RU2222996C1 - Biologically active food additive - Google Patents

Abstract

FIELD: food industry. SUBSTANCE: additive contains amino acids: alanine, arginine, aspartic acid, valine, histidine, glycine, glutamic acid, isoleucin, leucine, lysine, methionine, proline, serine, tyrosine, threonine, tryptophan, phenylalanine, and cystine; organic acids: succinic acid; vitamins: ascorbic acid, nicotinic acid, thiamine, riboflavin, and biotin; trace minerals: iron, copper, and zinc; and, according to invention, additive further contains alginic acid, bioflavonoid, pantothenic acid and pyridixin (both vitamins), iodine, and non-hydrolyzed biopolymer residues. All components are present in simplified proportions. EFFECT: enabled correction of primary function and body system disturbances associated with ecotoxicants, enhanced detoxification processes, and stimulated main protection functions in organism. 5 cl, 2 tbl

Description

 The invention relates to medicine and can be used as a biologically active food additive (BAA) in pharmacology and in the food industry.

 Among the therapeutic and prophylactic agents there is a large number of vitamin-mineral complexes designed to cover nutritional deficiencies and strengthen the body, as well as amino acid preparations enriched with individual vitamins and microelements (patent of the Russian Federation 2080871, A 61 K 38/01, publ. 1997. ), (Patent of the Russian Federation 2147808, A 23 D 9/00, publ. 1998).

 These dietary supplements are designed to restore the vital protective functions of the human body and are used directly with meals or the introduction of specialized foods in order to enrich the diet with individual nutrients and biologically active substances or their complex.

 However, known agents do not possess polyvalent antiecotoxic activity.

 The closest biologically active food supplement is the METIOVIT dietary supplement, which includes amino acids - alanine, arginine, aspartic acid, valine, histidine, glycine, glutamic acid, isoleucine, leucine, lysine, methionine, proline, serine, tyrosine, threonine, tryptophan , phenylalanine, cystine, organic acids - succinic acid, vitamins - ascorbic acid, nicotinic acid, thiamine, riboflavin, biotin, trace elements - iron, copper, zinc (patent of the Russian Federation 2105502, A 23 L 1/30, publ. 1998, )

 In addition, this preparation contains pectin, glucose, citric acid, baker's yeast autolysate.

 The drug is used to activate the body's immune system, to accelerate the recovery of the body in the postoperative period and after the treatment of cancer, to normalize metabolism in the treatment of cancer patients, for mental and energy activity, to remove radionuclides, heavy metals and other toxic from the body substances.

 However, the limitation of this drug is that it contains only a partial composition of the components necessary for activating the body’s immune system and cannot have polyvalent activity selectively for each of the groups of ecotoxicants.

 The problem solved by the invention is the creation of dietary supplements of increased activity and effectiveness, with multivalent anti-ecotoxic activity against environmental and other risk factors.

 The technical result of the claimed invention is the creation of dietary supplements with a polyvalent spectrum of action in relation to environmental and other risk factors, including professional; a drug that allows to stimulate the physical and mental development of children, especially those who live in environmentally disadvantaged areas; means of promoting rehabilitation after acute diseases, infections, poisoning, injuries, blood loss, as well as chronically ill; a means to compensate for the deficiency of natural factors, including amino acids, vitamins, trace elements, including iodine; Supplements that can stimulate the performance and resilience of the body in stress and extreme situations.

To solve this problem with achieving a technical result, a biologically active food supplement including amino acids - alanine, arginine, aspartic acid, valine, histidine, glycine, glutamic acid, isoleucine, leucine, lysine, methionine, proline, serine, tyrosine, threonine, tryptophan, phenylalanine, cystine, organic acids - succinic acid, vitamins - ascorbic acid, nicotinic acid, thiamine, riboflavin, biotin, trace elements - iron, copper, zinc, according to the invention additionally contains organic acids - alginic acid, bioflavonoids, vitamins - pantothenic acid, pyridoxine, trace elements - iodine, in the following ratio, wt.%:
Amino acids:
Alanine - 2.7-4.9
Arginine - 4.4-8.1
Aspartic acid - 1.9-3.6
Valine - 1.8-3.4
Histidine - 0.7-1.5
Glycine - 3.6-7.2
Glutamic acid - 5.8-10.8
Isoleucine - 2.2-4.1
Leucine - 4.3-8.2
Lysine - 3.5-5.5
Methionine - 0.8-1.7
Proline - 1.6-3.1
Serene - 3.1-5.7
Tyrosine - 1.6-3.1
Threonine - 1.3-2.6
Tryptophan - 0.5-1.2
Phenylalanine - 1.5-3.0
Cystine - 1.8-3.4
Organic acids
Succinic acid - 1.0-3.7
Alginic acid - 1.6-3.7
Bioflavonoid (Silybin) - 0.0003-0.0007
Vitamins:
Ascorbic acid - 1.4-5.3
Thiamine - 0.0017-0.1
Riboflavin - 0.03-0.2
Pantothenic acid - 0.001-0.22
Pyridoxine - 0.033-0.083
Niacin - 0.22-0.77
Biotin - 0.0003-0.0075
Trace elements:
Iron - 0.3-1.4
Copper - 0.00045-0.004
Zinc - 0.0015-0.005
Iodine - 0.0025-0.007
Unhydrolyzed Residues of Biopolymers - Else
There are additional options for the implementation of dietary supplements, in which it is advisable that:
- vitamins were selected in the following ratio of components, wt.%:
Ascorbic acid - 1.50-1.82
Thiamine - 0.0018-0.0026
Riboflavin - 0.0036-0.0052
Pantothenic acid - 0.002-0.004
Pyridoxine - 0.033-0.083
Niacin - 0.28-0.7
Biotin - 0.0025-0.006
- it additionally contained vitamins - folic acid and cyanocobalamin, and vitamins were selected in the following ratio of components, wt.%:
Ascorbic acid - 5.3
Thiamine - 0.083
Riboflavin - 0.083
Pantothenic acid - 0.166
Pyridoxine - 0.083
Nicotinic acid - 0.42
Biotin - 0.005
Folic Acid - 0.012-0.02
Cyanocobalamin - 0.0002-0.0003
- it additionally contained vitamins A, D, beta-carotene, tocopherol and the trace element Selenium, in the following ratio, wt.%:
Ascorbic acid - 5.3
Thiamine - 0.0022
Riboflavin - 0.0044
Pantothenic acid - 0.03
Pyridoxine - 0.063
Niacin - 0.24
Biotin - 0.005
Beta Carotene - 0.166
Tocopherol - 0.166
A - 0.045
D - 0.042-0.166
Selenium - 0,00083
The technical result of the claimed invention is achieved due to the synergistic action of biologically active groups of substances (free amino acids, vitamins, trace elements, succinic acid, alginic acid, bioflavonoids) in quantities and combinations that provide, at the same time, correction of primary disorders of body functions and systems associated with the complex ecotoxicants, intensification of the processes of detoxification and elimination of foreign components from the body, stimulation of the main protective functions of the body ma

 The main difference between the claimed dietary supplement and previously patented similar products based on amino acid mixtures as a product of hydrolysis of biopolymers is as follows.

 According to the content of free amino acids (43.1-81.1 wt.%), The claimed product exceeds the previously patented ones, in which the content of free amino acids varied within 12-30 wt.%, The content of essential amino acids in the claimed tool is 68% of the total amino acid content . In previously patented products, the content of essential amino acids varies between 8-14% of the total amino acid content. In addition, the composition of the claimed dietary supplement is significantly higher in the content of a number of free amino acids that provide protective functions of the body from the action of environmental risk factors (see table 1 at the end of the description).

 As can be seen from the above data, the content of free amino acids that provide anti-ecotoxic effect, for example, such as valine, isoleucine, leucine, lysine, serine and cystine, more than double their content in other known drugs. These differences are a significant drawback of previously known drugs, which do not allow their use as effective antiecotoxic agents.

 In addition, the composition of the declared dietary supplement includes organic acids, vitamins and trace elements. Their purpose is to enhance the main antiecotoxic effect of free amino acids, as well as to provide certain functions associated with an antiecotoxic effect, to cover natural deficiencies associated with nutritional defects and environmental features. For most of these components, the claimed dietary supplement is fundamentally different from previously patented products (see table. 2 at the end of the description).

 These advantages, as well as the features of the present invention are explained with various additional options for the composition of dietary supplements.

The high content of free amino acids in dietary supplements provides the following main antiecotoxic effects in conditions of chronic intoxication:
- glutamic acid, lysine, serine provides the normalization of processes in the central nervous system under the action of neurotoxicants;
- leucine, lysine, serine, cystine enhance immune defense, preventing the development of secondary immunodeficiencies when exposed to ecotoxicants;
- glutamic acid, isoleucine, leucine, lysine form the basis of a smooth endoplasmic reticulum of the liver and microsomal oxidases, which provide detoxification of organic xenobiotics, metabolism of drugs and alcohol;
- valine, glutamic acid, isoleucine stimulate physical development, the accumulation of muscle mass, the body's stability, compensating for the adverse effects of many ecotoxicants;
- Valine, leucine, isoleucine, lysine in combination with some other amino acids (phenylalanine, tryptophan, methionine, arginine) smooth out the signs of chronic fatigue syndrome.

Examples of carrying out the invention
Example 1
The ratio of components, wt.%:
Amino acids:
Alanine - 2.7
Arginine - 4.4
Aspartic Acid - 1.9
Valin - 1.8
Histidine - 0.7
Glycine - 3.6
Glutamic acid - 5.8
Isoleucine - 2.2
Leucine - 4.3
Lysine - 3.5
Methionine - 0.8
Proline - 1.6
Serene - 3.1
Tyrosine - 1.6
Threonine - 1.3
Tryptophan - 0.5
Phenylalanine - 1.5
Cystine - 1.8
Organic acids:
Succinic acid - 1.0
Alginic acid - 1.6
Bioflavonoid (Silybin) - 0.0003
Vitamins:
Ascorbic acid - 1.4
Thiamine - 0.0017
Riboflavin - 0.03
Pantothenic acid - 0.001
Pyridoxine - 0.033
Niacin - 0.22
Biotin - 0.0003
Trace elements:
Iron - 0.3
Copper - 0,00045
Zinc - 0.0015
Iodine - 0.0025
Fragrance - 5.0
Non-hydrolyzed residues of biopolymers - Else 47.30925
As a flavoring, any of the flavorings used in the food industry can be used.

 As studies have shown, this drug has a pronounced multivalent spectrum of action in relation to environmental and other risk factors indicated earlier for the achieved technical result. Supplements can be made in the form of capsules of 3 g or 6 g of the claimed composition of the components or in the form of a powder, which should be diluted in water, juice or any drink. However, for its effective use, it is necessary to increase the daily intake for children from 3 g to 6 g, and for adults - from 6 g to 9-12 g.

Example 2
The ratio of components, wt.%:
Amino acids:
Alanine - 4.5
Arginine - 7.3
Aspartic Acid - 3.2
Valin - 3.0
Histidine - 1.2
Glycine - 6.0
Glutamic acid - 9.7
Isoleucine - 3.7
Leucine - 7.17
Lysine - 5.0
Methionine - 1.3
Proline - 2.7
Serene - 5.2
Tyrosine - 2.7
Threonine - 2.2
Tryptophan - 0.8
Phenylalanine - 2.5
Cystine - 3.0
Organic acids:
Succinic acid - 3.33
Alginic acid - 3.33
Bioflavonoid (Silybin) - 0.0005
Vitamins:
Ascorbic acid - 3.3
Thiamine - 0.083
Riboflavin - 0.083
Pantothenic acid - 0.166
Pyridoxine - 0.07
Niacin - 0.67
Biotin - 0.006
Trace elements:
Iron - 0.9
Copper - 0.003
Zinc - 0.003
Iodine - 0.005
Fragrance - 3.0
Unhydrolyzed - Else
residues of biopolymers - (13.8805)
As studies have shown, this drug has a pronounced polyvalent spectrum of action in relation to environmental and other risk factors indicated earlier for the achieved technical result. Supplements can be made in the form of capsules of 3 g or 6 g of the claimed composition of the components or in the form of a powder, which should be diluted in water, juice or any drink. The daily dose per day for children is 3 g, for adults - 6 g.

Example 3
The ratio of components, wt.%:
Amino acids:
Alanine - 4.9
Arginine - 8.1
Aspartic Acid - 3.6
Valin - 3.4
Histidine - 1.5
Glycine - 7.2
Glutamic acid - 10.8
Isoleucine - 4.1
Leucine - 8.2
Lysine - 5.5
Methionine - 1.7
Proline - 3.1
Serene - 5.7
Tyrosine - 3.1
Threonine - 2.6
Tryptophan - 1.2
Phenylalanine 3.0
Cystine - 3.4
Organic acids:
Succinic acid - 3.7
Alginic acid - 3.7
Bioflavonoid (Silybin) - 0.0007
Vitamins:
Ascorbic acid - 5.3
Thiamine - 0.1
Riboflavin - 0.2
Pantothenic acid - 0.22
Pyridoxine - 0.083
Niacin - 0.77
Biotin - 0.0075
Trace elements:
Iron - 1.4
Copper - 0.004
Zinc - 0.005
Iodine - 0.007
Non-Hydrolyzed Residues of Biopolymers - Other (3,4028)
As studies have shown, this drug has a pronounced polyvalent spectrum of action in relation to environmental and other risk factors indicated earlier for the achieved technical result. Supplements can be made in the form of capsules of 3 g or 6 g of the claimed composition of the components or in the form of a powder. The drug is characterized by almost complete processing of raw materials - keratoproducts, baker's yeast, sea kale with the addition of the missing components to the indicated amounts: vitamins, trace elements, succinic acid. The daily dose per day for children is 3 g, for adults - 6 g.

In the first additional version of dietary supplements, optimized ratios of the components of the vitamin group are given. Vitamins are selected in the following ratio of components, wt.%:
Ascorbic acid (C) - 1.50-1.82
Thiamine (B1) - 0.0018-0.0026
Riboflavin (B2) - 0.0036-0.0052
Pantothenic acid (B3) - 0.002-0.004
Pyrodoxin (B6) - 0.033-0.083
Niacin (PP) - 0.28-0.7
Biotin (N) - 0.0025-0.006
Recommendations for using this option:
- environmental and occupational stress for any type of environmental pollution (heavy metals, radionuclides, organic xenobiotics, inorganic non-metallic pollution, photooxidants, etc.);
- children to improve physical and mental development, especially those living in ecologically disadvantaged areas and in conditions of a deficiency of natural factors (iodine, iron, nutritional deficiencies);
- convalescents after acute illnesses, operations, injuries, blood loss, poisoning and other diseases, chronic patients, the elderly and disabled people to increase metabolism and immune defense;
- chronic nutritional deficiencies, natural iodine, iron deficiency, especially for people living in environmentally disadvantaged areas and exposed to occupational risk factors;
- decreased performance, stress, chronic fatigue, extreme situations.

Example 4
The ratio of components, wt.%:
Amino acids:
Alanine - 4.5
Arginine - 7.3
Aspartic Acid - 3.2
Valin - 3.0
Histidine - 1.2
Glycine - 6.0
Glutamic acid - 9.7
Isoleucine - 3.7
Leucine - 7.17
Lysine - 5.0
Methionine - 1.3
Proline - 2.7
Serene - 5.2
Tyrosine - 2.7
Threonine - 2.2
Tryptophan - 0.8
Phenylalanine - 2.5
Cystine - 3.0
Organic acids:
Succinic acid - 3.33
Alginic acid - 3.33
Bioflavonoid (Silybin) - 0.0005
Vitamins:
Ascorbic acid - 1.50
Thiamine - 0.0018
Riboflavin - 0.0036
Pantothenic acid - 0.002
Pyridoxine - 0.033
Niacin - 0.28
Biotin - 0.0025
Trace elements:
Iron - 0.9
Copper - 0.003
Zinc - 0.003
Iodine - 0.005
Fragrance - 3.0
Non-Hydrolyzed Biopolymer Residues - Other (16,4356)
Example 5
The ratio of components, wt.%:
Amino acids:
Alanine - 4.5
Arginine - 7.3
Aspartic Acid - 3.2
Valin - 3.0
Histidine - 1.2
Glycine - 6.0
Glutamic acid - 9.7
Isoleucine - 3.7
Leucine - 7.17
Lysine - 5.0
Methionine - 1.3
Proline - 2.7
Serene - 5.2
Tyrosine - 2.7
Threonine - 2.2
Tryptophan - 0.8
Phenylalanine - 2.5
Cystine - 3.0
Organic acids:
Succinic acid - 3.33
Alginic acid - 3.33
Bioflavonoid (Silybin) - 0.0005
Vitamins:
Ascorbic acid - 1.82
Thiamine - 0.0026
Riboflavin - 0.0052
Pantothenic acid - 0.004
Pyridoxine - 0.083
Niacin - 0.7
Biotin - 0.006
Trace elements:
Iron - 0.9
Copper - 0.003
Zinc - 0.003
Iodine - 0.005
Fragrance - 3.0
Non-hydrolyzed Residues of Biopolymers - Other (15.6377)
In the second additional version of the dietary supplement, the mass of the main vitamins in the composition of the drug is increased, and the dietary supplement additionally contains vitamins - folic acid and cyancobalamin, and vitamins are selected in the following ratio of components, wt.%:
Ascorbic acid (C) - 5.3
Thiamine (B1) - 0,083
Riboflavin (B2) - 0,083
Pantothenic acid (B3) - 0.166
Pyridoxine (B6) - 0,083
Niacin (PP) - 0.42
Biotin (H) - 0.005
Folic Acid (Sun) - 0.012-0.02
Cyanocobalamin (B ₁₂ ) - 0.0002-0.0003
Recommendations for the use of the second option of dietary supplement (in this case, the drug also satisfies its purpose according to the first additional option):
- intensive environmental and occupational stress in the conditions of influence of enterprises of non-ferrous and ferrous metallurgy, petrochemicals, organic synthesis;
- with an intense load of organic xenobiotics and neurotropic chemicals;
- work in conditions associated with high mental, nervous and physical stress; eliminating the effects of stress.

Example 6
The ratio of components, wt.%:
Amino acids:
Alanine - 4.5
Arginine - 7.3
Aspartic Acid - 3.2
Valin - 3.0
Histidine - 1.2
Glycine - 6.0
Glutamic acid - 9.7
Isoleucine - 3.7
Leucine - 7.17
Lysine - 5.0
Methionine - 1.3
Proline - 2.7
Serene - 5.2
Tyrosine - 2.7
Threonine - 2.2
Tryptophan - 0.8
Phenylalanine - 2.5
Cystine - 3.0
Organic acids:
Succinic acid - 3.33
Alginic acid - 3.33
Bioflavonoid (Silybin) - 0.0005
Vitamins:
Ascorbic acid - 5.3
Thiamine - 0.083
Riboflavin - 0.083
Pantothenic acid - 0.166
Pyridoxine - 0.083
Nicotinic acid - 0.42
Biotin - 0.005
Folic Acid - 0.012
Cyanocobalamin - 0.0002
Trace elements:
Iron - 0.9
Copper - 0.003
Zinc - 0.003
Iodine - 0.005
Fragrance - 3.0
Non-Hydrolyzed Biopolymer Residues - Other (12,1063)
Example 7
The ratio of components, wt.%:
Amino acids:
Alanine - 4.5
Arginine - 7.3
Aspartic Acid - 3.2
Valin - 3.0
Histidine - 1.2
Glycine - 6.0
Glutamic acid - 9.7
Isoleucine - 3.7
Leucine - 7.17
Lysine - 5.0
Methionine - 1.3
Proline - 2.7
Serene - 5.2
Tyrosine - 2.7
Threonine - 2.2
Tryptophan - 0.8
Phenylalanine - 2.5
Cystine - 3.0
Organic acids:
Succinic acid - 3.33
Alginic acid - 3.33
Bioflavonoid (Silybin) - 0.0005
Vitamins:
Ascorbic acid - 5.3
Thiamine - 0.083
Riboflavin - 0.083
Pantothenic acid - 0.166
Pyridoxine - 0.083
Nicotinic acid - 0.42
Biotin - 0.005
Folic Acid - 0.02
Cyanocobalamin - 0.0003
Trace elements:
Iron - 0.9
Copper - 0.003
Zinc - 0.003
Iodine - 0.005
Fragrance - 3.0
Non-Hydrolyzed Biopolymer Residues - Other (12.0982)
In the third additional version of dietary supplements, optimized ratios of the components of the vitamin group are given when additional antioxidant agents are added to the preparation. In the third embodiment, the preparation additionally contains vitamins A, D, beta-carotene, tocopherol and the trace element Selenium (Se), in the following ratio, wt.%:
Ascorbic acid (C) - 5.3
Thiamine (B1) - 0.0022
Riboflavin (B2) - 0.0044
Pantothenic acid (B3) - 0.03
Pyridoxine (B6) - 0,063
Niacin (PP) - 0.24
Biotin (N) - 0.005
Beta Carotene - 0.166
Tocopherol (E) - 0.166
A - 0.045
D - 0.042-0.166
Selenium (Se) - 0,00083
In addition to the recommendations of the main drug, this option is recommended to be used:
- with intensive environmental and occupational exposure to oxidants, including radionuclides;
- in case of chronic cardiovascular diseases, convalescents, lipid metabolism disorders;
- in the prevention of cardiovascular diseases, secondary immunodeficiencies for older and elderly people, especially those living in conditions of environmental distress;
- to promote active longevity.

Example 8
The ratio of components, wt.%:
Amino acids:
Alanine - 4.5
Arginine - 7.3
Aspartic Acid - 3.2
Valin - 3.0
Histidine - 1.2
Glycine - 6.0
Glutamic acid - 9.7
Isoleucine - 3.7
Leucine - 7.17
Lysine - 5.0
Methionine - 1.3
Proline - 2.7
Serene - 5.2
Tyrosine - 2.7
Threonine - 2.2
Tryptophan - 0.8
Phenylalanine - 2.5
Cystine - 3.0
Organic acids:
Succinic acid - 3.33
Alginic acid - 3.33
Bioflavonoid (Silybin) - 0.0005
Vitamins:
Ascorbic acid - 5.3
Thiamine - 0.0022
Riboflavin - 0.0044
Pantothenic acid - 0.03
Pyridoxine - 0.063
Niacin - 0.24
Biotin - 0.005
Beta Carotene - 0.166
Tocopherol - 0.166
A - 0.045
D - 0.1
Trace elements:
Iron - 0.9
Copper - 0.003
Zinc - 0.003
Iodine - 0.005
Selenium - 0,00083
Fragrance - 3.0
Non-Hydrolyzed Biopolymer Residues - Other (12.13607)
As studies have shown, there are no contraindications for the use of the declared dietary supplement.

 As a raw material for the production of dietary supplements, hydrolysates of various biopolymers can be used, for example, beer, baker's yeast, keratoproducts, etc. To maintain this ratio of components, seaweed, succinic acid, vitamins, and trace elements are additionally used as additives.

 Supplements can be made in the form of capsules of 3 g or 6 g of the claimed composition of the components or in the form of a powder, which should be diluted in water, juice or any drink.

 Recommended doses for children: 3.0 g per day for 45-60 days in spring and autumn. Doses for adults: 6.0 g per day for 45-60 days in spring and autumn. For convalescents who are in extreme conditions of persons or if necessary to strengthen the prophylactic effect, these doses can be increased by 1.5-2 times.

 The most successfully declared biologically active food supplement is industrially applicable in medicine and the food industry, mainly in relation to environmental and other risk factors.

Claims (4)

1. A dietary supplement containing amino acids - alanine, arginine, aspartic acid, valine, histidine, glycine, glutamic acid, isoleucine, leucine, lysine, methionine, proline, serine, tyrosine, threonine, tryptophan, phenylalanine, cystine, organic acids - succinic acid, vitamins - ascorbic acid, nicotinic acid, thiamine, riboflavin, biotin, trace elements - iron, copper, zinc, characterized in that it additionally contains organic acids - alginic acid, bioflavonoid, vitamins - pantothenic acid y, pyridoxine, trace elements - iodine, biopolymers negidralizovannye residues at the following component ratio, wt.%: amino acids: Alanine 2.7-4.9 Arginine 4.4-8.1 Aspartic acid 1.9-3.6 Valine 1.8-3.4 Histidine 0.7-1.5 Glycine 3.6-7.2 Glutamic acid 5.8-10.8 Isoleucine 2.2-4.1 Leucine 4.3-8.2 Lysine 3.5-5.5 Methionine 0.8-1.7 Proline 1.6-3.1 Serine 3.1-5.7 Tyrosine 1.6-3.1 Threonine 1.3-2.6 Tryptophan 0.5-1.2 Phenylalanine 1.5-3.0 Cystine 1.8-3.4 organic acids: Succinic acid 1.0-3.7 Alginic acid 1.6-3.7 Bioflavonoid (Silybin) 0.0003-0.0007 vitamins: Ascorbic acid 1.4-5.3 Thiamine 0.0017-0.1 Riboflavin 0.0044-0.2 Pantothenic acid 0.001-0.22 Pyrodoxin 0.033-0.083 Nicotinic acid 0.22-0.77 Biotin 0.0025-0.0075 trace elements: Iron 0.3-1.4 Copper 0.00045-0.004 Zinc 0.0015-0.005 Iodine 0.0025-0.007 Non-hydrolyzed residues of biopolymers 2. The supplement according to claim 1, characterized in that the vitamins are selected in the following ratio of components, wt.%: Ascorbic acid 1.50-1.82 Thiamine 0.0018-0.0026 Riboflavin 0.0036-0.0052 Pantothenic acid 0.002-0.004 Pyridoxine 0.033-0.083 Nicotinic acid 0.28-0.7 Biotin 0.0025-0.006 3. The supplement according to claim 1, characterized in that it additionally contains vitamins - folic acid and cyancobalamin and vitamins selected in the following ratio of components, wt.%: Ascorbic acid 5.3 Thiamine 0.083 Riboflavin 0.083 Pantothenic acid 0.166 Pyridoxine 0.086 Nicotinic acid 0.42 Biotin 0.005 Folic Acid 0.012-0.02 Cyanocobalamin 0.0002-0.0003 4. The additive according to claim 1, characterized in that it additionally contains vitamins A, D beta-carotene, tocopherol and trace element selenium in the following ratio, wt.%: Ascorbic acid 5.3 Thiamine 0.0022 Riboflavin 0.0044 Pantothenic acid 0.03 Pyridoxine 0.063 Nicotinic acid 0.24 Biotin 0.005 Beta carotene 0.166 Tocopherol 0.166 A 0.045 D 0.042-0.166 Selenium 0,00083

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