RU2197975C2 - Biologically active supplement to food based on vegetable components for prophylaxis of pathological symptoms of climacteric syndrome - Google Patents

Abstract

FIELD: medicine, gynecology. SUBSTANCE: nutrient biologically active supplement comprises soybean flour and thyme, licorice and Leuzea carthamoides roots raw taken in the following ratio of components, wt.%: soybean flour, 99; raw of other components, 1. EFFECT: enhanced activity of product.

Description

 The invention relates to preventive medicine, namely to the development of biologically active food additives (BAA) containing plant elements with hormone-like properties belonging to such groups of chemical compounds as isoflavonoids, lignans, coumarins, in particular intended for the prevention of dishormonal pathological manifestations of menopause and postmenopausal syndrome in men and women.

 The invention can be used in preventive medicine, as well as in the technology of manufacturing food products (food industry) to create food additives that can be used as a means of restorative and normalizing hormonal status in the menopause.

 The greatest distribution in the treatment of menopausal syndrome is currently hormone therapy. Depending on the clinical manifestation of menopausal syndrome, “pure” estrogens and progestogens or combined estrogen-progestogen drugs may be indicated. In most cases, tablet “pure” estrogens are used, often in high doses and for a long time (up to 1 year or more). However, estrogen preparations have many side effects, including an increase in blood coagulability, an increase in the content of neutral fats in the blood, a violation of cholesterol metabolism and stagnation of bile, the development of peripheral edema, weight gain, increased blood pressure and with prolonged use can cause thrombophlebitis and thromboembolic complications, persistent arterial hypertension, obesity, cholelithiasis.

 Known methods for the prevention of pathological manifestations of menopausal syndrome in men and women associated with the use of adaptogenic drugs and immunomodulators that help increase the body's defenses (see, for example, patents RU 2125885 and RU 2114629).

 The disadvantage of using these tools is the inability to achieve the necessary effects of regulating metabolic processes that determine the occurrence of these pathological manifestations, and, in addition, when using these tools, it becomes necessary to take into account the individual sensitivity of the body that is predisposed to one or another hormonal disharmony, to the corresponding vitamin, hormonal or adaptogenic drug.

 Closest to the claimed invention is a preventive collection based on plant materials to reduce the manifestations of menopausal syndrome according to the patent of the Russian Federation 2125885. This collection contains the following ingredients, wt.%: Lemon balm leaves 7.0; root 10.0; nettle 3,5; motherwort herb 5.0; hop cones 10.0; hawthorn flowers 7.0; chamomile 6.0; mallow 12.5; mistletoe grass 6.5; rose hips 12.5; hibiscus flowers 15.0; bearberry leaves 5.0. The proposed fee is called "KMVEL".

 The disadvantage of this prophylactic is the impossibility of influencing the cause of menopause disorder, namely, a violation of the hormonal balance of the body, i.e. lack of targeted exposure. Such a collection only alleviates the condition and improves tolerance of unpleasant symptoms of menopause.

 The objective of the invention is the creation of an effective nutritional supplement for the prevention of dishormonal disorders that do not cause side effects, as well as the creation of active and targeted supportive agents for basic therapy of conditions associated with hormonal disorders.

 The problem is solved by the use of plant elements, which include biologically active substances - phytoestrogens that have an effect on the animal organism similar to the natural regulators of metabolic processes - hormones and thereby mediate a complex of effects that determine their above activity.

 Known plant elements, which contain substances with hormone-like properties, namely phytoestrogens, belonging to such groups of chemical compounds as isoflavonoids, lignans, coumarins, whose biological effect is manifested in the regulation of metabolic processes, similar to the action of hormones (see, for example: Bingham SA; Atkinson C; Liggins J. etc. - Phytoestrogens: where are we now? - Br J Nutr 1998 May; 79 (5): 393-406; Strom SS; Yamamura Y; Duphome CM etc. - Phytoestrogen intake and prostate cancer : a case-control study using a new database - Nutr Cancer 1999; 33 (1): 20-5). Effective doses of these substances with a hormone-like effect for humans are extremely small and are measured in micrograms.

 Plants were identified in which the content of substances belonging to such groups of chemical compounds as isoflavonoids, lignans, coumarins is highest. Soybeans belong to the group of chemical compounds such as isoflavonoids (Albertazzi P; Pansini F; Bottazzi M. Etc. - Dietary soy supplementation and phytoestrogen levels - Obstet Gynecol 1999 Aug; 94 (2): 229-31; Moyad MA / - Soy, disease prevention, and prostate cancer -Semin Urol Oncol 1999 May; 17 (2): 97-102).

 Food and medicinal plants that contain high levels of chemicals such as cumestans and lignans include thyme and licorice (Zava DT; Dollbaum CM; Blen M. - Estrogen and progestin bioactivity of foods, herbs, and spices.- Proc Soc Exp Biol Med, 1998 Mar; 217 (3): 369-78), as well as Leuzea (Kuzmitsky BB, Golubeva MB, Konoplya N.A. et al. - New possibilities for finding immunomodulators among compounds of steroid structure . - Pharmacology and Toxicology, 1990.- v. 53, 3. - pp. 20-21).

 Thus, it is proposed to create a new dietary supplement based on plant materials using soy flour, thyme, licorice roots and leuzea.

 With a common final effect, the mechanisms of action of these compounds are different. In addition, their content varies significantly in different plants. So, the highest level of isoflavonoids was found in soybeans, coumarins - in the left and licorice, lignans - in thyme. In addition, leuzea has a pronounced adaptogenic effect, and licorice has an immunomodulating effect. It was experimentally revealed that the combination of these plants, which exhibits complex hormonal, adaptogenic and immunomodulating effects, is most effective in the treatment and prevention of dishormonal pathological manifestations of menopause in men and women.

 Soybeans are currently widely used in dietary nutrition as a source of essential amino acids of non-animal origin, as a semi-finished product for the manufacture of mayonnaise, cheese, and meat substitute products. During cooking, the activity of phytohormones-isoflavonoids drops sharply. The use of soy flour, which has not been cooked, creates a good basis for a food supplement, being a source of essential acids, but at the same time this product also provides a source of phytoestrogens.

 Adding raw thyme, or licorice root, or leuzea, or any combination thereof, to soy flour in the following ratios, wt.%: Soybean flour - 99, dry extracts of the remaining components - 1; allows you to increase the effect of exposure and creates diversity when choosing a prophylactic agent in accordance with individual taste or allergic characteristics of the body. In this case, the daily intake of the supplement can be reduced to 30-40 g.

 The supplement is recommended for women during menopause and after it in case of problems, as well as for men over the age of 50.

 The manufacturing process of the additive is very simple and cheap, it does not require unique equipment. To prepare the additive, dried thyme and leuzea plants and licorice roots are ground to a homogeneous mass and added to soy flour in the appropriate proportion.

 The daily dose is 2 tablespoons (one in the morning and afternoon) dissolved in a glass of warm water. The duration of the supplement is 2 weeks - a month, followed by a break of 2 weeks - a month. The degree of effectiveness is determined by the duration of use.

 The proposed new biologically active food supplement of prophylactic action based on plant materials with a high content of phytohormones is highly effective in prevention and increases the effectiveness of treatment with other drugs.

 Raw materials for the manufacture of additives is cheap and affordable.

 The specified additive has no side effects on the body.

Claims (1)

 Biologically active food supplement for the prevention of pathological manifestations of menopausal syndrome based on plant elements, characterized in that it contains soy flour, dry extracts of thyme, licorice and levzea roots in the following ratio of components, wt.%: Soy flour 99, dry extracts of the remaining components - 1.