RU2235327C1 - Method of diagnosing exacerbation of reflector forms of cervical osteochondrosis - Google Patents

Abstract

FIELD: neurology.

SUBSTANCE: method envisages clinical X-ray investigation of blood serum to determine FNO-alpha level. When the latter is superior to 19.57 pg/ml, exacerbation of reflector forms of osteochondrosis of cervical backbone portion is diagnosed.

EFFECT: simplified diagnostic procedure, ensured safety without any undesired effects.

Description

The invention relates to medicine, namely to neurology.

It is known that exacerbation of reflex forms of cervical osteochondrosis is judged in the presence of patient complaints of pain and shooting in the neck, shoulder girdle and hands and the presence of vertebral neurological symptoms (limitation of the range of active movements in the affected area, pain on palpation of the muscles of the neck and shoulder girdle, pain points, positive symptoms of tension) (Scales, tests and questionnaires in medical rehabilitation / Edited by A.N. Belova, O.N. Schepetova. - M., 2002, 440 p.)

The disadvantage of this method is subjectivity, since the perception of pain depends on many factors (constitutional and personal characteristics, psycho-emotional stress, etc.), the need for special training of a neurologist.

The essence of the invention lies in the fact that along with clinical and X-ray studies in the blood of a patient, the method of enzyme immunoassay (ELISA) determines the level of serum tumor necrosis factor alpha (TNF-alpha) and at a level of TNF-alpha above 19.57 pg / ml the presence of exacerbation of reflex forms of cervical osteochondrosis.

It was found that with exacerbation of reflex forms of cervical osteochondrosis, the level of TNF-alpha is 19.57-278.73 pg / ml.

The method is as follows. In the presence of complaints and clinical manifestations, the patient is sampled from the ulnar vein, obtained by centrifugation at 1000 rpm for 30 min, blood serum in which the level of TNF-alpha is determined by ELISA tests.

The level of TNF-alpha above 19.57 pg / ml corresponds to an exacerbation of cervical osteochondrosis.

Example. Patient 3., 1960, p., Was admitted with complaints of pain in the neck with radiation to the left hand, paresthesia in the hands. Aggravation within 2 weeks. Objectively: movements in the cervical spine are limited to the left, to the right up to 45 °, back - up to 40 °, moderate pain during percussion of the spinous processes of C _IV , C _V , C _VI , C _VII , palpation of paravertebral points C _III-IV , C _IV-V , C _V-VI , C _VI-VII, anterior scalene muscle on the left. The tension of the long extensor of the back, trapezius and anterior scalene muscles on the left is moderately expressed. Tendon reflexes D = S, pathological reflexes were not detected. On the Rg-gram of the cervical spine - dystrophic changes in the form of osteochondrosis in segments C _3-4 , C _4-5 II-III period. The level of TNF-alpha is 34.24 pg / ml.

Diagnosis: vertebrogenic left-sided cervicobrachialgia, moderate pain.

In total, the proposed method examined 35 people with reflex forms of cervical osteochondrosis, all were clinically diagnosed with exacerbation of neurological manifestations. The level of TNF-alpha was 19.57-278.73 pg / ml.

The proposed diagnostic method is simple, minimally invasive, does not require special training of a neurologist, ensures the safety of diagnosis and has no side effects. It allows you to objectify the diagnosis of exacerbation, prescribe timely therapy.

Claims (1)

A method for the diagnosis of exacerbation of reflex forms of cervical osteochondrosis, including a clinical, X-ray examination, characterized in that in a patient's blood serum by ELISA, the content of TNF-alpha is determined and at a level of TNF-alpha above 19.57 pg / ml, exacerbation of reflex forms of osteochondrosis of the cervical region is diagnosed the spine.