RU2161507C1 - Method of disinfecting agent preparing - Google Patents

Abstract

FIELD: pharmaceutical industry. SUBSTANCE: invention relates to development of disinfecting and curative iodine-containing preparations. Method of preparing disinfecting agent is carried out by reaction of iodine chelating with products of copolymerization of ethylene and propylene oxides with C₁₂-C₁₄-alcohols fraction. Polyethylene oxide-400 is added to reaction mixture additionally. Components are taken in the following ratio, wt.-%: crystalline iodine, 10-15; copolymerization product, 50-60 and polyethylene oxide-400, 30-40. EFFECT: improved stability, decreased toxicity of preparation. 4 tbl, 1 ex

Description

 The invention relates to the pharmaceutical industry and for the creation of disinfectant and therapeutic iodine preparations.

 A number of drugs are known containing complex compounds of iodine with nonionic surfactants, and methods for their preparation.

 The best known method for producing iodinol is to mix an aqueous solution of iodine in potassium iodide with polyvinyl alcohol with a ratio of polyvinyl alcohol: iodine: potassium iodide: water 9-10: 1-1,2: 3-4: 1-7. The drug has antiseptic properties and is used as a therapeutic and disinfectant. However, the presence of potassium iodide significantly increases the cost of the drug.

There is also a method of producing iodine dextran complex, which consists in mixing iodine, potassium iodide and polyvinyl alcohol, keeping the mixture at room temperature for a day and then mixing it with an iron-dextran complex. The resulting mixture is heated with simultaneous sterilization at 100-120 ^o C for 60-80 minutes The purpose of the drug is the treatment of diseases associated with a lack of iodine and iron in animal organisms.

 The disadvantages of the drug can be considered a narrow range of its use and the inability to use it as a disinfectant.

 A known method of obtaining the drug iodophore, intended for the sanitary treatment of the udder of animals. To obtain the drug as a nonionic surfactant, water-soluble alkoxylated lanolin is used.

Closest to the proposed solution is a method for producing a disinfectant iodine (patent RU 2080079, 1997). According to the description of the specified tool is obtained by mixing crystalline iodine with the product of the copolymerization of ethylene oxide and propylene and alcohols fraction C ₁₂ -C ₁₄ 4. Iodine and copolymer are taken in the ratio (5-15): (95-85). The reaction is carried out at 34-42 ^o C for 2-24 hours. According to its effect on laboratory animals, iodine belongs to moderately hazardous compounds (hazard class III).

The LD _{50 of} iodine is 360 mg / kg (white mice). Iodez has a pronounced bactericidal effect against Staphylococcus aureus and Escherichia coli, has a disinfecting effect on various surfaces of equipment, indoor air, feed and animals themselves, and also affects the physiological state of animals.

 The main disadvantage of the described method is the instability of the resulting drug (a decrease in the content of active iodine during storage is 7-20%). In addition, the preparation of a preparation with a high iodine content requires long-term aging of iodine with a carrier - a copolymer.

In order to eliminate the above drawbacks, a disinfectant (called "pharmaiod" by the authors) is proposed - a complex compound of iodine with a carrier - a mixture of copolymerization products of ethylene and propylene oxides with a fraction of alcohols C ₁₂ -C ₁₄ and polyethylene oxide-400, taken in the ratio (60-90) : (40-10).

To obtain a product with a high content of active substance, the optimal composition of the product is proposed with the introduction of 10-15% crystalline iodine, 50-60% of the specified copolymerization product and 30-40% polyethylene oxide-400. In this case, the content of active iodine in the finished product is (10 ± 3)%. The stability of the drug increases by 7-10% compared with the drug iodine. To reduce the manufacturing time of the product, the reaction is carried out at 50-60 ^o C. The reaction is carried out for 2-3 hours

The introduction of polyethylene oxide-400 in the composition also helps to reduce its toxicity: LD ₅₀ is 584 mg / kg

Information confirming the possibility of carrying out the invention
Example 1

5.22 kg of copolymer were charged into a jacketed glass reactor with a mechanical stirrer. Then 1.3 kg of crystalline iodine was introduced with stirring, heating was turned on, and at 50-60 ^° C the mass was stirred until the particles of iodine disappeared (about two hours), after which 3.48 kg of polyethylene oxide-400 were added to the reaction mixture. The mixture was thoroughly mixed and allowed to cool to room temperature.

 The content of active iodine in the preparation was 10.8%.

 Table 1 shows the comparative characteristics of the iodine and farmayod preparations.

 The results of the study of the disinfecting activity of pharmaiod on various surfaces, as well as the study of the effectiveness of its disinfecting effect when treating the skin of the injection and surgical field, are presented in tables 2-4.

 It was found that the proposed composition based on iodine (pharmaiod) has a wide spectrum of antimicrobial as well as antiviral activity and can be used to disinfect surfaces at a concentration of 0.01% of the active substance (AI) for infections of bacterial and viral etiology. The most promising use of the drug for the treatment of skin is injection and surgical fields.

Claims (1)

A method of producing a disinfectant by a complexation reaction of iodine with a copolymerization product of ethylene and propylene oxides with a fraction of C ₁₂ - C ₁₄ alcohols, characterized in that polyethylene oxide-400 is introduced into the reaction mixture consisting of crystalline iodine and copolymerization product, while crystalline iodine, the copolymerization product and polyethylene oxide-400 are taken in the following ratio, wt.%:
Crystalline iodine - 10 - 15
The copolymerization product - 50 - 60
Polyethylene oxide-400 - 30 - 40

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