for technological equipment of pharmaceutical companies is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 0.5% or with the addition of hydrogen peroxide in concentrations up to 0.05%.

The same technical result is achieved by a means for complete disinfection, sterilization, detoxification and degassing based on xenon compounds, which for especially dangerous infections, potent poisons and toxic substances at temperatures from -40 to 100 ° C contains a complex of xenon hexafluoride with boron trifluoride in an aqueous solution or in a solution of 10-50% hydrofluoric acid with a ratio (in mol.%) complex / toxicant of from 1: 1 to 10: 1.

Biologically active additives.

The technical result in terms of dietary supplements is to expand the spectrum of action and scope.

The specified technical result is achieved in a biologically active additive based on xenon compounds, which is a complex of xenon hexafluoride with boron trifluoride in concentrations up to 0.5% or with a filler.

A biological additive for food products is an aqueous solution (filler) of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 0.07% or a complex in a solid state (without filler).

The biologically active additive for the preservation of grafts is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 0.5%. Shelf life - up to several days depending on the temperature +5 - + 25 ° C.

Dietary supplement for food storage is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 0.1%.

An additive for storing fresh meat is a treatment with a complex of xenon hexafluoride with boron trifluoride in the gas-vapor phase or with an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.1%.

The additive for storing fresh meat and meat and dairy products in sealed packaging is a complex of xenon hexafluoride with solid boron trifluoride in a concentration of up to 0.05%.

The shelf life of processed products under room conditions increases by 5-10 times.

A dietary supplement for perfumes and cosmetics is a complex of xenon hexafluoride with boron trifluoride in the solid state or in the form of an aqueous solution up to 0.07% or a solution in glycol of a complex of xenon hexafluoride with boron trifluoride at a concentration of up to 0.07%.

Means for the disposal, detoxification of waste, the disposal and disposal of especially dangerous toxic and toxic substances.

The technical result in terms of means for the disposal and detoxification of waste is to create a tool that allows you to dispose of toxic organic and inorganic substances and decompose toxic impurities to non-toxic products.

This technical result is achieved by a means for the disposal, detoxification of waste, the disposal and disposal of especially dangerous toxic and highly toxic substances based on xenon compounds, which is a complex based on xenon hexafluoride and boron trifluoride in the solid state, in the form of an aqueous solution or a vapor-gas phase in a molar ratio complex / toxicant from 1: 1 to 10: 1.

Pharmaceutical Compositions

An object of the invention in terms of pharmaceutical compositions is the search for chemicals - oxidizing agents, in action similar to hypochlorites and ozone. Their use in medical practice should not require special equipment for measuring concentration in aqueous solutions and compositions with other therapeutic drugs. These substances should not react with proteins and blood elements, should be less toxic and more effective than oxidizing agents and superoxidants used in medicine.

The achievement of the specified technical result is possible in a pharmaceutical composition having antibacterial, antimicrobial, fungicidal, anti-inflammatory, antiviral, analgesic and wound healing effects, containing a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% and a filler.

It is possible to perform a composition containing an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5%. Since the complex of xenon hexafluoride with boron trifluoride has high lipophilicity and water solubility, moreover, it has practically no vapor pressure and has a higher oxidation potential than xenon difluoride, not only an aqueous solution or physiological solution can be used as a filler, but also various oils, for example, sea buckthorn, olive or glycol.

Thus, the authors have developed a pharmaceutical composition of a wide spectrum of action, capable of universally treating infectious diseases based on water, physiological or oil at a concentration of xenon hexafluoride with boron trifluoride complex up to 0.5%, thereby significantly expanding the possibilities of pharmaceutical, preventive and therapeutic effects.

It is possible to perform the composition in the form of a solution of a complex of xenon hexafluoride with boron trifluoride for applications on the affected areas or in the form of a solution for irrigation of the affected areas in a concentration of up to 0.5%.

The composition may be intended for the treatment of purulent wounds, trophic ulcers or for the treatment of surgical wounds, fungal diseases of the skin and nail plates, for the removal and anesthesia of necrotic tissues during burns of chemical, thermal, radiant energy, as well as frostbite, pyoderma, inflammatory periodontal diseases, diseases genitals.

The indicated technical result is also achieved in a pharmaceutical composition having an antiviral effect, containing a complex of xenon hexafluoride with boron trifluoride at a concentration of 0.5% and an excipient.

This composition can be intended for the prevention and treatment of influenza type A, B and C, for the treatment of viral skin diseases, for the treatment of HIV infection, for the prevention and treatment of herpes, for the prevention and treatment of hepatitis.

The specified technical result is also achieved by a pharmaceutical composition for detoxifying the body, containing a complex of xenon hexafluoride with boron trifluoride at a concentration of 0.5% and an excipient.

The best examples of carrying out the invention.

A method of obtaining a complex of xenon hexafluoride with boron trifluoride.

The method includes the synthesis of a complex of xenon hexafluoride with boron trifluoride in liquid hydrogen fluoride in the systems:

A. HeF ₂ -F ₂ -BF ₃ ,

B. HeF ₄ -F ₂ -BF ₃ ,

B. HeF ₆ -BF ₃

in the temperature range 298-473 K. The limiting stage of the process is the stage of xenon hexafluoride formation. XeF ₆ · BF ₃ complex or XeF ionic compound $\genfrac{}{}{0ex}{}{\text{+}}{\text{5}}$ Bf $\genfrac{}{}{0ex}{}{\text{-}}{\text{4}}$ formed during the cooling of the reactor to room temperature - 10 min with the yield of the target product up to 98%.

Example 1. A solution of xenon difluoride 846.5 mg (5 mmol) in anhydrous hydrogen fluoride 100 ml was added to the autoclave and 216.0 mg fluorine gas (12.0 mmol) was added, 339 mg boron trifluoride gas (5 mmol) was added and heated XeF ₂ -F ₂ -BF _{3 system} (at a ratio of 1: 2.2: 1) up to 473K, holding at this temperature ~ 1 hour. After the synthesis reaction, the autoclave is cooled to 0 ° C (~ 10 min), and hydrogen fluoride is re-sublimated into another autoclave. The yield of the target product is 97%. Purity 99%.

Example 2. The synthesis conditions of the complex are the same, but the reaction is carried out at 423K ~ 2 hours. The yield of the target product 93%. Purity 97%.

Example 3. A solution of xenon tetrafluoride 1036.5 mg (5 mmol) in 100 ml of anhydrous hydrogen fluoride was added to the autoclave, and fluorine gas 228.2 mg (6.0 mmol) was added, gaseous boron trifluoride 339.0 (5 mmol) was added, and the XeF ₄ -F ₂ -BF ₃ system is heated (with a component ratio of 1: 1.2: 1) to 423 K, holding at this temperature is ~ 1 hour. After the synthesis reaction, the autoclave is cooled to 0 ° C (~ 10 min), and hydrogen fluoride is re-sublimated into another autoclave. The yield of the target product is 98%. Purity 99%.

Example 4. The conditions for the synthesis of the complex are the same, but the reaction is carried out at 403K ~ 3 hours. The yield of the target product 93%. Purity 95%.

Example 5. A solution of 1226.5 mg (5 mmol) of xenon hexafluoride in anhydrous hydrogen fluoride 100 ml was added to the autoclave, and gaseous boron trifluoride 339.0 (5 mmol) was added and the mixture was kept for ~ 10 min. After the synthesis reaction, the autoclave is cooled to 0 ° C (~ 10 min), and hydrogen fluoride is re-sublimated into another autoclave. The yield of the target product is 98%. Purity 99%.

An increase in the molar ratio in system A, B, and C of fluorine and boron trifluoride does not increase the yield of the complex.

Means for disinfection, sterilization, antiseptics and detoxification.

As chemical reagents, compositions from aqueous solutions of inorganic compounds of xenon and hydrogen peroxide are used in concentrations sufficient to destroy spores, bacteria, fungi and viruses, but safe for medical personnel and not showing high corrosion activity.

Means 1 for disinfection, sterilization, antiseptics, detoxification and degassing for especially dangerous infections - a complex of xenon hexafluoride and boron trifluoride in concentrations up to 1.5% and a filler.

Means 2 for disinfection, sterilization, antiseptics, detoxification of various surfaces in case of especially dangerous infections - an aqueous solution of a complex of xenon hexafluoride and boron trifluoride in concentrations up to 1.5%.

Means 3 for disinfection, sterilization, antiseptics, detoxification of various surfaces in case of especially dangerous infections - an aqueous solution of a complex of xenon hexafluoride and boron trifluoride in concentrations up to 1.5% with the addition of hydrogen peroxide in a concentration of not more than 0.3%.

Means 4 for disinfection and sterilization of contact lenses - an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of not more than 0.05%.

Means 5 for the disinfection and sterilization of dental and microsurgical instruments - an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 0.03%.

Means 6 for disinfection and sterilization of dental and microsurgical instruments - an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 0.03% with the addition of hydrogen peroxide in concentrations up to 0.03%.

Means 7 for disinfection and sterilization of technological equipment of pharmacological firms (without disassembling them) is an aqueous solution of a complex of xenon hexafluoride and boron trifluoride in concentrations up to 1.5%.

Means 8 for disinfection and sterilization of technological equipment of pharmacological firms (without disassembling them) is an aqueous solution of a complex of xenon hexafluoride and boron trifluoride in concentrations up to 1.5% with the addition of hydrogen peroxide in a concentration of not more than 0.05%.

Means 9 for disinfection, sterilization, detoxification and degassing of especially dangerous infections, potent poisons and toxic substances at temperatures from -40 to 100 ° C contains a complex of xenon hexafluoride with boron trifluoride in an aqueous solution or in a solution of 10-50% hydrofluoric acid in the ratio ( in mol.%) complex / toxicant up to 10: 1.

Starting materials.

Hydrogen peroxide - 98% concentration is a liquid that can be stored in a dark sealed vessel for decades.

The complex of xenon hexafluoride with boron trifluoride is a solid crystalline substance whose stability when stored in sealed fluoroplastic containers at room temperature is tens of years.

An aqueous solution of a complex of xenon hexafluoride with boron trifluoride is prepared immediately before use.

The treatment of solutions and surfaces with Means 1, 2, 3 is carried out with an exposure of at least 5 minutes by spraying, irrigation or in the vapor-gas phase. Means 1, 3 in solution or in the gas-vapor phase without and using compressed gases can be used to disinfect and sterilize especially dangerous infections (plague, cholera, anthrax and brucellosis in animal husbandry). The tool 2 can be used as a skin antiseptic for sterilizing the hands of surgeons and disinfecting the hands of medical personnel, as well as the operating, injection fields, birth canals. This remedy in 5 minutes is fully capable of suppressing bacteria, fungi, viruses.

Means 1, 2, 3, 5 and 6 exhibit bactericidal, virucidal, fungicidal and sporocidal properties and are effective for disinfection and sterilization of instruments and devices, including flexible and rigid endoscopes, medical instruments made of metal, platinum, glass used in dentistry and microsurgery. Disinfection and sterilization is carried out at a temperature of 0 to 25 ° C for 10-15 minutes. For the effective use of these products, organic contaminants should be removed from the products before they are processed. When processing medical devices that are simple in design, they use Tools 5 and 6. Processing is carried out for 15 minutes when they are completely immersed in the solution, ensuring that there are no air bubbles on the surface and all channels are filled. The thickness of the solution layer above the products should be at least 1 cm. When processing medical devices of complex design, Tools 7 and 8 are used in accordance with the instructional and methodological documents for these products. For disinfection of products from bacteria, germs, viruses and fungi, a 10-minute exposure in Tools 2 and 3 is sufficient. With prolonged contact (without exhaust ventilation) and when used on large surfaces, the aqueous solution does not irritate the mucous membranes of the eyes, respiratory organs .

Means 1, 2, 3 in a gas-vapor medium can also be used for disinfection and sterilization from microbes and fungal contamination of agricultural products, including grain products, root crops, and onions.

To date, aqueous solutions of inorganic xenon compounds have not been used to disinfect and sterilize contact lenses. When processing contact lenses with Means 4, in addition to the main task of destroying microorganisms, additional effects are achieved. Means 4 has high detergent properties in relation to organic and inorganic substances and various contaminants. Additives of xenon difluoride significantly improved the detergent properties of compositions for cleaning optics (RU No. 2065488). It is noted that the processing of modern contact lenses with this Tool helps to improve their optical properties by leaching the polymerization catalyst and additional polymerization of monomers and oligomers. In addition, the residual concentrations of Agent 4 in the volume of contact lenses keep them sterile for longer. Sterilization is performed by single or multiple immersion of contact lenses in Tool 4 for a period of more than 5 minutes, followed by their washing (by immersion) in distilled water or physiological saline.

Means 1, 2, 3, 5, 6, 7, and 8 process both aqueous solutions by washing the walls with a jet, and by spraying the means in their vapor-gas phase. The time required for processing reactors with a volume of 2.5 to 16 m ³ is from 15 to 30 minutes,

Means 1, 2, 3, 5, and 6 in the gas-vapor phase can be used to disinfect and sterilize hospital supplies, such as bedding, dressings, etc., as well as pacemakers, optics, rubber, metal, plastic, etc. P.

Means 1, 2, 3, 5 and 6 can be used for disinfection and sterilization of various surfaces and the environment (air) in warehouses for storing especially valuable items, in the premises of medical institutions: operating rooms, antiseptic, resuscitation chambers of surgical departments, in burn centers, maternity hospitals and children's wards of obstetric hospitals, in mobile tent-type hospitals.

Tools 1 and 2 can be used to disinfect and sterilize drugs and their components against microbial contamination.

Tools 2 and 3 can be used to disinfect and sterilize various surfaces at pH below 8.

Means 5-8 carry out the processing of both aqueous solutions and non-aqueous solutions by washing the walls with a jet, spraying means or their vapor-gas phase of various technological lines and reactors.

Means 1-3 and 5-8 can be used for disinfection and sterilization of various surfaces in warehouses for storing especially valuable items, in the premises of medical institutions: operating rooms, antiseptic, resuscitation chambers of surgical departments, in burn centers, maternity homes and obstetric wards hospitals, in the meat and dairy industry, veterinary medicine, mobile tent-type hospitals. The tool 9 can be used to destroy especially dangerous infections, potent poisons and toxic substances to non-toxic products. These funds have a pronounced biocidal effect.

Extemporaneously prepared means are stable in time sufficient for processing a typical military equipment by irrigation, their freezing temperature is below minus 20 ° С, they have a high extracting ability with respect to the main toxic substances.

Means 1, 2, 4, 6, 7, and 9 are prepared in advance, and additives in 3, 5, and 8 are administered immediately before use.

Example 6. The sporicidal activity of Agent 2 (XeF ₆ · BF ₃ ) was tested against the agar culture of Bacillus Subtilis Var. niger and ATCC 6633. Table 1 shows that the complete destruction of this culture occurs with a 5-minute exposure, at a concentration of Means 2 0.02% and a microbial load of 3.9 · 10 ⁵ .

Example 7. Table 2 shows the modes of disinfection of plastic dishes (without food debris) from intestinal, drip infections and anthrax by immersing it in disinfectant aqueous solutions (XeF ₃ ), (XeO ₃ + H ₂ O ₂ ), (Na ₄ XeO ₆ ) and Tools 2 (XeF ₆ · BF ₃ ). In the same table 2, for comparison, the modes of disinfection of plastic utensils (without food residues) from intestinal drip infections and anthrax with aqueous solutions of hydrogen peroxide with 0.5% detergent of the dibasic salt of calcium hypochlorite and acetic acid solution are shown.

Example 8. Table 3 shows the modes of disinfection of plastic dishes (with food debris) from intestinal, drip infections and anthrax by immersing it in disinfectant aqueous solutions (XeF ₂ ), (XeO ₃ + H ₂ O ₂ ), (Na ₄ XeO ₆ ) and Tools 2 (XeF ₆ · BF ₃ ). For comparison, the disinfection modes of plastic utensils (with food debris) from intestinal drip infections and anthrax with aqueous solutions of hydrogen peroxide with 0.5% detergent of the dibasic salt of calcium hypochlorite and a solution of peracetic acid are shown.

Example 9. Table 4 shows the sterilization modes of the endoscopes with Means 1 (XeF ₂ ), Means 3 (XeO ₃ ), Means 16 (Na ₄ XeO ₆ ) and Means 2 (XeF ₆ · BF ₃ ). In the same table 4, for comparison, sterilization modes of endoscopes are shown with Sidex sterilizing agents (USA), Lysoform - 3000 (Germany), Coldspor (USA) and gigisept FF (Germany).

Example 10. Table 5 shows the modes of gas sterilization of medical devices with formaldehyde, xenon difluoride, xenon trioxide with hydrogen peroxide and a complex of xenon hexafluoride with boron trifluoride. In the same table 5, for comparison, sterilization modes for formaldehyde vapor and formaldehyde solutions in ethyl alcohol are shown.

Example 11. Table 6 shows the modes of disinfecting surfaces of monolithic plastics by irrigation with solutions of disinfectant preparations. In the same table 6, for comparison, the modes of disinfecting surfaces of monolithic plastics by irrigation with solutions of disinfectants with a tribasic salt of calcium hypochlorite, hydrogen peroxide with 0.5% detergent and Deoxane 1 are shown. High disinfecting properties of xenon difluoride and a complex of xenon hexafluoride with boron trifluoride are shown .

Examples of the use of pharmaceutical compositions.

Example 12. A volunteer was treated for chronic ulcerative pyoderma. On the skin of the legs and the rear of the feet, calves and thighs, there were also many painful ulcers that merged together, at the bottom of which purulent and necrotic masses, sluggish granulations were visible. The edges of the ulcer are slightly elevated above the level of healthy skin, slightly infiltrated. The treatment was carried out as follows: sterile gauze or a tampon is moistened with an aqueous or oily solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% and applied to the affected skin for 15-20 minutes 4 times a day. The course of treatment is up to 10 days. After a week break, the cycle was repeated. Ulcers healed after 2-3 cycles of treatment.

Example 13. Studies on volunteers were carried out for various types of herpes diseases. The research results showed that in the first stages of the disease, when the patient feels a burning sensation on the lips, nose, under the armpits, i.e. to the lumbar girdle, it is sufficient to use an aqueous or oily solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% for up to 1 minute, a maximum of 2 times after 2-3 hours. At the stage when the first bubbles appear, application with solutions is carried out up to 2-3 minutes and 4-5 times a day. In this case, it is desirable to carry out applications without damaging the bubbles and, finally, at the stage of bubbles or scabs, carry out abundant wetting and applications up to 5-10 minutes 6-10 times a day. In all cases of treatment for herpes, healing took place without scarring and painlessly.

Example 14. A method of treating purulent wounds, trophic ulcers is that 2 times a day is treated by spraying, for example, from a spray, an aqueous or oil solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5%.

Example 15. A method of treating fungal and viral diseases of the skin or nail plates consists in applying a gauze moistened with an aqueous or oil solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% for 15-20 minutes.

Example 16. A method of treating tissue necrosis of a living organism with an analgesic effect resulting from mechanical (injury), chemical (acid, alkali), temperature (burns, frostbite), exposure to radiant energy, is that the affected area is treated with water, or physiological, or oily solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5%.

Example 17. The treatment of surgical wounds is that to prevent suppuration, the wound is treated with an aqueous or oily solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5%. Healing takes place without scars.

Example 18. A method of treating inflammatory periodontal diseases is that an aqueous or oily solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% in a volume of 10 ml is applied as applications for each half of the jaw. This method is very effective for the treatment of the inflammatory process in periodontium with an anesthetic effect, does not cause side effects and can be used in any dental institution.

Example 19. A method of treating inflammatory diseases of the internal genital organs of women and the genitals of men consists in treating them with aqueous or oily solutions of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% 2-3 times a day for 3-5 days.

Example 20. The patient is a man of 48 years. I got a burn on the right side of the face and a burn on the inside of the right hand (hand). Severe painful and stressful state (blisters formed on the arm and face). The treatment was carried out by first spraying with an aqueous or oily solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% (before drying) 4-6 times a day for 10 days. Pain and burning stopped after the first treatment with solutions. After the 7th day of treatment, young pink skin appeared, scabs almost all disappeared, and on the 10th day the skin became normal, the healing went without scars. On the hand of the right hand, where there was a very severe burn, slightly light skin remained on the site of deep burns.

Example 21. A dog, a German shepherd breed was treated for inflammation of the oral mucosa (stomatitis). Inflammation was ulcerative. Chewing was impaired in the dog, and frothy, viscous saliva was released from the oral cavity. The animal behaved uneasily, refused feed. The treatment was carried out by irrigation of the dog's oral cavity with an aqueous or oily solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% 3 times a day. A single dose for irrigation was 20 ml of solution. On day 5, discharge from the mouth stopped, the smell disappeared, on day 10, the ulcers healed.

Biologically active additives.

In perfumes and cosmetics, it is preferable to add to soaps, ointments, creams, lotions, shampoos, lipsticks, etc. a complex of xenon hexafluoride with boron trifluoride in solid form or in the form of an aqueous solution or a solution in glycol in a concentration of up to 0.5%.

Compounds based on xenon are introduced into food products at the production stage (for sausages, minced meat) at a concentration of up to 0.1% or at the stage of capping in sealed containers (for canned food) at a concentration of up to 0.05%.

For long-term storage of fresh meat, the product is treated in a gas-vapor medium with a complex of xenon hexafluoride with boron trifluoride or processed by dipping a solution of a complex of xenon hexafluoride with boron trifluoride with a concentration of up to 0.1% for 5-10 minutes and then packaging in a sealed container (with up to 0.05% of a complex of xenon hexafluoride with boron trifluoride). The shelf life of processed products under room conditions increases by 5-10 times.

To preserve the transplants, the latter are placed in an aqueous solution of the complex in a concentration of up to 0.5% or physiological saline until they are needed. Shelf life - up to several days depending on the temperature +5 - + 25 ° C.

Recycling, detoxification of waste, recycling and disposal of highly toxic substances and highly toxic substances.

The disposal and detoxification of toxic organic and inorganic substances and toxic emissions of industrial enterprises using xenon compounds is carried out as follows:

a) in the gas phase - in the gas-vapor phase with a solution of a complex of xenon hexafluoride and boron trifluoride;

b) in solutions - in the solid state by a complex based on xenon hexafluoride and boron trifluoride;

c) on hard surfaces - by washing with solutions based on a complex of xenon hexafluoride and boron trifluoride.

The concentration of oxidizing agents (a complex of xenon hexafluoride and boron trifluoride) is used depending on the concentration of toxic substances in a molar ratio complex / toxicant from 1: 1 to 10: 1.

A new highly effective method has been developed for purifying water from toxic impurities by xenon-based superoxidants in the processes of preparing drinking water, for the destruction of harmful impurities in industrial wastewater, for the destruction of toxic impurities in waste water from organochlorine derivatives of arsenic, phosphorus, sulfur and microbial contamination. Water purification improves the taste of water, discolours both drinking and wastewater, reduces the concentration of organic compounds in water and transfers difficultly oxidized substances, including poisons in non-toxic products, increases the content of oxygen, fluoride ion in water and destroys bacteria, viruses, fungi, microbes.

Means based on xenon compounds can not only neutralize dioxin derivatives, but also utilize chlorine derivatives, for example, hexachlorophen, to valuable products by fluorination, hydrolysis and oxidation in aqueous and non-aqueous media.

Fluorination and hydrolysis of hexachlorophene leads to the formation of 2,4,5-trichlorophenol, which itself is an insecticide and fungicide. 2,4,5-Trichlorophenoxyacetic acid derived from 2,4,5-trichlorophenol is an effective herbicide.

The intense herbicidal effect of the preparations of the chlorophenoxycarboxylic acid group, their salts and esters is due to their ability to inhibit the transport of auxins.

Derivatives of 2,4,5-trichlorophenol - 2,4,5-trichloroaniline - a valuable product in the synthesis of pesticides.

Industrial applicability.

Physico-chemical and oxidative properties of the complex of xenon hexafluoride with boron trifluoride (XeF ₆ · BF ₃ ).

A complex of xenon hexafluoride with boron trifluoride (XeF ₆ · BF ₃ ).

The complex of xenon hexafluoride with boron trifluoride is a solid crystalline powder of white color and does not have vapor pressure at room temperature. The solubility of salt in water is about 0.25 M at 25 ° C, but hydrolyzes with the formation of oxyfluorides, which are responsible for high biocidal properties and for the detoxification of especially toxic substances (unlike higher xenon fluorides, hydrolysis proceeds quietly without explosions, even at temperatures above 30 ° C The complex of xenon hexafluoride with boron trifluoride (XeF _b · BF ₃ ), on the basis of which pharmaceutical compositions of a wide spectrum of action have been created, has moderate toxicity to other oxidizing agents and superoxidants used in medicine. A heresy to the reaction of the complex of xenon hexafluoride with boron trifluoride (XeF ₆ · BF ₃ ) with water is associated with the prospect of using an aqueous solution of the complex of xenon hexafluoride with boron trifluoride (XeF ₆ · BF ₃ ) as an oxidizing, disinfecting and detoxification system, as well as the need optimizing the process of obtaining oxygen xenon compounds in aqueous media from a complex of xenon hexafluoride with boron trifluoride (XeF ₆ · BF ₃ ) and with the possibility of preparative isolation of pure xenon trioxide and sodium perxenonate.

The mechanism of action of superoxidants based on xenon compounds, resulting in the formation of highly active intermediate particles responsible for detoxification processes, is presented below:

1) The mechanism of the reaction of hydrolysis of XeF ₂

with a reaction rate constant k ₁ = (6.1 ± 0.6) · 10 ^-14 cm ³ / s.

2) XeF ₄ hydrolysis reaction mechanism

The mechanism includes 4 channels, the last two of which are indistinguishable due to the low bond breaking energy in the XeF molecule, D _O (Xe-F) = 8.1 ± 0.4 kJ / mol.

The rate constants k _1a = (4.2 ± 0.5) · 10 ^-15 , k _1b = (3.5 ± 1.2) · 10 ^{-15 are} determined from the reagent consumption and independently from the rate of product formation at T = 473 K , k _1c = (3.3 ± 0.4) · 10 ^-15 cm ³ / s.

3) XeF ₆ hydrolysis reaction mechanism

It is important to note that the channel with the formation of xenon tetrafluoride does not exist, although its heat of reaction is positive:

XeF ₆ + H ₂ O → XeF ₄ + HOF + HF + 48.3 kJ / mol.

Perhaps this is due to the prohibition of changing the valency of the xenon atom. The rate constant k ₃ = (3.5 ± 0.4) · 10 ^-15 cm ³ / s is determined.

The general regularity of the above systems is the formation directly in the first stage of the corresponding oxyfluorides while maintaining the valency of the xenon atom (+2, +4 and +6). In the case of the XeF ₂ reaction, the formation of xenon oxide is impossible due to thermodynamic instability (a very reactive compound of the FO-Xe-OF type seems to be formed).

Based on the analysis of the set of final products, the reactions studied, it is concluded that fast secondary reactions proceed in the studied systems, the rates of which are comparable in magnitude:

HOF + H ₂ O → HF + H ₂ O ₂ +64.4 kJ / mol

OF + H ₂ O → HF + HO ₂ +120.5 kJ / mol

F + H ₂ O → HF + OH + 67.7 kJ / mol.

Thus, the hydrolysis of the complex of xenon hexafluoride with boron trifluoride (XeF ₆ · BF ₃ ) proceeds in water with the formation of highly reactive compounds (in the first stage with the formation of XeOF ₄ + HBF ₄ molecules), such as hypofluorides (a new class of compounds), and then hydrogen peroxide and peroxide and hydroxide radicals having high oxidizing, disinfecting and detoxifying abilities.

As a result of the interaction of difluoride, tetrafluoride, xenon hexafluoride and the complex with a water molecule, very reactive xenon hypofluoride particles are formed in the xenon oxidation state, equal to +2, +4, +6: Xe (ОF) ₂ , XeOF ₂ and XeOF _4, respectively.

The complex of xenon hexafluoride with boron trifluoride and sodium perxenonate in aqueous and aqueous-organic solutions has an oxidizing potential exceeding 1.5 times xenon difluoride and xenon trioxide. In the hydrolysis of these inorganic oxidants in aqueous and aqueous-organic solutions, reactive intermediates are formed in the oxidation state of xenon +6, +8, capable of oxidizing supertoxicants such as dioxin derivatives at low temperatures.

Thus, the idea of developing “group antidotes” has a serious scientific basis. The concept of general toxicity mechanisms suggests that exposure to an organism of the most diverse substances in chemical structure and properties causes a limited number of responses. The universality of protective compensatory mechanisms determines the universal nature of the toxic effect, in which the violation of fundamental biochemical processes is realized. The general biochemical mechanisms of toxicity are a combination of two interacting processes - molecular damage mechanisms and compensatory detoxification mechanisms aimed at maintaining homeostasis.

Damages common to various substances form the basis for the formation of nonspecific syndromes. In acute pathology, they coincide with typical pathological conditions - hypoxia, collapse, hepatopathies, toxic pulmonary edema, etc.

To create a prophylactic antidote that protects against the toxic effects of lipophilic organic compounds, drugs are used that modify the activity of microsomal monooxygenases, as well as enzymes that provide conjugation reactions and stimulate the synthesis of conjugation substrates.

Superoxidants are able not only to provide protection from typical poisons - prooxidants, but also to weaken the toxic effects of hypoxic substances, during the action of which lipid peroxidation processes are enhanced, due to the generation of superoxide radical and other reactive oxygen species, due to disruption of the functioning of the mitochondrial electron transport chain. These drugs can also be useful in intoxications, accompanied by increased activity of "producing peroxide enzymes" - monoamine oxidases, aldehyde dehydrogenases, xanthine oxidases and others, as well as under the action of substances that induce the induction of cytochrome P-450, which leads to an increase in the generation of reactive oxygen species and lipid peroxidation .

Based on xenon compounds, drugs can be created that protect against chemicals that cause toxic pulmonary edema.

Knowing the molecular mechanisms of damage to the capillary-alveolar membrane and deciphering the stages of the formation of vasoactive substances in the lungs - thromboxane A ₂ , prostaglandins - made it possible to inhibit the development of the pathological process by inhibiting phospholipase A ₂ and "turning off" the arachidonic mechanism.

Finally, xenon compounds are hepatoprotectors, i.e. drugs that protect the body from hepatotropic poisons, for example, carbon tetrachloride, heliotrin, thioacetamide, etc.

Claims (12)

1. A method of obtaining a complex of xenon hexafluoride with boron trifluoride, including fluorination in the XeF ₂ - F ₂ - BF _{3 system} of xenon difluoride in anhydrous hydrogen fluoride with fluorine gas at a temperature of 298-373 K to xenon hexafluoride and complexing with boron trifluoride at a temperature of 298K and the molar ratio of reagents is 1: 2.2: 1. 2. A method of obtaining a complex of xenon hexafluoride with boron trifluoride, including fluorination in the XeF ₄ - F ₂ - BF _{3 system of} xenon tetrafluoride in anhydrous hydrogen fluoride with fluorine gas at a temperature of 298-373 K to xenon hexafluoride and complexing with boron trifluoride at a temperature of 298 K and a molar ratio of reactants of 1: 1.2: 1. 3. A method of obtaining a complex of xenon hexafluoride with boron trifluoride in anhydrous hydrogen fluoride from xenon hexafluoride at 298K and a molar ratio of reactants 1: 1. 4. Means for disinfection, sterilization, antiseptics, detoxification based on xenon compounds, characterized in that for especially dangerous infections it is a complex of xenon hexafluoride with boron trifluoride in concentrations up to 1.5% and a filler. 5. A means for disinfection, sterilization, antiseptics, detoxification based on xenon compounds, characterized in that for especially dangerous infections it is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in concentrations up to 1.5% or with the addition of hydrogen peroxide at a concentration of up to 0 , 3%. 6. A means for disinfection and sterilization, characterized in that for contact lenses is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of not more than 0.05%. 7. A means for disinfection, sterilization, antiseptics and detoxification based on xenon compounds, characterized in that for technological equipment of pharmacological firms it is an aqueous solution of a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% or with the addition of hydrogen peroxide in a concentration of more than 0.05%. 8. A tool for complete disinfection, sterilization, detoxification and degassing based on xenon compounds, characterized in that for especially dangerous infections, potent poisons and toxic substances at temperatures from -40 to 100 ° C it contains a complex of xenon hexafluoride with boron trifluoride in an aqueous solution or in a solution of 10-50% hydrofluoric acid with a ratio (mol.%) complex: toxicant = 1: 1 - 10: 1. 9. A pharmaceutical composition having antibacterial, antimicrobial, fungicidal, anti-inflammatory, analgesic and wound healing effects, characterized in that it contains a complex of xenon hexafluoride with boron trifluoride in a concentration of up to 0.5% and an excipient. 10. The composition according to claim 9, characterized in that for the treatment of purulent wounds, trophic ulcers, for the treatment of surgical wounds, for the treatment of fungal diseases of the skin and nail plates, for anesthesia and treatment of necrotic tissues with shock, chemical, thermal burns, radiant energy as well as frostbite, for the treatment of pyoderma, for the treatment of inflammatory periodontal diseases, for the treatment of genital diseases, for the treatment of viral skin diseases, for the prevention and treatment of herpes, for the treatment of skin diseases flax in the form of a solution for applications on the affected areas or a solution for irrigation of the affected areas. 11. Dietary supplement based on xenon compounds, characterized in that for the preservation of transplants, for perfumes and cosmetics, for food products, for storing food products, fresh meat and meat and dairy products in sealed packaging, it contains a complex of xenon hexafluoride with boron trifluoride in solid state, or in the vapor-gas phase, or in the form of an aqueous solution, or a solution in glycol in concentrations up to 0.5%. 12. A tool for the disposal, detoxification of waste, disposal and disposal of especially dangerous toxic substances and especially toxic substances based on xenon compounds, characterized in that it contains a complex of xenon hexafluoride with boron trifluoride in the solid state, in the form of an aqueous solution or in the vapor-gas phase at the molar ratio of complex: toxicant = 1: 1 - 10: 1.