RU2165270C1 - Method for treating narcotic addiction - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves excluding drug consumption, alleviating abstinence syndrome by means of anesthesia carried out by inhaling oxygen and neutral gas xenon mixture in (50:50) + (30:70) proportion during 1-5 min 1-7 times a day within 5-7 days. Medical preparations are concurrently administered and the physiotherapy procedures and psychotherapy sessions are added. EFFECT: enhanced effectiveness of treatment. 1 tbl

Description

 The invention relates to narcology and anesthesiology and can be used in medical practice in the treatment of drug addictions, phantom pains and pains of a different genesis.

 Known methods for the treatment of drug addiction, including drug withdrawal and relief of withdrawal symptoms with the help of drugs, followed by physiotherapy and psychotherapy sessions [see, for example, Kiseleva L.T. et al. “Methods of stopping opium withdrawal syndrome with calypsol (ketamine)”, Siberian Bulletin of Psychiatry and Narcology, 1997, N 4 (6), p. 37-39; Materials of the scientific conference "Effects of prednisone in heroin addicts during drug withdrawal", Grodno, 1993, part II, p. 310-311; Shabanov P.D. "Guide to Addiction," 2nd ed., Ed. "Doe", 1999, etc.].

The disadvantages of the known methods are:
- The duration of relief of withdrawal symptoms (more than 7 days);
- the need to use large doses of drugs (such as atropine, clonidine, pyrroxan, butyroxan, naltrexone, naloxone, painkillers, tranquilizers, antipsychotics, antidepressants) metabolized in the liver;
- high morbidity due to the need for puncture of the great vessels.

 The closest in technical essence and the achieved result to the claimed invention is a method for the treatment of drug addiction (ultrafast opioid detoxification), including drug withdrawal, relief of withdrawal symptoms by anesthesia with the simultaneous use of drugs, subsequent physiotherapy and psychotherapy sessions. Moreover, after taking the drug, large doses of antagonists (naloxone, naltrexone) are administered to intensively remove exogenous opiates from the central nervous system and the body as a whole. Relief of the resulting withdrawal syndrome is carried out by traditional anesthetics by means of endotracheal anesthesia with mechanical ventilation for many hours (6-8 hours). If necessary, the necessary medications are used simultaneously with or before anesthesia (for example, to maintain heart function, suppress pathological autonomic reactions, etc.) [see Bugrov A.V., Tsimbalov S.G., "Ultrafast opioid detoxification." Medical file, World, 2000, N 1, p. 32].

The disadvantages of the prototype are:
- the duration of anesthesia (8 hours), requiring a subsequent long recovery period (more than 2 months);
- high morbidity due to the need for intubation of the patient and puncture of the great vessels;
- the need to use large doses of drugs and anesthetics that are metabolized in the liver;
- the need for treatment in a specially equipped department of anesthesiology with the involvement of a group of specialists due to possible complications of the patient's condition: the presence of sclerotic vessels, requiring either a puncture of the central veins or venesection; physiological features that prevent intubation; acute and chronic diseases, etc.

 The objective of the present invention is to reduce the morbidity, toxicity and treatment time of drug addiction.

 The problem is solved in that in the known method of treatment of drug addiction, including drug withdrawal, relief of withdrawal symptoms by anesthesia with the simultaneous use of drugs, subsequent physiotherapy and psychotherapy sessions, according to the invention, anesthesia is carried out by inhalation of a mixture of oxygen with an inert gas xenon in the ratio ( 50:50) - (30:70) for 1-5 minutes 1-7 times a day for 5-7 days.

 The implementation of the method of treatment of drug addiction in the claimed conditions using the relief of the proposed sub-narcotic dosages of anesthetic (oxygen + xenon) during relief of withdrawal symptoms leads to a reduction in treatment time (pain relief for 5-7 days with the exception of the subsequent recovery period with a total duration of anesthesia of about 4 hours) reduction in morbidity (exclusion of intubation and the need for puncture of the main veins) and toxicity (dose reduction or complete exclusion of some drugs metabolized in the liver).

 Analysis of the known technical solutions allows us to conclude that the claimed invention is not known from the level of the studied technology and, therefore, meets the criterion of novelty. "

 The essence of the invention for a specialist does not follow explicitly from the prior art, which allows us to conclude that it meets the criterion of "inventive step".

 The possibility of treating drug addiction in the conditions of the proposed method using industrially produced anesthetics indicates the compliance of the invention with the criterion of "industrial applicability".

 The inventive "Method for the treatment of drug addiction" has passed clinical trials in the clinics of the Military Medical Institute (Tomsk).

 When implementing the proposed method for inhalation, xenon was used, approved for use by the Ministry of Health of the Russian Federation as an anesthetic. Registered under N 99/363/4 and is included in the State Register of Medicines. Temporary pharmacopoeial article 42-2891-97 approved on 08.10.99.

 Example 1. Relief of withdrawal symptoms.

 Patient K., 20 years old, having heroin addiction after heroin use up to 1 g / day. for 2 years.

 After taking the drug, she had symptoms of withdrawal symptoms in the form of pain in the muscles and joints and pathological autonomic reactions (salivation, runny nose), general irritability.

 Anesthesia was performed by inhalation of a mixture of oxygen with an inert gas xenon at a ratio of (50:50) for 5 minutes, after which all symptoms of withdrawal symptoms disappeared and reappeared after 2 hours. This procedure was repeated 7 times on the first day, 5 times on the second day , on the third day - 3 times, on the fourth - 2 times and on the fifth day - 1 time. Moreover, the duration of the bright interval (without pain) increased from 4 hours at the end of the first day to a stable disappearance of pain by the end of the fifth day.

 At the same time, medications (sedatives and antidepressants) were used. After stable relief of withdrawal symptoms, traditional physiotherapy and psychotherapy sessions were carried out.

 In the conditions of example 1, the drug dependence of other patients was treated in examples 2-3 with varying conditions within the claimed limits.

 At the same time, drug addiction treatment was carried out under the conditions of the prototype method (see Bugrov A.V., Tsimbalov S.G., "Ultrafast opioid detoxification", Medical file, Mir, 2000, No. 1, p. 32).

 The conditions for the implementation of the methods and the results of the treatment of drug addiction are shown in the table.

Notes:
1. In the conditions of the prototype method, the “+” sign in the column “Injury” means intubation, puncture of the great vessels, prolonged deep anesthesia, etc. (see table).

 2. The table does not include information on the number of toxic drugs (antagonists) used in the prototype method, but not used in the claimed method.

As can be seen from the above examples and table data, the use of the proposed method for the treatment of drug addiction compared with the method taken as a prototype (see Bugrov A.V., Tsimbalov S.G., “Ultrafast opioid detoxification.” Medical file, Mir, 2000, ., N 1, p. 32), provides the following technical and socially useful advantages:
- reduction of treatment time (pain relief in 5-7 days with a total duration of anesthesia of about 4 hours and the exclusion of the subsequent recovery period);
- reduction in morbidity (exclusion of intubation and the need for puncture of the main veins);
- reduction of toxicity (dose reduction or complete exclusion of certain drugs metabolized in the liver).

Claims (1)

 A method of treating drug addiction, including taking the drug, relieving withdrawal symptoms by anesthesia with the simultaneous use of drugs, subsequent physiotherapy and psychotherapy sessions, characterized in that the anesthesia is performed by inhalation of a mixture of oxygen with an inert gas xenon at a ratio of (50: 50) - (30 : 70) vol.% For 1 to 5 minutes 1 to 7 times a day for 5 to 7 days.

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