RU2234946C2 - Disinfecting agent - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: disinfecting agent comprises components taken in the following ratio, wt.-%: alkyldimethylbenzyl ammonium chloride, 17.5-24.0; bis-(3-aminopropyl)dodecylamine, 8.7-12.7; non-ionogenic surface-active substance, 4.0-7.0; ethylenediaminetetraacetic acid tetrasodium salt, 1.9-3.0; alkali, 1.5-4.0; water, the balance. Agent shows broad spectrum of effect and is used for treatment of apartments, rigid furniture, equipment, glassware in curative-prophylactic institutions, public utilities institutions and in social nutrition plants. Invention provides expanding spectrum in application of agent in combination with its high disinfecting activity.

EFFECT: enhanced effectiveness of agent.

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Description

The invention relates to medicine, to disinfectants.

Known disinfectant "LISAFIN" containing alkyldimethylbenzylammonium chloride, nonionic surfactant and water (Patent RU No. 2145238, A 61 L 2/18, 2000) [1] - prototype.

This well-known tool in addition to alkyldimethylbenzylammonium chloride also contains two more active components - glutaraldehyde and glyoxal. However, these components are toxic and volatile at room temperature, which makes it dangerous to use the known agent [1] in the presence of people. The spectrum of action of this known agent is not wide enough. In addition, the constant use of the same disinfectants leads to the emergence of resistant strains of microorganisms, and therefore the task of finding new highly active agents remains relevant.

The objective of the present invention is to expand the spectrum of use of the product, its high disinfecting activity as a result of the synergistic action of the components introduced into its composition with a decrease in the content of the active component and with the exclusion of volatile toxic components from the composition of the tool.

The problem is solved in that the disinfectant containing alkyldimethylbenzylammonium chloride, nonionic surfactant and water additionally contains bis (3-aminopronyl) dodecylamine, tetrasodium salt of ethylenediamine tetraacetic acid and alkali in the following ratio of components, wt.%:

Alkyldimethylbenzylammonium

chloride 17.5 - 24.0

Bis (3-aminopropyl) dodecylamine 8.7 - 12.7

Nonionic surface

active substance 4.0 - 7.0

Ethylenediamine tetrasodium salt

tetraacetic acid 1.9 - 3.0

Alkali 1.5 - 4.0

Water Else

Alkyldimethylbenzylammonium chloride is not active against the causative agent of tuberculosis. Bis (3-aminopropyl) -dedecylamine kills the cells of the causative agent of tuberculosis, but only in high concentrations. Unexpectedly, a synergistic effect of these two known active substances against the causative agent of tuberculosis was found. This synergistic effect is especially pronounced in the presence of a tetrasodium salt of ethylenediamine tetraacetic acid in an alkaline medium. This made it possible to abandon the use of toxic volatile components of the known agent [1] - glutaraldehyde - and glyoxal and reduce the concentration of the toxic component of alkyl dimethylbenylammonium chloride in the target product.

To prepare the product, alkyldimethylbenzylammonium chloride (Catamine AB) is used according to TU 2482-012-13164401094. A nonionic surfactant can be used, for example, in the form of an alkyl polyglucoside.

If the tool is supposed to be used for treating metal surfaces, it is advisable to introduce a corrosion inhibitor into it, for example, 4.0-6.0 wt.% Of a mixture of carboxylic acid derivatives and a copper inhibitor - the Kebokor 206 CU preparation manufactured by Keller and Boyacek, Hungary. To improve the presentation of the target product, a dye, for example, 0.0001-0.01 wt.% Yellow quinoline E-104 or acid bright blue anthraquinone, can be added to it.

The following are examples illustrating the invention.

Example 1. In 24.35 g of softened water, 11.0 g of bis (3-aminopropyl) dodecylamine was introduced under continuous stirring, and after it was completely dissolved, 42.0 g of a 50% aqueous solution of alkyl dimethylbenzylammonium chloride were successively added to the prepared solution (21 , 0 g in terms of pure substance), a nonionic surfactant in the form of 6 g of alkyl polyglucoside, 6.25 g of a 40% aqueous solution of tetrasodium salt of ethylenediamine tetraacetic acid (2.5 g in terms of pure substance), 5, 0 g of a 40% aqueous solution of potassium hydroxide (2.0 g in terms of to pure substance).

The prepared product was thoroughly mixed and bottled. A part of the finished product was taken and 5.2 g of Kebokor 206 CU corrosion inhibitor and 0.01 g of yellow quinoline E-104 dye stable in alkaline medium were introduced into it.

Example 2. Prepared a tool of the following composition, wt.%:

Alkyldamethylbenzylammonium chloride 175

Bis (3-aminopropyl) dodecylamine 8.7

Nonionic Surfactant 4.0

Ethylenediamine tetrasodium salt

tetraacetic acid 1.9

Sodium hydroxide 1.5

Water Else

Example 3. Prepared a tool of the following composition, wt.%:

Alkyldimethylbenzylammonium chloride 24.0

Bis (3-aminopropyl) dodecylamine 12.7

Nonionic Surfactant 7.0

Ethylenediamine tetrasodium salt

tetraacetic acid 3.0

Potassium hydroxide 4.0

Water Else

The agent of Examples 1-3 is a clear concentrate. It is used in the form of 0.02-2.0% aqueous solutions. The product is recommended for use at an ambient temperature of at least 18 ° C. It has detergent properties, mixes well with water. A sample of the product according to example 1 containing a corrosion inhibitor does not cause metal corrosion. The product is not compatible with soaps, anionic surfactants and synthetic detergents.

The new tool is active against a wide range of bacteria (including pathogens of tuberculosis, salmonella, typhoid fever, dysentery, diphtheria, scarlet fever, sexually transmitted diseases, anaerobic infections, pathogens of especially dangerous infections - plague, cholera, anthrax, and also against fungi (candidiasis, dermatophytosis) and viruses (including HIV infection, hepatitis A, B, C).

They use a new tool for disinfecting surfaces in rooms (including during general cleaning), hard furniture, sanitary equipment, ambulances, linen, toys, tableware and laboratory utensils, cleaning materials, patient care items, and medical supplies ( including flexible and rigid endoscopes, instruments for them, dental instruments, including rotating ones, saliva ejectors), in medical institutions. The tool is used for disinfection, combined with pre-sterilization cleaning of medical devices. It is used for disinfection at public catering facilities, at communal facilities (hotels, hostels, clubs and other public places), in baths, hairdressers, beauty salons, swimming pools, solariums, during disinfection and cleaning at railway transport and underground facilities, for the treatment of cabins and compartments of civil aviation vessels for mold control.

Working solutions of the new agent can be used for disinfection and pre-sterilization cleaning many times until the first signs of a change in their appearance compared to the original appear.

The new product meets the requirements of the “Normative indicators of safety and efficacy of disinfectants to be monitored during mandatory certification” No. 01-12 / 75-97, Moscow, Ministry of Health of the Russian Federation, 1998

Thus, the agent according to the invention is a disinfectant of a wide spectrum of action, repeated use. It is safe to use, since it does not contain volatile toxic components, and the content of active components in it is low.

Claims (1)

A disinfectant containing alkyldimethylbenzylammonium chloride, a nonionic surfactant and water, characterized in that it additionally contains bis (3-aminopropyl) dodecylamine, the tetrasodium salt of ethylenediamine tetraacetic acid and alkali in the following ratio, wt.%: Alkyldimethylbenzylammonium chloride 17.5-24.0 Bis (3-aminopropyl) dodecylamine 8.7-12.7 Nonionic surfactant 4.0-7.0 Ethylenediamine tetrasodium salt tetraacetic acid 1.9-3.0 Alkali 1.5-4.0 Water Else