RU2165757C1 - Treatment and prophylaxis means for treating young stock of agricultural animals and poultry - Google Patents

Abstract

FIELD: veterinary medicine. SUBSTANCE: means has, mas.%: tetracycline, 2.7-3.5; sulfadimidine, 7.5-8.5; thiamine bromide, 0.16-0.20; riboflavin, 0.051-0.062; ascorbic acid, 1.28-1.57; belotin, the balance. EFFECT: stimulated natural resistance factors, growth and development; accelerated arrival of physiological maturity. 5 tbl

Description

 The invention relates to veterinary medicine, relates to a composite agent and can be used for the prevention and treatment of pathologies of “open cavities” of calves, piglets, chickens of the gastrointestinal type (dyspepsia, gastroenterocolitis, colibacteriosis, salmonellosis, pasteurellosis, anaerobic dysentery) and respiratory (pneumonia, bronchopneum respiratory mycoplasmosis) diseases.

Diseases of young animals always proceed as general diseases with the defeat of the whole organism in a highly virulent form, as a rule, signs of acute gastrointestinal disorders are clinically manifested. The pathological state of an organism usually begins with a dysfunction or metabolic processes without the etiological participation of microorganisms, followed by the inclusion of microflora in the pathological process, which changes its properties, increases aggressiveness and virulence. The effectiveness of treatment and prevention is ensured by the intensity of the protective and restorative reactions while acting on the pathogen or association of pathogens. It is known that the overall resistance of newborns depends on the content of vitamins. In protection against infectious agents, the most important are vitamins A, group B (B ₆ , B ₃ , B _c , B ₂ ) and C, which, participating as a reversible redox system in the intermediate metabolism, has functional connections with the vitamins of the group B.

 The terravetin preparation for young farm animals containing oxytetracycline hydrochloride and glucose is already known (1).

 Also known is the drug rivicycline for young farm animals containing tetracycline, rifampicin and B vitamins (2).

Also known is the drug vitatetrin for young farm animals, containing tetracycline, B vitamins (B ₁ , B ₂ ) and vitamin C (3).

 All known drugs contain a tetracycline antibiotic in combination with another antibiotic and / or group B vitamins and vitamin C. A common disadvantage of known drugs is their lack of effectiveness due to the limited pharmacological effects and spectrum of antibacterial action.

The closest in technical essence to the claimed object is sulfatetrine, containing norsulfazole, tetracycline, thiamine bromide (vitamin B ₁ ), riboflavin (vitamin B ₂ ), ascorbic acid and fodder yeast as an additional source of vitamins and protein (4). Sulfatetrine is a universal therapeutic and prophylactic agent for young farm animals and poultry, which is used for gastrointestinal and respiratory diseases of calves, pigs and chickens. The therapeutic efficacy of sulfatetrin for gastrointestinal diseases is 90-95%, for respiratory diseases 92-97%, the preventive effectiveness is 80-85 and 82-86%, respectively. However, the stability of the drug is limited to 6 months.

 The purpose of the invention is the expansion of the arsenal of universal highly effective stable therapeutic agents with a composite formulation for young farm animals and poultry.

This goal is achieved by a therapeutic and prophylactic agent for young farm animals and poultry containing tetracycline, sulfadimesin, thiamine bromide (B ₁ ), riboflavin (B ₂ ), ascorbic acid and, as an additional source of B vitamins and protein, belotin.

 Belotin is a dry product obtained by microbiological processing of carbohydrate raw materials, containing at least 38% crude protein, 1.6% lysine and 1.3% methionine with cystine. Belotin is a mixture of inactivated biomass of non-pathogenic producer strains and residues of raw material processing and is intended for use as a protein feed mixture in feed for farm animals and poultry. In the table. 1 shows comparative characteristics of the main indicators of fodder yeast and belotin.

 Belotin is produced according to TU 9291-101-00479391-94 with rev. 1 (TU 9296-101-00479391-94).

In the claimed therapeutic agent tetracycline, sulfadimezin, thiamine bromide, riboflavin, ascorbic acid and belotin are taken in the following ratio, wt.%:
Tetracycline - 2.7-3.5
Sulfadimesin 7.5-8.5
Thiamine bromide - 0.16-0.20
Riboflavin - 0.051-0.062
Ascorbic acid - 1.28 -1.57
Belotin - Else
Optimum is the following ratio of components, wt.%:
Tetracycline - 3.43
Sulfadimezin - 8.0
Thiamine Bromide - 0.18
Riboflavin - 0.057
Ascorbic acid - 1.43
Belotin - Else
Therapeutic agent is used for gastrointestinal and respiratory diseases of calves, pigs, chickens. For therapeutic purposes - calves in a dose of 0.5-0.7, pigs - 0.4-0.5, chickens - 0.7-0.9 g / kg body weight 2 times a day daily until recovery, with a preventive purpose - 1 time per day for 2-3 days with gastrointestinal and 1-2 times a day for 5-20 days with respiratory diseases, calves and piglets at a dose of 0.2-0.3, chickens - 0.3- 0.5 g / kg body weight.

An analysis of the data in the scientific, technical and patent literature did not reveal a therapeutic and prophylactic agent for young farm animals and poultry with the claimed compositional formulation, which indicates compliance with the "novelty" criterion. The claimed therapeutic and prophylactic agent contains a highly effective composition of fundamentally different active principles - the antibiotic tetracycline and sulfanilamide - sulfadimezin, which are synergists, vitamins B ₁ , B ₂ , C and belotin as an additional source of B vitamins and protein, which helps to increase the body's resistance and eliminates development of side effects. As can be seen from the table. 1, Belotin contains almost all B vitamins, which are of primary importance for protection against infectious agents. So, vitamin B ₆ (420 mg / kg compared to 30.0 mg / kg in feed yeast) is involved in protein synthesis, vitamins B ₆ and B ₂ (161.4 mg / kg compared to 40.0 mg / kg in fodder yeast) are involved in phagocytosis, vitamin B (139.5 mg / kg compared to 60.0 mg / kg in fodder yeast) is necessary for the normal functioning of the adrenal glands, and it is known that a decrease in glucocorticosteroid synthesis negatively affects the body's defenses. Vitamin C has functional connections with group C vitamins, normalizes redox processes in the body, plays an important role in carbohydrate and protein metabolism, hormone synthesis, stimulates erythropoiesis and reticuloendothelial system, accelerates the formation of antibodies and has an antitoxic effect. The qualitative composition of the claimed funds provides a wide range of pharmacological effects, and the ratio of the components - the intensity of the action of ADV while ensuring harmlessness and eliminating side effects.

 In the table. 2 shows data on the stability of the claimed therapeutic and prophylactic agent, which was determined by samples of 3 series and evaluated by the following indicators: appearance, color; moisture content; quantitative content of components; toxicity (harmlessness in a test dose).

 The invention is illustrated by examples.

 Example 1. The rationale for therapeutic and prophylactic efficacy in gastrointestinal diseases of calves.

 On the farm, long-term unsuccessful due to diseases of newborn calves, 2 groups of clinically healthy calves aged 1-10 days were formed. The calves of both groups once a day for 3 days were used in the 1st group of the claimed therapeutic and prophylactic agent with the optimal ratio of components in the minimum prophylactic dose of 0.2 g / kg of live weight, in the 2nd group - sulfatetrin - in the maximum prophylactic dose of 0.3 g / kg live weight. In 1 group (25 goals) 2 calves fell ill (diagnosis - colibacillosis), in 2 group (28 goals) 4 calves fell ill (diagnosis: 1 calf - dyspepsia, 3 calf - colibacillosis). Preventive efficacy was 92 and 86%, respectively. Sick calves (symptoms: oppression, increased heart rate, respiration, dry nasal speculum, animal inactive, secretion of liquid feces mixed with casein) were treated with the same drugs. The calves of group 1 used the claimed agent at a dose of 0.7 g / kg live weight 2 times a day until clinical recovery. Calves of group 2 were used sulfatetrine at a dose of 0.7 g / kg body weight 2 times a day until clinical recovery. In group 1, normalization of the general condition was noted after an 8-fold giving of the drug, the period of the disease was 4 days. In group 2, normalization of the general condition in a calf with dyspepsia was noted after 9-fold giving of sulfatetrin, the period of illness was 4.5 days, in calves with colibacillosis after 10-fold giving of sulfatetrin, the period of pain was 5 days.

 In the table. Figure 3 shows the indicators of natural resistance of calves with gastrointestinal diseases before and after treatment.

 Example 2. The rationale for therapeutic and prophylactic efficacy in respiratory diseases of calves.

 In a long-term calf respiratory illness farm, 2 groups of clinically healthy calves aged 30-40 days were formed. Calves of both groups were used 2 times a day for 10 days in group 1 of the claimed therapeutic and prophylactic agent with an optimal ratio of components in the minimum prophylactic dose of 0.2 g / kg body weight, in group 2 - sulfatetrine in the maximum prophylactic dose of 0.3 g / kg live weight. In 1 group of 55 calves, 2 calves fell ill (diagnosis: pneumonia of mixed etiology), in 2 groups of 55 calves 5 calves fell ill (diagnosis: pneumonia of mixed etiology). The preventive efficacy in the groups was 96.4 and 90.9%, respectively.

 In the table. Figure 4 shows the indicators of natural resistance of calves in the groups before and after the course of prevention.

 Sick calves were treated with the same drugs at a maximum therapeutic dose of 0.7 g / kg body weight. The drugs were used 2 times a day until clinical recovery. In group 1, normalization of the general condition was noted after an 8-fold giving of the drug (the period of the disease was 4 days), in the 2nd group, after 10-fold giving (the period of the disease was 5 days).

 In the table. 5 shows indicators of natural resistance of calves before and after treatment.

 Example 3. The rationale for therapeutic and prophylactic efficacy in gastrointestinal diseases of piglets.

 Under the conditions of a pig farm unsuccessful for gastrointestinal diseases of piglets (colibacteriosis, salmonellosis and dysentery were recorded in different years), 2 groups of clinically healthy piglets of 30-35 days old were formed. Piglets of both groups 1 time per day for 3 days were used in group 1 of the claimed therapeutic and prophylactic agent with an optimal ratio of components in a dose of 0.3 g / kg live weight, in group 2 - sulfatetrine in a dose of 0.3 g / kg live weight . Signs of a gastrointestinal disease - fever, depression, refusal to feed, diarrhea, liquid feces with gray gas bubbles with a putrefactive odor - were noted in 1 group of 320 piglets in 24, in group 2 - out of 270 piglets in 21. According to the results laboratory tests diagnosed colibacteriosis. Sick piglets were treated in group 1 with the declared therapeutic and prophylactic agent, in group 2 - with sulfatetrin. The drugs were used 2 times a day until recovery at a dose of 0.5 g / kg body weight. In 1 group of 24 piglets, 23 recovered, 1 pig fell, the period of illness was 6.6 ± 0.6 days, therapeutic efficacy was 95.8%. In group 2 of 21 pigs, 19 recovered, 2 pigs died, the period of the disease was 7.8 ± 0.7 days, therapeutic efficacy was 90.5%.

 Example 4. The rationale for therapeutic and prophylactic efficacy in respiratory diseases of piglets.

 In the conditions of a pig farm unsuccessful for respiratory diseases of piglets of mixed virus-bacterial etiology, 2 groups of clinically healthy suckling pigs were formed. The piglets of both groups 2 times a day for 20 days were used in the 1st group of the claimed therapeutic and prophylactic agent with an optimal ratio of components at a dose of 0.3 g / kg live weight, in the 2nd group - sulfatetrine at a dose of 0.3 g / kg live weight . Signs of a respiratory disease - fever, loss of appetite, increased heart rate, cough, mucous and mucopurulent nasal discharge - were noted in 1 group of 151 pigs in 7 piglets, in group 2 - out of 147 in 14. Efficiency in groups was 95, 4 and 90.5%, respectively. Sick piglets were treated with the same drugs that were used 2 times a day until clinical recovery at a dose of 0.5 g / kg body weight. In 1 group of 7 piglets, all recovered, therapeutic efficacy was 100%, the period of illness was 8 days. In the 2nd group of 14 piglets, 13 piglets recovered, 1 piglet fell, therapeutic efficacy was 92.8%, the period of illness was 9 days.

 Example 5. The rationale for therapeutic efficacy in colibacteriosis of broiler chickens.

 In a poultry farm, after confirmation of the diagnosis of colibacteriosis, 2 groups of broiler chickens were formed. The chickens of both groups 2 times a day before recovery were used in the 1st group of the claimed therapeutic and prophylactic agent with an optimal ratio of components in a dose of 0.9 g / kg live weight, in the 2nd group - sulfatetrine in a dose of 0.9 g / kg live weight. In the 1st group of 13410 chickens, 13299 chickens recovered, therapeutic efficacy was 99.2%, and the period of illness was 5 days. In the 2nd group of 13,500 chickens, 12690 recovered, therapeutic efficacy was 94%, and the period of illness was 5 days.

 Studies conducted in the conditions of farms have confirmed the therapeutic and prophylactic effectiveness of the claimed agent in the gastrointestinal and respiratory diseases of young farm animals and poultry. It has been established that the use of the claimed agent provides stimulation of factors of natural resistance, against the background of which stimulation of growth and development occurs and as a result, the onset of physiological maturity is accelerated.

Sources of information taken into account:
1. Veterinary drugs / Handbook, ed. HELL. Tretyakova M .: Agropromizdat, 1985, p. 33.

 2. Veterinary medicine, 1993, N 6, p. 63.

 3. Veterinary drugs / Handbook, ed. HELL. Tretyakova M .: Agropromizdat, 1985, p. 31.

 4. Veterinary Medicine, 1991, N 11, p. 76-77 is a prototype.

Claims (1)

A therapeutic and prophylactic agent for young farm animals and poultry containing tetracycline, sulfanilamide, thiamine bromide, riboflavin, ascorbic acid and an additional source of B vitamins and protein, characterized in that it contains sulfadimesin as sulfanilamide, and as an additional source of group vitamins In protein Belotin in the following ratio, wt.%:
Tetracycline - 2.7 - 3.5
Sulfadimezin - 7.5 - 8.5
Thiamine bromide - 0.16 - 0.20
Riboflavin - 0.051 - 0.062
Ascorbic acid - 1.28 - 1.57
Belotin - Else

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