RU2104029C1 - Method of preparing an agent showing regenerative activity - Google Patents

Abstract

FIELD: medicine, chemical-pharmaceutical industry. SUBSTANCE: method of cream preparing involves preparing cream base, active addition containing phytoextracts, amino acids and trace elements that is mixed with cream base at definite regime. The obtained agent provides nutrition and regeneration of skin and can be used at traumas. EFFECT: improved method of preparing.

Description

 The invention relates to medicine, in particular to methods for producing biologically active mixtures of substances and chemical elements used to restore (regenerate) the functions of the human body.

A known method [1] of obtaining a means having regenerative activity, based on the preparation of the base by pouring in the reactor heated to 65-75 ^o C drinking water, adding to it with constant stirring for 25-35 minutes high molecular weight fraction C ₁₇ -C ₂₇ , lanolin triethanolamine and by adding to this mixture mink oil, stearin and glycerol, stirring for 15-30 min, followed by cooling to 18-24 ^o C the resulting composition, as well as the subsequent filling the mixture into the above obtained water-spirtoglitserinovyh e straktov calamus root, plantain leaves, grass succession, hop pellet, lavender oil, cooling the resulting mixture.

 However, this method does not allow to obtain highly effective agents with increased regenerative activity, due to the lack of operations and separate mixing modes of ingredients, such as extract of calamus roots, lavender oil and other extracts, in the absence of a mixture of amino acids, macro- and microelements.

 The essence of the invention is based on ensuring the conditions for the efficient production of agents with increased biological activity and an extended therapeutic focus, which is achieved by separating the operations of creating intermediate mixtures involving exactly the extract of calamus roots separately from other extracts and lavender oil, but together with newly present amino acids, macro- and microelements under the necessary regimes and conditions for mixing the ingredients.

The essential features characterizing the invention and sufficient for all cases to which the requested legal protection applies are common with the prototype preparation of the base by pouring drinking water into the reactor and heating to 65-75 ^o C, adding to it with constant stirring for 25-35 m polyol fraction C ₁₇ -C _27, lanolin triethanolamine and by adding to this mixture mink oil, stearin and glycerol, stirring for 15-30 min, followed by cooling to 18-24 ^o C obtained from tava and distinctive from the prototype heating to 60-70 ^o C water-spirtoglitserinovogo calamus root extract amount of 2.7 wt. %, adding with constant stirring for 10-90 min a composition consisting of the following components, wt.%:
Alanine - 0.00175 - 0.00700
Arginine - 0.00075 - 0.00135
Aminobutyric acid - 0.0000005 - 0.000005
Aspartic acid - 0.0010 - 0.0025
Valine - 0.00015 - 0.00020
Histidine - 0.00075 - 0.00135
Glycine - 0.0125 - 0.0215
Glutamic acid - 0.00125 - 0.02350
Isoleucine - 0.00015 - 0.00050
Leucine - 0.00025 - 0.00070
Lysine - 0.000040 - 0.000550
Methionine - 0.00005 - 0.00009
Proline - 0.0006 - 0.0075
Serene - 0.0004 - 0.0007
Tyrosine - 0.00015 - 0.00025
Threonine - 0.00035 - 0.00075
Phenylalanine - 0.000200 - 0.000475
Cystine - 0.0005 - 0.0006
Aluminum - 0.00000197 - 0.00002150
Iron - 0.000006 - 0.000120
Potassium - 0.005000 - 0.033112
Calcium - 0.0008160 - 0.0086195
Silicon - 0.00000999 - 0.00008120
Lithium - 0.0000001640 - 0.0000011875
Magnesium - 0.0006495 - 0.0111945
Manganese - 0.00002656 - 0.00002915
Copper - 0.000000905 - 0.000007500
Molybdenum - 0.0000000105 - 0.0000008750
Sodium - 0.0012435 - 0.0364610
Nickel - 0.0000000845 - 0.0000023105
Sulfur - 0.00005 - 0.00050
Titanium - 0.000000119 - 0.000001170
Phosphorus - 0.0000102 - 0.0000964
Filler (starch) - 0.471389498 - 0.340231708
The filler is used in connection with the use of the finished mixture, in which it is necessary, for small amounts of components, to create physically sensible dose volumes, including when used independently in medical practice.

As well as cooling the resulting composition to 16-20 ^o C, settling at the same temperature for 22-24 hours, pouring the resulting mixture together with water-alcohol-glycerin extracts, wt.%:
Plantain Leaves - 3.4
Grass Streaks - 1.6
Hop shots - 3.0
a basis consisting of the following components, wt.%:
High molecular alcohol fraction C ₁₇ -C ₂₇ - 1,5
Lanolin - 1.5
Triethanolamine - 0.5
Drinking water - 70.3
with the addition, wt.%:
Mink oil - 6.0
Glycerin - 4.0
Stearin - 2.0
heating the resulting mixture to 43-47 ^o C, adding to it 3.0 wt.% lavender oil, stirring for 15-20 minutes and cooling to 18-24 ^o C.

Example 1. A powder mixture consisting of the following components, wt.%:
Alanine - 0.00175
Arginine - 0,00075
Aminobutyric acid - 0.0000005
Aspartic acid - 0.0010
Valine - 0.00015
Histidine - 0,00075
Glycine - 0.0125
Glutamic acid - 0.00125
Isoleucine - 0.00015
Leucine - 0,00025
Lysine - 0.00004
Methionine - 0.00005
Proline - 0,0006
Serene - 0.0004
Tyrosine - 0.00015
Threonine - 0,00035
Phenylalanine - 0,0002
Cystine - 0.0005
Aluminum - 0.00000197
Iron - 0.000006
Potassium - 0.005
Calcium - 0,000816
Silicon - 0.00000999
Lithium - 0.000000164
Magnesium - 0,0006495
Manganese - 0.00002656
Copper - 0.000000905
Molybdenum - 0.0000000105
Sodium - 0.0012435
Nickel - 0.0000000845
Sulfur - 0.00005
Titanium - 0.000000119
Phosphorus - 0.0000102
Filler - 0.471389498
gradually add to the pre-heated to 60 ^o C extract of calamus roots in an amount of 2.7 wt.%, constantly stirring 10 minutes, cool to 16 ^o C and stand for 22 hours at the same temperature. Thereby, an active supplement is obtained.

Next, the basis of the tool is prepared. To do this, pour 70.3 wt.% Drinking water into the reactor and heat it to 65 ^o C. With constant stirring, pour, wt.%:
High molecular alcohol fraction C ₁₇ -C ₂₇ - 1,5
Lanolin - 1.5
Triethanolamine - 0.5,
stirring 25 min until an emulsion is obtained.

After that, the fat base, wt.%:
Mink oil - 6.0
Glycerin - 4.0
Stearin - 2.0,
stirring for 15 minutes and cooling to 18 ^o C.

Then, the active additive is poured into the base of the product, extracts of plantain leaves 3.4 wt.%, Grass of a series of 1.6 wt.% And hop hops 3.0 wt.%, The mixture is heated to 43 ^o C, 3.0 is added to it wt.% lavender oil, stirred for 15 minutes and cooled to 18 ^o C, then filtered to obtain a homogeneous mass and checked consumer qualities according to the standard - density, color, aroma (smell), etc. Biological qualities (properties) of the product are checked periodically and based on customer reviews in accordance with the following examples of use.

Example 2. Powdered composition of the mixture consisting of the following components, wt.%:
Alanine - 0.007
Arginine - 0.00135
Aminobutyric acid - 0.000005
Aspartic acid - 0.0025
Valin - 0,0002
Histidine - 0.00135
Glycine - 0.0215
Glutamic acid - 0.0235
Isoleucine - 0.0005
Leucine - 0.0007
Lysine - 0,00055
Methionine - 0.00009
Proline - 0.0075
Serene - 0,0007
Tyrosine - 0,00025
Threonine - 0,00075
Phenylalanine - 0.000475
Cystine - 0,0006
Aluminum - 0.0000215
Iron - 0.00012
Potassium - 0.033112
Calcium - 0.0086195
Silicon - 0.0000812
Lithium - 0.0000011875
Magnesium - 0.0111945
Manganese - 0.00002915
Copper - 0.0000075
Molybdenum - 0.000000875
Sodium - 0.036461
Nickel - 0.0000023105
Sulfur - 0,0005
Titanium - 0.00000117
Phosphorus - 0.0000964
Filler (starch) - 0,340231708,
gradually add pre-heated to 70 ^o C extract of calamus roots in the amount of 2.7 wt.%, constantly stirring 90 minutes, cool to 20 ^o C and stand for 24 hours at the same temperature. Thereby, an active supplement is obtained.

Next, the basis of the tool is prepared. To do this, pour 70.3 wt.% Drinking water into the reactor and heat it to 75 ^o C. With constant stirring, pour in the water, wt.%:
High molecular weight alcohol fraction C17-C27 - 1.5
Lanolin - 1.5
Triethanolamine - 0.5
mixing for 35 minutes to obtain an emulsion.

Then add the fatty base to the basis of the product, wt.%:
Mink oil - 6.0
Glycerin - 4.0
Stearin - 2.0
stirred for 30 minutes and cooled to 24 ^o C.

In the resulting composition, the active ingredient obtained above is poured, extracts of plantain leaves 3.4 wt. %, herbs of a series of 1.6 wt.%, hop grains 3.0 wt. %, heat this mixture to 47 ^o C, add 3.0 wt.% lavender oil to it, mix it for 20 minutes, cool to 24 ^o C, filter to obtain a homogeneous mass and check the consumer properties of the product according to the standard - density, color, aroma (smell), etc. Biological qualities (properties) of the product are checked periodically and based on consumer feedback, similar to the examples of using the product below.

 Examples of using the tool.

 Example 1. Patient S. applied for a burn to the palm of his hand. The degree of burn is the second. After using the product in aerosol form for 10 days, 3 times a day, skin healing was achieved, usually carried out for 25-30 days using other methods and means of treatment, which confirms the increased biological activity of the product obtained in example 1.

 Example 2. Patient T. was treated with a cut in the middle depth of the thumb. After using the funds obtained in example 2, 3 times a day, the wound healed completely after 7 days, which was previously known by means and methods was achieved only in 15-20 days. This confirms the increased therapeutic activity of this drug.

 Example 3. Patient F. complained of periodically occurring itching of the skin of the hands, feet, neck of an allergic origin. The use of this agent in the aerosol form obtained according to example 1, when applied twice after 2-3 hours, completely stopped the itching for several days, while the known means and methods help the patient after a much longer time (5-7 hours), and sometimes even did not lead to the desired result.

 Examples of the use of this tool have confirmed the wide therapeutic focus of the external use of the product obtained by this method and its high biological activity, which reduces the process of restoring normal functioning of a person and his organs.

Claims (1)

A method of obtaining a means having regenerative activity, which consists in preparing the base by pouring into the reactor and heating to 65 - 75 ^o With drinking water, adding to it with constant stirring for 25 35 minutes high molecular weight fraction C _{1 7} - C _{2 7} , lanolin and triethanolamine, adding to the mixture mink oil, stearin and glycerol, stirring for 15 30 minutes and then cooled to 18 to 24 ^o C the obtained composition, characterized in that heated to 60 70 ^o C vodospirtoglitserinovy calamus root extract to t he 2.7 wt. add with constant stirring over 10 to 90 minutes a composition consisting of the following components, wt. Alanine 0.00175 0.007
Arginine 0.00075 0.00135
Aminobutyric acid 0.0000005 0.000005
Aspartic acid 0.0010 0.0025
Valine 0.00015 0.0002
Histidine 0.00075 0.00135
Glycine 0.0125 0.0215
Glutamic acid 0.00125 0.0235
Isoleucine 0.00015 0.0005
Leucine 0.00025 0.0007
Lysine 0.000040 0.00055
Methionine 0.00005 0.00009
Proline 0.0006 0.0075
Serine 0.0004 0.0007
Tyrosine 0.00015 0.00025
Threonine 0.00035 0.00075
Phenylalanine 0.000200 0.000475
Cystine 0.0005 0.0006
Aluminum 0.00000197 0.0000215
Iron 0.000006 0.00012
Potassium 0.0005000 0.033112
Calcium 0.0008160 0.0086195
Lithium 0.0000001640 0.0000011875
Silicon 0.00000999 0.0000812
Magnesium 0.0006495 0.0111945
Manganese 0.00002656 0.00002915
Copper 0.000000905 0.0000075
Molybdenum 0.0000000105 0.000000875
Sodium 0.0012435 0.036461
Nickel 0.0000000845 0.0000023105
Sulfur 0.00005 0.0005
Titanium 0.000000119 0.00000117
Phosphorus 0.0000102 0.0000964
Filler (starch) 0.471389498 0.340231708
cool the resulting composition to 16 20 ^o C, stand at the same temperature for 22 24 hours, pour the resulting mixture together with water-alcohol glycerin extracts, wt. Plantain Leaves 3.4
Grass String 1.6
Hop Shot 3.0
a basis consisting of the following components, wt. High molecular weight alcohol of fraction C _{1 7} C _{2 7} - 1.5
Lanolin 1.5
Triethanolamine 0.5
Drinking water 70.3
with the addition, wt. Mink Oil 6.0
Glycerin 4.0
Stearin 2.0
heat the mixture to 43 47 ^o C, add to it 3.0 wt. lavender oil, stirred for 15 20 minutes and cooled to 18 - 24 ^o C.