RU2229897C2 - Bactericidal agent based on metal chelate complex - Google Patents

Abstract

FIELD: organic chemistry. SUBSTANCE: invention relates to bactericidal substances that can be used in medicine, veterinary science and food industry and in manufacturing goods of household designation: cleansing, washing and cosmetic goods. The bactericidal agent comprises chelates compounds of metals. The following compounds are used as a chelate ligand: bi- or polydentate ligands: anions of natural amino acids, or iminodiacetic and nitriletriacetic acids, and also C-substituted (at α-position to carboxyl group) derivatives of iminodiacetic and nitriletriacetic acids with different residues of amino acid fragments without aminocarboxyl group or alkylenediamiopolyacetic acids, and also C-substituted (at α-position to carboxyl group) derivatives of polyalkylene-polyaminopolyacetic acids with different residues of amino acid fragments without aminocarboxyl group, or derivatives of ω-phosphonocarboxylic and ethylenediphosphonotetrapropionic acids, or derivatives of ethylenetetra(thioacetic) and diethylenetrithiodiacetic acid or monoamine chelates wherein carboxyl groups are substituted with phosphonic groups. Ligand eliciting affinity to hydrogen ion is used as a monodentate. Invention provides enhancing antibacterial activity of ecological properties, enhancing resistance to external effect and reduced cost also. EFFECT: valuable properties of agents.

Description

The invention relates to bactericidal substances that can be used as antibacterial drugs in medicine, veterinary medicine, the food industry, as well as in the production of household goods: cleaning, washing, cosmetic products.

The closest analogue is a bactericide, including chelate complex compounds of metals (Journal of Inorganic Chemistry, 1991, vol. 36, issue 5, p. 1240).

The proposed bactericides, as well as the closest analogue, relate to chelate complexes of metals with organic ligands.

As chelate ligands, bi- or polydentate ligands of a fundamentally different structure and structure are used.

Monodentate ligands having an affinity for a hydrogen ion are used as an additional ligand.

The disadvantages of the closest analogue include its low environmental safety of the preparations during production and use, the relatively high cost of the preparations described in the work, and the low stability of the obtained complexes.

The problems to which the invention is directed are to increase the antimicrobial activity, which is achieved through the use of bi- and polydentate ligands of a certain structure, as well as a monodentate ligand having an affinity for a hydrogen ion; improving environmental properties, which is achieved through the use of natural amino acids; reducing the cost of bactericidal complexes due to the fact that cheap substances derived from protein-containing wastes are used as mono- and multidentate ligands; increased resistance to external influences during storage due to the fact that the proposed bactericidal substances are chelate complexes.

The solution of these problems is achieved by the fact that bactericides based on chelate metal complexes, including chelate metal complexes, contain a monodentate ligand that has affinity for a hydrogen ion, and bi- or polydentate ligands are used as a chelate ligand: anions of natural amino acids or iminodiacetic and nitrile triacetic acids as well as carbon-substituted (in the α-position to the carboxyl group) derivatives of iminodiacetic and nitrile triacetic acids with various residues of amino acid fragments ntov without aminocarboxylic group or alkilendiaminpoliuksusnye acid and uglerodzameschennye (in α-position to the carboxyl group) derivatives polialkilenpoliaminpoliuksusnyh acids with various residues amino acid fragments without aminocarboxylic group, or derivatives of ω-phosphonocarboxylic and etilendifosfonotetrapropionovoy acids or derivatives etilentetra (thioacetic) and dietilentritiodiuksusnoy acid or monoamine complexones in which carboxyl groups are replaced by phosphonic groups.

The proposed drugs have a common structure corresponding to the formula:

MLX

where M is a metal ion;

L - anions of natural amino acids (glycine, alanine, valine, leucine, isoleucine, phenylalanine, tyrosine, proline, oxyproline, serine, threonine, cysteine, cystine, methionine, tryptophan, aspartic acid, glutamic acid, arginine, lysine, histidine) amino acids;

iminodiacetic and nitrile triacetic acids, as well as carbon-substituted (in the α-position to the carboxyl group) derivatives of iminodiacetic and nitrile triacetic acids with various residues of amino acid fragments without an aminocarboxyl group;

alkylenediamine polyacetic acids, as well as carbon-substituted (in the α-position to the carboxyl group) derivatives of polyalkylene polyamine polyacetic acids with various residues of amino acid fragments without an aminocarboxyl group;

derivatives of ω-phosphonocarboxylic and ethylene diphosphonotetrapropionic acids;

derivatives of ethylenetetra (thioacetic) and diethylene triethodiacetic acid;

monoamine complexones in which carboxyl groups are replaced by phosphonic;

X - monodentate ligands with affinity for a hydrogen ion.

A method of producing bactericidal complexes.

Bactericidal complexes can be obtained by mixing organic bi- or polydentate ligands with metals or metal compounds and monodentate ligands.

The resulting bactericidal complexes have a pH of from 7.5 to 8.0.

Claims (1)

Bactericides based on chelate metal complexes, including chelate metal complexes, characterized in that they contain a monodentate ligand that has affinity for a hydrogen ion, and bi- or polydentate ligands are used as a chelate ligand: natural amino acid anions or iminodiacetic and nitrile triacetic acids, as well as carbon-substituted (in the α-position to the carboxyl group) derivatives of iminodiacetic and nitrile triacetic acids with various residues of amino acid fragments without aminocarboxy Flax group or alkilendiaminpoliuksusnye acid and uglerodzameschennye (in α-position to the carboxyl group) derivatives polialkilenpoliaminpoliuksusnyh acids with various residues amino acid fragments without aminocarboxylic group, or derivatives of ω-phosphonocarboxylic and etilendifosfonotetrapropionovoy acids or derivatives etilentetra (thioacetic) and dietilentritiodiuksusnoy acid or monoamine complexons in which carboxyl groups are replaced by phosphonic groups.