RU2210351C1 - Method for correcting remote aftereffects of radiation impact in low dosages - Google Patents

Abstract

FIELD: medicine, rehabilitation. SUBSTANCE: impact comes due to mechanic microvibrations from Vitaphon device at steadily alternating frequency in acoustic range of 0.03-18 kHz by successive cycles at 120±40sec duration, moreover, one should affect 5-6 pairs of points simultaneously along the whole central vertebral line at distance between vibrophons in every pair being 0.5-1 cm per 15-20 min daily for 5-15 d. The suggested method enables to correct lymphopoiesis due to improved hemogenesis in vertebral column under impact of mechanic microvibrations. EFFECT: higher efficiency of correction. 2 ex

Description

 The invention relates to medicine, more specifically to medical radiology, and may find application for the rehabilitation of liquidators of the consequences of radiation disasters.

 In connection with the development of nuclear energy in the world, cases of mass exposure to nuclear reaction products have become more frequent. A striking example of such an impact is the Chernobyl disaster. More than 200 thousand Russians were involved in the liquidation of the consequences of the Chernobyl accident. Until now, the study of the biological and medical consequences of this accident continues, the hallmark of which is the massive impact on the population of the adjacent territories and especially those directly involved in the elimination of its consequences. Most of them received external radiation doses of up to 25 cGy. Despite the relatively small officially registered dose loads of the so-called liquidators of the accident, various violations of their state of health are registered today, caused by combinations of the effects of radiation and other unfavorable factors when performing work to eliminate the consequences of the accident. They are expressed in diseases of the circulatory system (vascular, hypertension), musculoskeletal (joints), nervous, digestive and gastrointestinal tract. According to laboratory data, abnormalities of blood formation and especially lymphopoiesis (decreased immunity) are recorded. One of the probable causes of this symptomatology is the long delay of cesium-137 in the subcellular particles of skeletal muscle. All this leads to a deterioration in the quality of life of these people. The so-called cerebroasthenic syndrome occurs in more than 55% of liquidators (headache, dizziness, chronic fatigue, poor attention, irritability, fear, mood swings, physical and mental exhaustion, a sense of hopelessness, impotence).

 Rehabilitation of such patients involves symptomatic drug treatment. [Nikiforov A.M. and others. Diagnosis and medical rehabilitation of the liquidators of the consequences of the Chernobyl accident and other radiation disasters. Information letter of the Ministry of Health of the Russian Federation, M., 1995, 66 pp.] (Prototype).

 The authors note that in connection with complex somatic pathology, the main complaints of the liquidators are headaches, high blood pressure, pain in the osteoarticular and muscular systems, which are difficult to treat with traditional analgesics, vascular and non-steroidal anti-inflammatory drugs. Among the diseases of the cardiovascular system, the most common hypertension is also very resistant to treatment with traditional drugs. All this indicates the lack of effectiveness of the generally accepted symptomatic treatment, since it is non-specific. As for the correction of lymphopoiesis in these individuals, such methods have not been developed at all, and the correction of the abnormal function of most organs and systems is indirectly associated with the normalization of the lymphopoietic system.

 The technical result of the present invention consists in the correction of lymphopoiesis through the use of mechanical microvibration.

 This result is achieved by the fact that, in addition, the patient is exposed through mechanical microvibrations with a smoothly varying frequency in the acoustic range of 0.03-18 kHz in successive cycles of 120 ± 40 s duration, moreover, they act simultaneously and equally efficiently for 15-20 minutes daily for 5-15 days for 5-6 pairs of points along the center line of the spine with a distance between points in a pair of 0.5-1 cm.

Earlier [Patent 2126156 MKI G 01 N 33/53] we have shown that when radiation is applied in small doses, there is a steady decrease in the content of the fraction of lymphocytes, which form stable with a temperature of 37 ^o C rosettes with sheep erythrocytes, the so-called E-37-ROL. This was noted by us both among liquidators and children after long-term permanent residence in contaminated areas due to the deposition of cesium-137. This phenomenon was laid by us as the basis for the method of biological indication of radiation exposure on the human body in the threshold dose range (up to 0.2 Gy), for the registration of which there is no other specific method available. This made it possible to determine the fact of irradiation, especially in the long term, which is very important for an objective assessment of the health damage of people exposed to radiation.

 Our constant observations of the liquidators of the Chernobyl accident (1986) show that so far (16 years) the decrease in the E-37-ROL indicator has remained unchanged and, with a high degree of probability, such a decrease can continue.

 Our other study [Patent 2166924 MKI A 61 H 23/00], based on the previously discovered ability of microvibration of sound frequencies to penetrate to a sufficient depth in living tissues and produce vasodilation, is associated with the use of this phenomenon for blood enrichment with stem hematopoietic cells (CCM).

 Both of these facts we discovered earlier formed the basis for further research, namely the study of the possible effect of mechanical vibration on other blood parameters. Since sound vibrations propagating through the vertebral body cause activation of lymphopoiesis in the areas of bone marrow circulation, which is accompanied by an increase in the number of CCMs (CD 34+) by more than 3 times in 3-4 hours, we decided to study their effect on E-37- ROL (CD 4 + Leu 8+), a deficiency of which is observed among liquidators, as well as a specific dose-dependent index - the ratio of CD 4 + Leu 8+ / CD 8+, 11b +, which is less than unity in them at the rate that we found in healthy persons 4.7 ± 1.07. E-37-ROL and CD 8+, 11b + (Auto-ROL) are early forms of the T-cell immunity, including helper-suppressor cells, as well as normal killers, which together provide resistance to the body.

 It turned out that 40 minutes after exposure to sound vibrations by means of the Vitafon device [Patent 2022551, TU 9444.003.33 / 59359-95], the ratio of CD 4 + Leu 8+ / CD 8+, 11b + increases 2.6 times, and this effect is transient after 3-4 hours it disappears. This fact, however, prompted us to study the effect of sound vibrations on these indicators in order to find possible modes that give a longer lasting effect. At the same time, we proceeded from the opportunities provided by the Vitafon device. We experimentally found such vibration conditions: exposure with a smoothly changing frequency in the acoustic range of 0.03-18 kHz in successive cycles of 120 ± 40 s duration.

 Exposure to points along the entire central line of the spine can significantly improve hematopoiesis, since it is known that it is in these bones that about 42% of the active bone marrow of an adult is concentrated. And the impact on points located along the spine in pairs enhances the effect of vibration in each pair on the entire vertebral body.

 The exposure regimes that we found — daily for 15–20 min for 5–15 days — ensure the achievement of a persistent positive effect, which, as we have shown, lasts up to 6 months. This effect is expressed in an increase in the content of E-37-ROL in the blood by more than 2 times and the ratio of E-37-ROL / Auto-ROL by more than 3 times, normalization of blood pressure, and a decrease in head and musculoskeletal pains.

 Since the use of these acoustic exposures was envisaged in individuals with an increased risk of carcinogenesis due to their radiation exposure, we previously tested them in patients with benign tumors to determine whether these effects cause accelerated tumor growth. The study was performed in 30 patients with benign uterine tumors (fibromyomas) who underwent acoustic exposure in the indicated modes for 1 month. According to X-ray control data, no patient had tumor growth. On the contrary, there was a decrease in tumor volume - an average of 17% (p <0.001). This indicates a high safety of the impacts used.

 The essence of the method is illustrated by examples.

 EXAMPLE 1. B. K., 47 years old, 1986 Chernobyl accident liquidator. When working at the emergency unit, according to officially registered data, he received a dose load of 25 cGy. After a year, he began to have headaches, developed hypertension, and appeared to have disorders of the thyroid gland. He is constantly being treated at the place of residence and once every 5 years at the TsNIRRI clinic. The treatment is mainly symptomatic medication.

 04/25/2002, was admitted to the clinic TsNIRRI with complaints of pain in the left half of the chest, joint pain. Blood pressure 140/90.

 According to an ultrasound scan (ultrasound) of the thyroid gland, secondary hypothyroidism. Diffuse knobby goiter - nodes up to 4 mm in the left lobe of the gland.

 Ultrasound of the heart - post-infarction cardiosclerosis, ischemic heart disease.

 Ultrasound of the abdomen - no data were found for the pathology.

 Fibrogastroscopy (X-ray examination of such patients is limited as much as possible) - cicatricial deformity of the duodenal bulb. Peptic ulcer in the acute stage.

Blood test: Er-4.1 • 10 ¹² / L, L-4.35 • 10 ⁹ L, T-lymphocytes-54%, B-lymphocytes-4%, E-37-ROL-8%, Auto-ROL -8%, the ratio of E-37-ROL / Auto-ROL is 1.

 Along with the traditional symptomatic treatment, the patient underwent 5 sessions of acoustic microvibrations using the Vitafon device (000 “Vitafon”). To do this, in the supine position along the spine, 5 pairs of vibrophones were placed at an equal distance from each other and with a distance of 1 cm between them. At the same time, all-in vibrophones were subjected to in-phase exposure by microvibration in the acoustic range 0.03-18 kHz in successive cycles of 120 duration ± 40 s for 20 minutes Such exposure was carried out daily for 5 days.

 At the end of the course of treatment, the patient noted a significant improvement in health due to the disappearance of joint pain in the left half of the chest (corinfar was canceled), heart palpitations stopped, blood pressure returned to normal (110/80).

Blood counts: Er-3.8 • 10 ¹² / l, L-6.5 • 10 ⁹ / l, T-lymph. -56%, B-lymph. -31%, E-37-ROL-11%, Auto-ROL-4%, the ratio of E-37-ROL / Auto-ROL - 2.7.

May 17, 2002 (after 1 month) - I feel satisfactory, there are no complaints of pain in the chest and joints. Blood pressure is normal. Blood counts: Er-4 • 10 ¹² / l, L-6.8 • 10 ⁹ / l, T-lymph. -60%, B-lymph. -36%, E-37-ROL-13%, Auto-ROL-5%, the ratio of these indicators is 2.6.

 Conclusion: the patient's condition is satisfactory, the effect obtained during treatment is preserved.

 EXAMPLE 2. B. P., 38 years old, the liquidator of the 1986 Chernobyl accident, received a dose load of 22 cGy.

 In the clinic, TsNIRRI was treated from 11/01/99 to 12/06/99 with a diagnosis of vegetative-vascular dystonia, osteochondrosis of the cervical spine. Chronic sinusitis. Chronic prostatitis II Art. Subacute course.

 Upon receipt of a complaint of persistent pain in all parts of the spine, fatigue.

 Ultrasound of the thyroid gland - data for pathology were not identified.

 Ultrasound of the heart - left ventricular myocardial hypertrophy. Dopplerography of the vessels of the neck - the decrease in the maximum blood flow velocity in the pool of the left common artery is determined.

Blood test: Er-4.75 • 10 ¹² / l, L-5.3 • 10 ⁹ / l, T-lymph.-55%, B-lymph.-6%, E-37-ROL-1%, Auto-ROL-13%, the ratio of E-37-ROL / Auto-ROL is 0.08.

 The patient was prescribed a course of treatment using acoustic microvibrations as in example 1. 15 sessions were conducted - until the back pain disappeared.

At discharge: improvement of well-being, at the end of treatment, cessation of pain in the spine. Blood counts: Er -4.5 • 10 ¹² / l, L-5.8 • 10%, T-lymph.-59%, B-lymph.-6%, E-37-ROL-8%, Auto- ROL-16%. The ratio of these indicators is 0.5.

 After 6 months (in June 2000) was hospitalized at the TsNIRRI clinic for follow-up examination, and / b 1676. He had no complaints about pain in the spine. Received therapy for gastric ulcer. Blood counts: T-lymph.-71%, B-lymph.-30%, E-37-ROL-14%, Auto-ROL-13%, their ratio is 1.08. This indicates a persistent correction of lymphopoiesis.

 To date, the proposed method has treated 10 liquidators of the Chernobyl nuclear power plant, which almost for the first time carried out the correction of lymphopoiesis with obtaining a stable positive effect.

 The proposed method in comparison with the known has several significant advantages.

 1. The proposed method, in contrast to the known methods of rehabilitation of persons exposed to radiation in small doses, provides persistent pathognomonic correction of lymphopoiesis, which indirectly provides correction of the abnormal state of most organs and systems of the body.

 2. The method allows to weaken headaches and osteoarticular pains that are difficult to stop with conventional medications, as well as normalize blood pressure that is resistant to treatment with traditional drugs.

 The method was developed at TsNIRRI in conjunction with Vitafon LLC, underwent clinical testing in 10 patients with a positive result and is ready for implementation in medical practice for the treatment of the long-term effects of low-dose radiation exposure in people affected by nuclear accidents.

Claims (1)

 A method for correcting the long-term effects of radiation in small doses by symptomatic treatment, characterized in that they additionally carry out the action by means of mechanical microvibrations from the Vitafon device with a smoothly varying frequency in the acoustic range of 0.03-18 kHz in successive cycles of 120 ± 40 s duration, and they act simultaneously for 5-6 pairs of points along the entire central line of the spine with a distance between vibrophones in each pair of 0.5-1 cm for 15-20 minutes daily for 5-15 days.