RU2141663C1 - Method of prognostication of frequent respiratory diseases in children - Google Patents
Method of prognostication of frequent respiratory diseases in children Download PDFInfo
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- RU2141663C1 RU2141663C1 RU98107710A RU98107710A RU2141663C1 RU 2141663 C1 RU2141663 C1 RU 2141663C1 RU 98107710 A RU98107710 A RU 98107710A RU 98107710 A RU98107710 A RU 98107710A RU 2141663 C1 RU2141663 C1 RU 2141663C1
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Изобретение относится к медицине, а именно к педиатрии, и может быть, в частности, использовано для прогнозирования повторных острых заболеваний у детей дошкольного возраста. The invention relates to medicine, namely to pediatrics, and can be, in particular, used to predict repeated acute diseases in preschool children.
Известен единственный аналог-прототип, сущность которого заключается в том, что проводится определение в пуповинной крови антигенов локусов A, B и C системы HLA и при наличии одного из антигенов HLA - A32, B21, B27 или их сочетания прогнозируют частые респираторные заболевания в раннем возрасте /1/. The only analogue prototype is known, the essence of which lies in the fact that the umbilical cord blood is determined for the antigens of the A, B and C loci of the HLA system and, in the presence of one of the HLA antigens - A32, B21, B27 or their combination, frequent respiratory diseases are predicted /1/.
Недостатком известного прототипа является то, что антигены HLA - A32, B21, B27 не позволяют прогнозировать частые респираторные заболевания у детей дошкольного возраста в соответствии с различной частотой встречаемости антигенов HLA в разных возрастных группах. A disadvantage of the known prototype is that HLA antigens - A32, B21, B27 do not allow prediction of frequent respiratory diseases in preschool children in accordance with the different frequency of occurrence of HLA antigens in different age groups.
Заявляемый способ прогнозирования частых респираторных заболеваний у детей дошкольного возраста является новым и в литературе не описан. The inventive method for predicting frequent respiratory diseases in preschool children is new and is not described in the literature.
В основу изобретения положена задача прогнозирования частых респираторных заболеваний у детей дошкольного возраста. The basis of the invention is the prediction of frequent respiratory diseases in preschool children.
Задача решена тем, что в заявляемом способе в крови определяют антигены локусов A, B и C системы HLA и при наличии одного из антигенов HLA - A3, B7, B12, Cw6 или их сочетания прогнозируют частые респираторные заболевания у детей в дошкольном возрасте. The problem is solved in that in the claimed method, antigens of loci A, B and C of the HLA system are determined in blood and, in the presence of one of the HLA antigens, A3, B7, B12, Cw6 or a combination thereof, frequent respiratory diseases in children at preschool age are predicted.
Согласно изобретению определение в крови одного из антигенов HLA - A3, B7, B12, Cw6 или их сочетания позволяет прогнозировать частые респираторные заболевания у детей в дошкольном возрасте, что необходимо для планирования профилактических мероприятий и тактики ведения ребенка. According to the invention, the determination in the blood of one of the HLA antigens - A3, B7, B12, Cw6, or a combination thereof, allows predicting frequent respiratory diseases in preschool children, which is necessary for planning preventive measures and tactics for managing a child.
Способ апробирован на 324 детях дошкольного возраста. Прогноз частых респираторных заболеваний у детей дошкольного возраста на основании обнаружения в крови антигенов HLA: A3, B7, B12, Cw6 - соответствовал истинной частоте острых заболеваний у детей данной группы. The method was tested on 324 preschool children. The prognosis of frequent respiratory diseases in preschool children based on the detection of HLA antigens in the blood: A3, B7, B12, Cw6 - corresponded to the true frequency of acute diseases in children of this group.
Пример 1. История родов 4105. Example 1. The history of childbirth 4105.
Ребенок 27.09.88 г. рождения. Иммуногенетический статус ребенка: A10, B7, Cw2. В возрасте трех лет у ребенка часто отмечались респираторные заболевания (6 случаев ОРЗ), диагностированы бронхопневмония и гастроэнтерит. В 4 года отмечены два случая острого респираторного заболевания, гнойный отит, ветряная оспа, острый бронхит. В пять лет - 3 случая острого респираторного заболевания, средний отит, ринотрахеит. Child 09/27/88 birth. Immunogenetic status of the child: A10, B7, Cw2. At the age of three years, the child often had respiratory diseases (6 cases of acute respiratory infections), bronchopneumonia and gastroenteritis were diagnosed. At 4 years old, two cases of acute respiratory disease, purulent otitis media, chickenpox, acute bronchitis were noted. At five years old - 3 cases of acute respiratory disease, otitis media, rhinotracheitis.
Пример 2. История родов 3974. Example 2. The history of childbirth 3974.
Ребенок 4.12.86 г. рождения. Иммуногенетический статус ребенка: A32, B7, B12, Cw6. В три года отмечены 3 случая острого респираторного заболевания. В 4 года - три случая острого респираторного заболевания, острый отит, острый фарингит, тонзиллит. В 5 лет - два случая острого респираторного заболевания, два случая обострения хронического тонзиллита. Child 4.12.86 year of birth. Immunogenetic status of the child: A32, B7, B12, Cw6. At three years, 3 cases of acute respiratory disease were noted. At 4 years - three cases of acute respiratory disease, acute otitis media, acute pharyngitis, tonsillitis. At 5 years - two cases of acute respiratory disease, two cases of exacerbation of chronic tonsillitis.
Пример 3. История родов 3930. Example 3. The history of childbirth 3930.
Ребенок 14.11.88 г рождения. Иммуногенетический статус ребенка: A3, B13, Cw6. В три года - пять случаев острого респираторного заболевания, конъюнктивит, бронхит. Child born on 11/14/88. Immunogenetic status of the child: A3, B13, Cw6. At three years old - five cases of acute respiratory illness, conjunctivitis, bronchitis.
Источник информации
1. Патент РФ 1801215, кл. G 01 N 33/48, 1991.Sourse of information
1. RF patent 1801215, cl. G 01 N 33/48, 1991.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU98107710A RU2141663C1 (en) | 1998-04-24 | 1998-04-24 | Method of prognostication of frequent respiratory diseases in children |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU98107710A RU2141663C1 (en) | 1998-04-24 | 1998-04-24 | Method of prognostication of frequent respiratory diseases in children |
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| RU2141663C1 true RU2141663C1 (en) | 1999-11-20 |
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| RU98107710A RU2141663C1 (en) | 1998-04-24 | 1998-04-24 | Method of prognostication of frequent respiratory diseases in children |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2204134C2 (en) * | 2001-03-13 | 2003-05-10 | Кладова Ольга Викторовна | Method for predicting postinflammatory fibrosis of respiratory pathways at relapsing stenosing laryngotracheitis (croup) and relapsing obstructive bronchitis in children |
| RU2297003C1 (en) * | 2006-03-27 | 2007-04-10 | Наталья Николаевна Усейнова | Method for predicting repeated illness frequency in early age children suffering from acute respiratory tract diseases |
| RU2305838C1 (en) * | 2006-04-12 | 2007-09-10 | Валерия Анатольевна Шовкун | Method for predicting repeated respiratory diseases occurrence in early age children subjected to frequent and prolonged acute respiratory diseases |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991011717A1 (en) * | 1990-02-05 | 1991-08-08 | The University Of British Columbia | Rapid immunoblot diagnosis of acute mycoplasma pneumoniae |
| EP0519720A1 (en) * | 1991-06-18 | 1992-12-23 | Sanwa Kagaku Kenkyusho Co., Ltd. | Immunoassay of human granulocyte elastase |
| US5455159A (en) * | 1988-04-04 | 1995-10-03 | Univ Johns Hopkins | Method for early detection of lung cancer |
| US5534411A (en) * | 1993-07-30 | 1996-07-09 | Oravax, Inc. | Monoclonal IgA antibody specific for respiratory syncytial virus, a hybridoma cell line that produces this antibody amd methods of using the antibody to diagnose RSV infection |
-
1998
- 1998-04-24 RU RU98107710A patent/RU2141663C1/en active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455159A (en) * | 1988-04-04 | 1995-10-03 | Univ Johns Hopkins | Method for early detection of lung cancer |
| WO1991011717A1 (en) * | 1990-02-05 | 1991-08-08 | The University Of British Columbia | Rapid immunoblot diagnosis of acute mycoplasma pneumoniae |
| EP0519720A1 (en) * | 1991-06-18 | 1992-12-23 | Sanwa Kagaku Kenkyusho Co., Ltd. | Immunoassay of human granulocyte elastase |
| US5534411A (en) * | 1993-07-30 | 1996-07-09 | Oravax, Inc. | Monoclonal IgA antibody specific for respiratory syncytial virus, a hybridoma cell line that produces this antibody amd methods of using the antibody to diagnose RSV infection |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2204134C2 (en) * | 2001-03-13 | 2003-05-10 | Кладова Ольга Викторовна | Method for predicting postinflammatory fibrosis of respiratory pathways at relapsing stenosing laryngotracheitis (croup) and relapsing obstructive bronchitis in children |
| RU2297003C1 (en) * | 2006-03-27 | 2007-04-10 | Наталья Николаевна Усейнова | Method for predicting repeated illness frequency in early age children suffering from acute respiratory tract diseases |
| RU2305838C1 (en) * | 2006-04-12 | 2007-09-10 | Валерия Анатольевна Шовкун | Method for predicting repeated respiratory diseases occurrence in early age children subjected to frequent and prolonged acute respiratory diseases |
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