RU2180574C2 - An ointment to treat infected wounds - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: the method deals with treating purulent wounds by using an ointment which contains a biomass extract of red manure worms and red California worms of Eisenia foetidae type, and as an ointment base - polyethylenoxide 400 and 1500 obtained by melting at 35-41 C at the ratio of 7: 3. EFFECT: more cheaper preparation of higher activity, more available method to control biological activity of an ointment at the stage of industrial output. 1 tbl

Description

 The invention relates to medicine and can be used to treat purulent wounds.

Known ointment for the treatment of long non-healing wounds "Iruksol", including the microbial enzyme and lipophilic base when the content of components in 1 g of ointment:
Clostridiopeptidase A - 0.6 units
Chloramphenicol - 10 mg
Lipophilic base - Other
(Prospectus of the company "Pliva", Zagreb, Yugoslavia, "Iruksol").

 The use of Iruksol ointment in the treatment of long-term non-healing wounds is irrational for the following reasons: for large wounds, mandatory autodermoplasty is required, before using Iruxol ointment, it is necessary to excise necrotic tissues, which complicates its use, the ointment is not available for widespread use in surgical practice, since it is an expensive import agent (manufactured by the PLIVA company Yugoslavia in cooperation with the KNOLL company, Germany).

 The closest analogue to the proposed ointment is Vermin, a treatment for long-term non-healing wounds, containing an extract from biomass of red dung, red California worms of the species Eisenia foetidae and a hydrophobic fat-like base (patent 2119340, class A 61 K 35/56, 35/62 , 1998).

 The disadvantages of this tool are: as a basis, fat-like expensive substances of natural origin are used, in particular, lanolin and olive oil, and it is also difficult to extract the active principle from a fat base, which makes it difficult to control the ointment at the industrial production stage.

 The technical result consists in creating a cheaper drug with high activity and with the possibility of an affordable way to control the biological activity of the ointment at the stage of industrial production.

 The problem is solved by replacing an expensive natural fat base with a cheaper hydrophilic base. As a result, it is possible to implement affordable control by completely extracting the active principle into the aqueous phase.

 The invention consists in the following.

The ointment for the treatment of infected wounds contains biomass extract of red dung, red California worms of the species Eisenia foetidae, and polyethylene oxides as the ointment base in the following ratio of mass components, g:
Biomass extract of red dung, red California worms of the species Eisenia foetidae - 0.1-0.2
Polyethylene Oxides:
PEO - 400 - 70
PEO - 1500 - 29.9-29.8
Eisenia foetidae worms biomass extract is a protein preparation containing enzymes, immunomodulators, antibacterial components and repair factors.

PEO-400 - a viscous, transparent, colorless liquid, PEO-1500 - a solid substance with a melting point of 35-41 ^o C. They are highly soluble in water and ethanol, non-toxic, do not bind drugs, are physiologically indifferent, do not irritate tissues, are stable when storage, little sensitive to changes in pH, have a dehydrating effect. PEO-400 and PEO-1500 are cheap drugs approved for use in medicine (FS 42-1242-79) and commercially available by the domestic industry (Dzerzhinsk, Nizhny Novgorod Region, Kaprolactam JSC). By fusing PEO-400 with PEO-1500 at a temperature of 35-41 ^o C, a white polyethylene oxide gel is formed, a ointment-like consistency.

 The use of the biomass extract of worms allows you to act simultaneously on several factors of the wound healing process. Enzymes cleanse the wound of pus and non-viable tissue. Immunomodulators stimulate local immunity. The antibacterial component present in the extract substance inhibits the growth of pathogenic microflora. Repair factors contribute to wound healing and epithelization.

 The polyethylene oxide gel maintains a high activity of the substance, is non-toxic, does not have allergenic and mutagenic effects. An ointment based on a polyethylene oxide gel is cheap. Sufficient gross volumes of PEO-400 and PEO-1500 produced by the domestic industry make it possible to organize a cost-effective industrial production of highly active ointment for the treatment of infected wounds.

 For reference: the prices of 1 kg of PEO-400 and PEO-1500 are 12-13 rubles (in 1998 prices), which is almost 10 times cheaper than olive oil.

 The use of a polyethylene oxide gel as a carrier provides the possibility of simple aqueous extraction of a substance from an ointment and to obtain an extract that is easily amenable to biological activity control, which is provided for in the normative documentation in the technological process.

 Comparative results of studies of the effect of ointments on local immunity, assessed by the phagocytic activity of neutrophils in purulent wounds modeled on Wistar male rats in accordance with the “Methodological recommendations for experimental (preclinical) study of drugs for local treatment of purulent wounds” (Moscow, 1989), presented in the table.

 One ointment is made on the basis of lanolin and olive oil, the other on the basis of polyethylene oxide gel. The active principle in both cases is the biomass extract of the red California earthworm.

 As can be seen from the table, ointments containing biomass extract of red California earthworm are equally highly active in a purulent wound (with some advantage of ointments made on the basis of PEO-400 and PEO-1500).

 Thus, the proposed ointment, made on the basis of cheap domestic raw materials, has high biological activity and the possibility of its manufacture in an industrial way and can be recommended for the treatment of infected wounds.

Claims (1)

An ointment for the treatment of infected wounds, including biomass extract of red dung, California red worms of the species Eisenia foetidae and a base, characterized in that it contains a gel formed by fusing PEO-400 with PEO-1500 at a temperature of 35-41 ^o C in a ratio of 7 : 3, with the following mass ratio, g:
Biomass extract of red dung, red California worms of the species Eisenia foetidae - 0.1-0.2
Polyethylene Oxide-400 - 70
Polyethylene oxide-1500 - 29.9-29.8

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