RU2198652C2 - Suppositories of antiphlogistic and bactericidal action - Google Patents

Abstract

FIELD: veterinary pharmacology. SUBSTANCE: the method deals with technology for manufacturing medicinal forms - suppositories of antimicrobial, fungicidal and antiphlogistic action indicated for treatment and prophylaxis of post partum diseases in females of agricultural and domestic animals. The method consists in obtaining suppositories due to adding the product of dry distillation of hazel nut to polyethylene glycol used as filler at the following ratio of components: product of dry distillation of hazel nut 1.75-2.25%, filler - the rest. Suppositories in question are of bactericidal and fungicidal action and cause no irritation for mucous membrane. EFFECT: higher efficiency of therapy.

Description

 The invention relates to the field of veterinary pharmacology and for the creation of dosage forms - suppositories intended for the prevention and treatment of postpartum diseases of female farm and domestic animals.

 Known drug - furazolidone sticks, designed to prevent and treat inflammatory processes of various etiologies in the uterus, vagina and cervix in farm animals, made in the form of suppositories [1].

 A gelatin-glycerin base serves as a filler for these suppositories.

 The disadvantage of this drug is the lack of fungicidal action, while fungi play a significant role in the development of inflammatory processes in the genital organs of female agricultural and domestic animals. In addition, the disadvantage of these suppositories is their low activity, especially in terms of anti-inflammatory effect, which manifests itself in an increase in the duration of treatment and the mass of suppositories used to cure one animal [2].

 The closest in technological essence and the achieved effect is the drug, produced in the form of suppositories - "Prolevometrin", which we adopted as a prototype. The drug consists of a propolis extract with a solids content of 150 mg / kg, an antibiotic of chloramphenicol 0.25 g and as the basis of polyethylene glycol (PEG) [1].

 The disadvantage of this drug is the lack of fungicidal action and the presence of the antibiotic chloramphenicol. Antibiotics are known to have side effects: cause an allergic reaction, are immunosuppressants, and also have a toxic effect on the nervous system, blood, liver and other organs. The improper and unjustified use of antibiotics can lead to the emergence of antibiotic-resistant strains of pathogenic microbes [3].

 Moreover, antibiotics introduced into the uterine cavity, after 1-2 hours enter the milk, as a result of which during the entire course of treatment and after its completion for a long time (3-8 days) it can not be used in human food, equal to as well as dairy products prepared from it [4].

 The purpose of the invention is to increase the therapeutic and prophylactic effectiveness of suppositories by enhancing anti-inflammatory, bactericidal, as well as pronounced fungicidal effects in diseases of the genital organs of female agricultural and domestic animals.

 This goal is achieved by the fact that to the polyethylene glycol 400-1500, in the ratio (14. ..14.5%) :( 86 ... 85.5%), used as a filler for the manufacture of suppositories, a thick fraction of hazel obtained by dry sublimation of crushed wood in the amount of 1.75 ... 2.25%.

 For the manufacture of the above suppository for three years studied the microbial background in endometritis, cervicitis, vestibulo-vaginitis in various species of female agricultural and domestic animals.

 In microbiological studies of the genital organs of females, various strains of opportunistic bacteria and fungi of the genus Candida and Mucor were isolated, most of which were pathogenic and isolated in association.

 Subsequently, the sensitivity of bacterial and fungal strains isolated from the genital organs of sick females to the dense fraction of hazel obtained by dry sublimation of ground hazel wood was determined. It was found that this fraction has not only bactericidal, but also fungicidal action.

Suppositories are made as follows: polyethylene glycol 1500 is melted in a 10 liter reactor, after which, observing the ratio (14 ... 14.5%): (86 ... 85.5%), polyethylene glycol 400 is added to it. The hot mass is thoroughly mixed and cooled to a temperature of 60-70 ^o C.

Then a thick fraction of hazel in the amount of 1.75 ... 2.25% is introduced into the molten filler - polyethylene glycol and thoroughly stirred until a homogeneous state. The mass which has cooled down to 40-45 ^o С is poured into a duralumin socket made in such a way that when it is opened, one suppository is formed in each socket after cooling. Pre-forms are cooled in the refrigerator for 1 hour. Each suppository is packed in a plastic film, forming a package of 10 pieces.

 Ready-made suppositories are cylindrical sticks with a conical end, 80 mm long, 14 mm thick, 10 g for large animals, and 40 mm long, 10 mm thick, 5 g for small animals.

Suppositories are dense, elastic in texture, easily softened and melt at a temperature of a living organism (37-39 ^o С), brown color, specific smell.

Storage of the above suppositories is carried out in a dark place at a temperature of +2 ... + 10 ^o C for 12 months.

 Each series of gynecological suppositories is checked for the following indicators: appearance, color, smell, melting point, uniformity, average weight, authenticity, bactericidal and fungicidal activity.

 The proposed highly effective drug reduces the course of the inflammatory process, has a bactericidal and fungicidal effect in diseases of the genital organs of female agricultural and domestic animals, without irritating its mucous membrane.

Sources of information
1. Medicines for veterinary medicine. Directory. / Ed. F.G. Nabiev, R.N. Akhmadeeva. Part 2. Kazan, 2000.- P.348.

 2. Medicines in veterinary medicine. / Ed. Chervyakova, Evdokimova P.D., Vishner A.S. M .: Kolos, 1977.- S. 342.

 3. Epizootology with microbiology. / Ed. Bakulova I.A., Vedernikova V.A., Semenikhina A.S. M .: Kolos, 1997.- S. 55.

 4. Nezhdanov A.G. Environmental aspects of drug therapy for endometritis. // Materials of the All-Russian scientific conference on obstetrics, gynecology and biotechnology of animal reproduction. Voronezh, 1994.-S. 107-108.

Claims (1)

 Suppositories with anti-inflammatory and bactericidal action, containing the active substance and filler high and low molecular weight polyethylene glycol in the ratio (14-14.5%) :( 86-85.5%), characterized in that a thick fraction of the product is used as the active substance dry sublimation of hazel in the following ratio of components: a thick fraction of the product of dry sublimation of hazel 1.75-2.25%, the rest is filler.