RU2220151C2 - Steroid derivatives, methods for their preparing, pharmaceutical composition, treatment method, method for suppression of microorganisms growth - Google Patents
Steroid derivatives, methods for their preparing, pharmaceutical composition, treatment method, method for suppression of microorganisms growth Download PDFInfo
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- RU2220151C2 RU2220151C2 RU2000125277/04A RU2000125277A RU2220151C2 RU 2220151 C2 RU2220151 C2 RU 2220151C2 RU 2000125277/04 A RU2000125277/04 A RU 2000125277/04A RU 2000125277 A RU2000125277 A RU 2000125277A RU 2220151 C2 RU2220151 C2 RU 2220151C2
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- compound
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- optionally substituted
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
FIELD: organic chemistry, steroids, chemical technology, pharmacy. SUBSTANCE: invention describes some new steroid derivatives of the formula (I) wherein R3,R7,R12 represent independently OH, =O, C1-10-hydroxyalkyl, optionally substituted C1-10-aminoalkyl, possibly protected C1-10-hydroxyalkyloxy-group wherein OH-group is protected possibly, C2-10-acyloxy-group, possibly substituted C1-10-aminoalkyloxy-group, possibly substituted C1-10-aminoalkylcarboxy-group wherein amino-group is possibly protected or quaternized, H2N- HC(Q5)-C(O)-O- wherein Q5-side chain of any amino acid and amino-group is possibly protected, possibly substituted C1-10-guanidinoalkyloxy-group, C2-10-alkenyloxy-group, C1-10-cyanoalkyloxy-group, C1-10- azidoalkyloxy-group; R17 is possibly substituted C1-10-hydroxyalkyl wherein OH is optionally protected or optionally substituted C1-10-alkyloxy-C1-10-alkyl, optionally substituted C1-10-aminoalkyl, C2-10-acyl or its ketal derivatives, or binding group bound to the second steroid at position 17 wherein binding group represents C1-10- alkyleneoxy-C1-10-alkylene, or their pharmaceutically acceptable salts. Proposed compounds are antibacterial agents providing sensitivity of microorganisms (sensibilization) to effect of other antibiotics, among them erythromycin and novobiocin. EFFECT: improved preparing method, enhanced treatment method, valuable medicinal properties of compounds. 37 cl, 7 sch, 8 tbl, 8 ex
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Текст описания в факсимильном виде (см. графическую часть). Description text in facsimile form (see graphic part).
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2000125277/04A RU2220151C2 (en) | 1998-03-06 | 1998-03-06 | Steroid derivatives, methods for their preparing, pharmaceutical composition, treatment method, method for suppression of microorganisms growth |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2000125277/04A RU2220151C2 (en) | 1998-03-06 | 1998-03-06 | Steroid derivatives, methods for their preparing, pharmaceutical composition, treatment method, method for suppression of microorganisms growth |
Publications (2)
Publication Number | Publication Date |
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RU2000125277A RU2000125277A (en) | 2002-08-10 |
RU2220151C2 true RU2220151C2 (en) | 2003-12-27 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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RU2000125277/04A RU2220151C2 (en) | 1998-03-06 | 1998-03-06 | Steroid derivatives, methods for their preparing, pharmaceutical composition, treatment method, method for suppression of microorganisms growth |
Country Status (1)
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RU (1) | RU2220151C2 (en) |
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1998
- 1998-03-06 RU RU2000125277/04A patent/RU2220151C2/en active
Non-Patent Citations (1)
Title |
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ТРИНУС Ф.П. Фармакотерапевтический справочник. - Киев, Здоровья, 1989, с.387. J.Amer.Chem. Soc. (1996), v. 118, №7, р.1813-1814. * |
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