RU2124356C1 - Method of treatment of patients with vegetal dystonia syndrome - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: method involves a conventional medicinal therapy in combination with additional administration of 200 ml ozonized physiological solution. The latter is administrated by intravenous route, by drops, each other day, for 4-6 procedures. Solution is treated preliminary for 20 min by passage ozone-oxygen mixture containing 600-1200 mcg/l ozone at the rate 1 l/min. Method can be used for complex therapy of patients with vegetal disorders. EFFECT: enhanced effectiveness of treatment. 1 tbl, 3 ex

Description

 The present invention relates to the field of nervous diseases and can be used in the complex treatment of patients with impaired autonomic nervous system.

 A known method of treating autonomic dystonia syndrome using tablet dosage forms of antidepressants and blockers, tranquilizers, vitamins [1].

 However, the achievement of a positive therapeutic effect is associated with the use of compositions of various drugs, the combined effect of which adversely affects the functioning of other body systems, leading to very serious complications.

 As a prototype, a method for the treatment of autonomic dystonia syndrome was selected, including the use of tablet dosage forms, intramuscular and intravenous infusion of drugs. For intravenous infusion, in particular, nicotinic acid, which has antiplatelet and antioxidant properties, improves microcirculation, is included in the treatment regimen [2].

 However, despite the widespread use in clinical practice, the known method of treating autonomic dystonia syndrome is ineffective.

 Therefore, the task of the invention is to increase the effectiveness of the treatment of autonomic dystonia syndrome.

 The problem is solved in that in the known method for the treatment of autonomic dystonia syndrome by conducting complex therapy, including the use of tablet forms, intramuscular and intravenous infusion of drugs, according to the invention, 200 ml of ozonized physiological saline is administered intravenously every other day for 4-6 procedures.

 Experience with the use of OFR shows that in order to achieve a favorable effect and eliminate negative effects on the patient, it is sufficient to administer an OFR in a volume of 200 ml every other day for 4-6 procedures. Moreover, when conducting less than 4 procedures to increase the effectiveness of treatment was not observed. More than 6 procedures are impractical.

 The sources of scientific and patent information did not reveal information on the treatment of autonomic dystonia syndrome by use in complex therapy for intravenous infusion of ozone.

 Therefore, the set of essential features, providing increased effectiveness of the treatment of autonomic dystonia syndrome in the proposed method, meets the criteria of patentability "novelty" and "technical level".

 Ozonation of physiological saline is carried out on a medical ozone generator (COM-1), operating on the principle of a barrier discharge. The device was developed at the GNIIRS (N. Novgorod).

 Immediately before the procedure, the physiological saline bottle is treated for 20 minutes, passing an ozone-oxygen mixture containing 600 - 1200 μg of ozone in 1 liter of mixture, at a speed of 1 l / min. A container with ozonized saline solution is fixed in a tripod, a disposable system for intravenous drip infusions is connected and the procedure is started with an infusion rate of 60 - 70 drops in 1 min.

 The proposed method was treated 97 patients with the syndrome of autonomic dystonia of permanent paroxysmal course. The average age of patients was 25.6 years. The average duration of the disease is 3.8 years. The leading manifestation of autonomic dysfunction in patients was autonomic crisis (VC). In the inter-crisis period, cephalgic, anxiety-depressive and asthenic syndromes were most often noted. The control group consisted of 23 patients who were injected with normal saline.

 The state of the autonomic nervous system after treatment was evaluated according to the questionnaire to identify signs of autonomic changes, the results of an objective examination, indicators of rheoencephalography, cardiointervalography, radiothermometry and bicycle ergometry. Reactive and personal anxiety was investigated using the Stilberg test. To objectify a headache, the digital scale method from 0 to 10 points was used, followed by the calculation of the "headache index". Before and after each procedure, blood pressure and pulse were measured. The data obtained were used to calculate the general hemodynamics indices (systolic and cardiac output, mean and dynamic pressure, and total peripheral resistance) using the formulas. In addition to paraclinical examination, a biochemical blood test was performed in all patients. It included the study of the intensity of luminescence of chemiluminescence, the determination of the content of primary (diene conjugates) and final (Schiff base) molecular products of lipid peroxidation (POL), as well as enzymes of the antioxidant defense system (superoxide dismutase and catalase).

 The results of a paraclinical examination of patients treated using the internal infusion method of ozonized physiological saline are presented in the table in comparison with the control group of patients in the complex treatment of which ozonotherapy was not used.

 As can be seen from the table data, the use of OFR reduces the activity of lipid peroxidation, increasing the effectiveness of antioxidant protection. In addition to membrane-stabilizing properties, FGM has a pronounced analgesic and anti-anxiety effect. Clinically, a decrease in the frequency and severity of vegetative crises is observed in patients, sleep is normalized, general health improves, including on days unfavorable by meteorological factors.

 Without significantly changing the state of cerebral blood flow, OGF has a normalizing parasympathetic effect on the state of autonomic tone during sympathicopia, reduces the deficit of peripheral vasoconstriction, optimizes the autonomic activity, improves thermoregulation. When using OFR, the degree of tension in the functioning of the regulatory systems of the body decreases, the protective and adaptive capabilities of the autonomic nervous system increase.

 Example 1

 Patient O., 37 years old, was admitted to the clinic of nervous diseases with complaints of recurrent attacks of severe headache, accompanied by numbness of the hands, shortness of breath, palpitations, and a sense of fear of death. He considers himself ill for about 1 year, when after a long psycho-emotional stress these complaints arose. Over the past month, seizures began to occur almost daily. In neurological status, revitalization of tendon reflexes, tremor of fingers of extended arms, soreness of paravertebral points in the cervical spine was found.

 Diagnosis: syndrome of autonomic dystonia of the psychophysiological nature of the paroxysmal course, sympathoadrenal crises.

 The patient underwent a course of complex treatment, including the use of picomilon, tincture of valerian, pyroxaen, B vitamins, massage of the cervical collar zone, and electric sleep. Along with this, 5 intravenous ozone therapy procedures were carried out according to the method described above every other day. After the second procedure, the patient’s well-being improved significantly, the severity of symptoms during the attack decreased, the feeling of fear of death was transformed into general anxiety, shortness of breath and palpitations stopped. After completing the course of ozone therapy and before the patient was discharged from the hospital, she only once developed an abortive vegetative crisis, which stopped on her own after 2 hours.

 Example 2

 Patient Sh., 21 years old, was admitted to the clinic of nervous diseases with complaints of general weakness, irritability, a feeling of “interruptions” in the work of the heart, expanding headaches in the parietooccipital region, attacks with a sense of fear of death, shortness of breath, increased headache that occur spontaneously 2 - 3 times a month, for 2 years. There are no focal symptoms in the neurological status, acrohyperhidrosis, red persistent.

Diagnosis: autonomic dystonia syndrome, hereditary constitutional in nature. Permanently paroxysmal course. Panic attacks. Along with traditional treatment (tazepam, bellataminal, vitamin B ₁₂ , aminophylline, anaprilin, exercise therapy, underwater shower - massage), the patient underwent a course of intravenous drip infusions of ozonized physiological saline in the amount of 6 procedures every other day. Directly during the procedures, the patient subjectively noted slight drowsiness, a pleasant feeling of coolness throughout the body, and a decrease in headache. By the end of the course of ozone therapy, the headaches stopped, the patient stopped complaining of “interruptions” in the work of the heart, his mood improved. There were no vegetative crises during their stay in the hospital.

 Example 3

 Patient S., 30 years old, was admitted to the clinic of nervous diseases with complaints of poor, intermittent sleep, poor health due to weather changes and days unfavorable for meteorological factors, short temper, constant internal stress, "internal stress", sweating, periodic compressive headaches . 5 years ago, the patient suffered a closed head injury (concussion), after which the above complaints began to be disturbed. In neurological status - revitalization of tendon reflexes, tremor of the eyelids, acrohyperhidrosis, blood pressure 150/90 mm RT. Art.

 Diagnosis: consequences of a closed head injury. The syndrome of autonomic dystonia of the permanent course with cephalgic and dissominal manifestations.

 The combination of basic drugs used to treat the patient included pyrroxen, corinfar, berlidorn, anaprilin, B vitamins, amitriptyline. From physiotherapy, circular douche, MFI, head massage were used. The course of ozone therapy, begun in the first days of the patient’s stay in the hospital, consisted of 5 procedures that were carried out every other day. After the third intravenous drip infusion of ozonized physiological saline, sleep normalized, which made it possible to refuse to take sleeping pills. After the fifth procedure, the patient herself noted a significant decrease in headache, an improvement in overall well-being, including on days unfavorable for meteorological factors, and a decrease in general anxiety. By the time the patient was discharged from the hospital, blood pressure had stabilized at 120-125/80 mmHg. Art.

Sources of information
1. Wayne A.M., Voznesenskaya T.G. et al. Diseases of the autonomic nervous system. M., 1991.

 2. Mashkovsky M.D. Medicines M .: Medicine, 1991.

Claims (1)

 A method for the treatment of autonomic dystonia syndrome by conducting complex therapy, including the use of tablet forms, intramuscular and intravenous infusion of drugs, characterized in that 200 ml of physiological saline, pre-treated for 20 minutes, is passed intravenously every other day for 4 to 6 procedures through it an ozone-oxygen mixture containing 600 - 1200 μg / l of ozone at a rate of 1 l / min.

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