RU2195979C2 - Method for influencing bone tissue reparative regeneration - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves exposing bone defect zone to high frequency electromagnetic field in alternating two action units during the first days after operation. Each of the units is designed as resonance oscillation circuit and has inductance coil and capacitor connected in series. The first action unit has cylindrical inductance coil with detachable winding. The second action unit has flexible dielectric ribbon bearing M flat inductance coils which windings are connected in series and concordantly. When applying action, amplitude-modulated sinusoid signal which carrying frequency belongs to 100-1000 kHz and modulation frequency to 10-1000 kHz range is sent to action unit outputs. Two procedures of 15 min duration are administered daily. The first procedure is done by means of the first action unit and the second one with the second action unit. 3-5 ml of blood is taken from patient vein and 2-3 ml of calcium gluconate are injected into bone defect zone beginning from the seventh day after the operation. The procedures are administered three times a day every second day and then pause is taken for 7 days and the then the procedures are repeated. Preparations containing calcium salts are applied to skin beginning from the tenth day after the operation. Eight procedures are applied every second day and then the procedures are done daily during 25-30 days. EFFECT: enhanced effectiveness of treatment.

Description

 The stimulating effect of a weak electric current on bone tissue regeneration is known [1].

 Electrical stimulation increases the amount of adenosine triphosphoric acid, which is a universal source of biological energy in regenerating bone tissue, improves the energy supply of the healing process of bone wounds.

 A known method of influencing the reparative regeneration of bone tissue, which consists in the fact that the area of the bone defect is affected by alternating current in the frequency range of 0.4-120 Hz in the longitudinal direction [2]. The exposure is carried out using electrodes, so only the electric field acts on the area of the bone defect.

 The best results when stimulating bone tissue regeneration are obtained when exposed to an alternating electromagnetic field with a carrier frequency in the range of 100 - 1000 kHz, a modulated frequency in the range of 10 - 1000 Hz using an inductive emitter without galvanic contact with a biological object [3].

 The closest in essence and the resulting effect is a method of influencing bone tissue regeneration, the description of which is given in patent 2165272, cl. 7 A 61 N 2/04 [4].

 The known method of influencing bone tissue regeneration is carried out by repeatedly exposing the area of the bone defect in the postoperative period with an alternating electromagnetic field of high frequency through an exposure element.

 The impact is carried out in a non-contact way by placing a section with a bone defect in the radial longitudinal field of the winding of the inductor, to which a sinusoidal oscillation signal is supplied.

 This method is highly effective in osteosynthesis by the Ilizarov method, but has limited capabilities in the presence of a large bone defect.

 The objective of the invention is the expansion of capabilities by ensuring the formation of bone regenerate in the presence of a bone defect of large length.

 This is achieved by the fact that in the method of influencing the reparative regeneration of bone tissue, which consists in the fact that the area of the bone defect is affected by physical factors, according to the subject invention, from the first days after the operation, the area of the bone defect is affected alternately by two exposure elements. The role of the exposure element is played by an inductive emitter, which is an integral part of the oscillating circuit containing an additional capacitor connected in series with the emitter winding. The first inductive radiator forms a longitudinally radial electromagnetic field, the second inductive radiator forms a transverse electromagnetic field, an amplitude-modulated sinusoidal signal with a carrier frequency in the range of 100-1000 kHz and a modulation frequency in the range of 10-1000 Hz two procedures are carried out daily for a duration of 15 minutes each, the first procedure is carried out with an inductive radiator forming a longitudinal radial field, the second procedure is carried out with and from the 7th day after the operation, 3-5 ml of blood are taken from the patient’s vein from the vein of the transverse field, 2-3 ml of calcium gluconate is added and injected into the area of the bone defect, the procedure is carried out three times every other day, then a break is taken during 7 days and the procedure is repeated, from the 10th day after the operation, preparations with calcium salts are applied to the skin over the defect area, 8 procedures are performed every other day, the procedures are carried out daily for 25-30 days.

 The essence of the invention lies in the fact that during the formation of a bone regenerate in the area of the bone defect, the effect is carried out by exposing the area of the bone defect to an external electromagnetic high-frequency field formed by an amplitude-modulated sinusoidal signal with a carrier frequency in the range of 100 - 1000 kHz and a modulation frequency in the range of 10 - 1000 Hz. The exposure is carried out using two exposure elements, of which the first forms a longitudinally radial electromagnetic field, and the second transverse. The exposure is carried out alternately, initially using the first exposure element, and then using the second exposure element. To the procedure of electromagnetic stimulation of the separative process, additional medicinal procedures are carried out.

 The proposed method for the formation of bone regenerate is as follows.

 An operation is performed - closed osteosynthesis - with an external fixation device, followed by resection of the pathological bone area within healthy tissues. From the first days after the operation (3-4 days), an external influence element is installed on the bone resection zone, the role of which is played by the winding of the inductor, which is an integral part of the resonant oscillatory circuit. A cylindrical inductor is made with a detachable winding [5, 6]; an amplitude-modulated sinusoidal signal with a carrier frequency of 100 - 1000 kHz and a modulation frequency in the range of 10 - 1000 Hz is fed to the terminals of the exposure element. The frequency of the generator is equal to the resonant frequency of the oscillating circuit formed by the inductance of the coil winding and the capacitance of the capacitor connected in series with the winding. During the procedure, the modulation frequency changes (sways) in the range of 10 - 100 Hz. The swing period is 2-3 seconds. The duration of the procedure is 15 minutes, the current flowing through the oscillating circuit is not more than 7 μA. At the end of 15 minutes, the coil is removed. The above coil forms a longitudinal radial electromagnetic field. Then, a second exposure element is placed on the limb, which contains a flexible dielectric tape on which M flat coils are fixed, the windings of which are connected in series and according to [7].

 Each of the coils contains a solid dielectric frame in the form of petals arranged radially and with a gap, and a winding made in the form of a spiral. The wire of each coil of the winding alternately bends around all the petals, while from wire to coil the wire bends around one or the other side of each petal. The number of petals is odd. The exposure element also contains a capacitor connected in series with the winding. The impact element is wrapped around the limbs and secured. An amplitude-modulated sinusoidal signal with a carrier frequency in the range of 100-1000 kHz and a modulation frequency in the range of 100-1000 Hz is fed to the conclusions of the exposure element. The frequency of the generator is equal to the resonant frequency of the oscillatory circuit formed by the inductance of the windings of all the coils and the capacitance of the capacitor. During the procedure, the modulation frequency changes (sways) within 100 - 1000 Hz, the sweep period is 10-12 seconds. The duration of the procedure is 15 minutes. The current flowing through the oscillating circuit is not more than 7 μA. After the procedure, the emitter is removed from the limb of the patient. On the 7th day after surgery, 3-5 ml of blood is taken from the patient’s vein, 2-3 ml of calcium gluconate is added and injected into the area of the bone defect. The procedure is carried out every other day, three times. Then a break is taken for 7 days and the procedure is repeated. From the 10th day after the operation, preparations with calcium salts (calcium chloride, calcium gluconate) are applied to the skin over the resection zone. A tissue towel is moistened in a solution, laid on a limb and wrapped in plastic wrap, after which exposure elements are placed on the limb in turn. This procedure is carried out every other day. Stimulation is carried out within 25-30 days, depending on the bone defect. During the procedure, blood pressure and pulse are measured 15-20 minutes after the end of the procedure and every day following the procedure before the next session of exposure to the electromagnetic field. The proposed method allows to create the most optimal mode of formation of bone regenerate.

 The method was tested experimentally at the trauma unit of the Omsk city emergency hospital 2. Positive results were obtained.

Sources of information
1. V.A. Landa et al. On the question of the mechanism of the stimulating effect of electric current on the reparative regeneration of bone tissue. - Bulletin of experimental biology and medicine, 1978, 9, p. 361-362.

 2. Copyright certificate of the USSR 497021, cl. A 61 N 5/00, bull. 48, 1975

 3. W.R. Aidy. Frequency and energy windows when exposed to weak electromagnetic currents on living tissue. - TIIER, t. 68, 1, January 1980, p. 140-147.

 4. RF patent 2165272, cl. 7 A 61 N 2/04.

 5. RF patent 1772830, cl. H 01 F 17/02.

 6. RF patent 2103758, cl. H 01 F 17/02.

 7. Application for invention 99114818/14 from 07.07.99,

Claims (1)

 A method for influencing bone tissue regeneration, namely, that physical factors influence the region of the bone defect, characterized in that from the first days after the operation, the zone of the bone defect is exposed to the high-frequency electromagnetic field alternately with two exposure elements, each of the exposure elements is made in in the form of a resonant oscillatory circuit and contains inductance coil and capacitor connected in series, the first exposure element contains a cylindrical coil with a detachable winding, the second exposure element contains a flexible dielectric tape on which M flat inductors are fixed, the windings of which are connected in series and, when exposed to the terminals of the exposure element, an amplitude-modulated signal with a carrier frequency in the range of 100-1000 is supplied from the energy source kHz, modulation frequency in the range of 10-1000 Hz, two procedures are performed daily for 15 minutes each, the first procedure is carried out with the first exposure element, the second one t with the second exposure element, from the 7th day after the operation, 3-5 ml of blood are taken from the patient’s vein, 2-3 ml of calcium gluconate are added and injected into the area of the bone defect, the procedures are carried out three times a day, then take a break for 7 days and the procedure is repeated, from 10 days after the operation, preparations with calcium salts are applied to the skin over the defect zone, 8 procedures are performed every other day, the procedures are carried out daily for 25-30 days.