RU2220732C2 - Agent normalizing renal function and method for it preparing - Google Patents

Agent normalizing renal function and method for it preparing Download PDF

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Publication number
RU2220732C2
RU2220732C2 RU2001129544/15A RU2001129544A RU2220732C2 RU 2220732 C2 RU2220732 C2 RU 2220732C2 RU 2001129544/15 A RU2001129544/15 A RU 2001129544/15A RU 2001129544 A RU2001129544 A RU 2001129544A RU 2220732 C2 RU2220732 C2 RU 2220732C2
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Russia
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agent
molecular weight
concentration
renal function
normalizing
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RU2001129544/15A
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Russian (ru)
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RU2001129544A (en
Inventor
Ю.М. Мустаева
Н.В. Мельников
Т.И. Варламова
Ф.Н. Нигамов
М.Х. Козырева
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Государственное унитарное предприятие "Иммунопрепарат"
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Priority to RU2001129544/15A priority Critical patent/RU2220732C2/en
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Abstract

FIELD: medicine, nephrology, pharmacy. SUBSTANCE: invention relates to production of medicinal agents from animal raw. Pharmacological agent represents low-molecular fraction from agricultural animals kidney extract and as an active component it comprises complex of amino acids in the concentration from 3.0 to 4.0 mg/ml by amine nitrogen and peptides in the concentration from 9.0 to 11.0 mg/ml. Preparation exhibits absorption peak in ultraviolet spectrum at wavelength 270 ± 5 nm and molecular mass value 10-15 kDa, not above. For preparing agent kidney tissue of slaughter agricultural animals is milled, extracted with acetic acid, prepared substrate is frozen at temperature (-5)-(-20) C followed by thawing and clearance and low- -molecular fraction is isolated by ultrafiltration method on membranes with selectivity 10-15 kDa. To the prepared filtrate stabilizing agent is added, sterilized, poured into ampoules and lyophilized. Prepared agent is used in the dose 0.1-0.25 mg/kg of body mass for 10 days that provides effective normalization of renal function. EFFECT: improved preparing method, enhanced effectiveness and valuable medicinal properties of agent. 3 cl, 8 tbl

Description

Текст описания в факсимильном виде (см. графическую часть)н Description text in facsimile form (see graphic part)

Claims (3)

1. Фармакологическое средство для нормализации функций почек, представляющее собой низкомолекулярную фракцию экстракта почечной ткани сельскохозяйственных животных, отличающееся тем, что в качестве активного начала содержит комплекс аминокислот в концентрации от 3,0 до 4,0 мг/мл по аминному азоту и пептидов в концентрации от 9,0 до 11,0 мг/мл, имеющий максимум поглощения в ультрафиолетовом спектре при длине волны (270±5) нм и характеризующийся величиной молекулярной массы не более 10-15 кД.1. A pharmacological agent for normalizing renal function, which is a low molecular weight fraction of the extract of the renal tissue of farm animals, characterized in that it contains an amino acid complex in a concentration of from 3.0 to 4.0 mg / ml for amine nitrogen and peptides in a concentration from 9.0 to 11.0 mg / ml, having a maximum absorption in the ultraviolet spectrum at a wavelength of (270 ± 5) nm and characterized by a molecular weight of not more than 10-15 kDa. 2. Способ получения фармакологического средства для нормализации функций почек, включающий измельчение ткани почек убойных сельскохозяйственных животных, ее экстракцию уксусной кислотой и выделение низкомолекулярной фракции экстракта, отличающийся тем, что полученный после экстракции субстрат подвергают замораживанию при температуре (-5)-(-20)°С с последующими оттаиванием и осветлением, выделяют низкомолекулярную фракцию методом ультрафильтрации на мембранах с селективностью 10-15 кД, к полученному фильтрату добавляют стабилизатор, стерилизуют, разливают в ампулы и лиофилизируют.2. A method of obtaining a pharmacological agent for normalizing renal function, including grinding the kidney tissue of slaughtered farm animals, extracting it with acetic acid and isolating a low molecular weight fraction of the extract, characterized in that the substrate obtained after extraction is subjected to freezing at a temperature of (-5) - (- 20) ° C, followed by thawing and clarification, a low molecular weight fraction is isolated by ultrafiltration on membranes with a selectivity of 10-15 kD, a stabilizer is added to the obtained filtrate, they are poured, poured into ampoules and lyophilized. 3. Способ нормализации функциональной активности почек путем применения фармакологического средства, представляющего собой низкомолекулярную фракцию экстракта почечной ткани сельскохозяйственных животных, отличающийся тем, что используют средство по п.1 в дозе 0,1-0,25 мг/кг массы тела в течение 10 дней.3. A method of normalizing the functional activity of the kidneys by using a pharmacological agent, which is a low molecular weight fraction of the extract of the renal tissue of farm animals, characterized in that the agent according to claim 1 is used in a dose of 0.1-0.25 mg / kg body weight for 10 days .
RU2001129544/15A 2001-11-01 2001-11-01 Agent normalizing renal function and method for it preparing RU2220732C2 (en)

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RU2001129544A RU2001129544A (en) 2003-07-10
RU2220732C2 true RU2220732C2 (en) 2004-01-10

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA010723B1 (en) * 2006-06-22 2008-10-30 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Medicament normalizing kidney functions and method for preparing thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
АЛЬ-ШУКРИ С.Х. и др. Введение в биорегулирующую терапию при урологических болезнях. - СПб.: Наука, 1996, с. 10, 71 и 72. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA010723B1 (en) * 2006-06-22 2008-10-30 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Medicament normalizing kidney functions and method for preparing thereof

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PC43 Official registration of the transfer of the exclusive right without contract for inventions

Effective date: 20180328

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